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  1. Article ; Online: Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection.

    Maggio, Roberto / Corsini, Giovanni U

    Pharmacological research

    2020  Volume 157, Page(s) 104837

    MeSH term(s) Antitussive Agents ; Betacoronavirus ; Bromhexine ; COVID-19 ; Coronavirus Infections ; Expectorants ; Humans ; Pandemics ; Peptidyl-Dipeptidase A ; Pneumonia, Viral ; Protease Inhibitors ; SARS Virus ; SARS-CoV-2 ; Virus Internalization
    Chemical Substances Antitussive Agents ; Expectorants ; Protease Inhibitors ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Bromhexine (Q1J152VB1P)
    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2020.104837
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  2. Article ; Online: Effects of plyometric training on different 8-week training intensity distributions in well-trained endurance runners.

    Filipas, Luca / Bonato, Matteo / Maggio, Alice / Gallo, Gabriele / Codella, Roberto

    Scandinavian journal of medicine & science in sports

    2022  Volume 33, Issue 3, Page(s) 200–212

    Abstract: The aim of this four-armed parallel group randomized-controlled trial was to evaluate if plyometric training could have different effects on running performance and physiological adaptations depending on the training intensity distribution (TID) in an 8- ... ...

    Abstract The aim of this four-armed parallel group randomized-controlled trial was to evaluate if plyometric training could have different effects on running performance and physiological adaptations depending on the training intensity distribution (TID) in an 8-week intervention in endurance athletes. Sixty well-trained male runners (age: 34 ± 6 years, relative ⩒O
    MeSH term(s) Humans ; Male ; Adult ; Plyometric Exercise ; Muscle Strength/physiology ; Running/physiology ; Nutritional Status ; Lactic Acid ; Physical Endurance/physiology ; Athletic Performance/physiology
    Chemical Substances Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2022-11-16
    Publishing country Denmark
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1077418-x
    ISSN 1600-0838 ; 0905-7188
    ISSN (online) 1600-0838
    ISSN 0905-7188
    DOI 10.1111/sms.14257
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  3. Article: Mesenchymal Stem Cell in Pancreatic Islet Transplantation.

    Barachini, Serena / Biso, Letizia / Kolachalam, Shivakumar / Petrini, Iacopo / Maggio, Roberto / Scarselli, Marco / Longoni, Biancamaria

    Biomedicines

    2023  Volume 11, Issue 5

    Abstract: Pancreatic islet transplantation is a therapeutic option for achieving physiologic regulation of plasma glucose in Type 1 diabetic patients. At the same time, mesenchymal stem cells (MSCs) have demonstrated their potential in controlling graft rejection, ...

    Abstract Pancreatic islet transplantation is a therapeutic option for achieving physiologic regulation of plasma glucose in Type 1 diabetic patients. At the same time, mesenchymal stem cells (MSCs) have demonstrated their potential in controlling graft rejection, the most fearsome complication in organ/tissue transplantation. MSCs can interact with innate and adaptive immune system cells either through direct cell-cell contact or through their secretome including exosomes. In this review, we discuss current findings regarding the graft microenvironment of pancreatic islet recipient patients and the crucial role of MSCs operation as cell managers able to control the immune system to prevent rejection and promote endogenous repair. We also discuss how challenging stressors, such as oxidative stress and impaired vasculogenesis, may jeopardize graft outcomes. In order to face these adverse conditions, we consider either hypoxia-exposure preconditioning of MSCs or human stem cells with angiogenic potential in organoids to overcome islets' lack of vasculature. Along with the shepherding of carbon nanotubes-loaded MSCs to the transplantation site by a magnetic field, these studies look forward to exploiting MSCs stemness and their immunomodulatory properties in pancreatic islet transplantation.
    Language English
    Publishing date 2023-05-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11051426
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  4. Article ; Online: Unraveling the Functional Significance of Unstructured Regions in G Protein-Coupled Receptors.

    Maggio, Roberto / Fasciani, Irene / Petragnano, Francesco / Coppolino, Maria Francesca / Scarselli, Marco / Rossi, Mario

    Biomolecules

    2023  Volume 13, Issue 10

    Abstract: Unstructured regions in functional proteins have gained attention in recent years due to advancements in informatics tools and biophysical methods. G protein-coupled receptors (GPCRs), a large family of cell surface receptors, contain unstructured ... ...

