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Article: Antenatal Screening for Toxoplasmosis and Rubella in Saudi Arabia: Assessing the Need for Screening.

Al-Mughales, Jamil / Al-Rabia, Mohammed W

2023 Volume 16, Page(s) 3897–3905

Abstract: Objective: Antenatal screening programs are highly recommended to limit maternal and neonatal infections such as toxoplasmosis and rubella. This study aimed to assess the seroprevalence of maternal toxoplasma and rubella among pregnant women tested ... ...

Abstract	Objective: Antenatal screening programs are highly recommended to limit maternal and neonatal infections such as toxoplasmosis and rubella. This study aimed to assess the seroprevalence of maternal toxoplasma and rubella among pregnant women tested during antenatal screening at the King Abdulaziz University Hospital, Saudi Arabia. Methods: This descriptive cross-sectional study targeted pregnant women attending the King Abdulaziz University Hospital, Jeddah, Saudi Arabia, during the period of 2019-2022 for antenatal follow-up. This study included 3653 pregnant women who attended an antenatal screening. The clinical consequences of pregnancy were evaluated and categorized into six main categories based on the related complications and comorbidities of the pregnant women. The data were analyzed using the SPSS program as a descriptive statistic, and an ANOVA was used to test the associations. Results: The study findings showed that 12% of women were seropositive for toxoplasmosis and 71.4% were seropositive for rubella, and it found that almost all women (except two) were seronegative for Toxo IgM (immunoglobulin M) and rubella IgM, which indicates the absence of recent infections during the pregnancy. Approximately 19% and 4% of women who had no comorbidities experienced complicated pregnancies and delivery, respectively. Moreover, 1.3% of the pregnant women had comorbidities, complicated pregnancies, and problems during delivery. The mean Toxo IgG level was significantly higher in women with normal pregnancies than in those with other pregnancies. Rubella immunoglobulin levels did not significantly correlate with pregnancy or delivery problems. Conclusion: The seropositivity prevalence of toxoplasma Ig M and rubella Ig M were very low at the King Abdulaziz University Hospital, Saudi Arabia, indicating absence of current infections. However, the benefits of routine antenatal screening in pregnant women remain unclear. This study was conducted at one hospital, with a limited sample of participants, and did not yield adequate evidence to recommend a broader implementation of antenatal testing for toxoplasmosis and rubella.
Language	English
Publishing date	2023-12-06
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2453343-9
ISSN	1178-2390
ISSN	1178-2390
DOI	10.2147/JMDH.S438895
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Synergistic Activity of 3-Hydrazinoquinoxaline-2-Thiol in Combination with Penicillin Against MRSA.

Elfadil, Abdelbagi / Ibrahem, Karem / Abdullah, Hani / Mokhtar, Jawahir A / Al-Rabia, Mohammed W / Mohammed, Hafsa Alawad

Infection and drug resistance

2024 Volume 17, Page(s) 355–364

Abstract: Background: The growing resistance seen in various antibiotics, including those considered as last-resort options, underscores the pressing need for novel approaches and new substances to address MRSA infections. Combining antibiotics as a treatment ... ...

Abstract	Background: The growing resistance seen in various antibiotics, including those considered as last-resort options, underscores the pressing need for novel approaches and new substances to address MRSA infections. Combining antibiotics as a treatment approach can enhance effectiveness, expand the range of targeted bacteria, and minimize the likelihood of resistance emergence. This approach holds promise in addressing the escalating issue of antibiotic resistance. Purpose: This study seeks to investigate the potential synergy between 3-hydrazinoquinoxaline-2-thiol and penicillin against a diverse array of MRSA isolates, thereby providing insights into their combined antimicrobial action. Methods: Twenty-two clinical MRSA isolates subjected to broth microdilution to determine the Minimum Inhibitory Concentrations (MICs) of 3-hydrazinoquinoxaline-2-thiol and penicillin. Subsequently, a checkerboard assay was employed to evaluate the interaction between 3-hydrazinoquinoxaline-2-thiol and penicillin, focusing on the Fractional Inhibitory Concentration Index (FICI). Results: The MICs of penicillin and 3-hydrazinoquinoxaline-2-thiol were determined for 22 clinical MRSA strains. Penicillin exhibited MICs within a range of 1024 to 128 µg/mL, while 3-hydrazinoquinoxaline-2-thiol displayed MICs varying from 64 to 8 µg/mL. Remarkably, the combination of 3-hydrazinoquinoxaline-2-thiol and penicillin yielded a synergistic effect, resulting in a significant reduction of MICs by up to 64-fold. Conclusion: The potential of 3-hydrazinoquinoxaline-2-thiol in combination with penicillin as a viable solution against MRSA appears promising. However, to establish its practical utility, further extensive testing and experiments are essential.
Language	English
Publishing date	2024-01-31
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S448843
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Article: Cardiac Injury Biomarkers and the Risk of Death in Patients with COVID-19: A Systematic Review and Meta-Analysis.

