LIVIVO - Search results -

Search results

Result 1 - 10 of total 9735

Search options

Article: Ruan Jian Qing Mai's Formula Promotes Bone Marrow-Derived Mesenchymal Stem Cell Migration and Proliferation.

Zong, Yuan / Zhang, Yongkang / Xv, Yongcheng / Fang, Yudong / Zhao, Cheng / Wang, Yuzhen / Cao, Yemin

Alternative therapies in health and medicine

2023 Volume 29, Issue 8, Page(s) 172–177

Abstract: Objective: To investigate the response of (BM-MSCs) to the Ruan Jian Qing Mai formula (RJQM ...

Abstract	Objective: To investigate the response of (BM-MSCs) to the Ruan Jian Qing Mai formula (RJQM) in the treatment of atherosclerotic occlusion (ASO), and consequently promoting the development of collateral circulation and angiogenesis. Method: 35 male rats were randomly assigned to 6 experimental groups and A control group. 0.9% NaCl solution and 2.7, 5.4, 10.8, 16.2, 21.6, and 27 g × kg-1 × d-1 of RJQM formula were gavaged to the experimental groups twice a day for 8 days. After the last administration, medicated serum was prepared from the blood collected from the abdominal aorta. The human BM-MSCs were divided into an experimental group and a control group. A blank group of cells was added with a complete medium without rat serum; an experimental group of cells was added with the prepared drug-containing serum. Under hypoxic conditions, the drug-containing serum was used to treat BM-MSCs and/or endothelial cells of human umbilical vein (HUVECs). A Cell counting kit (CCK8) was used to detect cell proliferation. Western blot (WB) and quantitative real-time PCR (qPCR) were used to identify related genes expression. Results: The results of this study showed that the purity of the BM-MSCs was >95%. The drug-containing serum significantly rise in CCND1 expression (encoding cyclin D1) and MYC, especially when the concentration of medicated serum was 10.8 g × kg-1 × d-1. Treatment of either BM-MSCs or HUVECs alone or both with medicated serum aids in the spread of mesenchymal stem cells from the bone marrow to HUVECs. qPCR results showed that the mRNA expression of CCL2, CCL3, CCL25, IL8, IGF1, and PDGFB increased dramatically after treatment with medicated serum. The expression of the corresponding receptors for these up-regulated chemokines was detected in BM-MSCs, and it was found that CXCR1, CXCR4, CXCR7, and PDGFRB were up-regulated. Conclusion: This study provides a preliminary understanding of the mechanism of RJQM in the treatment of ASO.
MeSH term(s)	Humans ; Male ; Rats ; Animals ; Endothelial Cells ; Bone Marrow ; Cell Proliferation ; Signal Transduction ; Mesenchymal Stem Cells/metabolism
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4504: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Effect of the Ruan Jian Qing Mai Recipe on Wound Healing in Diabetic Mice and Prediction of its Potential Targets.

Zhang, Pei / Wang, Zefeng / Shi, Yongjia / Yao, Guangtao / Cao, Yemin / Zhang, Jiange

Combinatorial chemistry & high throughput screening

2022 Volume 26, Issue 2, Page(s) 392–409

Abstract: Background: The "Ruan Jian Qing Mai (RJQM) recipe" is a traditional Chinese medicine (TCM ...

