Article ; Online: Cordycepin: a bioactive metabolite of C
Journal of biomolecular structure & dynamics
2020 Volume 40, Issue 8, Page(s) 3745–3752
Abstract: Spike protein and main proteases of SARS-CoV-2 have been identified as potential therapeutic targets and their inhibition may lead to the reticence of viral entry and replication in the host body. Despite several efforts; till now no specific drugs are ... ...
| Abstract | Spike protein and main proteases of SARS-CoV-2 have been identified as potential therapeutic targets and their inhibition may lead to the reticence of viral entry and replication in the host body. Despite several efforts; till now no specific drugs are available to treat SARS-CoV-2. Considering all these challenges, the main objective of the present study was to establish therapeutic potential of cordycepin against COVID-19 as a conventional therapeutic strategy. In the present study; molecular interaction study was performed to assess potential binding affinity of cordycepin with SARS-CoV-2 target proteins using computational approach. Additionally, network pharmacology was used to understand cordycepin-protein interactions and their associated pathways in human body. Cordycepin is under clinical trial (NCT00709215) and possesses structural similarity with adenosine except that, it lacks a 3' hydroxyl group in its ribose moiety and hence it served as a poly(A) polymerase inhibitor and terminate premature protein synthesis. Additionally, it is known that functional RNAs of SARS-CoV-2 genome are highly 3'-plyadenylated and leading to synthesis of all viral proteins and if cordycepin can destabilize SARS-CoV-2 RNAs by inhibiting polyadenylation process then it may step forward in terms of inhibition of viral replication and multiplication in the host. Moreover, cordycepin showed strong binding affinity with SARS-CoV-2 spike protein (-145.3) and main proteases (-180.5) that further corroborate therapeutic potential against COVID-19. Since cordycepin has both pre-clinical and clinical information about antiviral activities, therefore; it is suggested to the world community to undertake repurposing cordycepin to test efficacy and safety for the treatment of COVID-19. |
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| MeSH term(s) | Antiviral Agents/chemistry ; Clinical Trials as Topic ; Cordyceps/metabolism ; Deoxyadenosines ; Humans ; Peptide Hydrolases/metabolism ; Polyadenylation ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; COVID-19 Drug Treatment |
| Chemical Substances | Antiviral Agents ; Deoxyadenosines ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Peptide Hydrolases (EC 3.4.-) ; cordycepin (GZ8VF4M2J8) |
| Language | English |
| Publishing date | 2020-11-23 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 49157-3 |
| ISSN | 1538-0254 ; 0739-1102 |
| ISSN (online) | 1538-0254 |
| ISSN | 0739-1102 |
| DOI | 10.1080/07391102.2020.1850352 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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