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Article: Research in the Time of COVID-19: Challenges of Research Ethics Committees.

Reyes, Marita

Journal of the ASEAN Federation of Endocrine Societies

2020 Volume 35, Issue 1, Page(s) 29–32

Abstract: Compliance with ethics guidelines for research are even more critical in the time of emergency public health situations such as a pandemic. Underpinned by the principles laid out in the 1979 Belmont report, conduct of research at any time should focus on ...

Abstract	Compliance with ethics guidelines for research are even more critical in the time of emergency public health situations such as a pandemic. Underpinned by the principles laid out in the 1979 Belmont report, conduct of research at any time should focus on respect for persons, beneficence and justice. Certain Standard Operating Procedures (SOPs) in research ethics committees may be revised to provide a quicker turn-around and timely review. Key elements in effective review of studies include rigorousness, responsiveness and timeliness. It is crucial to recognize that ethics review committees share responsibility with researchers and its institutions, funding agencies and regulatory agencies for upholding ethical principles in research at all times.
Language	English
Publishing date	2020-05-23
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2893162-2
ISSN	2308-118X ; 0857-1074
ISSN (online)	2308-118X
ISSN	0857-1074
DOI	10.15605/jafes.035.01.07
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Research in the time of covid-19: Challenges of research ethics committees

Reyes, Marita

J. ASEAN Fed. Endocr. Soc.

Abstract	Compliance with ethics guidelines for research are even more critical in the time of emergency public health situations such as a pandemic. Underpinned by the principles laid out in the 1979 Belmont report, conduct of research at any time should focus on respect for persons, beneficence and justice. Certain Standard Operating Procedures (SOPs) in research ethics committees may be revised to provide a quicker turn-around and timely review. Key elements in effective review of studies include rigorousness, responsiveness and timeliness. It is crucial to recognize that ethics review committees share responsibility with researchers and its institutions, funding agencies and regulatory agencies for upholding ethical principles in research at all times.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #678596
Database	COVID19

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Article ; Online: Isolation and Characterization of Extracellular Vesicles in Human Bowel Lavage Fluid.

Alorda-Clara, Marina / Reyes, Jose / Trelles-Guzman, Marita Grimanesa / Florido, Monica / Roca, Pilar / Pons, Daniel Gabriel / Oliver, Jordi

International journal of molecular sciences

2023 Volume 24, Issue 8

Abstract: Colorectal cancer (CRC) is the third most common cancer worldwide and is detected in late stages because of a lack of early and specific biomarkers. Tumors can release extracellular vesicles (EVs), which participate in different functions, such as ... ...

Abstract	Colorectal cancer (CRC) is the third most common cancer worldwide and is detected in late stages because of a lack of early and specific biomarkers. Tumors can release extracellular vesicles (EVs), which participate in different functions, such as carrying nucleic acids to target cells; promoting angiogenesis, invasion, and metastasis; and preparing an adequate tumor microenvironment. Finally, bowel lavage fluid (BLF) is a rarely used sample that is obtained during colonoscopy. It presents low variability and protein degradation, is easy to handle, and is representative of EVs from tumor cells due to proximity of the sample collection. This sample has potential as a research tool and possible biomarker source for CRC prognosis and monitoring. In this study, EVs were isolated from human BLF by ultracentrifugation, then characterized by transmission electron microscopy and atomic force microscopy. EV concentration was determined by nanoparticle tracking analysis, and tetraspanins were determined by Western blot, confirming correct EV isolation. RNA, DNA, and proteins were isolated from these EVs; RNA was used in real-time PCR, and proteins were used in an immunoblotting analysis, indicating that EV cargo is optimal for use and study. These results indicate that EVs from BLF can be a useful tool for CRC study and could be a source of biomarkers for the diagnosis and monitoring of CRC.
MeSH term(s)	Humans ; Therapeutic Irrigation ; Biomarkers/metabolism ; Microscopy, Electron, Transmission ; Neoplasms/metabolism ; Extracellular Vesicles/metabolism ; RNA/metabolism ; Tumor Microenvironment
Chemical Substances	Biomarkers ; RNA (63231-63-0)
Language	English
Publishing date	2023-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24087391
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Article: Result of the first two rounds of the colorectal cancer screening program in the Balearic Islands (Spain).

