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Article ; Online: Structural identification and anti-neuroinflammatory effects of a pectin-arabinoglucuronogalactan complex, AOPB-1-1, isolated from Asparagus officinalis.

Yang, Junqiang / Liao, Yuechan / Cao, Chao / Yu, Qian / Zhang, Dawei / Yan, Chunyan

International journal of biological macromolecules

2024 Volume 268, Issue Pt 1, Page(s) 131593

Abstract: Asparagus officinalis L. is a horticultural crop that contains a variety of bioactive compounds with anti-inflammatory effects. Aqueous extracts of A. officinalis can noticeably improve the learning and memory function of model mice. Herein, a pectin- ... ...

Abstract	Asparagus officinalis L. is a horticultural crop that contains a variety of bioactive compounds with anti-inflammatory effects. Aqueous extracts of A. officinalis can noticeably improve the learning and memory function of model mice. Herein, a pectin-arabinoglucuronogalactan complex (AOPB-1-1) with a relative molecular weight of 90.8 kDa was isolated from A. officinalis. The repeating structural unit of AOPB-1-1 was identified through monosaccharide composition, methylation analysis, uronic acid reduction, partial acid hydrolysis, and nuclear magnetic resonance spectroscopy. AOPB-1-1 contains the rhamnogalacturonan-I (RG-I) domain of pectin polysaccharides (PPs) and arabinoglucuronogalactan (AGG) regions. The backbone of the AGG region is composed of →3,6)-β-D-Galp-(1→ and →4)-β-D-Glcp-(1→ residues substituted at the 4-position to the →4)-α-D-GalAp-(1→ residues of the RG-I main chain. The anti-neuroinflammatory activity of AOPB-1-1 suggests that it can significantly reduce the content of inflammatory cytokines, including nitric oxide (NO), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) and inhibit the expression of inflammatory genes including cyclooxygenase-2 (COX2), nitric oxide synthase (iNOS), TNF-α, IL-6, and interleukin-1β (IL-1β) in LPS-stimulated BV2 cells. Furthermore, its inhibitory effects on TNF-α and IL-6 levels were even better than those of minocycline. The significant anti-neuroinflammatory activity of AOPB-1-1 suggests its applicability as a therapeutic option for the treatment of Alzheimer's disease.
Language	English
Publishing date	2024-04-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131593
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Zs.B 2374: Show issues

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Article ; Online: Which Specific Exercise Models Are Most Effective on Global Cognition in Patients with Cognitive Impairment? A Network Meta-Analysis.

Yang, Junchao / Dong, Yunfeng / Yan, Shuting / Yi, Longyan / Qiu, Junqiang

International journal of environmental research and public health

2023 Volume 20, Issue 4

Abstract: 1) Introduction: Physical exercise interventions can impart significant cognitive benefits to older adults suffering from cognitive impairment (CI). However, the efficacy of these interventions can vary widely, depending on the type, intensity, duration ...

Abstract	(1) Introduction: Physical exercise interventions can impart significant cognitive benefits to older adults suffering from cognitive impairment (CI). However, the efficacy of these interventions can vary widely, depending on the type, intensity, duration and frequency of exercise. (2) Aim: To systematically review the efficacy of exercise therapy on global cognition in patients with CI using a network meta-analysis (NMA). (3) Methods: The PubMed, Embase, Sport Discus (EBSCO) and Cochrane Library databases were electronically searched to collect randomized controlled trials (RCTs) on exercise for patients with CI from inception to 7 August 2022. Two reviewers independently screened the literature, extracted data, and assessed the risk of bias of the included studies. The NMA was performed using the consistency model. (4) Results: A total of 29 RCTs comprising 2458 CI patients were included. The effects of different types of exercise on patients with CI were ranked as follows: multicomponent exercise (SMD = 0.84, 95% CI 0.31 to 1.36,
MeSH term(s)	Humans ; Aged ; Network Meta-Analysis ; Exercise ; Cognition ; Cognitive Dysfunction ; Exercise Therapy
Language	English
Publishing date	2023-02-04
Publishing country	Switzerland
Document type	Meta-Analysis ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20042790
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Article ; Online: Global scientific trends in continuous renal replacement therapy from 2000 to 2023: A bibliometric and visual analysis.

Tao, ZhongBin / Feng, YanDong / Wang, Jie / Zhou, YongKang / Yang, JunQiang

Blood purification

2024

Abstract: Introduction: Continuous renal replacement therapy (CRRT) is one of the most widely used blood purification and organ support methods in the ICU. However, the development process, the current status, hotspots, and future trends of CRRT remain unclear.!## ...

