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Article: Primary Anterior Thoracic Wall Abscess with Osteomyelitis by

Murthy, Neetha S / Mahale, Rashmi P / Mvs, Krishna Karthik

2023 Volume 15, Issue 4, Page(s) 613–615

Abstract: Salmonella ... ...

Abstract	Salmonella enterica
Language	English
Publishing date	2023-07-10
Publishing country	Germany
Document type	Case Reports
ZDB-ID	2461120-7
ISSN	0974-7826 ; 0974-2727
ISSN (online)	0974-7826
ISSN	0974-2727
DOI	10.1055/s-0043-1768949
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Article ; Online: Arsenic and adipose tissue: an unexplored pathway for toxicity and metabolic dysfunction.

Khandayataray, Pratima / Samal, Dibyaranjan / Murthy, Meesala Krishna

Environmental science and pollution research international

2024 Volume 31, Issue 6, Page(s) 8291–8311

Abstract: Arsenic-contaminated drinking water can induce various disorders by disrupting lipid and glucose metabolism in adipose tissue, leading to insulin resistance. It inhibits adipocyte development and exacerbates insulin resistance, though the precise impact ... ...

Abstract	Arsenic-contaminated drinking water can induce various disorders by disrupting lipid and glucose metabolism in adipose tissue, leading to insulin resistance. It inhibits adipocyte development and exacerbates insulin resistance, though the precise impact on lipid synthesis and lipolysis remains unclear. This review aims to explore the processes and pathways involved in adipogenesis and lipolysis within adipose tissue concerning arsenic-induced diabetes. Although arsenic exposure is linked to type 2 diabetes, the specific role of adipose tissue in its pathogenesis remains uncertain. The review delves into arsenic's effects on adipose tissue and related signaling pathways, such as SIRT3-FOXO3a, Ras-MAP-AP-1, PI(3)-K-Akt, endoplasmic reticulum stress proteins, CHOP10, and GPCR pathways, emphasizing the role of adipokines. This analysis relies on existing literature, striving to offer a comprehensive understanding of different adipokine categories contributing to arsenic-induced diabetes. The findings reveal that arsenic detrimentally impacts white adipose tissue (WAT) by reducing adipogenesis and promoting lipolysis. Epidemiological studies have hinted at a potential link between arsenic exposure and obesity development, with limited research suggesting a connection to lipodystrophy. Further investigations are needed to elucidate the mechanistic association between arsenic exposure and impaired adipose tissue function, ultimately leading to insulin resistance.
MeSH term(s)	Humans ; Arsenic/toxicity ; Insulin Resistance ; Diabetes Mellitus, Type 2/metabolism ; Obesity/chemically induced ; Adipose Tissue/metabolism ; Lipids/toxicity
Chemical Substances	Arsenic (N712M78A8G) ; Lipids
Language	English
Publishing date	2024-01-02
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-31683-2
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Article ; Online: Silver nanoparticle ecotoxicity and phytoremediation: a critical review of current research and future prospects.

Samal, Dibyaranjan / Khandayataray, Pratima / Sravani, Meesala / Murthy, Meesala Krishna

Environmental science and pollution research international

2024 Volume 31, Issue 6, Page(s) 8400–8428

Abstract: Silver nanoparticles (AgNPs) are widely used in various industries, including textiles, electronics, and biomedical fields, due to their unique optical, electronic, and antimicrobial properties. However, the extensive use of AgNPs has raised concerns ... ...

Abstract	Silver nanoparticles (AgNPs) are widely used in various industries, including textiles, electronics, and biomedical fields, due to their unique optical, electronic, and antimicrobial properties. However, the extensive use of AgNPs has raised concerns about their potential ecotoxicity and adverse effects on the environment. AgNPs can enter the environment through different pathways, such as wastewater, surface runoff, and soil application and can interact with living organisms through adsorption, ingestion, and accumulation, causing toxicity and harm. The small size, high surface area-to-volume ratio, and ability to generate reactive oxygen species (ROS) make AgNPs particularly toxic. Various bioremediation strategies, such as phytoremediation, have been proposed to mitigate the toxic effects of AgNPs and minimize their impact on the environment. Further research is needed to improve these strategies and ensure their safety and efficacy in different environmental settings.
MeSH term(s)	Silver/toxicity ; Biodegradation, Environmental ; Metal Nanoparticles/toxicity ; Reactive Oxygen Species/metabolism ; Anti-Infective Agents
Chemical Substances	Silver (3M4G523W1G) ; Reactive Oxygen Species ; Anti-Infective Agents
Language	English
Publishing date	2024-01-05
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-31669-0
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Article ; Online: Investigating the toxic mechanism of iron oxide nanoparticles-induced oxidative stress in tadpole (Duttaphrynus melanostictus): A combined biochemical and molecular study.

