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  1. Article ; Online: Lecanemab for Alzheimer Disease: Is It Worth It?

    Nelson, Sarah E / Lopez, Oscar L

    Neurology

    2024  Volume 102, Issue 7, Page(s) e209265

    MeSH term(s) Humans ; Alzheimer Disease ; Antibodies, Monoclonal, Humanized
    Chemical Substances lecanemab (12PYH0FTU9) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000209265
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  2. Article: Can the introduction of companion plants increase biological control services of key pests in organic squash?

    Lopez, Lorena / Liburd, Oscar E.

    Entomologia experimentalis et applicata. 2022 May, v. 170, no. 5

    2022  

    Abstract: Florida (USA) is a major producer of squash, Cucurbita pepo L. (Cucurbitaceae), with approximated ... was released alone or together with sweet alyssum, Lobularia maritima (L.) Desv. (Brassicaceae ...

    Abstract Florida (USA) is a major producer of squash, Cucurbita pepo L. (Cucurbitaceae), with approximated 16% of the US production in 2019, valued at about 35 million USD. Major insect pests, including the sweetpotato whitefly MEAM1, Bemisia tabaci Gennadius (Hemiptera: Aleyrodidae), and the melon aphid, Aphis gossypii Glover (Hemiptera: Aphididae), jeopardize plant development and transmit viruses of economic importance that can cause up to 50% yield loss in squash crops. Pesticides are generally used for insect management in squash, but the development of insecticide resistance and their non‐target effects are major concerns. A combination of non‐pesticidal approaches was evaluated, including intercropping flowering plants, augmentation, and conservation biological control to manage key pests in organic squash. Refugia increased natural enemies around the squash; however, only a few beneficial arthropods moved from the companion plants towards the squash plants. Whitefly densities and squash silverleaf ratings were reduced, whereas natural enemies were more abundant when the predatory mite Amblyseius swirskii Athias‐Henriot (Acari: Phytoseiidae) was released alone or together with sweet alyssum, Lobularia maritima (L.) Desv. (Brassicaceae). All companion plants used in this study increased natural enemies, but only African marigolds and sweet alyssum ultimately increased biological control activities.
    Keywords Amblyseius swirskii ; Aphis gossypii ; Bemisia tabaci ; Cucurbita pepo ; Lobularia maritima ; biological control ; insect control ; insecticide resistance ; plant development ; predatory mites ; refuge habitats ; squashes ; Florida
    Language English
    Dates of publication 2022-05
    Size p. 402-418.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 216272-6
    ISSN 0013-8703
    ISSN 0013-8703
    DOI 10.1111/eea.13147
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    Z 1216: Show issues

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  3. Article ; Online: Scientific Autobiography: On Brain Health and Cognitive Fitness Into the Later Years of Life-Journey of a Behavioral Neurologist of Aging.

    Lopez, Oscar L

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    2018  Volume 26, Issue 11, Page(s) 1184–1189

    MeSH term(s) Aged ; Aging/physiology ; Alzheimer Disease/epidemiology ; Alzheimer Disease/history ; Argentina ; Brain/physiology ; Cognition/physiology ; History, 20th Century ; History, 21st Century ; Humans ; Neurology/history ; Ohio
    Language English
    Publishing date 2018-07-24
    Publishing country England
    Document type Autobiography ; Editorial ; Historical Article
    ZDB-ID 1278145-9
    ISSN 1545-7214 ; 1064-7481
    ISSN (online) 1545-7214
    ISSN 1064-7481
    DOI 10.1016/j.jagp.2018.07.002
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  4. Article ; Online: Prediction of primal and retail cut weights, tissue composition and yields of youthful cattle carcasses using computer vision systems; whole carcass camera and/or ribeye camera.

    Segura, José / Aalhus, Jennifer L / Prieto, Nuria / Zawadski, Sophie / Scott, Haley / López-Campos, Óscar

    Meat science

    2023  Volume 199, Page(s) 109120

    Abstract: The application of two computer vision systems (CVS) was evaluated to predict primal and retail cut composition in youthful beef carcasses. Left carcass sides from a total of 634 animals were broken down into primal cuts, scanned using dual-energy x-ray ... ...

