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  1. Article ; Online: Treatment-induced neuropathy of diabetes: an underdiagnosed entity.

    Quiroz-Aldave, Juan Eduardo / Del Carmen Durand-Vásquez, María / Puelles-León, Susan Luciana / Concepción-Urteaga, Luis Alberto / Concepción-Zavaleta, Marcio José

    The Lancet. Neurology

    2023  Volume 22, Issue 3, Page(s) 201–202

    MeSH term(s) Humans ; Peripheral Nervous System Diseases ; Diabetes Mellitus, Type 2
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(23)00029-7
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    Zs.A 5955: Show issues Location:
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  2. Article ; Online: Thyroid dysfunction and female infertility. A comprehensive review.

    Concepción-Zavaleta, Marcio José / Coronado-Arroyo, Julia Cristina / Quiroz-Aldave, Juan Eduardo / Concepción-Urteaga, Luis Alberto / Paz-Ibarra, José

    Diabetes & metabolic syndrome

    2023  Volume 17, Issue 11, Page(s) 102876

    Abstract: Introduction: Female infertility is defined as the inability to achieve pregnancy following one year of consistent, unprotected sexual intercourse. Among the various endocrine factors contributing to this complex issue, thyroid dysfunction assumes a ... ...

    Abstract Introduction: Female infertility is defined as the inability to achieve pregnancy following one year of consistent, unprotected sexual intercourse. Among the various endocrine factors contributing to this complex issue, thyroid dysfunction assumes a pivotal and noteworthy role.
    Methods: A narrative review, encompassing 134 articles up to 2023, was conducted utilizing the PubMed/Medline, EMBASE, and Scielo databases. The primary focus of this review was to investigate the effects of thyroid dysfunction on female infertility.
    Results: Thyroid disorders exert a significant influence on folliculogenesis, fertilization, and implantation processes. Thyroid autoimmunity, although associated with diminished ovarian reserve, does not typically necessitate levothyroxine therapy. On the other hand, both subclinical and overt hypothyroidism often require levothyroxine treatment to enhance fertility and optimize obstetric outcomes. Hyperthyroidism warrants prompt intervention due to its heightened risk of miscarriage. Furthermore, thyroid dysfunction exerts notable effects on assisted reproductive technologies, underscoring the importance of achieving euthyroidism prior to ovarian stimulation.
    Conclusion: Women presenting with thyroid dysfunction must undergo meticulous and individualized assessments since fertility outcomes, whether achieved through natural conception or assisted reproductive technologies, can be significantly influenced by thyroid-related factors.
    MeSH term(s) Pregnancy ; Female ; Humans ; Thyroxine/therapeutic use ; Infertility, Female/complications ; Infertility, Female/drug therapy ; Thyroid Diseases/complications ; Hypothyroidism/complications
    Chemical Substances Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2023-10-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2023.102876
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  3. Article ; Online: Drug-induced hypothyroidism in tuberculosis.

    Quiroz-Aldave, Juan Eduardo / Durand-Vásquez, María Del Carmen / Gamarra-Osorio, Elman Rolando / Concepción-Urteaga, Luis Alberto / Pecho-Silva, Samuel / Rodríguez-Hidalgo, Luis Alejandro / Concepción-Zavaleta, Marcio José

    Expert review of endocrinology & metabolism

    2024  Volume 19, Issue 3, Page(s) 199–206

    Abstract: Introduction: Adverse reactions to tuberculosis treatment can impact patient adherence and prognosis. Hypothyroidism is a frequent adverse reaction caused using ethionamide, prothionamide, and para-aminosalicylic acid and is often underdiagnosed.: ... ...