Abstract	Background: The "Ruan Jian Qing Mai (RJQM) recipe" is a traditional Chinese medicine (TCM), which has been found to have significant curative effects on diabetic ulcers in the clinic for a long time. Previous research has shown that RJQM can improve diabetic skin wound healing and promote angiogenesis. However, the active ingredients of the RJQM recipe and its pharmacological mechanism of treatment for diabetic skin wound healing still remain unclear.This study aims to investigate the effect of the RJQM recipe on diabetic wound healing, and to identify the possible active ingredients and their mechanism. Methods: First, a skin injury model was established in diabetic mice, and wound healing was evaluated by hematoxylin-eosin (HE) staining, quantitative reverse transcription-polymerase chain reaction (RT-qPCR), and western blot analysis. Second, the chemical constituents of the RJQM recipe were analyzed and identified by ultra pressure liquid chromatography-mass spectrometry (UPLC-MS). Finally, the possible targets of drug treatment for diabetic skin injury were analyzed by network pharmacology and verified by in vitro experiments using cell culture. Results: (1) In the full-thickness skin injury model, the skin wound healing rate and healing area were significantly increased in mice treated with the RJQM recipe compared with those of the model group. The results of immunofluorescence staining showed that the RJQM recipe could increase the expression of VEGF protein and promote the proliferation of vascular smooth muscle cells and the formation of microvessels, and RT-qPCR results found that the mRNA expression of angiogenesis-related factors in the RJQM recipe group was significantly higher than that in the model group. (2) A total of 25 compounds were identified by UPLC-MS. (3) According to the results of network pharmacology, the therapeutic effect of the RJQM recipe on diabetic skin injury may be related to S6 (quercetin), S1 (typhaneoside), S18 (isoliquiritigenin), protein kinase B-α (Akt1), phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1), insulin-like growth factor I receptor (IGF1R), vascular endothelial growth factor-a (VEGF-a), signal transducer and activator of transcription-3 (STAT3) and phosphoinositide 3-kinase-protein kinase B (PI3K-Akt) signaling pathways. Based on the predictions by network pharmacology, we proved that the drug could treat diabetic skin damage by activating the PI3K-Akt-VEGF signaling pathway. Conclusion: The RJQM recipe promotes the formation of granulation tissue during the process of wound healing and exerts a good therapeutic effect on diabetic skin wound healing.
MeSH term(s)	Animals ; Mice ; Proto-Oncogene Proteins c-akt ; Vascular Endothelial Growth Factor A ; Phosphatidylinositol 3-Kinases ; Chromatography, Liquid ; Diabetes Mellitus, Experimental/drug therapy ; Tandem Mass Spectrometry ; Wound Healing
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Vascular Endothelial Growth Factor A ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	English
Publishing date	2022-04-19
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/1386207325666220418095316
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5577: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Bie-Jia-Ruan-Mai-Tang, a Chinese Medicine Formula, Inhibits Retinal Neovascularization in Diabetic Mice Through Inducing the Apoptosis of Retinal Vascular Endothelial Cells.

Liu, Qiu-Ping / Chen, Yu-Ying / Yu, Yuan-Yuan / An, Pei / Xing, Yi-Zhuo / Yang, Hong-Xuan / Zhang, Yin-Jian / Rahman, Khalid / Zhang, Lei / Luan, Xin / Zhang, Hong

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 959298

Abstract: ... Jia-Ruan-Mai-Tang (BJ), a Chinese medicine formula, has a good therapeutic effect on PDR clinically ...

Abstract	Proliferative diabetic retinopathy (PDR) is one of the main complications of diabetes, mainly caused by the aberrant proliferation of retinal vascular endothelial cells and the formation of new blood vessels. Traditional Chinese medicines possess great potential in the prevention and treatment of PDR. Bie-Jia-Ruan-Mai-Tang (BJ), a Chinese medicine formula, has a good therapeutic effect on PDR clinically; however, the mechanism of action involved remains unclear. Therefore, we investigated the effect of BJ on PDR through
Language	English
Publishing date	2022-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.959298
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Mating system and progeny genetic diversity of Camellia oleifera ‘Ruan Zhi’

Zhang, Zijie / Li, Yue / Meng, Jingxiang / Pan, Daofeng / Yang, Ci

Journal of forestry research. 2019 Oct., v. 30, no. 5

2019

Abstract: ... we evaluated the mating system and genetic diversity of a series of cultivars of C. oleifera ‘Ruan Zhi ... by C. oleifera ‘Ruan Zhi’. We recommend selecting individuals for high genetic gain from the progenies ...

