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  1. Article ; Online: Impact of an interdisciplinary patient care model and routine screening on clinical outcomes in patients with hepatitis C.

    Lam, Vincent / Dimaculangan, Christine

    Innovations in pharmacy

    2023  Volume 14, Issue 2

    Abstract: Testing for hepatitis C in hospital emergency departments (ED) and linkage to care to clinics have been reported to provide the most opportunity for screening patients and facilitating continuum of care. Treatment model initiatives have expanded to ... ...

    Abstract Testing for hepatitis C in hospital emergency departments (ED) and linkage to care to clinics have been reported to provide the most opportunity for screening patients and facilitating continuum of care. Treatment model initiatives have expanded to include telehealth services and open treatment capacity to non-physician providers, such as pharmacists. This study's objective was to assess the impact of implementing automated routine screening for hepatitis C virus (HCV) and a clinical pharmacist into the interdisciplinary care model on HCV diagnosis and treatment outcomes. This retrospective cohort study compared outcomes in a pre-intervention and post-intervention group. Patients were screened and diagnosed with HCV at Jersey City Medical Center (JCMC) and completed linkage to care at JCMC Center for Comprehensive Care. Interventions were the implementation of automated routine HCV screening in the ED and addition of a clinical pharmacist to the interdisciplinary patient care model. Primary endpoints analyzed the number of patients who have achieved sustained virologic response after 12 weeks of treatment (SVR12) and patients who have completed treatment with no reported record of SVR12. Secondary endpoints analyzed the number of patients lost to follow-up, appointment type, time spent in appointments, and clinical pharmacist specialist interventions. Data was collected as categorical variables and chi-squared tests assessed if there were differences between the two samples. Data was collected from 46 patients in the pre-intervention group and 37 patients in the post-intervention group. Patients consisted of mostly males. Ages ranged from 27 to 83 years old. Race included Black, White, Asian, and Other. This study's results showed the positive impact on implementation of routine screening, telehealth services, and an interdisciplinary team approach to HCV diagnosis and management. Given the timeframe, it also showed the potential positive impact on these interventions during a global pandemic.
    Language English
    Publishing date 2023-10-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2689516-X
    ISSN 2155-0417 ; 2155-0417
    ISSN (online) 2155-0417
    ISSN 2155-0417
    DOI 10.24926/iip.v14i2.5114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Evaluation of the Safety and Tolerability of Sodium-Glucose Co-transporter 2 Inhibitors in the Older Population: A Systematic Review.

    Edwards, Sarah / Lam, Christine / Thomas, Lindsay

    The Senior care pharmacist

    2023  Volume 38, Issue 7, Page(s) 276–287

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Aged ; Humans ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ISSN 2639-9636
    ISSN 2639-9636
    DOI 10.4140/TCP.n.2023.276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A Review of the Benefits 3D Printing Brings to Patients with Neurological Diseases.

    Gander, Christine / Shi, Kejing / Nokhodchi, Ali / Lam, Matthew

    Pharmaceutics

    2023  Volume 15, Issue 3

    Abstract: This interdisciplinary review focuses on how flexible three-dimensional printing (3DP) technology can aid patients with neurological diseases. It covers a wide variety of current and possible applications ranging from neurosurgery to customizable ... ...

    Abstract This interdisciplinary review focuses on how flexible three-dimensional printing (3DP) technology can aid patients with neurological diseases. It covers a wide variety of current and possible applications ranging from neurosurgery to customizable polypill along with a brief description of the various 3DP techniques. The article goes into detail about how 3DP technology can aid delicate neurosurgical planning and its consequent outcome for patients. It also covers areas such as how the 3DP model can be utilized in patient counseling along with designing specific implants involved in cranioplasty and customization of a specialized instrument such as 3DP optogenetic probes. Furthermore, the review includes how a 3DP nasal cast can contribute to the development of nose-to-brain drug delivery along with looking into how bioprinting could be used for regenerating nerves and how 3D-printed drugs could offer practical benefits to patients suffering from neurological diseases via polypill.
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15030892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Advancing linguistic and epistemic equity for sex, gender and diversity in oncology care research: Moving forward and together as a community.