    Abstract Introduction: Adverse reactions to tuberculosis treatment can impact patient adherence and prognosis. Hypothyroidism is a frequent adverse reaction caused using ethionamide, prothionamide, and para-aminosalicylic acid and is often underdiagnosed.
    Areas covered: We searched Scielo, Scopus, and EMBASE databases, including 67 articles. Antitubercular drug-induced hypothyroidism has a prevalence of 17%. It occurs after 2 to 3 months of treatment and resolves within 4 to 6 weeks after discontinuation. It is postulated to result from the inhibition of thyroperoxidase function, blocking thyroid hormone synthesis. Symptoms are nonspecific, necessitating individualized thyroid-stimulating hormone measurement for detection. Specific guidelines for management are lacking, but initiation of treatment with levothyroxine, as is customary for primary hypothyroidism, is recommended. Discontinuation of antitubercular drugs is discouraged, as it may lead to unfavorable consequences.
    Expert opinion: Antitubercular drug-induced hypothyroidism is more common than previously thought, affecting one in six MDR-TB patients. Despite diagnostic and treatment recommendations, implementation is hindered in low-income countries due to the lack of certified laboratories. New drugs for tuberculosis treatment may affect thyroid function, requiring vigilant monitoring for complications, including hypothyroidism.
    MeSH term(s) Humans ; Hypothyroidism/chemically induced ; Antitubercular Agents/adverse effects ; Antitubercular Agents/therapeutic use ; Tuberculosis/drug therapy
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1080/17446651.2024.2307525
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  4. Article ; Online: Ifosfamide-induced nephrotoxicity in oncological patients.

    Quiroz-Aldave, Juan Eduardo / Durand-Vásquez, María Del Carmen / Chávez-Vásquez, Freddy Shanner / Rodríguez-Angulo, Alexandra Noelia / Gonzáles-Saldaña, Sonia Elizabeth / Alcalde-Loyola, Carlos César / Coronado-Arroyo, Julia Cristina / Zavaleta-Gutiérrez, Francisca Elena / Concepción-Urteaga, Luis Alberto / Haro-Varas, Juan Carlos / Concepción-Zavaleta, Marcio José

    Expert review of anticancer therapy

    2024  Volume 24, Issue 1-2, Page(s) 5–14

    Abstract: Introduction: Ifosfamide is an alkylating chemotherapeutic agent used in the treatment of various neoplasms. Its main adverse effects include renal damage.: Areas covered: A comprehensive review was conducted, including 100 articles from the Scielo, ... ...

    Abstract Introduction: Ifosfamide is an alkylating chemotherapeutic agent used in the treatment of various neoplasms. Its main adverse effects include renal damage.
    Areas covered: A comprehensive review was conducted, including 100 articles from the Scielo, Scopus, and EMBASE databases. Ifosfamide-induced nephrotoxicity is attributed to its toxic metabolites, such as acrolein and chloroacetaldehyde, which cause mitochondrial damage and oxidative stress in renal tubular cells. Literature review found a 29-year average age with no gender predominance and a mortality of 13%. Currently, no fully effective strategy exists for preventing ifosfamide-induced nephrotoxicity; however, hydration, forced diuresis, and other interventions are employed to limit renal damage. Long-term renal function monitoring is essential for patients treated with ifosfamide.
    Expert opinion: Ifosfamide remains essential in neoplasm treatment, but nephrotoxicity, often compounded by coadministered drugs, poses diagnostic challenges. Preventive strategies are lacking, necessitating further research. Identifying timely risk factors can mitigate renal damage, and a multidisciplinary approach manages established nephrotoxicity. Emerging therapies may reduce ifosfamide induced nephrotoxicity.
    MeSH term(s) Humans ; Ifosfamide/adverse effects ; Antineoplastic Agents, Alkylating/adverse effects ; Kidney
    Chemical Substances Ifosfamide (UM20QQM95Y) ; Antineoplastic Agents, Alkylating
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1080/14737140.2023.2290196
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    Zs.A 5907: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: From liver to hormones: The endocrine consequences of cirrhosis.

    Quiroz-Aldave, Juan Eduardo / Gamarra-Osorio, Elman Rolando / Durand-Vásquez, María Del Carmen / Rafael-Robles, Luciana Del Pilar / Gonzáles-Yovera, Jhean Gabriel / Quispe-Flores, María Alejandra / Concepción-Urteaga, Luis Alberto / Román-González, Alejandro / Paz-Ibarra, José / Concepción-Zavaleta, Marcio José

    World journal of gastroenterology

    2024  Volume 30, Issue 9, Page(s) 1073–1095

    Abstract: Hepatocrinology explores the intricate relationship between liver function and the endocrine system. Chronic liver diseases such as liver cirrhosis can cause endocrine disorders due to toxin accumulation and protein synthesis disruption. Despite its ... ...