Murthy, Meesala Krishna / Khandayataray, Pratima / Mohanty, Chandra Sekhar / Pattanayak, Rojalin

Environmental toxicology and pharmacology

2024 Volume 107, Page(s) 104432

Abstract: Metal oxide nanomaterials have toxicity towards aquatic organisms, especially microbes and invertebrates, but little is known about their impact on amphibians. We conducted a study on Duttaphrynus melanostictus (D. melanostictus) tadpoles to explore the ... ...

Abstract	Metal oxide nanomaterials have toxicity towards aquatic organisms, especially microbes and invertebrates, but little is known about their impact on amphibians. We conducted a study on Duttaphrynus melanostictus (D. melanostictus) tadpoles to explore the chronic toxicity effects of iron oxide nanoparticles (IONPs) and the underlying mechanisms of IONPs-induced oxidative stress. IONPs exposure led to increased iron accumulation in the blood, liver, and kidneys of tadpoles, significantly affecting blood parameters and morphology. Higher IONPs concentrations (10 and 50 mg L
MeSH term(s)	Animals ; Muramidase ; Larva/metabolism ; Molecular Docking Simulation ; Ferric Compounds/toxicity ; Ferric Compounds/chemistry ; Oxidative Stress ; Superoxide Dismutase/metabolism ; Albumins/pharmacology ; Magnetic Iron Oxide Nanoparticles
Chemical Substances	Muramidase (EC 3.2.1.17) ; Ferric Compounds ; Superoxide Dismutase (EC 1.15.1.1) ; Albumins
Language	English
Publishing date	2024-03-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1318302-3
ISSN	1872-7077 ; 1382-6689
ISSN (online)	1872-7077
ISSN	1382-6689
DOI	10.1016/j.etap.2024.104432
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Article ; Online: Valorization of coffee bean processing waste for bioethanol production: comparison and evaluation of mass transfer effects in fermentations using free and encapsulated cells of Saccharomyces cerevisiae.

Divyashri, G / Tulsi, N P / Murthy, T P Krishna / Shreyas, S / Kavya, R / Jaishree, I K

Bioprocess and biosystems engineering

2024 Volume 47, Issue 2, Page(s) 169–179

Abstract: Coffee husk, an agricultural waste abundant in carbohydrates and nutrients, is typically discarded through landfills, mixed with animal fodder, or incinerated. However, in alignment with sustainable development principles, researchers worldwide are ... ...

Abstract	Coffee husk, an agricultural waste abundant in carbohydrates and nutrients, is typically discarded through landfills, mixed with animal fodder, or incinerated. However, in alignment with sustainable development principles, researchers worldwide are exploring innovative methods to harness the value of coffee husk, transforming it into profitable products. One such avenue is the biotechnological approach to bioethanol production from agricultural wastes, offering an eco-friendly alternative to mitigate the adverse effects of fossil fuels. This study delves into the feasibility of utilizing coffee husk as a substrate for bioethanol production, employing and comparing various hydrolysis methods. The enzymatic hydrolysis method outshone thermochemical and thermal approaches, yielding 1.84 and 3.07 times more reducing sugars in the hydrolysate, respectively. In examining bioethanol production, a comparison between free and encapsulated cells in enzyme hydrolysate revealed that free-cell fermentation faced challenges due to cell viability issues. Under specific fermentation conditions, bioethanol yield (0.59 and 0.83 g of bioethanol/g of reducing sugar) and productivity (0.1 and 0.12 g/L h) were achieved for free and encapsulated cells, respectively. However, it was noted that bioethanol production by encapsulated cells was more significantly influenced by internal mass transfer effects, as indicated by the Thiele modulus and effectiveness factor. In conclusion, our findings underscore the potential of coffee husk as a valuable substrate for bioethanol production, showcasing its viability in contributing to sustainable and eco-friendly practices.
MeSH term(s)	Fermentation ; Coffea ; Saccharomyces cerevisiae ; Biofuels ; Ethanol ; Carbohydrates ; Sugars ; Hydrolysis ; Animal Feed
Chemical Substances	Biofuels ; Ethanol (3K9958V90M) ; Carbohydrates ; Sugars
Language	English
Publishing date	2024-01-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1476357-6
ISSN	1615-7605 ; 1432-0797 ; 1615-7591
ISSN (online)	1615-7605 ; 1432-0797
ISSN	1615-7591
DOI	10.1007/s00449-023-02961-7
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Article ; Online: A Review on Caspases: Key Regulators of Biological Activities and Apoptosis.