Trelles Guzmán, Marita Grimanesa / Novella Duran, Maria Teresa / Heredia Centeno, M Luisa / Florido Garcia, Monica / Sanchez-Contador Escudero, Maria Del Carmen / Iyo Miyashiro, Eduardo Yun / Ortega Moya, Silvia Patricia / Miro Viamonte, Elisa / Artigues Vives, Guillem / Gelabert Zornoza, Joan / Garcia Cortez, Paul David / Lucero Pizones, Juan Antonio / Rodriguez Hidalgo, Carolina / Ruiz Rubi, Alicia / Roca Salom, María Del Pilar / Sastre-Serra, Jorge / Reyes Moreno, Jose

Gastroenterologia y hepatologia

2021 Volume 45 Suppl 1, Page(s) 55–57

Title translation	Resultado de las 2 primeras rondas del programa de cribado de cáncer colorrectal en las Islas Baleares (España).
MeSH term(s)	Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Early Detection of Cancer ; Humans ; Spain
Language	Spanish
Publishing date	2021-02-02
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2020.12.001
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Article ; Online: Why did people not get vaccinated against COVID-19? Results from a nationwide survey among Mexican adults

Wrzecionkowska, Dagmara / Stephens, Christopher R. / Gutierrez Reyes, Juan Pablo

medRxiv

Abstract: ... marital status, educational level, age, BMI, testing for COVID-19, and the perception of COVID-19 (severe and ...

Abstract	Objective: To explore the reasons for not getting vaccinated against COVID-19. Material and methods: In October 2021, a nationwide structured telephone survey (disproportionate stratified sampling) was conducted regarding COVID-19 pandemics, including vaccination experience. To examine associations between inoculation and other characteristics, the chi-square test and logistic regression analysis were applied. Results: Out of 3,126 adults, 68% reported complete vaccination and 21% only the first dose, while 11% remained unvaccinated. Non-vaccination was associated with being younger, male, without a partner, low socioeconomic level, and no previous diagnosis of hypertension, obesity or diabetes. Furthermore, the non-vaccinated were less likely to have tested for COVID-19, and more likely to consider COVID-19 as low severity and not real compared with the vaccinated. Using logistic regression models: place of residence, marital status, educational level, age, BMI, testing for COVID-19, and the perception of COVID-19 (severe and real) were significant predictors of non-vaccination, with the model with 89% accuracy. The predominant reasons for not getting vaccinated were: 63% external barriers (e.g., not being able to attend an appointment), and 37% internal motives (e.g., vaccine does not work). Conclusions: The causes of non-vaccination against COVID-19 are related to both social and geographical determinants. Addressing external barriers is necessary in order to promote equity in vaccination. Reviewing the results in the context of earlier studies on the willingness to vaccinate, the gap between intention and vaccination is notable.
Keywords	covid19
Language	English
Publishing date	2024-01-17
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2024.01.17.24301326
Database	COVID19

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Article ; Online: Why didn’t people get vaccinated against COVID-19? Results from a nationwide survey among Mexican adults

Wrzecionkowska, Dagmara / Stephens, Christopher R. / Gutiérrez Reyes, Juan Pablo

medRxiv

Abstract: ... marital status, educational level, age, BMI, testing for COVID-19, and the perception of COVID-19 (severe and ...

Abstract	Objective: To explore the reasons for not getting vaccinated against COVID-19. Material and methods: In October 2021, a nationwide structured telephone survey (disproportionate stratified sampling) was conducted regarding COVID-19 pandemics, including vaccination experience. To examine associations between inoculation and other characteristics, the chi-square test and logistic regression analysis were applied. Results: Out of 3,126 adults, 68% reported complete vaccination and 21% only the first dose, while 11% remained unvaccinated. Non-vaccination was associated with being younger, male, without a partner, low socioeconomic level, and no previous diagnosis of hypertension, obesity or diabetes. Furthermore, the non-vaccinated were less likely to have tested for COVID-19, and more likely to consider COVID-19 as low severity and not real compared with the vaccinated. Using logistic regression models: place of residence, marital status, educational level, age, BMI, testing for COVID-19, and the perception of COVID-19 (severe and real) were significant predictors of non-vaccination, with the model with 89% accuracy. The predominant reasons for not getting vaccinated were: 63% external barriers (e.g., not being able to attend an appointment), and 37% internal motives (e.g., vaccine does not work). Conclusions: The causes of non-vaccination against COVID-19 are related to both social and geographical determinants. Addressing external barriers is necessary in order to promote equity in vaccination. Reviewing the results in the context of earlier studies on the willingness to vaccinate, the gap between intention and vaccination is notable.
Keywords	covid19
Language	English
Publishing date	2024-01-17
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2024.01.17.24301326
Database	COVID19

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Article ; Online: Beyond Lipoprotein(a) plasma measurements: Lipoprotein(a) and inflammation.

