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  1. Article: "How was tuberculosis known to the world?"

    Jain, Rashi

    The Indian journal of tuberculosis

    2020  Volume 67, Issue 4, Page(s) 456–458

    Abstract: Tuberculosis is a well-known disease in the Indian subcontinent. This disease always poses challenges in front of the clinician for its proper treatment. However, its discovery was equally challenging. It took a great effort of many clinicians after ... ...

    Abstract Tuberculosis is a well-known disease in the Indian subcontinent. This disease always poses challenges in front of the clinician for its proper treatment. However, its discovery was equally challenging. It took a great effort of many clinicians after which this disease was known to the world. History of tuberculosis is not only extensive but dramatic as well.
    MeSH term(s) Global Health ; History, 18th Century ; History, Ancient ; Humans ; Tuberculosis/epidemiology ; Tuberculosis/history ; Tuberculosis/therapy
    Language English
    Publishing date 2020-07-12
    Publishing country India
    Document type Historical Article ; Journal Article
    ZDB-ID 603129-8
    ISSN 0019-5707 ; 0019-5705
    ISSN 0019-5707 ; 0019-5705
    DOI 10.1016/j.ijtb.2020.07.011
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  2. Article ; Online: Diagnosis of extra pulmonary tuberculosis: An update on novel diagnostic approaches.

    Jain, Rashi / Gupta, Gopika / Mitra, D K / Guleria, Randeep

    Respiratory medicine

    2024  Volume 225, Page(s) 107601

    Abstract: Tuberculosis (TB) remains a major global public health problem worldwide. Though Pulmonary TB (PTB) is mostly discussed, one in five cases of TB present are extrapulmonary TB (EPTB) that manifests conspicuous diagnostic and management challenges with ... ...

    Abstract Tuberculosis (TB) remains a major global public health problem worldwide. Though Pulmonary TB (PTB) is mostly discussed, one in five cases of TB present are extrapulmonary TB (EPTB) that manifests conspicuous diagnostic and management challenges with respect to the site of infection. The diagnosis of EPTB is often delayed or even missed due to insidious clinical presentation, pauci-bacillary nature of the disease, and lack of laboratory facilities in the resource limited settings. Culture, the classical gold standard for the diagnosis of tuberculosis, suffers from increased technical and logistical constraints in EPTB cases. Other than culture, several other tests are available but their feasibility and effciacy for the detection of EPTB is still the matter of interest. We need more specific and precise test/s for the various forms of EPTB diagnosis which can easily be applied in the routine TB control program is required. A test that can contribute remarkably towards improving EPTB case detection reducing the morbidity and mortality is the utmost requirement. In this review we described the scenario of molecular and other noval methods available for laboratory diagnosis of EPTB, and also discussed the challenges linked with each diagnostic method. This review will make the readers aware of new emerging diagnostic techniques in the field of EPTB diagnosis. They can make an informed decision to choose the appropriate one according to the test availability, their clinical settings and financial considerations.
    MeSH term(s) Humans ; Tuberculosis/diagnosis ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Extrapulmonary ; Morbidity
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2024.107601
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  3. Article: Repurposing metocurine as main protease inhibitor to develop novel antiviral therapy for COVID-19.

    Jain, Rashi / Mujwar, Somdutt

    Structural chemistry

    2020  Volume 31, Issue 6, Page(s) 2487–2499

    Abstract: The outbreak of severe acute respiratory syndrome coronavirus-2 is causing a serious disaster through coronavirus disease-19 (COVID-19) around the globe. A large segment of the population from every corner of the world is already infected with this ... ...