Abstract	Camellia oleifera Abel. is an important economic tree species of southern China. In this study, we evaluated the mating system and genetic diversity of a series of cultivars of C. oleifera ‘Ruan Zhi’. A total of 159 individuals from the progenies of four cultivars were tested by simple sequence repeat molecular markers. Results reveal that 11 pairs of primers showed polymorphism and their polymorphism information content value was greater than 0.73, suggesting that these primers could be used to identify the genetic diversity of open-pollinated populations. The average number of effective alleles (Ne = 4.88) was significantly different from the average number of alleles (Na = 12.18), and their distribution in the sample population was not uniform. The average observed heterozygosity (Ho = 0.96) was greater than the average expected heterozygosity (He = 0.79), and the population heterozygote was excessive. Shannon index was 1.84 and populations showed high genetic diversity. As regards to the mating system, the multilocus outcrossing rate was 0.996, and the single locus 0.866. These results indicate a high degree of outcrossing by C. oleifera ‘Ruan Zhi’. We recommend selecting individuals for high genetic gain from the progenies of cultivars because of outcrossing characteristics and genetic diversity for application to germplasm conservation and promotion.
Keywords	alleles ; Camellia oleifera ; cultivars ; genetic improvement ; genetic markers ; genetic variation ; germplasm conservation ; heterozygosity ; loci ; mating systems ; microsatellite repeats ; open pollination ; outcrossing ; progeny ; trees ; China
Language	English
Dates of publication	2019-10
Size	p. 1805-1810.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	2299615-1
ISSN	1993-0607 ; 1007-662X
ISSN (online)	1993-0607
ISSN	1007-662X
DOI	10.1007/s11676-018-0732-4
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: Granule of BU-XIN RUAN-MAI Attenuates the Patients' Angina Pectoris of Coronary Heart Disease via Regulating miR-542-3p/GABARAP Signaling.

Yan, Dong / Zhao, Li-Li / Yue, Bo-Wen / Qian, Hui / Zhang, Zi-Han / Wang, Ning / Yan, Shi-Hai / Qian, Yu-Liang

Evidence-based complementary and alternative medicine : eCAM

2019 Volume 2019, Page(s) 1808419

Abstract: ... in the modern society. This study aims to investigate the effect of Granule of BU-XIN RUAN-MAI (BXRM ... RUAN-MAI-mediated protective activity against this disease.: Methods: The effects of Granule of BU ... XIN RUAN-MAI on clinical symptoms of patients' angina were indicated by hemorheology indicators ...

Abstract	Objective: Coronary heart disease (CHD) has been regarded as a serious and common disease in the modern society. This study aims to investigate the effect of Granule of BU-XIN RUAN-MAI (BXRM) on angina pectoris of coronary heart disease and to explore the molecular mechanisms underlying Granule of BU-XIN RUAN-MAI-mediated protective activity against this disease. Methods: The effects of Granule of BU-XIN RUAN-MAI on clinical symptoms of patients' angina were indicated by hemorheology indicators including high shear of blood viscosity, low shear of blood viscosity, plasma viscosity, erythrocyte rigidity index, D-D dimer, fibrinogen content, and lipid content. The effects of Granule of BU-XIN RUAN-MAI on isoprenaline-induced myocardial cell injury were determined by conducting H&E staining and by performing ELISA to examine the serum content of MDA, SOD, Na Results: Granule of BU-XIN RUAN-MAI significantly attenuated the clinical symptoms of patients' angina by improving the patients' heart rate and by decreasing the level of hemorheology indicators and also by reducing the serum content of TC, TG, LDL, and elevated HDL content. H&E staining demonstrated that Granule of BU-XIN RUAN-MAI ameliorated the myocardial ischemia in a dose-dependent manner. Besides, Granule of BU-XIN RUAN-MAI downregulated serum MDA content and upregulated the content of SOD, Na Conclusion: Granule of BU-XIN RUAN-MAI is an excellent prescription for treatment of coronary heart disease by suppressing inflammation and NAPDH-mediated oxidative stress. The miR-542-3p/GABARAP axis is required for Granule of BU-XIN RUAN-MAI, exhibiting its protective activity against the pectoris of coronary heart disease.
Language	English
Publishing date	2019-12-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2019/1808419
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5995: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Granule of BU-XIN RUAN-MAI Attenuates the Patients’ Angina Pectoris of Coronary Heart Disease via Regulating miR-542-3p/GABARAP Signaling