Abstract	Introduction: Continuous renal replacement therapy (CRRT) is one of the most widely used blood purification and organ support methods in the ICU. However, the development process, the current status, hotspots, and future trends of CRRT remain unclear. Method: The WoSCC database was used to analyze CRRT research evolution and theme trends. VOSviewer was used to construct co-authorship, co-occurrence, co-citation, and network visualizations. Citespace is used to detect bursts for co-occurrence items. Several important subtopics were reviewed and discussed in more detail. Results: Global publications increased from 56 in 2000 to 398 in 2023, a 710.71% increase. Blood Purification published the most manuscripts, followed by International Journal of Artificial Organs. The United States, the San Bortolo Hospital, and Bellomo, R were the most productive and impactful institution, country, and author respectively. Based on co-occurrence cluster analysis, five clusters emerged: (1) Clinical applications and management of CRRT; (2) Sepsis and CRRT; (3) CRRT anticoagulant management; (4) CRRT and antibiotic pharmacokinetics and pharmacodynamics; and (5) Comparison of CRRT and intermittent hemodialysis. COVID-19, initiation, ECOMO, cefepime, guidelines, cardiogenic shock, biomarker and outcome were the latest high-frequency keywords or strongest bursts, indicating the emerging frontiers of CRRT. Conclusions: There has been widespread publication and citation of CRRT research in the past two decades. We provide an overview of current trends, global collaboration patterns, basic knowledge, research hotspots, and emerging frontiers.
Language	English
Publishing date	2024-02-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	605548-5
ISSN	1421-9735 ; 0253-5068
ISSN (online)	1421-9735
ISSN	0253-5068
DOI	10.1159/000536312
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Zs.A 1872: Show issues

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Article ; Online: Rutin Attenuates Oxidative Stress Via PHB2-Mediated Mitophagy in MPP

Lai, Xiaoyi / Zhang, Yongjiang / Wu, Jiannan / Shen, Mengmeng / Yin, Shiyi / Yan, Junqiang

Neurotoxicity research

2023 Volume 41, Issue 3, Page(s) 242–255

Abstract: Oxidative stress plays a crucial role in the occurrence and development of Parkinson's disease (PD). Rutin, a natural botanical ingredient, has been shown to have antioxidant properties. Therefore, the aim of this study was to investigate the ... ...

Abstract	Oxidative stress plays a crucial role in the occurrence and development of Parkinson's disease (PD). Rutin, a natural botanical ingredient, has been shown to have antioxidant properties. Therefore, the aim of this study was to investigate the neuroprotective effects of rutin on PD and the underlying mechanisms. MPP
MeSH term(s)	Humans ; Reactive Oxygen Species/metabolism ; Antioxidants/pharmacology ; Mitophagy ; 1-Methyl-4-phenylpyridinium/toxicity ; Rutin/pharmacology ; NF-E2-Related Factor 2/metabolism ; Neuroblastoma ; Oxidative Stress ; Cell Line, Tumor ; Parkinson Disease/drug therapy ; Microtubule-Associated Proteins/metabolism ; Apoptosis
Chemical Substances	Reactive Oxygen Species ; Antioxidants ; 1-Methyl-4-phenylpyridinium (R865A5OY8J) ; Rutin (5G06TVY3R7) ; NF-E2-Related Factor 2 ; Microtubule-Associated Proteins
Language	English
Publishing date	2023-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2036826-4
ISSN	1476-3524 ; 1029-8428
ISSN (online)	1476-3524
ISSN	1029-8428
DOI	10.1007/s12640-023-00636-5
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Zs.A 5749: Show issues

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Article ; Online: Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Disease: A Meta-Analysis.

Sun, Wenjie / Yan, Junqiang / Wu, Jiannan / Ma, Hongxia

Medical science monitor : international medical journal of experimental and clinical research

2022 Volume 28, Page(s) e935074

Abstract: BACKGROUND Non-visual effects of the retina have been increasingly confirmed in developing Parkinson disease (PD). Light therapy (LT) has been proven to be an effective non-pharmacotherapy for improving the prognosis of PD, but the pathway of action is ... ...