Sahoo, Gayatri / Samal, Dibyaranjan / Khandayataray, Pratima / Murthy, Meesala Krishna

Molecular neurobiology

2023 Volume 60, Issue 10, Page(s) 5805–5837

Abstract: Caspases are proteolytic enzymes that belong to the cysteine protease family and play a crucial role in homeostasis and programmed cell death. Caspases have been broadly classified by their known roles in apoptosis (caspase-3, caspase-6, caspase-7, ... ...

Abstract	Caspases are proteolytic enzymes that belong to the cysteine protease family and play a crucial role in homeostasis and programmed cell death. Caspases have been broadly classified by their known roles in apoptosis (caspase-3, caspase-6, caspase-7, caspase-8, and caspase-9 in mammals) and in inflammation (caspase-1, caspase-4, caspase-5, and caspase-12 in humans, and caspase-1, caspase-11, and caspase-12 in mice). Caspases involved in apoptosis have been subclassified by their mechanism of action as either initiator caspases (caspase-8 and caspase-9) or executioner caspases (caspase-3, caspase-6, and caspase-7). Caspases that participate in apoptosis are inhibited by proteins known as inhibitors of apoptosis (IAPs). In addition to apoptosis, caspases play a role in necroptosis, pyroptosis, and autophagy, which are non-apoptotic cell death processes. Dysregulation of caspases features prominently in many human diseases, including cancer, autoimmunity, and neurodegenerative disorders, and increasing evidence shows that altering caspase activity can confer therapeutic benefits. This review covers the different types of caspases, their functions, and their physiological and biological activities and roles in different organisms.
MeSH term(s)	Caspases/metabolism ; Apoptosis ; Humans ; Animals ; Inflammation/enzymology ; Inflammation/pathology ; Cell Death ; Catalytic Domain ; Neurodegenerative Diseases/enzymology ; Neurodegenerative Diseases/pathology
Chemical Substances	Caspases (EC 3.4.22.-)
Language	English
Publishing date	2023-06-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-023-03433-5
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Article ; Online: Chromium toxicity and its remediation by using endophytic bacteria and nanomaterials: A review.

Murthy, Meesala Krishna / Khandayataray, Pratima / Samal, Dibyaranjan

Journal of environmental management

2022 Volume 318, Page(s) 115620

Abstract: Chromium (Cr) is a crucial element for all life forms. Various anthropogenic activities have been responsible for environmental contamination with Cr (VI) in recent years. For this review, articles were collected using electronic databases such as Web of ...

Abstract	Chromium (Cr) is a crucial element for all life forms. Various anthropogenic activities have been responsible for environmental contamination with Cr (VI) in recent years. For this review, articles were collected using electronic databases such as Web of Science, Pubmed, ProQuest, and Google Scholar as per the guidelines of PRISMA-2015, applying the Boolean search methods. Chromium can cause severe health complications in humans and animals and threatens the surrounding environment, with negative impacts on crop yield, development, and quality. Hence, monitoring Cr contamination is essential, and various remediation technologies have emerged in the past 50 years to reduce the amount of Cr in the environment. This review focuses on chromium exposure and the associated environmental health risks. We also reviewed sustainable remediation processes, with emphasis on nanoparticle and endophytic remediation processes.
MeSH term(s)	Animals ; Bacteria ; Chromium/analysis ; Chromium/toxicity ; Environmental Pollution ; Environmental Restoration and Remediation ; Humans
Chemical Substances	Chromium (0R0008Q3JB)
Language	English
Publishing date	2022-06-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2022.115620
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Article ; Online: Gender differences in the young-onset persistent delusional disorder.

Arasappa, Rashmi / Chithra, Nellai K / Kulkarni, Karishma R / Muliyala, Krishna Prasad / Murthy, Pratima / Kesavan, Muralidharan

Asian journal of psychiatry

2023 Volume 86, Page(s) 103653

Abstract: ... Gender differences in marital and employment status were significant (p-0.001). Delusion of infidelity ...

Abstract	We conducted a retrospective chart review to examine the gender differences in young onset Persistent Delusional Disorder (PDD) subjects (N = 236) with onset of illness before the age of 30 years. Gender differences in marital and employment status were significant (p-0.001). Delusion of infidelity and erotomania were more common in females, while males had more body dysmorphic and persecutory delusions (X
MeSH term(s)	Male ; Female ; Humans ; Adult ; Delusions/epidemiology ; Schizophrenia, Paranoid/epidemiology ; Sex Factors ; Retrospective Studies ; Comorbidity ; Substance-Related Disorders
Language	English
Publishing date	2023-05-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2456678-0
ISSN	1876-2026 ; 1876-2018
ISSN (online)	1876-2026
ISSN	1876-2018
DOI	10.1016/j.ajp.2023.103653
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Article: Ligand-based pharmacophore modeling and QSAR approach to identify potential dengue protease inhibitors.