    Abstract Unstructured regions in functional proteins have gained attention in recent years due to advancements in informatics tools and biophysical methods. G protein-coupled receptors (GPCRs), a large family of cell surface receptors, contain unstructured regions in the form of the i3 loop and C-terminus. This review provides an overview of the functional significance of these regions in GPCRs. GPCRs transmit signals from the extracellular environment to the cell interior, regulating various physiological processes. The i3 loop, located between the fifth and sixth transmembrane helices, and the C-terminus, connected to the seventh transmembrane helix, are determinant of interactions with G proteins and with other intracellular partners such as arrestins. Recent studies demonstrate that the i3 loop and C-terminus play critical roles in allosterically regulating GPCR activation. They can act as autoregulators, adopting conformations that, by restricting G protein access, modulate receptor coupling specificity. The length and unstructured nature of the i3 loop and C-terminus provide unique advantages in GPCR interactions with intracellular protein partners. They act as "fishing lines", expanding the radius of interaction and enabling GPCRs to tether scaffolding proteins, thus facilitating receptor stability during cell membrane movements. Additionally, the i3 loop may be involved in domain swapping between GPCRs, generating novel receptor dimers with distinct binding and coupling characteristics. Overall, the i3 loop and C-terminus are now widely recognized as crucial elements in GPCR function and regulation. Understanding their functional roles enhances our comprehension of GPCR structure and signaling complexity and holds promise for advancements in receptor pharmacology and drug development.
    MeSH term(s) Receptors, G-Protein-Coupled/metabolism ; Signal Transduction/physiology ; GTP-Binding Proteins/metabolism ; Receptors, Cell Surface/metabolism ; Cell Membrane/metabolism
    Chemical Substances Receptors, G-Protein-Coupled ; GTP-Binding Proteins (EC 3.6.1.-) ; Receptors, Cell Surface
    Language English
    Publishing date 2023-09-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13101431
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  5. Article ; Online: Vitamin E supplementation (alone or with other antioxidants) and stroke: a meta-analysis.

    Maggio, Enrico / Bocchini, Valeria Proietti / Carnevale, Roberto / Pignatelli, Pasquale / Violi, Francesco / Loffredo, Lorenzo

    Nutrition reviews

    2023  

    Abstract: Context: A previous study showed that vitamin E is effective in reducing the incidence of myocardial infarction only when it is taken in the absence of other antioxidants. It is unclear if it also reduces the incidence of stroke.: Objective: The aim ... ...

    Abstract Context: A previous study showed that vitamin E is effective in reducing the incidence of myocardial infarction only when it is taken in the absence of other antioxidants. It is unclear if it also reduces the incidence of stroke.
    Objective: The aim of this meta-analysis is to compare the effect of vitamin E supplementation alone or combined with other antioxidants on the incidence of stroke.
    Data sources: A search was performed in the following databases: PubMed, ISI Web of Science, SCOPUS, and Cochrane Library.
    Data extraction: Sixteen randomized controlled trials were selected to evaluate the effect of vitamin E supplementation on stroke.
    Data analysis: The range of vitamin E doses used was 33-800 IU. The follow-up period ranged from 6 months to 9.4 years. Compared with controls, when vitamin E was given alone it did not reduce the incidence of ischemic and hemorrhagic stroke. Conversely, compared with controls, supplementation of vitamin E with other antioxidants reduced ischemic stroke (random effects, RR: 0.91; 95% CI: 0.84-0.99; P = 0.02) but with a significant increase in hemorrhagic stroke (random effects, RR: 1.22; 95% CI: 1.0-1.48; P = 0.04).
    Conclusions: Supplementation with vitamin E alone is not associated with stroke reduction. Instead, supplementation of vitamin E with other antioxidants reduces the incidence of ischemic stroke but increases the risk of hemorrhagic stroke, cancelling any beneficial effect derived. Thus, vitamin E is not recommended in stroke prevention.
    Systematic review registration: PROSPERO registration no. CRD42022258259.
    Language English
    Publishing date 2023-09-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82067-2
    ISSN 1753-4887 ; 0029-6643
    ISSN (online) 1753-4887
    ISSN 0029-6643
    DOI 10.1093/nutrit/nuad114
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  6. Article: Long-Term Functional Limitations on Cardiopulmonary Exercise Testing in Emotion-Triggered Takotsubo Syndrome.

    Jabbour, Jean Pierre / Arcari, Luca / Cacciotti, Luca / Magrì, Damiano / Recchioni, Tommaso / Valeri, Livia / Maggio, Enrico / Vizza, Carmine Dario / Badagliacca, Roberto / Papa, Silvia

    Journal of clinical medicine

    2024  Volume 13, Issue 4

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13041163
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  7. Article: Bilateral adrenal hemorrhage: learning notes from clinical practice and literature review.

    Aloini, Maria Elena / Manella, Sara / Biondo, Irene / Maggio, Roberta / Roberto, Guido / Ricci, Francesca / Lardo, Pina / Addario Chieco, Paola / Stigliano, Antonio

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1233710

    Abstract: Adrenal hemorrhage is a rare, but important, diagnosis to recognize, in particular when there is involvement of both adrenal glands. Bilateral adrenal hemorrhage can in fact lead to adrenal insufficiency, with dramatic consequences if not promptly ... ...