    Abstract The application of two computer vision systems (CVS) was evaluated to predict primal and retail cut composition in youthful beef carcasses. Left carcass sides from a total of 634 animals were broken down into primal cuts, scanned using dual-energy x-ray absorptiometry for the prediction of tissue composition and fabricated into retail cuts. Cold carcass camera (CCC) images led to higher R
    MeSH term(s) Cattle ; Animals ; Body Composition ; Meat ; Absorptiometry, Photon ; Bone and Bones ; Artificial Intelligence
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 753319-6
    ISSN 1873-4138 ; 0309-1740
    ISSN (online) 1873-4138
    ISSN 0309-1740
    DOI 10.1016/j.meatsci.2023.109120
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    In stock of ZB MED Bonn / Germany

    Z 4037: Show issues

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  5. Article ; Online: ENGAGE and EMERGE: Truth and consequences?

    Kuller, Lewis H / Lopez, Oscar L

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2021  Volume 17, Issue 4, Page(s) 692–695

    Abstract: The potential benefit of the anti-amyloid drug aducanumab based on results of recent EMERGE and ENGAGE clinical trials has generated great controversy and has very important implications for the future of anti-amyloid drug therapies. The two trials of 18- ...

    Abstract The potential benefit of the anti-amyloid drug aducanumab based on results of recent EMERGE and ENGAGE clinical trials has generated great controversy and has very important implications for the future of anti-amyloid drug therapies. The two trials of 18-month duration were done in patients with mild cognitive impairment (MCI) and early dementia. The ENGAGE trial showed no benefit while the high-dose EMERGE trial initially also showed no benefit but with longer follow-up there was a significant positive benefit. A recent review form the U.S. Food and Drug Administration (FDA) Advisory Committee was negative while the FDA Office of Neurological Drugs was positive and the statisticians negative. This has generated debate about whether the drug should be approved, disapproved, require a new clinical trial, or approved for a subsample only. The implications for treating both MCI and Alzheimer's disease (AD) patients with anti-amyloid drugs is very substantial as well as the brain amyloid-AD-dementia hypothesis.
    MeSH term(s) Aged ; Alzheimer Disease/drug therapy ; Amyloid ; Antibodies, Monoclonal, Humanized/therapeutic use ; Biomarkers ; Cognitive Dysfunction/drug therapy ; Dose-Response Relationship, Drug ; Drug Approval ; Humans ; Treatment Outcome
    Chemical Substances Amyloid ; Antibodies, Monoclonal, Humanized ; Biomarkers ; aducanumab (105J35OE21)
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.12286
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  6. Article: Lanthanide-Doped ZnO Nanoparticles: Unraveling Their Role in Cytotoxicity, Antioxidant Capacity, and Nanotoxicology.

    Mejía-Méndez, Jorge L / Navarro-López, Diego E / Sanchez-Martinez, Araceli / Ceballos-Sanchez, Oscar / Garcia-Amezquita, Luis Eduardo / Tiwari, Naveen / Juarez-Moreno, Karla / Sanchez-Ante, Gildardo / López-Mena, Edgar R

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: This study used a sonochemical synthesis method to prepare (La, Sm)-doped ZnO nanoparticles (NPs). The effect of incorporating these lanthanide elements on the structural, optical, and morphological properties of ZnO-NPs was analyzed. The cytotoxicity ... ...

    Abstract This study used a sonochemical synthesis method to prepare (La, Sm)-doped ZnO nanoparticles (NPs). The effect of incorporating these lanthanide elements on the structural, optical, and morphological properties of ZnO-NPs was analyzed. The cytotoxicity and the reactive oxygen species (ROS) generation capacity of ZnO-NPs were evaluated against breast (MCF7) and colon (HT29) cancer cell lines. Their antioxidant activity was analyzed using a DPPH assay, and their toxicity towards
    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13020213
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  7. Article ; Online: Enhancing antioxidant properties of CeO

    Ceballos-Sanchez, Oscar / Navarro-López, Diego E / Mejía-Méndez, Jorge L / Sanchez-Ante, Gildardo / Rodríguez-González, Vicente / Sánchez-López, Angélica Lizeth / Sanchez-Martinez, Araceli / Duron-Torres, Sergio M / Juarez-Moreno, Karla / Tiwari, Naveen / López-Mena, Edgar R

    Biomaterials science

    2024  Volume 12, Issue 8, Page(s) 2108–2120

    Abstract: The antioxidant capabilities of nanoparticles are contingent upon various factors, including their shape, size, and chemical composition. Herein, novel Nd-doped ... ...

    Abstract The antioxidant capabilities of nanoparticles are contingent upon various factors, including their shape, size, and chemical composition. Herein, novel Nd-doped CeO
    MeSH term(s) Antioxidants/pharmacology ; Antioxidants/chemistry ; Neodymium ; Nanoparticles/chemistry ; Nanostructures ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry
    Chemical Substances Antioxidants ; Neodymium (2I87U3734A) ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d3bm02107f
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  8. Article: AT1 receptor downregulation: A mechanism for improving glucose homeostasis.