Dong Yan / Li-li Zhao / Bo-wen Yue / Hui Qian / Zi-han Zhang / Ning Wang / Shi-hai Yan / Yu-liang Qian

Evidence-Based Complementary and Alternative Medicine, Vol

2019 Volume 2019

Abstract: ... in the modern society. This study aims to investigate the effect of Granule of BU-XIN RUAN-MAI (BXRM ... RUAN-MAI-mediated protective activity against this disease. Methods. The effects of Granule of BU-XIN ... RUAN-MAI on clinical symptoms of patients’ angina were indicated by hemorheology indicators including ...

Abstract	Objective. Coronary heart disease (CHD) has been regarded as a serious and common disease in the modern society. This study aims to investigate the effect of Granule of BU-XIN RUAN-MAI (BXRM) on angina pectoris of coronary heart disease and to explore the molecular mechanisms underlying Granule of BU-XIN RUAN-MAI-mediated protective activity against this disease. Methods. The effects of Granule of BU-XIN RUAN-MAI on clinical symptoms of patients’ angina were indicated by hemorheology indicators including high shear of blood viscosity, low shear of blood viscosity, plasma viscosity, erythrocyte rigidity index, D-D dimer, fibrinogen content, and lipid content. The effects of Granule of BU-XIN RUAN-MAI on isoprenaline-induced myocardial cell injury were determined by conducting H&E staining and by performing ELISA to examine the serum content of MDA, SOD, Na+/K+-ATPase, cAMP, and the content of inflammatory factors in isoprenaline-induced rats. Meanwhile, western blot and real time PCR were used to determine the expression of genes involved in oxidation and energy metabolism, and real time PCR was also used for determination of miR-542-3p expression. Luciferase reporter assay was conducted to test the binding sites of miR-542-3p on GABARAP 3′UTR. The chemical compositions of Granule of BU-XIN RUAN-MAI were determined by liquid LC-QTOF-MS. Results. Granule of BU-XIN RUAN-MAI significantly attenuated the clinical symptoms of patients’ angina by improving the patients’ heart rate and by decreasing the level of hemorheology indicators and also by reducing the serum content of TC, TG, LDL, and elevated HDL content. H&E staining demonstrated that Granule of BU-XIN RUAN-MAI ameliorated the myocardial ischemia in a dose-dependent manner. Besides, Granule of BU-XIN RUAN-MAI downregulated serum MDA content and upregulated the content of SOD, Na+/K+-ATPase, and cAMP in isoprenaline-induced rats. Granule of BU-XIN RUAN-MAI significantly improved oxidation stress by increasing PPARα expression, and it inhibited ...
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Actinopolyspora alba sp. nov. and Actinopolyspora erythraea sp. nov., isolated from a salt field, and reclassification of Actinopolyspora iraqiensis Ruan et al. 1994 as a heterotypic synonym of Saccharomonospora halophila.

Tang, Shu-Kun / Wang, Yun / Klenk, Hans-Peter / Shi, Rong / Lou, Kai / Zhang, Yun-Jiao / Chen, Chao / Ruan, Ji-Sheng / Li, Wen-Jun

International journal of systematic and evolutionary microbiology

2010 Volume 61, Issue Pt 7, Page(s) 1693–1698

Abstract: ... that Actinopolyspora iraqiensis (Ruan et al., 1994) be transferred to the genus Saccharomonospora as a heterotypic ...