    Abstract Hepatocrinology explores the intricate relationship between liver function and the endocrine system. Chronic liver diseases such as liver cirrhosis can cause endocrine disorders due to toxin accumulation and protein synthesis disruption. Despite its importance, assessing endocrine issues in cirrhotic patients is frequently neglected. This article provides a comprehensive review of the epidemiology, pathophysiology, diagnosis, and treatment of endocrine disturbances in liver cirrhosis. The review was conducted using the PubMed/Medline, EMBASE, and Scielo databases, encompassing 172 articles. Liver cirrhosis is associated with endocrine disturbances, including diabetes, hypoglycemia, sarcopenia, thyroid dysfunction, hypogonadotropic hypogonadism, bone disease, adrenal insufficiency, growth hormone dysfunction, and secondary hyperaldosteronism. The optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and continuous glucose monitoring system, respectively. Sarcopenia can be assessed through imaging and functional tests, while other endocrine disorders are evaluated using hormonal assays and imaging studies. Treatment options include metformin, glucagon-like peptide-1 analogs, sodium-glucose co-transporter-2 inhibitors, and insulin, which are effective and safe for diabetes control. Established standards are followed for managing hypoglycemia, and hormone replacement therapy is often necessary for other endocrine dysfunctions. Liver transplantation can address some of these problems.
    MeSH term(s) Humans ; Blood Glucose Self-Monitoring ; Sarcopenia/diagnosis ; Sarcopenia/etiology ; Sarcopenia/therapy ; Blood Glucose/metabolism ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/therapy ; Endocrine System/metabolism ; Diabetes Mellitus/epidemiology ; Insulin/therapeutic use ; Hypoglycemia/complications
    Chemical Substances Blood Glucose ; Insulin
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v30.i9.1073
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    Zs.A 6039: Show issues Location:
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  6. Article ; Online: Pleuropericardial compromise associated with Graves' disease - a diagnostic challenge.

    Paz-Ibarra, José Luis / Sueldo-Espinoza, Diego Enrique / Concha-Tamo, Ronald Vicente / Zamamé-Ramírez, Vladimir / Concepción-Zavaleta, Marcio José

    Endokrynologia Polska

    2022  Volume 73, Issue 2, Page(s) 381–382

    Abstract: Not required for Clinical Vignette. ...

    Abstract Not required for Clinical Vignette.
    MeSH term(s) Antithyroid Agents/therapeutic use ; Graves Disease/complications ; Graves Disease/diagnosis ; Humans
    Chemical Substances Antithyroid Agents
    Language English
    Publishing date 2022-04-05
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 419270-9
    ISSN 2299-8306 ; 0423-104X
    ISSN (online) 2299-8306
    ISSN 0423-104X
    DOI 10.5603/EP.a2022.0019
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    Zs.A 204: Show issues Location:
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  7. Article ; Online: Does level of education influence mortality of SARS-CoV-2 in a developing country?

    Concepción-Zavaleta, Marcio José / Coronado-Arroyo, Julia Cristina / Zavaleta-Gutiérrez, Francisca Elena / Concepción-Urteaga, Luis Alberto

    International journal of epidemiology

    2020  Volume 49, Issue 6, Page(s) 2091–2093

    MeSH term(s) COVID-19/mortality ; Educational Status ; Humans ; Peru/epidemiology ; SARS-CoV-2
    Language English
    Publishing date 2020-11-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 187909-1
    ISSN 1464-3685 ; 0300-5771
    ISSN (online) 1464-3685
    ISSN 0300-5771
    DOI 10.1093/ije/dyaa193
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    Zs.A 893: Show issues Location:
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  8. Article ; Online: Pancreatic Enzyme Elevation Patterns in Patients With Diabetic Ketoacidosis: Does Severe Acute Respiratory Syndrome Coronavirus 2 Play a Role?

