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  1. Article: An interview with Jerry Gurwitz. Interview by David Bates.

    Gurwitz, Jerry H

    Joint Commission journal on quality and patient safety

    2006  Volume 32, Issue 12, Page(s) 667–671

    MeSH term(s) Aged ; Awards and Prizes ; Geriatrics/standards ; Health Services Research ; Humans ; Medication Errors/prevention & control ; Nursing Homes/standards ; Polypharmacy ; Safety Management ; United States
    Language English
    Publishing date 2006-12
    Publishing country Netherlands
    Document type Interview
    ZDB-ID 1189890-2
    ISSN 1938-131X ; 1549-425X ; 1553-7250 ; 1070-3241 ; 1549-3741
    ISSN (online) 1938-131X ; 1549-425X
    ISSN 1553-7250 ; 1070-3241 ; 1549-3741
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  2. Article ; Online: COVID-19 vaccine hesitancy: Lessons from Israel.

    Gurwitz, David

    Vaccine

    2021  Volume 39, Issue 29, Page(s) 3785–3786

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Israel ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-05-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2021.05.085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ethical tradeoffs in SARS-CoV-2 vaccine development: Assuring fair availability for low-income countries.

    Gurwitz, David

    Vaccine

    2021  Volume 39, Issue 7, Page(s) 1027

    MeSH term(s) Biomedical Research ; COVID-19 ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; Viral Vaccines
    Chemical Substances COVID-19 Vaccines ; Viral Vaccines
    Language English
    Publishing date 2021-02-03
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2021.01.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Africa's reforestation: European Union and United States should step up.

    Gurwitz, David

    Nature

    2021  Volume 589, Issue 7840, Page(s) 19

    MeSH term(s) Africa ; Conservation of Natural Resources/economics ; Conservation of Natural Resources/methods ; Droughts/prevention & control ; European Union/economics ; Forestry/economics ; Forestry/organization & administration ; Global Warming/prevention & control ; Humans ; United States
    Language English
    Publishing date 2021-01-05
    Publishing country England
    Document type Letter
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-03642-1
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  5. Article ; Online: Artificial intelligence utility for drug development: ChatGPT and beyond.

    Gurwitz, David / Shomron, Noam

    Drug development research

    2023  Volume 85, Issue 2, Page(s) e22121

    Language English
    Publishing date 2023-10-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604587-x
    ISSN 1098-2299 ; 0272-4391
    ISSN (online) 1098-2299
    ISSN 0272-4391
    DOI 10.1002/ddr.22121
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  6. Article ; Online: Repurposing current therapeutics for treating COVID-19: A vital role of prescription records data mining.

    Gurwitz, David

    Drug development research

    2020  Volume 81, Issue 7, Page(s) 777–781

    Abstract: Since its outbreak in late 2019, the SARS-Cov-2 pandemic already infected over 3.7 million people and claimed more than 250,000 lives globally. At least 1 year may take for an approved vaccine to be in place, and meanwhile millions more could be infected, ...

    Abstract Since its outbreak in late 2019, the SARS-Cov-2 pandemic already infected over 3.7 million people and claimed more than 250,000 lives globally. At least 1 year may take for an approved vaccine to be in place, and meanwhile millions more could be infected, some with fatal outcome. Over thousand clinical trials with COVID-19 patients are already listed in ClinicalTrials.com, some of them for assessing the utility of therapeutics approved for other conditions. However, clinical trials take many months, and are typically done with small cohorts. A much faster and by far more efficient method for rapidly identifying approved therapeutics that can be repurposed for treating COVID-19 patients is data mining their past and current electronic health and prescription records for identifying drugs that may protect infected individuals from severe COVID-19 symptoms. Examples are discussed for applying health and prescription records for assessing the potential repurposing (repositioning) of angiotensin receptor blockers, estradiol, or antiandrogens for reducing COVID-19 morbidity and fatalities. Data mining of prescription records of COVID-19 patients will not cancel the need for conducting controlled clinical trials, but could substantially assist in trial design, drug choice, inclusion and exclusion criteria, and prioritization. This approach requires a strong commitment of health provides for open collaboration with the biomedical research community, as health provides are typically the sole owners of retrospective drug prescription records.
    MeSH term(s) Antiviral Agents/classification ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/virology ; Clinical Trials as Topic ; Data Mining ; Drug Repositioning ; Electronic Health Records ; Humans ; Retrospective Studies ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Time Factors
    Chemical Substances Antiviral Agents
    Keywords covid19
    Language English
    Publishing date 2020-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604587-x
    ISSN 1098-2299 ; 0272-4391
    ISSN (online) 1098-2299
    ISSN 0272-4391
    DOI 10.1002/ddr.21689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics.