Reyes-Soffer, Gissette / Westerterp, Marit

Pharmacological research

2021 Volume 169, Page(s) 105689

Abstract: Genome wide association, epidemiological, and clinical studies have established high lipoprotein(a) [Lp(a)] as a causal risk factor for atherosclerotic cardiovascular disease (ASCVD). Lp(a) is an apoB100 containing lipoprotein covalently bound to ... ...

Abstract	Genome wide association, epidemiological, and clinical studies have established high lipoprotein(a) [Lp(a)] as a causal risk factor for atherosclerotic cardiovascular disease (ASCVD). Lp(a) is an apoB100 containing lipoprotein covalently bound to apolipoprotein(a) [apo(a)], a glycoprotein. Plasma Lp(a) levels are to a large extent determined by genetics. Its link to cardiovascular disease (CVD) may be driven by its pro-inflammatory effects, of which its association with oxidized phospholipids (oxPL) bound to Lp(a) is the most studied. Various inflammatory conditions, such as rheumatoid arthritis (RA), systemic lupus erythematosus, acquired immunodeficiency syndrome, and chronic renal failure are associated with high Lp(a) levels. In cases of RA, high Lp(a) levels are reversed by interleukin-6 receptor (IL-6R) blockade by tocilizumab, suggesting a potential role for IL-6 in regulating Lp(a) plasma levels. Elevated levels of IL-6 and IL-6R polymorphisms are associated with CVD. Therapies aimed at lowering apo(a) and thereby reducing plasma Lp(a) levels are in clinical trials. Their results will determine if reductions in apo(a) and Lp(a) decrease cardiovascular outcomes. As we enter this new arena of available treatments, there is a need to improve our understanding of mechanisms. This review will focus on the role of Lp(a) in inflammation and CVD.
MeSH term(s)	Animals ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Humans ; Inflammation/blood ; Inflammation/etiology ; Inflammation/metabolism ; Lipoprotein(a)/blood ; Lipoprotein(a)/metabolism ; Lipoprotein(a)/physiology
Chemical Substances	Lipoprotein(a)
Language	English
Publishing date	2021-05-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2021.105689
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Zs.A 721: Show issues

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Article ; Online: Implementing evidence-based practices: considerations for the hospice setting.

Sanders, Sara / Mackin, Melissa Lehan / Reyes, Jimmy / Herr, Keela / Titler, Marita / Fine, Perry / Forcucci, Chris

The American journal of hospice & palliative care

2010 Volume 27, Issue 6, Page(s) 369–376

Abstract: With increased regulation and scrutiny of outcomes, hospice programs are being challenged to consider the implementation of evidence-based practices (EBPs). This study reports findings from hospice director interviews and staff focus groups, which ... ...

Abstract	With increased regulation and scrutiny of outcomes, hospice programs are being challenged to consider the implementation of evidence-based practices (EBPs). This study reports findings from hospice director interviews and staff focus groups, which occurred following the completion of a multifaceted translating research into practice (TRIP) intervention designed to promote evidence-based pain management practices. The purpose of this article is to provide background on the use of EBPs, to report facilitators and barriers to overall implementation of pain management EBPs in hospice, and to provide recommendations for hospices interested in increasing the use of EBPs. Three areas for evaluation prior to implementing an EBP initiative in hospices were identified: community, agency, and staff cultures. Recommendations for implementation of EBPs in hospices are provided.
MeSH term(s)	Adult ; Evidence-Based Medicine ; Female ; Focus Groups ; Guideline Adherence ; Health Plan Implementation/methods ; Health Services Research ; Hospice Care/methods ; Hospices/methods ; Humans ; Male ; Middle Aged ; Neoplasms/therapy ; Pain Management ; Physician Executives ; Quality Assurance, Health Care/methods ; United States
Language	English
Publishing date	2010-02-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1074344-3
ISSN	1938-2715 ; 1049-9091
ISSN (online)	1938-2715
ISSN	1049-9091
DOI	10.1177/1049909109358695
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Article ; Online: Apolipoprotein(a) production and clearance are associated with plasma IL-6 and IL-18 levels, dependent on ethnicity.