Alzahrani, Sami H / Al-Rabia, Mohammed W

Cardiology research and practice

2021 Volume 2021, Page(s) 9363569

Abstract: Background: Cardiac complications may develop in a proportion of patients with the novel coronavirus disease (COVID-19), which may influence their prognosis.: Objectives: To assess the role of cardiac injury biomarkers measured on admission and ... ...

Abstract	Background: Cardiac complications may develop in a proportion of patients with the novel coronavirus disease (COVID-19), which may influence their prognosis. Objectives: To assess the role of cardiac injury biomarkers measured on admission and during hospitalization as risk factors for subsequent death in COVID-19 patients. Methods: A systematic review and meta-analysis was carried out involving cohort studies that compared the levels of cardiac injury biomarkers in surviving and dead COVID-19 patients. Cardiac injury is defined as an elevation of the definitive markers (cardiac troponin (cTnI and cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP)) above the 99th percentile upper reference limit. Secondary markers included creatine kinase-myocardial bound (CK-MB), myoglobin, interleukin-6 (IL-6), and C-reactive protein (CRP). The risk of death and the differences in marker concentrations were analyzed using risk ratios (RRs) and standardized mean differences (SMDs), respectively. Results: Nine studies met the inclusion criteria (1799 patients, 53.36% males, 20.62% with cardiac injury). The risk of death was significantly higher in patients with elevated cTn than those with normal biomarker levels (RR = 5.28, Conclusion: COVID-19 patients with elevated cTn on admission, possibly due to immune-mediated myocardial injury, are at increased risk for mortality. This requires further radiographic investigations, close monitoring, and aggressive care to reduce the risk of severe complications and death.
Language	English
Publishing date	2021-03-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2506187-2
ISSN	2090-0597 ; 2090-8016
ISSN (online)	2090-0597
ISSN	2090-8016
DOI	10.1155/2021/9363569
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Article: Correlation of thyroid antibodies with TSH, T3 and T4 hormones in patients diagnosed with autoimmune thyroid disorders.

Al-Rabia, Mohammed W

Pakistan journal of pharmaceutical sciences

2017 Volume 30, Issue 2(Suppl.), Page(s) 607–612

Abstract: The serum concentrations of anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies are directly correlate in the induction and diagnosis of autoimmune thyroid disorders (AITDs). Therefore, the evaluation of serum anti-TPO and anti- ...

Abstract	The serum concentrations of anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies are directly correlate in the induction and diagnosis of autoimmune thyroid disorders (AITDs). Therefore, the evaluation of serum anti-TPO and anti-TG antibodies in relation to thyroid function test parameters including thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4). This evaluation would be helpful in early diagnosis of abnormal thyroid function and associated autoimmune thyroid diseases. In this cross-sectional study, the serum anti-TPO, anti-TG, T3, T4 and TSH levels of 311 suspected patients of autoimmune thyroid disorders and 40 control subjects were evaluated. The data were presented as mean, ± standard deviations of the mean. Pearson correlation and chi-square tests were used to assess the correlation coefficients and significance in the contingency tables. The thyroid function test parameters in normal and AITDs suspected patients were significantly different in correlation to elevated serum levels of anti-TPO antibody. A significant association was detected between female gender and elevated levels of anti-TPO (P value = 0.047). A higher percentage of women showed elevated levels of anti-TG, but it was not statistically significant (P value= 0.107). The findings of the study reveal a strong correlation between thyroid function test and thyroid antibodies levels, elaborating the clinical importance of thyroid antibodies in clinical examination and follow-up of patients with autoimmune thyroid disorders.
MeSH term(s)	Adult ; Autoantibodies/blood ; Autoantibodies/immunology ; Autoimmune Diseases/blood ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/immunology ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Sex Characteristics ; Thyroglobulin/immunology ; Thyroid Diseases/blood ; Thyroid Diseases/diagnosis ; Thyroid Diseases/immunology ; Thyroid Function Tests ; Thyroid Hormones/immunology ; Thyroiditis, Autoimmune/blood ; Thyroiditis, Autoimmune/diagnosis ; Thyroiditis, Autoimmune/immunology ; Thyrotropin/immunology ; Triiodothyronine/immunology ; Young Adult
Chemical Substances	Autoantibodies ; Thyroid Hormones ; Triiodothyronine (06LU7C9H1V) ; Thyrotropin (9002-71-5) ; Thyroglobulin (9010-34-8)
Language	English
Publishing date	2017-06-22
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Article ; Online: A Machine Learning Approach for Monitoring and Classifying Healthcare Data-A Case of Emergency Department of KSA Hospitals.