    Abstract The outbreak of severe acute respiratory syndrome coronavirus-2 is causing a serious disaster through coronavirus disease-19 (COVID-19) around the globe. A large segment of the population from every corner of the world is already infected with this dreadful pathogen with a high mortality rate. These numbers are increasing drastically causing a situation of a global pandemic. Although after the continuous scientific efforts, we are still not having any specific drug or vaccine for the SARS-CoV-2 pathogen to date and there is an urgent need to develop a newer therapy to counter the COVID-19 global pandemic. Thus, in the current study, a framework for computational drug repurposing is established, and based on their safety profile, metocurine was chosen as a safe and effective drug candidate for developing therapy against the viral Mpro enzyme of SARS-CoV-2 for the treatment of COVID-19.
    Keywords covid19
    Language English
    Publishing date 2020-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2018832-8
    ISSN 1572-9001 ; 1040-0400
    ISSN (online) 1572-9001
    ISSN 1040-0400
    DOI 10.1007/s11224-020-01605-w
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  4. Article ; Online: Modified NAP test: A simple and Responsive Nitrosating Methodology for Risk Evaluation of NDSRIs.

    Sharma, Nitish / Patel, Rashi / Bothara, Tejaswini / Jain, Sonali / Shah, Ravi P

    Journal of pharmaceutical sciences

    2023  Volume 112, Issue 5, Page(s) 1333–1340

    Abstract: N-Nitroso compounds have been listed as one of the cohorts of concern as per ICH M7. In recent years, the regulatory focus has shifted from common nitrosamines to nitroso-impurities of drug products. Thus, the detection and quantification of unacceptable ...

    Abstract N-Nitroso compounds have been listed as one of the cohorts of concern as per ICH M7. In recent years, the regulatory focus has shifted from common nitrosamines to nitroso-impurities of drug products. Thus, the detection and quantification of unacceptable levels of nitrosamine drug substance-related impurities are of great concern for analytical scientists during drug development. Moreover, risk assessment of nitrosamines is also an essential part of the regulatory filling. For risk assessment, the Nitrosation Assay Procedure suggested by WHO expert group in 1978 is being followed. However, it could not be adopted by the pharmaceutical industries due to the limitation of drug solubility and artefact formation in the test conditions. In this work, we have optimized an alternative nitrosation test to investigate the likelihood of direct nitrosation. The technique is simple, where the drug solubilized in an organic solvent is incubated at 37°C with a nitrosating agent named tertiary butyl nitrite in a 1:10 molar ratio. LC-UV/MS-based chromatographic method was developed to separate drug substances and respective nitrosamine impurities using the C18 analytical column. The methodology was successfully tested on five drugs with varying structural chemistry. The procedure is straightforward, effective, and quick for the nitrosation of secondary amines. This modified nitrosation test and WHO prescribed nitrosation test have been compared and found that the modified methodology is more effective and time-saving.
    MeSH term(s) Nitrosamines ; Nitroso Compounds ; Amines/chemistry ; Nitrosation
    Chemical Substances Nitrosamines ; Nitroso Compounds ; Amines
    Language English
    Publishing date 2023-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2023.02.024
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  5. Article ; Online: Overall and Event Free Survival of Childhood Cancer - Report From a Hospital-based Cancer Registry in Northern India, 2013-21.

    Arora, Ramandeep Singh / Kumari, Rashmi / Adhana, Arun / Tripathi, Rashi / Sachdev, Mansi / Jain, Prachi

    Indian pediatrics

    2023  Volume 60, Issue 7, Page(s) 531–536

    Abstract: Objective: Using data from a hospital-based cancer registry (HBCR) in the private sector in Northern India, we provide overall survival (OS) and event-free survival (EFS) for childhood cancer patients.: Methods: All newly diagnosed childhood (age <18 ...