Poola, Anushka A / Prabhu, Prithvi S / Murthy, T P Krishna / Murahari, Manikanta / Krishna, Swati / Samantaray, Mahesh / Ramaswamy, Amutha

Frontiers in molecular biosciences

2023 Volume 10, Page(s) 1106128

Abstract: The viral disease dengue is transmitted by the Aedes mosquito and is commonly seen to occur in the tropical and subtropical regions of the world. It is a growing public health concern. To date, other than supportive treatments, there are no specific ... ...

Abstract	The viral disease dengue is transmitted by the Aedes mosquito and is commonly seen to occur in the tropical and subtropical regions of the world. It is a growing public health concern. To date, other than supportive treatments, there are no specific antiviral treatments to combat the infection. Therefore, finding potential compounds that have antiviral activity against the dengue virus is essential. The NS2B-NS3 dengue protease plays a vital role in the replication and viral assembly. If the functioning of this protease were to be obstructed then viral replication would be halted. As a result, this NS2B-NS3 proves to be a promising target in the process of anti-viral drug design. Through this study, we aim to provide suggestions for compounds that may serve as potent inhibitors of the dengue NS2B-NS3 protein. Here, a ligand-based pharmacophore model was generated and the ZINC database was screened through ZINCPharmer to identify molecules with similar features. 2D QSAR model was developed and validated using reported 4-Benzyloxy Phenyl Glycine derivatives and was utilized to predict the IC50 values of unknown compounds. Further, the study is extended to molecular docking to investigate interactions at the active pocket of the target protein. ZINC36596404 and ZINC22973642 showed a predicted pIC50 of 6.477 and 7.872, respectively. They also showed excellent binding with NS3 protease as is evident from their binding energy of -8.3and -8.1 kcal/mol, respectively. ADMET predictionsofcompounds have shown high drug-likeness. Finally, the molecular dynamic simulations integrated with MM-PBSA binding energy calculations confirmedboth identified ZINC compounds as potential hit moleculeswith good stability.
Language	English
Publishing date	2023-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2023.1106128
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Article ; Online: Structure-based virtual screening of natural compounds against wild and mutant (R1155K, A1156T and D1168A) NS3-4A protease of Hepatitis C virus.

Samantaray, Mahesh / Pattabiraman, Ramya / Murthy, T P Krishna / Ramaswamy, Amutha / Murahari, Manikanta / Krishna, Swati / Kumar, S Birendra

Journal of biomolecular structure & dynamics

2023 , Page(s) 1–18

Abstract: NS3-4A, a serine protease, is a primary target for drug development against Hepatitis C Virus (HCV). However, the effectiveness of potent next-generation protease inhibitors is limited by the emergence of mutations and resulting drug resistance. To ... ...

Abstract	NS3-4A, a serine protease, is a primary target for drug development against Hepatitis C Virus (HCV). However, the effectiveness of potent next-generation protease inhibitors is limited by the emergence of mutations and resulting drug resistance. To address this, in this study a structure-based drug design approach is employed to screen a large library of 7320 natural compounds against both wild-type and mutant variants of NS3-4A protease. Telaprevir, a widely used protease inhibitor, was recruited as the control drug. The top 10 compounds with favorable binding affinities underwent drug-likeness evaluation. Based on ADMET studies, complexes of NP_024762 and NP_006776 were selected for molecular dynamic simulations. Principal component analysis (PCA) was employed to explore the conformational space and protein dynamics of the protein-ligand complex using a Free Energy Landscape (FEL) approach. The cosine values obtained from FEL analysis ranged from 0 to 1, and eigenvectors with cosine values below 0.2 were chosen for further analysis. To forecast binding free energies and evaluate energy contributions per residue, the MM-PBSA method was employed. The results highlighted the crucial role of amino acids in the catalytic domain for the binding of the protease with phytochemicals. Stable associations between the top compounds and the target protease were confirmed by the formation of hydrogen bonds in the binding pocket involving residues: His1057, Gly1137, Ser1139, and Ala1157. These findings suggest the potential of these compounds for further validation through biological evaluation.Communicated by Ramaswamy H. Sarma.
Language	English
Publishing date	2023-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2246583
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