Abstract	BACKGROUND Non-visual effects of the retina have been increasingly confirmed in developing Parkinson disease (PD). Light therapy (LT) has been proven to be an effective non-pharmacotherapy for improving the prognosis of PD, but the pathway of action is unclear, and there is a lack of a unified and standardized LT regimen. We aimed to evaluate the efficacy and safety of various LT measures in improving motor and non-motor symptoms in patients with idiopathic PD via a meta-analysis. MATERIAL AND METHODS CENTRAL, EMBASE, CINAHL, PEDro, and PubMed were searched for randomized controlled trials (RCTs) investigating the efficacy of LT for PD. Cochrane's Risk of bias tool and the GRADE approach were used to assess evidence quality. A meta-analysis and subgroup analyses evaluated the differences in efficacy produced by the different LT protocols. Trial sequential analysis (TSA) verified the analyses outcome and quantified the statistical relevance of the data.[color=#0e101a] [/color] RESULTS Patients receiving LT had significantly better scores for motor function (MD=-4.68, 95% Cl -8.25 to -1.12, P=0.01) compared with the control group exposed to dim-red light. In addition, in terms of non-motor symptoms, depression (SMD=-0.27, 95% Cl -0.52 to -0.02, P=0.04) and sleep disturbance-related scores (MD=3.45, 95% Cl 0.12 to 6.78, P=0.04) similarly showed significant optimization after receiving LT. CONCLUSIONS The results of this meta-analysis show strong evidence that LT has significant efficacy on motor and non-motor function in PD patients.
MeSH term(s)	Humans ; Parkinson Disease/diagnosis ; Parkinson Disease/therapy ; Phototherapy/methods ; Phototherapy/standards ; Prognosis ; Symptom Assessment/methods ; Treatment Outcome
Language	English
Publishing date	2022-01-07
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.935074
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Zs.A 4924: Show issues

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Article: Oral pyruvate prevents high-intensity interval exercise-induced metabolic acidosis in rats by promoting lactate dehydrogenase reaction.

Che, Kaixuan / Yang, Yanping / Zhang, Jun / Feng, Lin / Xie, Yan / Li, Qinlong / Qiu, Junqiang

Frontiers in nutrition

2023 Volume 10, Page(s) 1096986

Abstract: Introduction: There is no denying the clinical benefits of exogenous pyruvate in the treatment of pathological metabolic acidosis. However, whether it can prevent exercise physiological metabolic acidosis, delay the occurrence of exercise fatigue, and ... ...

Abstract	Introduction: There is no denying the clinical benefits of exogenous pyruvate in the treatment of pathological metabolic acidosis. However, whether it can prevent exercise physiological metabolic acidosis, delay the occurrence of exercise fatigue, and improve the beneficial effects of exercise and its internal mechanism remain unclear. Methods: We randomly divided 24 male SD rats into 3 groups: one group was a control without exercise (CC, Results: Pyruvate supplementation significantly reversed the decrease of pHe, BE, HCO Discussion: This study provides compelling evidence that oral pyruvate attenuates HIIE-induced intracellular and extracellular acidification, possibly due to increased activity of LDHA, which promotes the absorption of H
Language	English
Publishing date	2023-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1096986
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Article ; Online: Effects of three weeks base training at moderate simulated altitude with or without hypoxic residence on exercise capacity and physiological adaptations in well-trained male runners.

Yi, Longyan / Wu, Jian / Yan, Bing / Wang, Yang / Zou, Menghui / Zhang, Yimin / Li, Feifei / Qiu, Junqiang / Girard, Olivier

PeerJ

2024 Volume 12, Page(s) e17166

Abstract: Objectives: To test the hypothesis that 'live high-base train high-interval train low' (HiHiLo) altitude training, compared to 'live low-train high' (LoHi), yields greater benefits on performance and physiological adaptations.: Methods: Sixteen young ...

Abstract	Objectives: To test the hypothesis that 'live high-base train high-interval train low' (HiHiLo) altitude training, compared to 'live low-train high' (LoHi), yields greater benefits on performance and physiological adaptations. Methods: Sixteen young male middle-distance runners (age, 17.0 ± 1.5 y; body mass, 58.8 ± 4.9 kg; body height, 176.3 ± 4.3 cm; training years, 3-5 y; training distance per week, 30-60 km.wk Results: Peak oxygen uptake and running performance did not differ before and after the intervention in either group (all Conclusions: Well-trained runners undertaking base training at moderate simulated altitude for 3 weeks, with or without hypoxic residence, showed no performance improvement, also with unchanged time-domain heart rate variability and exercise-induced arterial hypoxemia responses.
MeSH term(s)	Male ; Humans ; Adolescent ; Altitude ; Exercise Tolerance ; Oxygen Consumption/physiology ; Hypoxia ; Adaptation, Physiological ; Oxygen
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.17166
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Article ; Online: Nur77 increases mitophagy and decreases aggregation of α-synuclein by modulating the p-c-Abl/p-PHB2 Y121 in α-synuclein PFF SH-SY5Y cells and mice.