    Abstract Objective: Using data from a hospital-based cancer registry (HBCR) in the private sector in Northern India, we provide overall survival (OS) and event-free survival (EFS) for childhood cancer patients.
    Methods: All newly diagnosed childhood (age <18 years) cancer patients in our HBCR registered between March 1, 2013 till July 31, 2021 were eligible. 3-year and 5-year OS (death was an event), EFSc (death, progression/relapse was an event), and EFSa (death, progression/relapse, abandonment of treatment was an event) were calculated using the Kaplan-Meier method. Regression analysis was done to see their association with demographic, diagnostic and treatment variables.
    Results: 705 newly diagnosed children (36.2% female) with cancer were registered. Common cancers were leukemias (26%), CNS tumors (20%) and bone tumors (16%). 202 (28.6%) had experienced an event at median follow up of 1.95 years (range 0-8.14 years), which included 23 (3.3%) who abandoned treatment. The 3-year OS, EFSc, EFSa were 70.8%, 64.4% and 63.6%, respectively. Correspondingly, 5-year OS, EFSc, EFSa were 66%, 58.6% and 57.5%, respectively. There was no significant difference by age group, gender, nationality, and if cancer directed treatment initiated elsewhere. The OS, EFSa and EFSc by the main and the extended International Childhood Cancer Classification categories varied significantly (P<0.001).
    Conclusion: We add more recent registry-based OS data on childhood cancer in India and present the first estimates on EFS.
    MeSH term(s) Child ; Humans ; Female ; Adolescent ; Male ; Neoplasms/epidemiology ; Neoplasms/therapy ; Progression-Free Survival ; Retrospective Studies ; Hospitals ; Registries ; Recurrence ; Disease-Free Survival
    Language English
    Publishing date 2023-02-20
    Publishing country India
    Document type Journal Article
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
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  6. Article ; Online: Repurposing metocurine as main protease inhibitor to develop novel antiviral therapy for COVID-19

    Jain, Rashi / Mujwar, Somdutt

    Structural Chemistry ; ISSN 1040-0400 1572-9001

    2020  

    Keywords Physical and Theoretical Chemistry ; Condensed Matter Physics ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s11224-020-01605-w
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: A Comparative Evaluation of Xylitol Chewing Gum and a Combination of IgY + Xylitol Chewable Tablet on Salivary

    Jain, Rashi L / Tandon, Sandeep / Rai, Tripti S / Mathur, Rinku / Soni, Kamal K / Rawat, Manju

    International journal of clinical pediatric dentistry

    2022  Volume 15, Issue Suppl 2, Page(s) S212–S220

    Abstract: ... the : How to cite this article: Jain RL, Tandon S, Rai TS, ...

    Abstract Aim: The study was designed for evaluation and comparison of the efficacy of Xylitol chewing gum and a combination of IgY + Xylitol chewable tablet (Nodecay
    Materials and methods: About 120 children belonging to 6-12 years age-group were enrolled into this "double-blind randomized control clinical trial" according to the selection criteria. They were randomly assigned to three groups of 40 each: Group I-Xylitol chewing gum, Group II-IgY + Xylitol Chewable tablet (Nodecay
    Result: There was a "significant" difference in the number of "
    Conclusion: The combination of IgY + Xylitol (Nodecay
    Clinical significance: Passive immunization with immunoglobulin Y is known not only to decrease the
    How to cite this article: Jain RL, Tandon S, Rai TS,
    Language English
    Publishing date 2022-05-24
    Publishing country India
    Document type Journal Article
    ISSN 0974-7052
    ISSN 0974-7052
    DOI 10.5005/jp-journals-10005-2162
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  8. Article ; Online: Sarcoidosis: an orphan disease needs to be adopted.

    Jain, Rashi / Mohan, Anant / Kumari, Rinkee / Guleria, Randeep

    Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG

    2019  Volume 36, Issue 1, Page(s) 89–90

    MeSH term(s) Diffusion of Innovation ; Humans ; Prevalence ; Prognosis ; Rare Diseases/diagnosis ; Rare Diseases/epidemiology ; Rare Diseases/therapy ; Sarcoidosis/diagnosis ; Sarcoidosis/epidemiology ; Sarcoidosis/therapy
    Language English
    Publishing date 2019-05-01
    Publishing country Italy
    Document type Letter
    ZDB-ID 1339192-6
    ISSN 2532-179X ; 1124-0490
    ISSN (online) 2532-179X
    ISSN 1124-0490
    DOI 10.36141/svdld.v36i1.6953
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  9. Article: Exploring the molecular underpinning of psoriasis and its associated comorbidities through network approach: cross talks of genes and pathways.