    Vinette, Billy / Tock, Wing Lam / Sant'Ana, Ricardo Souza Evangelista / Cassivi, Christine / Lemonde, Manon / Maheu, Christine

    Canadian oncology nursing journal = Revue canadienne de nursing oncologique

    2024  Volume 34, Issue 1, Page(s) 79–81

    Language English
    Publishing date 2024-01-01
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2033138-1
    ISSN 2368-8076 ; 1181-912X
    ISSN (online) 2368-8076
    ISSN 1181-912X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Review of the Benefits 3D Printing Brings to Patients with Neurological Diseases

    Christine Gander / Kejing Shi / Ali Nokhodchi / Matthew Lam

    Pharmaceutics, Vol 15, Iss 892, p

    2023  Volume 892

    Abstract: This interdisciplinary review focuses on how flexible three-dimensional printing (3DP) technology can aid patients with neurological diseases. It covers a wide variety of current and possible applications ranging from neurosurgery to customizable ... ...

    Abstract This interdisciplinary review focuses on how flexible three-dimensional printing (3DP) technology can aid patients with neurological diseases. It covers a wide variety of current and possible applications ranging from neurosurgery to customizable polypill along with a brief description of the various 3DP techniques. The article goes into detail about how 3DP technology can aid delicate neurosurgical planning and its consequent outcome for patients. It also covers areas such as how the 3DP model can be utilized in patient counseling along with designing specific implants involved in cranioplasty and customization of a specialized instrument such as 3DP optogenetic probes. Furthermore, the review includes how a 3DP nasal cast can contribute to the development of nose-to-brain drug delivery along with looking into how bioprinting could be used for regenerating nerves and how 3D-printed drugs could offer practical benefits to patients suffering from neurological diseases via polypill.
    Keywords 3D drug printing ; personalized medicine ; neurosurgery ; bioprinting ; implants ; Pharmacy and materia medica ; RS1-441
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Protein diversification through post-translational modifications, alternative splicing, and gene duplication.

    Goldtzvik, Yonathan / Sen, Neeladri / Lam, Su Datt / Orengo, Christine

    Current opinion in structural biology

    2023  Volume 81, Page(s) 102640

    Abstract: Proteins provide the basis for cellular function. Having multiple versions of the same protein within a single organism provides a way of regulating its activity or developing novel functions. Post-translational modifications of proteins, by means of ... ...

    Abstract Proteins provide the basis for cellular function. Having multiple versions of the same protein within a single organism provides a way of regulating its activity or developing novel functions. Post-translational modifications of proteins, by means of adding/removing chemical groups to amino acids, allow for a well-regulated and controlled way of generating functionally distinct protein species. Alternative splicing is another method with which organisms possibly generate new isoforms. Additionally, gene duplication events throughout evolution generate multiple paralogs of the same genes, resulting in multiple versions of the same protein within an organism. In this review, we discuss recent advancements in the study of these three methods of protein diversification and provide illustrative examples of how they affect protein structure and function.
    MeSH term(s) Alternative Splicing ; Gene Duplication ; Evolution, Molecular ; Protein Isoforms/genetics ; Protein Processing, Post-Translational
    Chemical Substances Protein Isoforms
    Language English
    Publishing date 2023-06-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1068353-7
    ISSN 1879-033X ; 0959-440X
    ISSN (online) 1879-033X
    ISSN 0959-440X
    DOI 10.1016/j.sbi.2023.102640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Racial and Ethnic Variation in Healthcare Utilization Before and During the COVID-19 Pandemic: Differential Effects for Overall Versus Telehealth Care.

    Haderlein, Taona P / Hamilton, Alison B / Masheb, Robin M / Mullur, Rashmi / Lam, Christine A / Washington, Donna L

    Journal of general internal medicine

    2024  Volume 39, Issue 5, Page(s) 886–888

    MeSH term(s) Humans ; COVID-19/ethnology ; COVID-19/epidemiology ; Telemedicine ; Patient Acceptance of Health Care/ethnology ; Patient Acceptance of Health Care/statistics & numerical data ; Male ; Ethnicity ; Female ; Healthcare Disparities/ethnology ; United States/epidemiology ; SARS-CoV-2 ; Middle Aged ; Pandemics ; Adult ; Aged ; Racial Groups
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-023-08592-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Effect of Dipeptidyl Peptidase-4 Inhibitors on Macrovascular and Microvascular Complications of Diabetes Mellitus: A Systematic Review.