    Gurwitz, David

    Drug development research

    2020  Volume 81, Issue 5, Page(s) 537–540

    Abstract: At the time of writing this commentary (February 2020), the coronavirus COVID-19 epidemic has already resulted in more fatalities compared with the SARS and MERS coronavirus epidemics combined. Therapeutics that may assist to contain its rapid spread and ...

    Abstract At the time of writing this commentary (February 2020), the coronavirus COVID-19 epidemic has already resulted in more fatalities compared with the SARS and MERS coronavirus epidemics combined. Therapeutics that may assist to contain its rapid spread and reduce its high mortality rates are urgently needed. Developing vaccines against the SARS-CoV-2 virus may take many months. Moreover, vaccines based on viral-encoded peptides may not be effective against future coronavirus epidemics, as virus mutations could make them futile. Indeed, new Influenza virus strains emerge every year, requiring new immunizations. A tentative suggestion based on existing therapeutics, which would likely be resistant to new coronavirus mutations, is to use available angiotensin receptor 1 (AT1R) blockers, such as losartan, as therapeutics for reducing the aggressiveness and mortality from SARS-CoV-2 virus infections. This idea is based on observations that the angiotensin-converting enzyme 2 (ACE2) very likely serves as the binding site for SARS-CoV-2, the strain implicated in the current COVID-19 epidemic, similarly to strain SARS-CoV implicated in the 2002-2003 SARS epidemic. This commentary elaborates on the idea of considering AT1R blockers as tentative treatment for SARS-CoV-2 infections, and proposes a research direction based on datamining of clinical patient records for assessing its feasibility.
    MeSH term(s) Angiotensin II Type 1 Receptor Blockers/pharmacology ; Angiotensin Receptor Antagonists/pharmacology ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus/genetics ; Betacoronavirus/isolation & purification ; Binding Sites ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; SARS-CoV-2
    Chemical Substances Angiotensin II Type 1 Receptor Blockers ; Angiotensin Receptor Antagonists ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604587-x
    ISSN 1098-2299 ; 0272-4391
    ISSN (online) 1098-2299
    ISSN 0272-4391
    DOI 10.1002/ddr.21656
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  8. Article ; Online: Genomics and the future of psychopharmacology: MicroRNAs offer novel therapeutics
.

    Gurwitz, David

    Dialogues in clinical neuroscience

    2019  Volume 21, Issue 2, Page(s) 131–148

    Abstract: MicroRNAs (miRNAs) are short, noncoding RNAs functioning as regulators of the transcription of protein-coding genes in eukaryotes. During the last two decades, studies on miRNAs indicate that they have potential as diagnostic and prognostic biomarkers ... ...

    Abstract MicroRNAs (miRNAs) are short, noncoding RNAs functioning as regulators of the transcription of protein-coding genes in eukaryotes. During the last two decades, studies on miRNAs indicate that they have potential as diagnostic and prognostic biomarkers for a wide range of cancers. Research interest in miRNAs has moved to embrace further medical disciplines, including neuropsychiatric disorders, comparing miRNA expression and mRNA targets between patient and control blood samples and postmortem brain tissues, as well as in animal models of neuropsychiatric disorders. This manuscript reviews recent findings on miRNAs implicated in the pathology of mood disorders, schizophrenia, and autism, as well as their diagnostic potential, and their potential as tentative targets for future therapeutics. The plausible contribution of X chromosome miRNAs to the larger prevalence of major depression among women is also evaluated.
.
    MeSH term(s) Brain/metabolism ; Gene Expression Regulation ; Genomics/trends ; Humans ; Mental Disorders/etiology ; Mental Disorders/genetics ; Mental Disorders/therapy ; MicroRNAs/genetics ; Neuronal Plasticity/genetics ; Psychopharmacology/methods ; Psychopharmacology/trends
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2019-10-21
    Publishing country France
    Document type Journal Article
    ZDB-ID 2188781-0
    ISSN 1958-5969 ; 1294-8322
    ISSN (online) 1958-5969
    ISSN 1294-8322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Whole-genome sequencing for combatting antibiotic resistance.

    Gurwitz, David

    Drug development research

    2018  Volume 80, Issue 1, Page(s) 3–5

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Drug Resistance, Microbial/drug effects ; Drug Resistance, Microbial/physiology ; Humans ; Whole Genome Sequencing/methods ; Whole Genome Sequencing/trends
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2018-12-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 604587-x
    ISSN 1098-2299 ; 0272-4391
    ISSN (online) 1098-2299
    ISSN 0272-4391
    DOI 10.1002/ddr.21496
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  10. Article ; Online: Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics

    Gurwitz, David

    Drug Development Research

    2020  Volume 81, Issue 5, Page(s) 537–540

    Keywords Drug Discovery ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 604587-x
    ISSN 1098-2299 ; 0272-4391
    ISSN (online) 1098-2299
    ISSN 0272-4391
    DOI 10.1002/ddr.21656
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