Yin, Shiyi / Shen, Mengmeng / Zhang, Yongjiang / Wu, Jiannan / Song, Run / Lai, Xiaoyi / Tian, Zhenzhen / Wang, Tingting / Jin, Weina / Yan, Junqiang

European journal of medicinal chemistry

2024 Volume 268, Page(s) 116251

Abstract: Parkinson's disease (PD) is characterized by the progressive death of dopamine (DA) neurons and the pathological accumulation of α-synuclein (α-syn) fibrils. In our previous study, simulated PHB2 phosphorylation was utilized to clarify the regulatory ... ...

Abstract	Parkinson's disease (PD) is characterized by the progressive death of dopamine (DA) neurons and the pathological accumulation of α-synuclein (α-syn) fibrils. In our previous study, simulated PHB2 phosphorylation was utilized to clarify the regulatory role of c-Abl in PHB2-mediated mitophagy in PD models. In this investigation, we employed an independently patented PHB2Y121 phosphorylated antibody in the PD model to further verify that the c-Abl inhibitor STI571 can impede PHB2Y121 phosphorylation, decrease the formation of α-Syn polymers, and improve autophagic levels. The specific involvement of Nur77 in PD pathology has remained elusive. We also investigate the contribution of Nur77, a nuclear transcription factor, to α-syn and mitophagy in PD. Our findings demonstrate that under α-syn, Nur77 translocates from the cytoplasm to the mitochondria, improving PHB-mediated mitophagy by regulating c-Abl phosphorylation. Moreover, Nur77 overexpression alleviates the expression level of pS129-α-syn and the loss of DA neurons in α-syn PFF mice, potentially associated with the p-c-Abl/p-PHB2 Y121 axis. This study provides initial in vivo and in vitro evidence that Nur77 protects PD DA neurons by modulating the p-c-Abl/p-PHB2 Y121 axis, and STI571 holds promise as a treatment for PD.
MeSH term(s)	Mice ; Humans ; Animals ; alpha-Synuclein/metabolism ; Mitophagy ; Imatinib Mesylate ; Neuroblastoma/pathology ; Parkinson Disease/metabolism ; Dopaminergic Neurons/metabolism
Chemical Substances	alpha-Synuclein ; Imatinib Mesylate (8A1O1M485B)
Language	English
Publishing date	2024-02-23
Publishing country	France
Document type	Journal Article
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2024.116251
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Zs.B 784: Show issues

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Article ; Online: Targeting DAD1 gene with CRISPR-Cas9 system transmucosally delivered by fluorinated polylysine nanoparticles for bladder cancer intravesical gene therapy.

Tang, Dongdong / Yan, Yang / Li, Yangyang / Li, Yuqing / Tian, Junqiang / Yang, Li / Ding, Hui / Bashir, Ghassan / Zhou, Houhong / Ding, Qiuxia / Tao, Ran / Zhang, Shaohua / Wang, Zhiping / Wu, Song

Theranostics

2024 Volume 14, Issue 1, Page(s) 203–219

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Mice ; Animals ; Humans ; Urinary Bladder/pathology ; Polylysine/metabolism ; CRISPR-Cas Systems/genetics ; Urinary Bladder Neoplasms/therapy ; Urinary Bladder Neoplasms/drug therapy ; Nanoparticles ; Genetic Therapy
Chemical Substances	Polylysine (25104-18-1)
Language	English
Publishing date	2024-01-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.88550
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Article: Variations in the Intestinal Microbiota of the Chinese Soft-Shelled Turtle (

Liu, Naicheng / Zhang, Peng / Xue, Mingyang / Xiao, Zidong / Zhang, Mengjie / Meng, Yan / Fan, Yuding / Qiu, Junqiang / Zhang, Qinghua / Zhou, Yong

Animals : an open access journal from MDPI

2023 Volume 13, Issue 18

Abstract: The microbial community structure in aquaculture water plays an important role in the intestinal microbial diversity of aquatic animals. The Chinese soft-shelled turtle (SST) ( ...

Abstract	The microbial community structure in aquaculture water plays an important role in the intestinal microbial diversity of aquatic animals. The Chinese soft-shelled turtle (SST) (
Language	English
Publishing date	2023-09-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13182971
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