    Lopez, Diana L / Casillas, Oscar E / Jaramillo, Hiram J / Romero-Garcia, Tatiana / Vazquez-Jimenez, J Gustavo

    World journal of diabetes

    2023  Volume 14, Issue 3, Page(s) 170–178

    Abstract: There is a pathophysiological correlation between arterial hypertension and diabetes mellitus, established since the pre-diabetic state in the entity known as insulin resistance. It is known that high concentrations of angiotensin-II enable chronic ... ...

    Abstract There is a pathophysiological correlation between arterial hypertension and diabetes mellitus, established since the pre-diabetic state in the entity known as insulin resistance. It is known that high concentrations of angiotensin-II enable chronic activation of the AT1 receptor, promoting sustained vasoconstriction and the consequent development of high blood pressure. Furthermore, the chronic activation of the AT1 receptor has been associated with the development of insulin resistance. From a molecular outlook, the AT1 receptor signaling pathway can activate the JNK kinase. Once activated, this kinase can block the insulin signaling pathway, favoring the resistance to this hormone. In accordance with the previously mentioned mechanisms, the negative regulation of the AT1 receptor could have beneficial effects in treating metabolic syndrome and type 2 diabetes mellitus. This review explains the clinical correlation of the metabolic response that diabetic patients present when receiving negatively regulatory drugs of the AT1 receptor.
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2583471-X
    ISSN 1948-9358
    ISSN 1948-9358
    DOI 10.4239/wjd.v14.i3.170
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  9. Article ; Online: Miticidal Tools for Management of Southern Red Mites Infesting Southern Highbush Blueberries

    López, Lorena / Liburd, Oscar E.

    Insects. 2023 June 21, v. 14, no. 7

    2023  

    Abstract: Tetranychid outbreaks have been detected since 2016 in southern highbush blueberries (SHB); however, it was not until 2019 that the southern red mite (SRM), Oligonychus ilicis (Acari: Tetranychidae) was confirmed as the pest causing severe bronzing and ... ...

    Abstract Tetranychid outbreaks have been detected since 2016 in southern highbush blueberries (SHB); however, it was not until 2019 that the southern red mite (SRM), Oligonychus ilicis (Acari: Tetranychidae) was confirmed as the pest causing severe bronzing and stunting, in multiple Florida and Georgia commercial blueberry plantings. To date, only three miticides (fenazaquin, fenpyroximate, and acequinocyl) have been registered for use in SHB and there are no clear guidelines on how to manage SRM in SHB. Similarly, there is no knowledge regarding the existence of natural enemies of SRM in SHB. This is the first report of naturally occurring predatory mites (Amblyseius sp. and Neoseiulus ilicis) associated with SRM in SHB. Predatory mites were recorded in blueberry bushes after treatment with seven miticides used to suppress SRM populations including spiromesifen, acequinocyl, sulfur, sulfur + molasses, bifenazate, fenpyroximate, and fenazaquin. The number of SRM recorded per leaf and averaged plant damage ratings (0 = no bronzing–4 = 100% bronzing) were used to evaluate miticide efficacy. Additionally, the presence or absence of predatory mites per sample was recorded. Fenpyroximate used as the standard miticide, significantly reduced mite numbers seven days after application, as well as acequinocyl and fenazaquin. Fenpyroximate and fenazaquin demonstrated the best performance for managing O. ilicis on SHB and treated bushes demonstrated significantly less bronzing compared with the control plants. These miticides were also safe to naturally occurring predatory mites. Lastly, the level of growers’ awareness regarding SRM was assessed using surveys in 2020 to design adequate educational materials available to the grower community.
    Keywords Amblyseius ; Neoseiulus ; Oligonychus ilicis ; bifenazate ; blueberries ; fenpyroximate ; leaves ; mites ; molasses ; pests ; plant damage ; spiromesifen ; sulfur ; Florida ; Georgia
    Language English
    Dates of publication 2023-0621
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects14070573
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  10. Article ; Online: Vascular disease and cerebral amyloid deposition.

    Lopez, Oscar L / Maillard, Pauline

    Neurology

    2018  Volume 90, Issue 14, Page(s) 635–636

    MeSH term(s) Amyloid beta-Peptides ; Atherosclerosis ; Cerebral Amyloid Angiopathy ; Dementia ; Humans ; Vascular Stiffness
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2018-03-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000005242
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