    Plasencia-Dueñas, Esteban Alberto / Concepción-Zavaleta, Marcio José / Gonzáles-Yovera, Jhean Gabriel

    Pancreas

    2021  Volume 50, Issue 2, Page(s) e19–e21

    MeSH term(s) Adolescent ; Adult ; Aged ; Amylases/blood ; COVID-19/complications ; COVID-19/enzymology ; Diabetic Ketoacidosis/enzymology ; Female ; Humans ; Lipase/blood ; Male ; Middle Aged ; SARS-CoV-2
    Chemical Substances Lipase (EC 3.1.1.3) ; Amylases (EC 3.2.1.-)
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632831-3
    ISSN 1536-4828 ; 0885-3177
    ISSN (online) 1536-4828
    ISSN 0885-3177
    DOI 10.1097/MPA.0000000000001728
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    Zs.A 2160: Show issues Location:
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  9. Article ; Online: Is COVID-19 a risk factor for severe preeclampsia? Hospital experience in a developing country.

    Coronado-Arroyo, Julia Cristina / Concepción-Zavaleta, Marcio José / Zavaleta-Gutiérrez, Francisca Elena / Concepción-Urteaga, Luis Alberto

    European journal of obstetrics, gynecology, and reproductive biology

    2020  Volume 256, Page(s) 502–503

    MeSH term(s) Adult ; Aspartate Aminotransferases/metabolism ; Asymptomatic Infections/epidemiology ; C-Reactive Protein/metabolism ; COVID-19/epidemiology ; COVID-19/metabolism ; Cesarean Section ; Cohort Studies ; Eclampsia/epidemiology ; Female ; Fetal Death ; HELLP Syndrome/epidemiology ; Humans ; Leukocytosis/epidemiology ; Lymphopenia/epidemiology ; Middle Aged ; Peru/epidemiology ; Pre-Eclampsia/epidemiology ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Young Adult
    Chemical Substances C-Reactive Protein (9007-41-4) ; Aspartate Aminotransferases (EC 2.6.1.1)
    Keywords covid19
    Language English
    Publishing date 2020-09-14
    Publishing country Ireland
    Document type Letter
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2020.09.020
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    Zs.A 837: Show issues Location:
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  10. Article: Cushing disease in pediatrics: an update.

    Concepción-Zavaleta, Marcio José / Armas, Cristian David / Quiroz-Aldave, Juan Eduardo / García-Villasante, Eilhart Jorge / Gariza-Solano, Ana Cecilia / Durand-Vásquez, María Del Carmen / Concepción-Urteaga, Luis Alberto / Zavaleta-Gutiérrez, Francisca Elena

    Annals of pediatric endocrinology & metabolism

    2023  Volume 28, Issue 2, Page(s) 87–97

    Abstract: Cushing disease (CD) is the main cause of endogenous Cushing syndrome (CS) and is produced by an adrenocorticotropic hormone (ACTH)-producing pituitary adenoma. Its relevance in pediatrics is due to the retardation of both growth and developmental ... ...

    Abstract Cushing disease (CD) is the main cause of endogenous Cushing syndrome (CS) and is produced by an adrenocorticotropic hormone (ACTH)-producing pituitary adenoma. Its relevance in pediatrics is due to the retardation of both growth and developmental processes because of hypercortisolism. In childhood, the main features of CS are facial changes, rapid or exaggerated weight gain, hirsutism, virilization, and acne. Endogenous hypercortisolism should be established after exogenous CS has been ruled out based on 24-hour urinary free cortisol, midnight serum or salivary cortisol, and dexamethasone suppression test; after that, ACTH dependence should be established. The diagnosis should be confirmed by pathology. The goal of treatment is to normalize cortisol level and reverse the signs and symptoms. Treatment options include surgery, medication, radiotherapy, or combined therapy. CD represents a challenge for physicians owing to its multiple associated conditions involving growth and pubertal development; thus, it is important to achieve an early diagnosis and treatment in order to control hypercortisolism and improve the prognosis. Its rarity in pediatric patients has led physicians to have limited experience in its management. The objective of this narrative review is to summarize the current knowledge about the pathophysiology, diagnosis, and treatment of CD in the pediatric population.
    Language English
    Publishing date 2023-06-30
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2800460-7
    ISSN 2287-1292 ; 2287-1012
    ISSN (online) 2287-1292
    ISSN 2287-1012
    DOI 10.6065/apem.2346074.037
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