    Taylor, Olesya M / Lam, Christine

    Current therapeutic research, clinical and experimental

    2020  Volume 93, Page(s) 100596

    Abstract: Background: The World Health Organization estimates that diabetes is the seventh leading cause of death. Uncontrolled diabetes may cause severe consequences such as cardiovascular (CV) events (myocardial infarction, stroke, or CV mortality), lower- ... ...

    Abstract Background: The World Health Organization estimates that diabetes is the seventh leading cause of death. Uncontrolled diabetes may cause severe consequences such as cardiovascular (CV) events (myocardial infarction, stroke, or CV mortality), lower-extremity amputations, and end-stage renal disease. Microvascular complications include retinopathy, autonomic and peripheral neuropathy, nephropathy, and diabetic ulcers. Major CV outcomes trials that were by the Food and Drug Administration for all new antihyperglycemia medications for patients at high risk for CV events were recently completed for all 4 US-marketed dipeptidyl peptidase-4 (DPP-4) inhibitors.
    Objective: To present a comprehensive review of the clinical trials that evaluate macrovascular and microvascular complications reported with DPP-4 inhibitors in patients with type 2 diabetes mellitus.
    Methods: In this review, we analyzed published articles in PubMed and Ovid databases between January 2008 and September 2019 that evaluated the effect of DPP-4 inhibitors on macrovascular and microvascular complications in patients with type 2 diabetes mellitus.
    Results: A total of 18 studies, which included randomized controlled trials and meta-analyses were assessed. Current evidence demonstrates that the addition of DPP-4 inhibitors to standard antihyperglycemic and CV risk reduction treatment has not shown CV benefit relative to placebo in contrast to recently published studies for other medications within the glucagon-like peptide 1 agonist and sodium-glucose co-transporter 2 inhibitor classes. Notably, the potential risk for heart failure hospitalizations may exist for saxagliptin, and this effect is not extrapolated as a class effect. Based on our review, DPP-4 inhibitors may not influence microvascular complications in patients with diabetes. However, some studies have shown that saxagliptin and linagliptin may slow down the progression of albuminuria in patients with type 2 diabetes mellitus. The overall quality of the studies included in this review was high due to the inclusion of randomized controlled trials and meta-analyses.
    Conclusions: DPP-4 inhibitors were found to have a neutral effect on macrovascular and microvascular complications, with the exception of saxagliptin, which may increase the risk for heart failure hospitalizations.
    Language English
    Publishing date 2020-07-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 205697-5
    ISSN 1879-0313 ; 0011-393X
    ISSN (online) 1879-0313
    ISSN 0011-393X
    DOI 10.1016/j.curtheres.2020.100596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Point-of-care-ultrasound for the assessment of post-renal transplant recipients.

    Uy, Michael / Lam, Cameron / Guo, Yanbo / Bansal, Rahul / Hae, Richard / Gangji, Azim / Ribic, Christine / Lambe, Shahid

    Canadian Urological Association journal = Journal de l'Association des urologues du Canada

    2024  Volume 18, Issue 4, Page(s) 110–114

    Abstract: Introduction: Postoperative imaging for deceased donor renal transplants is often delayed, as these surgeries occur after-hours. These delays can be critical in identifying immediate complications. To our knowledge, there are no formal training programs ...