    Abstract Adrenal hemorrhage is a rare, but important, diagnosis to recognize, in particular when there is involvement of both adrenal glands. Bilateral adrenal hemorrhage can in fact lead to adrenal insufficiency, with dramatic consequences if not promptly recognized and treated. It is normally caused by systemic conditions that lead to the vasoconstriction and thrombosis of the adrenal vein. Oftentimes, the clinical diagnosis of this condition can be very challenging, as its signs and symptoms are generalized and nonspecific (abdominal pain, nausea, and fatigue). Here, we present the cases of two patients admitted to the Emergency Department in 2016 and 2022 with acute abdominal pain, having recently undergone surgery and subsequently prescribed low-molecular-weight heparin. In both cases, laboratory results revealed neutrophilic leukocytosis and an unexplained anemia. Due to the persistence of abdominal pain despite medication, a CT scan was performed, showing an enlargement of both adrenal glands suggestive of bilateral adrenal hemorrhage. Adrenal function was tested that correlated with a diagnosis of adrenal insufficiency, and both patients were promptly treated with parenteral hydrocortisone as a result. On 5 years' follow-up from the acute event, the second patient's adrenal function had returned to normal, and he has not needed further adrenal replacement therapy; the first patient however demonstrated persistence of adrenal failure requiring replacement therapy. In this paper, through our experience and a literature analysis, we will aim to outline some clues to identify patients at potential risk of bilateral adrenal hemorrhage.
    MeSH term(s) Male ; Humans ; Adrenal Gland Diseases/complications ; Adrenal Gland Diseases/diagnosis ; Hemorrhage/diagnosis ; Hemorrhage/etiology ; Adrenal Insufficiency/complications ; Adrenal Insufficiency/diagnosis ; Adrenal Insufficiency/drug therapy ; Hydrocortisone/therapeutic use ; Abdominal Pain/diagnosis ; Abdominal Pain/etiology
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2023-11-03
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1233710
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  8. Article: Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection

    Maggio, Roberto / Corsini, Giovanni U

    Pharmacol Res

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #101948
    Database COVID19

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  9. Article ; Online: Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection

    Maggio, Roberto / Corsini, Giovanni U.

    Pharmacological Research

    2020  Volume 157, Page(s) 104837

    Keywords Pharmacology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 1043-6618
    DOI 10.1016/j.phrs.2020.104837
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: In-vitro Approaches to Investigate the Detrimental Effect of Light on Dopaminergic Neurons.

    Fasciani, Irene / Petragnano, Francesco / Bono, Federica / Aloisi, Gabriella / Mutti, Veronica / Pardini, Carla / Carli, Marco / Scarselli, Marco / Vaglini, Francesca / Angelucci, Adriano / Fiorentini, Chiara / Lozzi, Luca / Missale, Cristina / Maggio, Roberto / Rossi, Mario

    Neuroscience

    2024  Volume 544, Page(s) 104–116

    Abstract: Our recent study revealed that fluorescent lamp light can penetrate deep into the brain of mice and rats leading to the development of typical histological characteristics associated with Parkinson's disease such as the loss of dopamine neurons in the ... ...

    Abstract Our recent study revealed that fluorescent lamp light can penetrate deep into the brain of mice and rats leading to the development of typical histological characteristics associated with Parkinson's disease such as the loss of dopamine neurons in the substantia nigra. Monochromatic LED lights were thus used in this work to deepen our knowledge on the effects of the major wavelength peaks of fluorescent light on mouse and human dopaminergic cells. In particular, we exposed immortalized dopaminergic MN9D neuronal cells, primary cultures of mouse mesencephalic dopaminergic cells and human dopaminergic neurons differentiated from induced pluripotent stem cells (hiPSC) to different LED light wavelengths. We found that chronic exposure to LED light reduced overall undifferentiated MN9D cell number, with the most significant effects observed at wavelengths of 485 nm and 610 nm. Moreover, LED light especially at 610 nm was able to negatively impact on the survival of mouse mesencephalic dopaminergic cells and of human dopaminergic neurons derived from hiPSC. Notably, differentiated MN9D dopaminergic cells, which closely resemble mature dopamine neuronal phenotype, acutely exposed for 3 h at 610 nm, showed a clear increase in ROS production and cytotoxicity compared to controls undifferentiated MN9D cells. These increases were even more pronounced by the co-treatment with the oxidative agent H
    MeSH term(s) Humans ; Animals ; Rats ; Dopaminergic Neurons ; Parkinson Disease/pathology ; Hydrogen Peroxide/pharmacology ; Mesencephalon ; Substantia Nigra
    Chemical Substances Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2024.01.009
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