    Choudhary, Saumya / Khan, Noor Saba / Verma, Rashi / Saxena, Pallavi / Singh, Harpreet / Jain, Arun Kumar / Thomas, George / Pradhan, Dibyabhaba / Kumar, Neeraj

    3 Biotech

    2023  Volume 13, Issue 5, Page(s) 130

    Abstract: Patients with psoriasis often complain of several linked disorders including autoimmune and cardiometabolic diseases. Understanding of molecular link between psoriasis and associated comorbidities would be of great interest at the point of patient care ... ...

    Abstract Patients with psoriasis often complain of several linked disorders including autoimmune and cardiometabolic diseases. Understanding of molecular link between psoriasis and associated comorbidities would be of great interest at the point of patient care management. Integrative unbiased network approach, indicates significant unidirectional gene overlap between psoriasis and its associated comorbid condition including obesity (31 upregulated and 26 downregulated), ischemic stroke (14 upregulated and 2 downregulated), dyslipidaemia (5 upregulated, 5 downregulated), atherosclerosis (8 upregulated and 1 downregulated) and type II diabetes (5 upregulated, 5 downregulated). The analysis revealed substantial gene sharing among the different psoriasis-associated comorbidities. Molecular comorbidity index determining the strength of the interrelation between psoriasis and its comorbidities indicates prevalence of dyslipidaemia followed by type II diabetes among psoriasis patients. The Jaccard coefficient indices revealed psoriasis shared maximum number of biological pathways with dyslipidaemia followed by type 2 diabetes, ischemic stroke, obesity and atherosclerosis. Moreover, pathway annotation highlighted nearly 45 shared pathways amongst psoriasis and its comorbidities and a substantial number of shared pathways was found among multi-morbidities. Overall, the present study established conceivable link between psoriasis and comorbid diseases. The shared genes and overlapped pathways may be explored as a common productive target for psoriasis and its comorbid conditions.
    Supplementary information: The online version contains supplementary material available at 10.1007/s13205-023-03533-y.
    Language English
    Publishing date 2023-04-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-023-03533-y
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  10. Article ; Online: T-cell signature cytokines distinguish pulmonary sarcoidosis from pulmonary tuberculosis.

    Jain, Rashi / Kumari, Rinkee / Chakraborty, Sushmita / Mitra, Dipendra K / Mohan, Anant / Hadda, Vijay / Madan, Karan / Guleria, Randeep

    European journal of immunology

    2023  Volume 53, Issue 10, Page(s) e2250255

    Abstract: Sarcoidosis is a systemic inflammatory disorder characterized by tissue infiltration due to mononuclear phagocytes and lymphocytes and associated noncaseating granuloma formation. Pulmonary sarcoidosis (PS) shares a number of clinical, radiological, and ... ...

    Abstract Sarcoidosis is a systemic inflammatory disorder characterized by tissue infiltration due to mononuclear phagocytes and lymphocytes and associated noncaseating granuloma formation. Pulmonary sarcoidosis (PS) shares a number of clinical, radiological, and histopathological characteristics with that of pulmonary tuberculosis (PTB). Due to this, clinicians face issues in differentiating between PS and PTB in a substantial number of cases. There is a lack of any specific biomarker that can diagnose PS distinctively from PTB. We compared T-cell-based signature cytokines in patients with PS and PTB. In this study, we proposed a serum biomarker panel consisting of cytokines from cells: T helper (Th) 1 [interferon-gamma (IFN-γ); tumor necrosis factor-alpha (TNF-α)], Th9 [interleukin (IL)-9], Th17 [IL-17], and T regulatory (Treg) [IL-10; transforming growth factor-beta (TGF-β)]. We performed the principal component analysis that demonstrated that our serum cytokine panel has a significant predictive ability to differentiate PS from PTB. Our results could aid clinicians to improve the diagnostic workflow for patients with PS in TB endemic settings where the diagnosis between PS and PTB is often ambiguous.
    MeSH term(s) Humans ; Cytokines ; Sarcoidosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/diagnosis ; Interferon-gamma ; Tumor Necrosis Factor-alpha ; Biomarkers
    Chemical Substances Cytokines ; Interferon-gamma (82115-62-6) ; Tumor Necrosis Factor-alpha ; Biomarkers
    Language English
    Publishing date 2023-07-28
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202250255
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