    Abstract Introduction: Postoperative imaging for deceased donor renal transplants is often delayed, as these surgeries occur after-hours. These delays can be critical in identifying immediate complications. To our knowledge, there are no formal training programs for point-of-care ultrasound (POCUS) in this setting; therefore, we aimed to develop and evaluate a feasible and practical POCUS curriculum for the assessment of a renal transplant graft.
    Methods: Urology and nephrology transplant physicians completed a three-hour online course, followed by a five-hour hands-on seminar for sonographic scanning. Simulated patients with transplanted kidneys were used. Course material was developed with licensed ultrasound technologists based on Sonography Canada national competency profiles. Pre- and post-course surveys focused on user confidence, while pre- and post-course multiple-choice questionnaires assessed theoretical knowledge.
    Results: Twelve participants were included, six of whom were urologists. Theoretical knowledge in POCUS improved significantly (p<0.001). Confidence in manipulation of ultrasound controls, Doppler imaging, and POCUS of the transplant kidney also improved (all p<0.001, d>2.0). Participants indicated an increased likelihood of POCUS use in clinical practice and that training should be integrated into a transplant fellowship.
    Conclusions: We introduced a novel and guideline-based POCUS curriculum that leveraged local ultrasound educators and found improved theoretical knowledge and skill confidence in our cohort of transplant physicians. This course will serve as the first step toward a validated competency-based training system for POCUS use in the immediate post-renal transplant setting, and likely will be incorporated into the training of the modern transplant physician.
    Language English
    Publishing date 2024-02-21
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2431403-1
    ISSN 1911-6470
    ISSN 1911-6470
    DOI 10.5489/cuaj.8531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Assessment of Visual Function With Cotoretigene Toliparvovec in X-Linked Retinitis Pigmentosa in the Randomized XIRIUS Phase 2/3 Study.

    Lam, Byron L / Pennesi, Mark E / Kay, Christine N / Panda, Sushil / Gow, James A / Zhao, Guolin / MacLaren, Robert E

    Ophthalmology

    2024  

    Abstract: Purpose: Cotoretigene toliparvovec (BIIB112/AAV8-RPGR) is an investigational vector-based gene therapy designed to provide a full-length, codon-optimized, retinitis pigmentosa GTPase regulator (RPGR) protein to individuals with RPGR-associated X-linked ... ...

    Abstract Purpose: Cotoretigene toliparvovec (BIIB112/AAV8-RPGR) is an investigational vector-based gene therapy designed to provide a full-length, codon-optimized, retinitis pigmentosa GTPase regulator (RPGR) protein to individuals with RPGR-associated X-linked retinitis pigmentosa (XLRP). We assessed efficacy and safety of cotoretigene toliparvovec subretinal gene therapy.
    Design: Part 2 of the XIRIUS trial (NCT03116113) was a Phase 2/3, 12-month, randomized (1:1:1), dose-expansion study.
    Participants: Males aged ≥10 years with RPGR-associated XLRP were included.
    Methods: Participants were randomized 1:1:1 to subretinal cotoretigene toliparvovec low dose (5 × 10
    Main outcome measures: The primary endpoint was the percentage of participants meeting microperimetry responder criteria (≥7 dB improvement at ≥5 of 16 central loci). Secondary endpoints included change from baseline in retinal sensitivity at the central 16 loci and the entire 68 loci at 12 months and change from baseline in low-luminance visual acuity (LLVA) at 12 months; and the proportion of eyes with a ≥15 and ≥10 LLVA ETDRS letter change from baseline at month 12.
    Results: Because of the impact of COVID-19, enrollment ended before reaching the initial target, leaving the trial underpowered. Twenty-nine participants were included (low dose n=10, high dose n=10, control n=9). At month 12, the percentage of participants meeting microperimetry responder criteria was not significantly different between cotoretigene toliparvovec (low dose, 37.5%, P=0.3181; high dose, 25.0%, P=0.5177) and control (22.2%). Mean change from baseline in microperimetry sensitivity, however, significantly improved with the low dose versus control at month 12 (P=0.0350). Significant improvement in LLVA occurred with low dose versus control at month 12 (33.3% difference [80% CI, 14.7-55.2]; P=0.0498). Three ocular-related serious adverse events occurred in the low-dose group versus 7 in the high-dose group.
    Conclusions: The primary microperimetry endpoint was not met. Significant improvements in LLVA and mean microperimetry and fewer serious adverse events were observed with low-dose cotoretigene toliparvovec.
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2024.02.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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