Article ; Online: Repurposing medicinal compounds for blood cancer treatment.
2015 Volume 94, Issue 8, Page(s) 1267–1276
Abstract: Drug development is being continuously scrutinised for its lack of productivity. Novel drug development is associated with high costs, high failure rates and lengthy development process. These downfalls combined with a huge demand in blood cancer for new ...
| Abstract | Drug development is being continuously scrutinised for its lack of productivity. Novel drug development is associated with high costs, high failure rates and lengthy development process. These downfalls combined with a huge demand in blood cancer for new therapeutic treatments have led many to consider the method of drug repurposing. Finding new therapeutic indications for already established drug substances is known as redirecting, repositioning, reprofiling, or repurposing of drugs. Off-patent and on-patent drugs can be screened for additional targets and new indications thus bringing them to clinical trials at a faster pace. This approach offers smaller research groups, such as those that are academic based, into the drug development industry. Drug repurposing can make use of previously published data concerning dosage, toxicology and mechanism of activity. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Animals ; Antineoplastic Agents/administration & dosage ; Benzamides/administration & dosage ; Drug Delivery Systems/methods ; Drug Delivery Systems/trends ; Drug Repositioning/methods ; Drug Repositioning/trends ; Hematologic Neoplasms/diagnosis ; Hematologic Neoplasms/drug therapy ; Humans ; Imatinib Mesylate ; Piperazines/administration & dosage ; Pyrimidines/administration & dosage ; Treatment Outcome | |||||
| Chemical Substances | Antineoplastic Agents ; Benzamides ; Piperazines ; Pyrimidines ; Imatinib Mesylate (8A1O1M485B) | |||||
| Language | English | |||||
| Publishing date | 2015-08 | |||||
| Publishing country | Germany | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 1064950-5 | |||||
| ISSN | 1432-0584 ; 0939-5555 ; 0945-8077 | |||||
| ISSN (online) | 1432-0584 | |||||
| ISSN | 0939-5555 ; 0945-8077 | |||||
| DOI | 10.1007/s00277-015-2412-1 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Uh III Zs.181: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.