Ragab, Mahmoud / Kateb, Faris / Al-Rabia, Mohammed W / Hamed, Diaa / Althaqafi, Turki / Al-Ghamdi, Abdullah S Al-Malaise

International journal of environmental research and public health

2023 Volume 20, Issue 6

Abstract: The Emergency Departments (EDs), in hospitals located in a few important areas in Saudi Arabia, experience a heavy inflow of patients due to viral illnesses, pandemics, and even on a few special occasions events such as Hajj or Umrah, when pilgrims ... ...

Abstract	The Emergency Departments (EDs), in hospitals located in a few important areas in Saudi Arabia, experience a heavy inflow of patients due to viral illnesses, pandemics, and even on a few special occasions events such as Hajj or Umrah, when pilgrims travel from one region to another with severe disease conditions. Apart from the EDs, it is critical to monitor the movements of patients from EDs to other wards inside the hospital or in the region. This is to track the spread of viral illnesses that require more attention. In this scenario, Machine Learning (ML) algorithms can be used to classify the data into many classes and track the target audience. The current research article presents a Machine Learning-based Medical Data Monitoring and Classification Model for the EDs of the KSA hospitals and is named MLMDMC-ED technique. The most important aim of the proposed MLMDMC-ED technique is to monitor and track the patient's visits to the EDs, the treatment given to them based on the Canadian Emergency Department Triage and Acuity Scale (CTAS), and their Length Of Stay (LOS) in the hospital, based on their treatment requirements. A patient's clinical history is crucial in terms of making decisions during health emergencies or pandemics. So, the data should be processed so that it can be classified and visualized in different formats using the ML technique. The current research work aims at extracting the textual features from the patients' data using the metaheuristic Non-Defeatable Genetic Algorithm II (NSGA II). The data, collected from the hospitals, are classified using the Graph Convolutional Network (GCN) model. Grey Wolf Optimizer (GWO) is exploited for fine-tuning the parameters to optimize the performance of the GCN model. The proposed MLMDMC-ED technique was experimentally validated on the healthcare data and the outcomes indicated the improvements of the MLMDMC-ED technique over other models with a maximum accuracy of 91.87%.
MeSH term(s)	Canada ; Emergency Service, Hospital ; Hospitals ; Delivery of Health Care ; Machine Learning ; Triage/methods
Language	English
Publishing date	2023-03-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20064794
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Article ; Online: GC-MS Analysis and Microbiological Evaluation of Caraway Essential Oil as a Virulence Attenuating Agent against

Fekry, Mona / Yahya, Galal / Osman, Ali / Al-Rabia, Mohammed W / Mostafa, Islam / Abbas, Hisham A

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 23

Abstract: The emergence of resistant microbes threatens public health on our planet, and the emergence of resistant bacteria against the most commonly used antibiotics necessitates urgent alternative therapeutic options. One way to fight resistant microbes is to ... ...

Abstract	The emergence of resistant microbes threatens public health on our planet, and the emergence of resistant bacteria against the most commonly used antibiotics necessitates urgent alternative therapeutic options. One way to fight resistant microbes is to design new antimicrobial agents, however, this approach takes decades of research. An alternative or parallel approach is to target the virulence of bacteria with natural or synthetic agents. Active constituents from medicinal plants represent a wide library to screen for natural anti-virulence agents. Caraway is used as a traditional spice and in some medicinal applications such as carminative, antispasmodic, appetizer, and expectorant. Caraway essential oil is rich in terpenes that were previously reported to have antimicrobial activities. In our study, we tested the caraway essential oil in sub-inhibitory concentration as a virulence agent against the Gram-negative bacteria
Language	English
Publishing date	2022-12-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27238532
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Article: Enhanced Gravitational Search Optimization with Hybrid Deep Learning Model for COVID-19 Diagnosis on Epidemiology Data.

Ragab, Mahmoud / Choudhry, Hani / H Asseri, Amer / Binyamin, Sami Saeed / Al-Rabia, Mohammed W

Healthcare (Basel, Switzerland)

2022 Volume 10, Issue 7

Abstract: Effective screening provides efficient and quick diagnoses of COVID-19 and could alleviate related problems in the health care system. A prediction model that combines multiple features to assess contamination risks was established in the hope of ... ...