Abstract	Three actinomycetal strains, designated YIM 90479, YIM 90480(T) and YIM 90600(T), were isolated from a salt field in Xinjiang province, North-west China and subjected to polyphasic taxonomic study. All three strains were moderately halophilic and were able to grow on agar at NaCl concentrations of up to 20-25 % (w/v). No growth was observed in the absence of NaCl. Good growth occurred at 37 °C and 15 % (w/v) NaCl. The cell walls of the three strains were of the type IV variety and their phospholipid patterns were type PIII. MK-9 (H(4)) and MK-10 (H(4)) or MK-9 (H(4)) and MK-9 (H(2)) were the predominant menaquinones. iso-C(16 : 0) and anteiso-C(17 : 0) or anteiso-C(15 : 0) and anteiso-C(17 : 0) were the major fatty acids. The G+C contents of the genomic DNA were 66.4-68.3 mol%. Based on differential phenotypic, chemotaxonomic and phylogenetic characteristics and the results of DNA-DNA hybridization tests, the three novel stains represent two novel species, for which the names Actinopolyspora alba sp. nov. and Actinopolyspora erythraea sp. nov. are proposed. The type strains of the species are YIM 90480(T) ( = DSM 45004(T) = KCTC 19119(T)) and YIM 90600(T) ( = CCTCC M 208247(T) = KCTC 19372(T)). In addition, we propose that Actinopolyspora iraqiensis (Ruan et al., 1994) be transferred to the genus Saccharomonospora as a heterotypic synonym of Saccharomonospora halophila based on present research results.
MeSH term(s)	Actinomycetales/classification ; Actinomycetales/genetics ; Actinomycetales/isolation & purification ; Bacterial Typing Techniques ; Base Composition ; China ; DNA, Bacterial/genetics ; Fatty Acids/chemistry ; Molecular Sequence Data ; Nucleic Acid Hybridization ; Phospholipids/chemistry ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Salts/chemistry ; Sequence Analysis, DNA ; Soil Microbiology ; Vitamin K 2/chemistry
Chemical Substances	DNA, Bacterial ; Fatty Acids ; Phospholipids ; RNA, Ribosomal, 16S ; Salts ; Vitamin K 2 (11032-49-8)
Language	English
Publishing date	2010-08-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijs.0.022319-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 409: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: [Comparison of An-Fa-Te with Bie-Jia-Ruan-Gan-Tablet on prevention of liver fibrosis].

Cai, Wei-min / Tao, Jun / Zhang, Bin-bin / Dong, Feng-qin / Liu, Rong-hua

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

2004 Volume 12, Issue 8, Page(s) 499

MeSH term(s)	Animals ; Carbon Tetrachloride ; Cattle ; Drugs, Chinese Herbal/therapeutic use ; Liver/chemistry ; Liver Cirrhosis, Experimental/chemically induced ; Liver Cirrhosis, Experimental/metabolism ; Liver Cirrhosis, Experimental/prevention & control ; Rats ; Rats, Sprague-Dawley ; Tissue Extracts/therapeutic use
Chemical Substances	Drugs, Chinese Herbal ; Tissue Extracts ; Carbon Tetrachloride (CL2T97X0V0)
Language	Chinese
Publishing date	2004-08
Publishing country	China
Document type	Comparative Study ; Journal Article
ISSN	1007-3418
ISSN	1007-3418
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: [The medicinal serum of yi-shen ruan-jian san antagonized the effect of aristolochic acid on human proximal tubular epithelial cells in vitro].

Fang, Jing / Chen, Yi-pu / Yang, Yan-fang / Zhang, Mei

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2005 Volume 30, Issue 9, Page(s) 704–708

Abstract: Objective: To evaluate whether the medicinal serum of Yi-shen Ruan-jian san can antagonize ... salt (AA-Na) with or without 10% concentration of Yi-shen Ruan-jian san medicinal serum ... with or without the medicinal serum of Yi-shen Ruan-jian san (P > 0.05). No epithelial-myofibroblast ...