Groenen, Anouk G / Matveyenko, Anastasiya / Matienzo, Nelsa / Halmos, Benedek / Zhang, Hanrui / Westerterp, Marit / Reyes-Soffer, Gissette

Atherosclerosis

2024 Volume 391, Page(s) 117474

Abstract: Background and aims: High plasma lipoprotein (a) [Lp(a)] levels are associated with increased atherosclerotic cardiovascular disease (ASCVD), in part attributed to elevated inflammation. High plasma Lp(a) levels inversely correlate with apolipoprotein ( ... ...

Abstract	Background and aims: High plasma lipoprotein (a) [Lp(a)] levels are associated with increased atherosclerotic cardiovascular disease (ASCVD), in part attributed to elevated inflammation. High plasma Lp(a) levels inversely correlate with apolipoprotein (a) [(APO(a)] isoform size. APO(a) isoform size is negatively associated with APO(a) production rate (PR) and positively associated with APO(a) fractional catabolic rate (FCR). We asked whether APO(a) PR and FCR (kinetics) are associated with plasma levels of interleukin (IL)-6 and IL-18, pro-inflammatory interleukins that promote ASCVD. Methods: We used samples from existing data of APO(a) kinetic studies from an ethnically diverse cohort (n = 25: 10 Black, 9 Hispanic, and 6 White subjects) and assessed IL-6 and IL-18 plasma levels. We performed multivariate linear regression analyses to examine the relationships between predictors APO(a) PR or APO(a) FCR, and outcome variables IL-6 or IL-18. In these analyses, we adjusted for parameters known to affect Lp(a) levels and APO(a) PR and FCR, including race/ethnicity and APO(a) isoform size. Results: APO(a) PR and FCR were positively associated with plasma IL-6, independent of isoform size, and dependent on race/ethnicity. APO(a) PR was positively associated with plasma IL-18, independent of isoform size and race/ethnicity. APO(a) FCR was not associated with plasma IL-18. Conclusions: Our studies demonstrate a relationship between APO(a) PR and FCR and plasma IL-6 or IL-18, interleukins that promote ASCVD. These studies provide new insights into Lp(a) pro-inflammatory properties and are especially relevant in view of therapies targeting APO(a) to decrease cardiovascular risk.
MeSH term(s)	Humans ; Apoprotein(a) ; Interleukin-6 ; Ethnicity ; Interleukin-18 ; Kinetics ; Apolipoproteins A ; Lipoprotein(a) ; Atherosclerosis ; Protein Isoforms/metabolism
Chemical Substances	Apoprotein(a) (EC 3.4.21.-) ; Interleukin-6 ; Interleukin-18 ; Apolipoproteins A ; Lipoprotein(a) ; Protein Isoforms
Language	English
Publishing date	2024-02-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2024.117474
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Article: National estimates of kinship size and composition among adults with activity limitations in the United States.

Reyes, Adriana M / Schoeni, Robert F / Freedman, Vicki A

Demographic research

2021 Volume 45, Page(s) 1097–1114

Abstract: ... differences across race/ethnicity, education, and marital status. We also estimate the number of helpers ...

Abstract	Background: The number of adults living with limitations in daily activities in the United States is large, and projected to increase. Families, which are becoming more complex, are critical to the wellbeing of this population. Objective: We present national estimates of the size and composition of kin networks for adults with activity limitations. Methods: We use the 2013 Panel Study of Income Dynamics to assess kin relationships of adults aged 40 and older with an activity limitation. We assess kin relations up and down one generation and horizontally, including spouses, adult children, parents, siblings, step-kin, parent-in-laws, children-in-law, and sibling-in-laws. We estimate kinship size and differences across race/ethnicity, education, and marital status. We also estimate the number of helpers. Results: Adults with activity limitations have a substantial number of adult kin: 9.1 on average, while only 12% have fewer than four kin. Spouses and adult biological children, the most common caregivers, account for less than one-third of these kin. Kin networks are much larger among those who report their background as Hispanic rather than non-Hispanic white or Black, married rather than unmarried, and less-than-college rather than college-educated. Conclusions: Despite concerns about increasing family complexity, we find that 88% of individuals with a limitation have four or more family members, and as kin size increases the average number of kin helping increases from one to two. Contribution: We provide estimates of kinship size and composition for adults with disabilities, assessing the number of kin, types of kin, and sociodemographic differences.
Language	English
Publishing date	2021-11-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2003725-9
ISSN	2363-7064 ; 1435-9871
ISSN (online)	2363-7064
ISSN	1435-9871
DOI	10.4054/demres.2021.45.36
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