Abstract	Effective screening provides efficient and quick diagnoses of COVID-19 and could alleviate related problems in the health care system. A prediction model that combines multiple features to assess contamination risks was established in the hope of supporting healthcare workers worldwide in triaging patients, particularly in situations with limited health care resources. Furthermore, a lack of diagnosis kits and asymptomatic cases can lead to missed or delayed diagnoses, exposing visitors, medical staff, and patients to 2019-nCoV contamination. Non-clinical techniques including data mining, expert systems, machine learning, and other artificial intelligence technologies have a crucial role to play in containment and diagnosis in the COVID-19 outbreak. This study developed Enhanced Gravitational Search Optimization with a Hybrid Deep Learning Model (EGSO-HDLM) for COVID-19 diagnoses using epidemiology data. The major aim of designing the EGSO-HDLM model was the identification and classification of COVID-19 using epidemiology data. In order to examine the epidemiology data, the EGSO-HDLM model employed a hybrid convolutional neural network with a gated recurrent unit based fusion (HCNN-GRUF) model. In addition, the hyperparameter optimization of the HCNN-GRUF model was improved by the use of the EGSO algorithm, which was derived by including the concepts of cat map and the traditional GSO algorithm. The design of the EGSO algorithm helps in reducing the ergodic problem, avoiding premature convergence, and enhancing algorithm efficiency. To demonstrate the better performance of the EGSO-HDLM model, experimental validation on a benchmark dataset was performed. The simulation results ensured the enhanced performance of the EGSO-HDLM model over recent approaches.
Language	English
Publishing date	2022-07-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare10071339
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Article: The Prevalence and Risk Factors of Trichosporonosis at King Abdulaziz University Hospital.

Alboloshi, Ghassan J / Jiman-Fatani, Asif A / Attallah, Dalya / Mokhtar, Jawahir A / Al-Abdullah, Nabeela Abdullah / Alkuwaity, Khalil / Kaki, Reham / Al-Rabia, Mohammed W / Alfadil, Abdelbagi / Ibrahem, Karem / Teklemariam, Addisu D / Harakeh, Steve

International journal of general medicine

2024 Volume 17, Page(s) 1297–1310

Abstract: Background: Fungal infections, especially those caused have emerged as a significant medical concern over the past three decades, particularly among immunocompromised patients. However, recent studies have highlighted the increasing prevalence of fungal ...

Abstract	Background: Fungal infections, especially those caused have emerged as a significant medical concern over the past three decades, particularly among immunocompromised patients. However, recent studies have highlighted the increasing prevalence of fungal infections resembling yeast other than Purpose: The current study aimed to explore the clinical epidemiology of Methods: This retrospective study aimed to assess the clinical epidemiology of Results: This study encompassed 21 participants, categorized into four distinct age groups. Moreover, this study indicated Conclusion: This study contributes valuable epidemiological insights into trichosporonosis, highlighting the need for enhanced surveillance and preventive strategies in healthcare settings. Further research is warranted to optimize treatment approaches and infection control measures, ultimately reducing the burden of
Language	English
Publishing date	2024-04-03
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S449511
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Article: RETRACTED: Fahmy et al. Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo/In Vivo Evaluation.

Fahmy, Usama A / Badr-Eldin, Shaimaa M / Ahmed, Osama A A / Aldawsari, Hibah M / Tima, Singkome / Asfour, Hani Z / Al-Rabia, Mohammed W / Negm, Aya A / Sultan, Muhammad H / Madkhali, Osama A A / Alhakamy, Nabil A

Pharmaceutics

2024 Volume 16, Issue 2

Abstract: This journal retracts the article "Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo/In Vivo Evaluation" [ ... ]. ...

Abstract	This journal retracts the article "Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo/In Vivo Evaluation" [...].
Language	English
Publishing date	2024-01-29
Publishing country	Switzerland
Document type	Retraction of Publication
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics16020189
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Thymoquinone is a natural antibiofilm and pathogenicity attenuating agent in

Al-Rabia, Mohammed W / Asfour, Hani Z / Alhakamy, Nabil A / Abdulaal, Wesam H / Ibrahim, Tarek S / Abbas, Hisham A / Salem, Ibrahim M / Hegazy, Wael A H / Nazeih, Shaimaa I

Frontiers in cellular and infection microbiology

2024 Volume 14, Page(s) 1382289

Abstract: Pseudomonas ... ...

Abstract	Pseudomonas aeruginosa
MeSH term(s)	Animals ; Mice ; Virulence/genetics ; Pseudomonas aeruginosa ; Biofilms ; Quorum Sensing ; Virulence Factors/metabolism ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/metabolism ; Benzoquinones
Chemical Substances	thymoquinone (O60IE26NUF) ; Virulence Factors ; Anti-Bacterial Agents ; Bacterial Proteins ; Benzoquinones
Language	English
Publishing date	2024-04-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2024.1382289
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