Abstract	Objective: To evaluate whether the medicinal serum of Yi-shen Ruan-jian san can antagonize the fibrogenic effect of human proximal tubular epithelial cell line (HKC) activated by aristolochic acid (AA) in vitro. Method: The HKC was incubated in the media containing 40 mg x L(-1) aristolochic acid sodium salt (AA-Na) with or without 10% concentration of Yi-shen Ruan-jian san medicinal serum. Then the cell proliferation and cytotoxicity of HKC were determined by MTF and lactate dehydrogenase (LDH) release assay respectively, the antigen expression of cytokeratin and alpha-smooth muscle actin on HKC was detected by immunocytochemistry, the mRNA expression of transforming growth factor-beta1 (TGF-beta1), connective tissue growth factor (CTGF), plasminogen activator inhibitor-1 (PAI-1), tissue inhibitor of metalloproteinase-1 (TIMP-1) and type I Collagen (Col I) of HKC was measured by RT-PCR, and their protein expression was measured by ELISA or Western blot. Result: No cytotoxic effect was found in HKC after stimulation of AA-Na with or without the medicinal serum of Yi-shen Ruan-jian san (P > 0.05). No epithelial-myofibroblast transdifferentiation was found in HKC after AA-Na stimulation. The mRNA and protein expression of TGF-beta1, CTGF, PAI-1 and TIMP-1 of HKC was significantly upregulated by AA-Na (P < 0.05). The above-mentioned enhanced mRNA and protein expression, except for PAI-1, was significantly downregulated by the medicinal serum of Yi-shen Ruan-jian san, compared with the control (normal rat serum in the same concentration) (P < 0.05). Conclusion: The fibrogenic effects of HKC activated by AA are antagonized by Yi-shen Ruan-jian san, through downregulating the expression of promoting excellular matrix (ECM) synthesis factors (TGF-beta1, CTGF) and inhibiting ECM degradation factor (TIMP-1).
MeSH term(s)	Animals ; Aristolochic Acids/antagonists & inhibitors ; Aristolochic Acids/toxicity ; Cell Line ; Cell Proliferation/drug effects ; Connective Tissue Growth Factor ; Drug Combinations ; Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/toxicity ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Immediate-Early Proteins/biosynthesis ; Immediate-Early Proteins/genetics ; Intercellular Signaling Peptides and Proteins/biosynthesis ; Intercellular Signaling Peptides and Proteins/genetics ; Kidney Tubules, Proximal/cytology ; L-Lactate Dehydrogenase/metabolism ; Male ; Materia Medica/pharmacology ; Plants, Medicinal/chemistry ; Plasminogen Activator Inhibitor 1/biosynthesis ; Plasminogen Activator Inhibitor 1/genetics ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Rats ; Rats, Sprague-Dawley ; Serum ; Tissue Inhibitor of Metalloproteinase-1/biosynthesis ; Tissue Inhibitor of Metalloproteinase-1/genetics ; Transforming Growth Factor beta/biosynthesis ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta1
Chemical Substances	Aristolochic Acids ; CCN2 protein, human ; CCN2 protein, rat ; Drug Combinations ; Drugs, Chinese Herbal ; Immediate-Early Proteins ; Intercellular Signaling Peptides and Proteins ; Materia Medica ; Plasminogen Activator Inhibitor 1 ; RNA, Messenger ; TGFB1 protein, human ; Tgfb1 protein, rat ; Tissue Inhibitor of Metalloproteinase-1 ; Transforming Growth Factor beta ; Transforming Growth Factor beta1 ; Connective Tissue Growth Factor (139568-91-5) ; L-Lactate Dehydrogenase (EC 1.1.1.27)
Language	Chinese
Publishing date	2005-06-30
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3056: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Recent Progress in Modification of Polyphenylene Oxide for Application in High-Frequency Communication.

Liao, Lingyuan / Ruan, Wenhong / Zhang, Mingqiu / Lin, Musong

Materials (Basel, Switzerland)

2024 Volume 17, Issue 5

Abstract: With the rapid development of highly integrated electronic devices and high-frequency microwave communication technology, the parasitic resistance-capacitance ( ...

Abstract	With the rapid development of highly integrated electronic devices and high-frequency microwave communication technology, the parasitic resistance-capacitance (
Language	English
Publishing date	2024-02-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17051086
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito