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Article ; Online: Acaricidal activity of Mexican plants against Rhipicephalus microplus resistant to amitraz and cypermethrin.

Peniche-Cardeña, Álvaro / Sosa-Rueda, Javier / Rosado-Aguilar, José A / Rodríguez-Vivas, Roger I / Fernández, José J / Cen-Pacheco, Francisco

Veterinary parasitology

2022 Volume 307-308, Page(s) 109733

Abstract: This study evaluates the acaricidal activity of Mexican native plants against a Rhipicephalus microplus population resistant to both amitraz and cypermethrin. To explore the activities of plants, the larvicidal effects of 72 Kupchan fractions (Hex, DCM, ... ...

Abstract	This study evaluates the acaricidal activity of Mexican native plants against a Rhipicephalus microplus population resistant to both amitraz and cypermethrin. To explore the activities of plants, the larvicidal effects of 72 Kupchan fractions (Hex, DCM, AcOEt and MeOH:H
MeSH term(s)	Acaricides/pharmacology ; Animals ; Larva ; Mexico ; Plants ; Pyrethrins ; Rhipicephalus ; Toluidines
Chemical Substances	Acaricides ; Pyrethrins ; Toluidines ; cypermethrin (1TR49121NP) ; amitraz (33IAH5017S)
Language	English
Publishing date	2022-05-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	196831-2
ISSN	1873-2550 ; 0304-4017
ISSN (online)	1873-2550
ISSN	0304-4017
DOI	10.1016/j.vetpar.2022.109733
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Article: Acaricidal activity of Mexican plants against Rhipicephalus microplus resistant to amitraz and cypermethrin

Peniche-Cardeña, Álvaro / Sosa-Rueda, Javier / Rosado-Aguilar, José A. / Rodríguez-Vivas, Roger I. / Fernández, José J. / Cen-Pacheco, Francisco

Veterinary parasitology. 2022 July, v. 307-308

2022

Abstract	This study evaluates the acaricidal activity of Mexican native plants against a Rhipicephalus microplus population resistant to both amitraz and cypermethrin. To explore the activities of plants, the larvicidal effects of 72 Kupchan fractions (Hex, DCM, AcOEt and MeOH:H₂O) of 18 plant species collected in Veracruz, Mexico were studied. The evaluation of the Kupchan fractions against double resistant R. microplus indicated that the fractions of Annona globiflora (Hex, LC₅₀ = 0.007% w/v; DCM, LC₅₀ = 0.007% w/v), Annona scleroderma (Hex, LC₅₀ = 0.08% w/v; DCM, LC₅₀ = 0.02% w/v), and Litchi chinensis (Hex, LC₅₀ = 0.79% w/v; DCM, LC₅₀ = 0.54% w/v) showed the greatest larvicidal activities. To identify the presence of additive, synergistic, or antagonistic effects, the acaricidal activity of binary mixtures of the most active fractions of A. globiflora, A. scleroderma, L. chinensis and Citrus sinensis were also evaluated. The latter was chosen as it is easy to obtain due to its substantial presence in agricultural activity locally and globally. The results showed synergistic interaction of the fraction Hex of C. sinensis with the fractions of Hex and DCM of L. chinensis. The most active larvicidal fractions were tested against engorged ticks of R. microplus by adult immersion test at concentration of 2.5% w/v. The Hex and DCM fractions from A. globiflora and A. scleroderma were the most active, causing 100% mortality. The Hex and DCM fractions of L. chinensis exhibited approximately 50% mortality, while the other evaluated fractions did not show efficacy at this concentration. Therefore, it is evident that the fractions of these plants have the potential to be used in either combined or single form as effective alternatives in the control of R. microplus zoonoses.
Keywords	Annona ; Citrus sinensis ; Litchi chinensis ; Rhipicephalus microplus ; acaricidal properties ; adults ; amitraz ; cypermethrin ; larvicides ; mortality ; synergism ; veterinary parasitology ; zoonoses ; Mexico
Language	English
Dates of publication	2022-07
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	196831-2
ISSN	1873-2550 ; 0304-4017
ISSN (online)	1873-2550
ISSN	0304-4017
DOI	10.1016/j.vetpar.2022.109733
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Article: Intrasession Reliability Analysis for Oscillometric Blood Pressure Method Using a Digital Blood Pressure Monitor in Peruvian Population.

Barrios-Fernandez, Sabina / Sosa-Sánchez, Eduardo Manuel / Carlos-Vivas, Jorge / Muñoz-Bermejo, Laura / Morenas-Martín, Jesús / Apolo-Arenas, María Dolores / Adsuar, Jose Carmelo / Domínguez-Muñoz, Francisco Javier

Healthcare (Basel, Switzerland)

2022 Volume 10, Issue 2

Abstract: Blood Pressure (BP) is one of the most used measured clinical parameters in health promotion and intervention. BP measures can vary due to different parameters, so we aim to study the intrasession test-retest reliability for an oscillometric method using ...

Abstract	Blood Pressure (BP) is one of the most used measured clinical parameters in health promotion and intervention. BP measures can vary due to different parameters, so we aim to study the intrasession test-retest reliability for an oscillometric method using a digital tensiometer in the Peruvian population aged over 15 with and without a diagnosis of hypertension (HT). Data were taken from the Demographic and Family Health Survey conducted in Peru in 2019. Technicians had to follow a standardized protocol on the conditions to carry out a valid and reliable measurement. Relative reliability was excellent in most cases (intraclass correlation coefficient > 0.9); absolute reliability was excellent (standard error of measurement < 5%) and smallest real difference < 10% in most cases. The Bland-Altman plot showed a systematic error of 2.36 for systolic BP in men and 2.16 in women, and 0.823 for diastolic BP in men and 0.71 for diastolic BP in women. Results suggest that the oscillometric method with a digital blood pressure monitor was reliable in absolute and relative terms in this population, so it could be used as a reliable control test to measure changes after an intervention.
Language	English
Publishing date	2022-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare10020209
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Article ; Online: ResUHUrge: A Low Cost and Fully Functional Ventilator Indicated for Application in COVID-19 Patients.

Vivas Fernández, Francisco José / Sánchez Segovia, José / Martel Bravo, Ismael / García Ramos, Carlos / Ruiz Castilla, Daniel / Gamero López, José / Andújar Márquez, José Manuel

Sensors (Basel, Switzerland)

2020 Volume 20, Issue 23

Abstract: Although the cure for the SARS-CoV-2 virus (COVID-19) will come in the form of pharmaceutical solutions and/or a vaccine, one of the only ways to face it at present is to guarantee the best quality of health for patients, so that they can overcome the ... ...

Abstract	Although the cure for the SARS-CoV-2 virus (COVID-19) will come in the form of pharmaceutical solutions and/or a vaccine, one of the only ways to face it at present is to guarantee the best quality of health for patients, so that they can overcome the disease on their own. Therefore, and considering that COVID-19 generally causes damage to the respiratory system (in the form of lung infection), it is essential to ensure the best pulmonary ventilation for the patient. However, depending on the severity of the disease and the health condition of the patient, the situation can become critical when the patient has respiratory distress or becomes unable to breathe on his/her own. In that case, the ventilator becomes the lifeline of the patient. This device must keep patients stable until, on their own or with the help of medications, they manage to overcome the lung infection. However, with thousands or hundreds of thousands of infected patients, no country has enough ventilators. If this situation has become critical in the Global North, it has turned disastrous in developing countries, where ventilators are even more scarce. This article shows the race against time of a multidisciplinary research team at the University of Huelva, UHU, southwest of Spain, to develop an inexpensive, multifunctional, and easy-to-manufacture ventilator, which has been named ResUHUrge. The device meets all medical requirements and is developed with open-source hardware and software.
MeSH term(s)	Biomedical Engineering ; COVID-19/therapy ; Costs and Cost Analysis ; Equipment Design ; Humans ; Intermittent Positive-Pressure Ventilation/economics ; Intermittent Positive-Pressure Ventilation/instrumentation ; Intermittent Positive-Pressure Ventilation/statistics & numerical data ; Pandemics ; Positive-Pressure Respiration/economics ; Positive-Pressure Respiration/instrumentation ; Positive-Pressure Respiration/statistics & numerical data ; SARS-CoV-2 ; Spain ; User-Computer Interface ; Ventilators, Mechanical/economics
Language	English
Publishing date	2020-11-27
Publishing country	Switzerland
Document type	Journal Article ; Validation Study
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s20236774
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Article ; Online: Extended Model Predictive Controller to Develop Energy Management Systems in Renewable Source-Based Smart Microgrids with Hydrogen as Backup. Theoretical Foundation and Case Study

Francisco J. Vivas Fernández / Francisca Segura Manzano / José Manuel Andújar Márquez / Antonio J. Calderón Godoy

Sustainability, Vol 12, Iss 8969, p

2020 Volume 8969

Abstract: This article presents a methodological foundation to design and experimentally test a Model Predictive Controller (MPC) to be applied in renewable source-based microgrids with hydrogen as backup. The Model Predictive Controller has been developed with ... ...

Abstract	This article presents a methodological foundation to design and experimentally test a Model Predictive Controller (MPC) to be applied in renewable source-based microgrids with hydrogen as backup. The Model Predictive Controller has been developed with the aim to guarantee the best energy distribution while the microgrid operation is optimized considering both technical and economic parameters. As a differentiating element, this proposal provides a solution to the problem of energy management in real systems, addressing technological challenges such as charge management in topologies with direct battery connection, or loss of performance associated with equipment degradation or the required dynamics in the operation of hydrogen systems. That is, the proposed Model Predictive Controller achieves the optimization of microgrid operation both in the short and in the long-term basis. For this purpose, a generalized multi-objective function has been defined that considers the energy demand, operating costs, system performance as well as the suffered and accumulated degradation by microgrid elements throughout their lifespan. The generality in the definition of the model and cost function, allows multi-objective optimization problems to be raised depending on the application, topology or design criteria to be considered. For this purpose, a heuristic methodology based on artificial intelligence techniques is presented for the tuning of the controller parameters. The Model Predictive Controller has been validated by simulation and experimental tests in a case study, where the performance of the microgrid under energy excess and deficit situations has been tested, considering the constrains defined by the degradation of the systems that make up the microgrid. The designed controller always made it possible to guarantee both the power balance and the optimal energy distribution between systems according to the predefined priority and accumulated degradation, while guaranteeing the maximum operating voltage of the system ...
Keywords	model predictive control ; energy management system ; renewable source-based smart microgrid ; hydrogen backup systems ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	600
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Pedagogical Proposal of Tele-Exercise Based on "Square Stepping Exercise" in Preschoolers: Study Protocol.

Domínguez-Muñoz, Alberto / Carlos-Vivas, Jorge / Barrios-Fernandez, Sabina / Adsuar, José Carmelo / Morenas-Martín, Jesús / Garcia-Gordillo, Miguel Angel / Domínguez-Muñoz, Francisco Javier

International journal of environmental research and public health

2021 Volume 18, Issue 16

Abstract: Early childhood education aims to achieve the motor, cognitive, emotional, and social development of preschoolers by providing them with a variety of learning opportunities. The square-stepping exercise (SSE) is a balance and lower limb strength training ...

Abstract	Early childhood education aims to achieve the motor, cognitive, emotional, and social development of preschoolers by providing them with a variety of learning opportunities. The square-stepping exercise (SSE) is a balance and lower limb strength training programme used to prevent falls and stimulate cognitive function in older adults. This project aims to propose an SSE tele-exercise (Tele-SSE) protocol to evaluate its effects on the motor and cognitive development of children aged between 3 and 6 years. A randomized controlled trial with experimental (Tele-SSE) and control (general education) groups will be carried out. The application of Tele-SSE will be performed for 9 months (three times per week) and one additional follow-up after the intervention at the beginning of the next academic year. One-hundred and two preschoolers will be recruited and randomly distributed into the two groups: experimental (
MeSH term(s)	Accidental Falls ; Aged ; Child ; Child, Preschool ; Cognition ; Exercise ; Exercise Therapy ; Hand Strength ; Humans ; Infant ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2021-08-16
Publishing country	Switzerland
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph18168649
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Article ; Online: Intrasession Reliability Analysis for Oscillometric Blood Pressure Method Using a Digital Blood Pressure Monitor in Peruvian Population

Sabina Barrios-Fernandez / Eduardo Manuel Sosa-Sánchez / Jorge Carlos-Vivas / Laura Muñoz-Bermejo / Jesús Morenas-Martín / María Dolores Apolo-Arenas / Jose Carmelo Adsuar / Francisco Javier Domínguez-Muñoz

Healthcare, Vol 10, Iss 209, p

2022 Volume 209

Abstract: Blood Pressure (BP) is one of the most used measured clinical parameters in health promotion and intervention. BP measures can vary due to different parameters, so we aim to study the intrasession test–retest reliability for an oscillometric method using ...

Abstract	Blood Pressure (BP) is one of the most used measured clinical parameters in health promotion and intervention. BP measures can vary due to different parameters, so we aim to study the intrasession test–retest reliability for an oscillometric method using a digital tensiometer in the Peruvian population aged over 15 with and without a diagnosis of hypertension (HT). Data were taken from the Demographic and Family Health Survey conducted in Peru in 2019. Technicians had to follow a standardized protocol on the conditions to carry out a valid and reliable measurement. Relative reliability was excellent in most cases (intraclass correlation coefficient > 0.9); absolute reliability was excellent (standard error of measurement < 5%) and smallest real difference < 10% in most cases. The Bland–Altman plot showed a systematic error of 2.36 for systolic BP in men and 2.16 in women, and 0.823 for diastolic BP in men and 0.71 for diastolic BP in women. Results suggest that the oscillometric method with a digital blood pressure monitor was reliable in absolute and relative terms in this population, so it could be used as a reliable control test to measure changes after an intervention.
Keywords	intraclass correlation coefficient ; standard error of measurement ; smallest real difference ; blood pressure ; electronic device ; health promotion ; Medicine ; R
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Polypill Strategy in Secondary Cardiovascular Prevention.

Castellano, Jose M / Pocock, Stuart J / Bhatt, Deepak L / Quesada, Antonio J / Owen, Ruth / Fernandez-Ortiz, Antonio / Sanchez, Pedro L / Marin Ortuño, Francisco / Vazquez Rodriguez, Jose M / Domingo-Fernández, Alexandra / Lozano, Iñigo / Roncaglioni, Maria C / Baviera, Marta / Foresta, Andreana / Ojeda-Fernandez, Luisa / Colivicchi, Furio / Di Fusco, Stefania A / Doehner, Wolfram / Meyer, Antje /

Schiele, François / Ecarnot, Fiona / Linhart, Aleš / Lubanda, Jean-Claude / Barczi, Gyorgy / Merkely, Bela / Ponikowski, Piotr / Kasprzak, Marta / Fernandez Alvira, Juan M / Andres, Vicente / Bueno, Hector / Collier, Timothy / Van de Werf, Frans / Perel, Pablo / Rodriguez-Manero, Moises / Alonso Garcia, Angeles / Proietti, Marco / Schoos, Mikkel M / Simon, Tabassome / Fernandez Ferro, Jose / Lopez, Nicolas / Beghi, Ettore / Bejot, Yannick / Vivas, David / Cordero, Alberto / Ibañez, Borja / Fuster, Valentin

The New England journal of medicine

2022 Volume 387, Issue 11, Page(s) 967–977

Abstract: Background: A polypill that includes key medications associated with improved outcomes (aspirin, angiotensin-converting-enzyme [ACE] inhibitor, and statin) has been proposed as a simple approach to the secondary prevention of cardiovascular death and ... ...

Abstract	Background: A polypill that includes key medications associated with improved outcomes (aspirin, angiotensin-converting-enzyme [ACE] inhibitor, and statin) has been proposed as a simple approach to the secondary prevention of cardiovascular death and complications after myocardial infarction. Methods: In this phase 3, randomized, controlled clinical trial, we assigned patients with myocardial infarction within the previous 6 months to a polypill-based strategy or usual care. The polypill treatment consisted of aspirin (100 mg), ramipril (2.5, 5, or 10 mg), and atorvastatin (20 or 40 mg). The primary composite outcome was cardiovascular death, nonfatal type 1 myocardial infarction, nonfatal ischemic stroke, or urgent revascularization. The key secondary end point was a composite of cardiovascular death, nonfatal type 1 myocardial infarction, or nonfatal ischemic stroke. Results: A total of 2499 patients underwent randomization and were followed for a median of 36 months. A primary-outcome event occurred in 118 of 1237 patients (9.5%) in the polypill group and in 156 of 1229 (12.7%) in the usual-care group (hazard ratio, 0.76; 95% confidence interval [CI], 0.60 to 0.96; P = 0.02). A key secondary-outcome event occurred in 101 patients (8.2%) in the polypill group and in 144 (11.7%) in the usual-care group (hazard ratio, 0.70; 95% CI, 0.54 to 0.90; P = 0.005). The results were consistent across prespecified subgroups. Medication adherence as reported by the patients was higher in the polypill group than in the usual-care group. Adverse events were similar between groups. Conclusions: Treatment with a polypill containing aspirin, ramipril, and atorvastatin within 6 months after myocardial infarction resulted in a significantly lower risk of major adverse cardiovascular events than usual care. (Funded by the European Union Horizon 2020; SECURE ClinicalTrials.gov number, NCT02596126; EudraCT number, 2015-002868-17.).
MeSH term(s)	Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Aspirin/adverse effects ; Aspirin/therapeutic use ; Atorvastatin/adverse effects ; Atorvastatin/therapeutic use ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/prevention & control ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Ischemic Stroke/prevention & control ; Myocardial Infarction/complications ; Myocardial Infarction/prevention & control ; Myocardial Infarction/therapy ; Platelet Aggregation Inhibitors/adverse effects ; Platelet Aggregation Inhibitors/therapeutic use ; Ramipril/adverse effects ; Ramipril/therapeutic use ; Secondary Prevention/methods
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Platelet Aggregation Inhibitors ; Atorvastatin (A0JWA85V8F) ; Ramipril (L35JN3I7SJ) ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2022-08-26
Publishing country	United States
Document type	Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMoa2208275
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Article ; Online: Clinical profile and prognosis in patients on oral anticoagulation before admission for COVID-19.

Rivera-Caravaca, José Miguel / Núñez-Gil, Iván J / Vivas, David / Viana-Llamas, María C / Uribarri, Aitor / Becerra-Muñoz, Víctor Manuel / Trabattoni, Daniela / Fernández Rozas, Inmaculada / Feltes, Gisela / López-Pais, Javier / El-Battrawy, Ibrahim / Macaya, Carlos / Fernandez-Ortiz, Antonio / Estrada, Vicente / Marín, Francisco

European journal of clinical investigation

2020 Volume 51, Issue 1, Page(s) e13436

Abstract: Background: The coronavirus disease 2019 (COVID-19) shows high morbidity and mortality, particularly in patients with concomitant cardiovascular diseases. Some of these patients are under oral anticoagulation (OAC) at admission, but to date, there are ... ...

Abstract	Background: The coronavirus disease 2019 (COVID-19) shows high morbidity and mortality, particularly in patients with concomitant cardiovascular diseases. Some of these patients are under oral anticoagulation (OAC) at admission, but to date, there are no data on the clinical profile, prognosis and risk factors of such patients during hospitalization for COVID-19. Design: Subanalysis of the international 'real-world' HOPE COVID-19 registry. All patients with prior OAC at hospital admission for COVID-19 were suitable for the study. All-cause mortality was the primary endpoint. Results: From 1002 patients included, 110 (60.9% male, median age of 81.5 [IQR 75-87] years, median Short-Form Charlson Comorbidity Index [CCI] of 1 [IQR 1-3]) were on OAC at admission, mainly for atrial fibrillation and venous thromboembolism. After propensity score matching, 67.9% of these patients died during hospitalization, which translated into a significantly higher mortality risk compared to patients without prior OAC (HR 1.53, 95% CI 1.08-2.16). After multivariate Cox regression analysis, respiratory insufficiency during hospitalization (HR 6.02, 95% CI 2.18-16.62), systemic inflammatory response syndrome (SIRS) during hospitalization (HR 2.29, 95% CI 1.34-3.91) and the Short-Form CCI (HR 1.24, 95% CI 1.03-1.49) were the main risk factors for mortality in patients on prior OAC. Conclusions: Compared to patients without prior OAC, COVID-19 patients on OAC therapy at hospital admission showed lower survival and higher mortality risk. In these patients on OAC therapy, the prevalence of several comorbidities is high. Respiratory insufficiency and SIRS during hospitalization, as well as higher comorbidity, pointed out those anticoagulated patients with increased mortality risk.
MeSH term(s)	Aged ; Aged, 80 and over ; Anticoagulants/therapeutic use ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; COVID-19/mortality ; Comorbidity ; Factor Xa Inhibitors/therapeutic use ; Female ; Heart Failure/epidemiology ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation ; Heparin/therapeutic use ; Heparin, Low-Molecular-Weight/therapeutic use ; Hospital Mortality ; Humans ; Intensive Care Units ; Male ; Multivariate Analysis ; Prognosis ; Propensity Score ; Proportional Hazards Models ; Renal Insufficiency/epidemiology ; Respiration, Artificial ; Respiratory Insufficiency/epidemiology ; Risk Factors ; SARS-CoV-2 ; Sepsis/epidemiology ; Systemic Inflammatory Response Syndrome/epidemiology ; Thromboembolism/epidemiology ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/epidemiology
Chemical Substances	Anticoagulants ; Factor Xa Inhibitors ; Heparin, Low-Molecular-Weight ; Heparin (9005-49-6)
Keywords	covid19
Language	English
Publishing date	2020-11-07
Publishing country	England
Document type	Journal Article
ZDB-ID	186196-7
ISSN	1365-2362 ; 0014-2972 ; 0960-135X
ISSN (online)	1365-2362
ISSN	0014-2972 ; 0960-135X
DOI	10.1111/eci.13436
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Article ; Online: Immune synapse instructs epigenomic and transcriptomic functional reprogramming in dendritic cells.

Alcaraz-Serna, Ana / Bustos-Morán, Eugenio / Fernández-Delgado, Irene / Calzada-Fraile, Diego / Torralba, Daniel / Marina-Zárate, Ester / Lorenzo-Vivas, Erika / Vázquez, Enrique / Barreto de Albuquerque, Juliana / Ruef, Nora / Gómez, Manuel José / Sánchez-Cabo, Fátima / Dopazo, Ana / Stein, Jens V / Ramiro, Almudena / Sánchez-Madrid, Francisco

Science advances

2021 Volume 7, Issue 6

Abstract: Understanding the fate of dendritic cells (DCs) after productive immune synapses (postsynaptic DCs) with T cells during antigen presentation has been largely neglected in favor of deciphering the nuances of T cell activation and memory generation. Here, ... ...

Abstract	Understanding the fate of dendritic cells (DCs) after productive immune synapses (postsynaptic DCs) with T cells during antigen presentation has been largely neglected in favor of deciphering the nuances of T cell activation and memory generation. Here, we describe that postsynaptic DCs switch their transcriptomic signature, correlating with epigenomic changes including DNA accessibility and histone methylation. We focus on the chemokine receptor
MeSH term(s)	Cell Movement ; Dendritic Cells ; Epigenomics ; Lymph Nodes ; Receptors, CCR7 ; Synapses ; Transcriptome
Chemical Substances	Receptors, CCR7
Language	English
Publishing date	2021-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abb9965
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