LIVIVO - Search results -

Search results

Result 1 - 10 of total 29000

Search options

Article ; Online: Identification of absorbed compounds of Xiao Yao San Jia Wei and pharmacokinetic study in depressed rats by force swimming stress.

Shan, Chenxiao / Li, Jia / Sun, Bo / Zhou, Runze / Xu, Min / Zhao, Qiulong / Ren, Ping / Wen, Hongmei / Huang, Xi

RSC advances

2022 Volume 12, Issue 8, Page(s) 4455–4468

Abstract: Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia ...

Abstract	Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia in the Jiang Su Province Hospital of Chinese Medicine. Unfortunately, the proper dosage of this formulation is still unclear due to its limited chemical and pharmacokinetic profiles. Thus, in the present study, a sensitive, precise, and rapid procedure for the identification of absorbed compounds (Cs) in the plasma of depressed rats together with a pharmacokinetic analysis was established with the help of ultra-flow liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UFLC-Q-TOF MS/MS) and ultra-flow liquid chromatography coupled with electrospray ionization triple quadrupole tandem mass spectrometry (UFLC-QQQ MS/MS). Based on the characteristic fragmentation, neutral loss, mass defect filter, relevant literature and reference standards, 225 Cs in the XYSJW extract and 20 Cs in the plasma of the depressed rats were tentatively recognized
Language	English
Publishing date	2022-02-04
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d1ra08778a
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Integrating network pharmacology and pharmacological validation to explore the effect of Shi Wei Ru Xiang powder on suppressing hyperuricemia.

Li, Qiang / Liu, Peng / Wu, Chen / Bai, Lijie / Zhang, Zhongyun / Bao, Zilu / Zou, Min / Ren, Zhaoxiang / Yuan, Lin / Liao, Maochuan / Lan, Zhou / Yin, Shijin / Chen, Lvyi

Journal of ethnopharmacology

2022 Volume 298, Page(s) 115679

Abstract: Ethnopharmacological relevance: Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal ...

Abstract	Ethnopharmacological relevance: Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal formula with the effect of dispelling dampness and dispersing cold. In clinical practice, SWR is generally used for the treatment of hyperuricemia (HUA). However, its exact pharmacological mechanism remains unclear. Aims of the study: To preliminarily elucidate the regulatory effects and possible mechanisms of SWR on hyperuricemia using network pharmacology and experimental validation. Materials and methods: A mouse model of hyperuricemia was used to evaluate the alleviating effect of SWR on hyperuricemia. The major components of SWR were acquired by UPLC-Q/TOF-MS. The potential molecular targets and associated signaling pathways were predicted through network pharmacology. The mechanism of action of SWR in ameliorating hyperuricemia was further investigated by pharmacological evaluation. Results: Mice with hyperuricemia and renal dysfunction were ameliorated by SWR. The 36 components of SWR included phenolic acids, terpenoids, alkaloids and flavonoids were identified. Network pharmacological analysis showed the involvement of the above compounds, and 115 targets were involved to treat hyperuricemia, involving multiple biological processes and different signaling pathways. Pharmacological experiments validated that SWR ameliorated hyperuricemic nephropathy in mice by modulating the mitogen-activated protein kinase (MAPK) signaling pathway, nuclear factor kappaB (NF-κB) signaling pathway and NOD-like receptor signaling pathway. Conclusion: MAPK signaling pathway, NF-κB signaling pathway and NOD-like receptor signaling pathway play important roles in the therapeutic effects of SWR on hyperuricemia.
MeSH term(s)	Animals ; Drugs, Chinese Herbal/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Hyperuricemia/drug therapy ; Hyperuricemia/metabolism ; Medicine, Tibetan Traditional ; Mice ; NF-kappa B ; NLR Proteins ; Network Pharmacology ; Powders/therapeutic use
Chemical Substances	Drugs, Chinese Herbal ; NF-kappa B ; NLR Proteins ; Powders
Language	English
Publishing date	2022-09-01
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115679
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1494: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A new non-stationary standardised streamflow index using the climate indices and the optimal anthropogenic indices as covariates in the Wei River Basin, China

Mingming Ren / Shanhu Jiang / Liliang Ren / Baisha Weng / Menghao Wang / Hao Cui / Chong-Yu Xu

Journal of Hydrology: Regional Studies, Vol 51, Iss , Pp 101649- (2024)

2024

Abstract: Study region: Catchment area above the Huaxian station along the Wei River Basin, China. Study ... applicable to the variable streamflow sequence of the Wei River Basin based on the climate index and ... model is more suitable for quantifying anthropogenic factors in the Wei River Basin. The NSSI performs ...

Abstract	Study region: Catchment area above the Huaxian station along the Wei River Basin, China. Study focus: This study attempts to construct a new Non-stationary Standardized Streamflow Index (NSSI) applicable to the variable streamflow sequence of the Wei River Basin based on the climate index and the optimal anthropogenic index, and analyse the drought characteristics of the basin. The climate index is used to quantify climate change factors and three anthropogenic indices are used to quantify the factor of human activities, including the reservoir index, the human-induced index calculated based on the Variable Infiltration Capacity (VIC) hydrological model and the Long Short-Term Memory (LSTM) model machine learning approach, respectively. New hydrological insights for the region: The human-induced index based on the LSTM model is more suitable for quantifying anthropogenic factors in the Wei River Basin. The NSSI performs better than the SSI in drought identification. The NSSI based on the LSTM model can capture more frequent severe drought and extreme drought events. The frequency of severe drought and extreme drought is higher in summer and autumn than in the others. The NSSI can better characterize the hydrological drought processes under a non-stationary condition, thus it can provide a more effective reference for regional drought assessment and related policy-making from the perspective of a changing environment.
Keywords	Non-stationary standardized streamflow index ; Hydrological drought ; Climate index ; Anthropogenic index ; Physical geography ; GB3-5030 ; Geology ; QE1-996.5
Subject code	550
Language	English
Publishing date	2024-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Identification of absorbed compounds of Xiao Yao San Jia Wei and pharmacokinetic study in depressed rats by force swimming stress

Shan, Chenxiao / Li, Jia / Sun, Bo / Zhou, Runze / Xu, Min / Zhao, Qiulong / Ren, Ping / Wen, Hongmei / Huang, Xi

RSC advances. 2022 Feb. 04, v. 12, no. 8

2022

Abstract: Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia ...

Abstract	Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia in the Jiang Su Province Hospital of Chinese Medicine. Unfortunately, the proper dosage of this formulation is still unclear due to its limited chemical and pharmacokinetic profiles. Thus, in the present study, a sensitive, precise, and rapid procedure for the identification of absorbed compounds (Cs) in the plasma of depressed rats together with a pharmacokinetic analysis was established with the help of ultra-flow liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UFLC-Q-TOF MS/MS) and ultra-flow liquid chromatography coupled with electrospray ionization triple quadrupole tandem mass spectrometry (UFLC-QQQ MS/MS). Based on the characteristic fragmentation, neutral loss, mass defect filter, relevant literature and reference standards, 225 Cs in the XYSJW extract and 20 Cs in the plasma of the depressed rats were tentatively recognized via UFLC-Q-TOF MS/MS and UFLC-QQQ MS/MS. Then, the 12 major absorbed Cs in the depressed rats after oral XYSJW administration were chosen to further investigate its pharmacokinetic profile by UFLC-QQQ MS/MS. This study provides a systematic approach for the rapid and qualitative analysis of absorbed Cs in depressed rats and investigating the pharmacokinetics of XYSJW. More importantly, our work provides key information on the chemical and pharmacokinetic profiles of XYSJW in vitro and in vivo, which may benefit its therapeutic efficacy and further pharmacological studies involving this formulation.
Keywords	Oriental traditional medicine ; anorexia ; electrospray ionization mass spectrometry ; hospitals ; liquid chromatography ; pharmacokinetics ; qualitative analysis ; tandem mass spectrometry ; therapeutics
Language	English
Dates of publication	2022-0204
Size	p. 4455-4468.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/d1ra08778a
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Integrating network pharmacology and pharmacological validation to explore the effect of Shi Wei Ru Xiang powder on suppressing hyperuricemia

Li, Qiang / Liu, Peng / Wu, Chen / Bai, Lijie / Zhang, Zhongyun / Bao, Zilu / Zou, Min / Ren, Zhaoxiang / Yuan, Lin / Liao, Maochuan / Lan, Zhou / Yin, Shijin / Chen, Lvyi

Journal of ethnopharmacology. 2022 Nov. 15, v. 298

2022

Abstract: Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal formula with the effect ...

Abstract	Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal formula with the effect of dispelling dampness and dispersing cold. In clinical practice, SWR is generally used for the treatment of hyperuricemia (HUA). However, its exact pharmacological mechanism remains unclear. To preliminarily elucidate the regulatory effects and possible mechanisms of SWR on hyperuricemia using network pharmacology and experimental validation. A mouse model of hyperuricemia was used to evaluate the alleviating effect of SWR on hyperuricemia. The major components of SWR were acquired by UPLC-Q/TOF-MS. The potential molecular targets and associated signaling pathways were predicted through network pharmacology. The mechanism of action of SWR in ameliorating hyperuricemia was further investigated by pharmacological evaluation. Mice with hyperuricemia and renal dysfunction were ameliorated by SWR. The 36 components of SWR included phenolic acids, terpenoids, alkaloids and flavonoids were identified. Network pharmacological analysis showed the involvement of the above compounds, and 115 targets were involved to treat hyperuricemia, involving multiple biological processes and different signaling pathways. Pharmacological experiments validated that SWR ameliorated hyperuricemic nephropathy in mice by modulating the mitogen-activated protein kinase (MAPK) signaling pathway, nuclear factor kappaB (NF-κB) signaling pathway and NOD-like receptor signaling pathway. MAPK signaling pathway, NF-κB signaling pathway and NOD-like receptor signaling pathway play important roles in the therapeutic effects of SWR on hyperuricemia.
Keywords	cold ; flavonoids ; hyperuricemia ; kidney diseases ; mechanism of action ; mice ; mitogen-activated protein kinase ; models ; pharmacology ; terpenoids ; therapeutics ; traditional medicine ; transcription factor NF-kappa B
Language	English
Dates of publication	2022-1115
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115679
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 90/710: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Jia Wei Xiao Yao San ameliorates chronic stress-induced depression-like behaviors in mice by regulating the gut microbiome and brain metabolome in relation to purine metabolism.

Ji, Shuai / Han, Shuangshuang / Yu, Lin / Du, Lijing / You, Yanting / Chen, Jieyu / Wang, Ming / Wu, Shengwei / Li, Shasha / Sun, Xiaomin / Luo, Ren / Zhao, Xiaoshan

Phytomedicine : international journal of phytotherapy and phytopharmacology

2022 Volume 98, Page(s) 153940

Abstract: ... Jia Wei Xiao Yao San (JWXYS) is considered a potential antidepressant. However, the pharmacological ...

Abstract	Background: The pathogenesis of depression remains largely unknown. Accumulating evidence demonstrates the existence of a complex relationship between gut microbiome composition and brain functions. Jia Wei Xiao Yao San (JWXYS) is considered a potential antidepressant. However, the pharmacological mechanisms of JWXYS have not yet been clarified. Purpose: This study aimed to explore the effects of JWXYS on chronic stress-induced depression-like behaviors in mice. Methods: A chronic restraint stress mouse model of depression was established. JWXYS was administered, and the responses of these mice to treatment were evaluated through several behavioral tests. The activity of astrocytes and microglia was detected by specific fluorescent labels. Inflammatory cytokines were quantified in intestinal and cerebral tissues. An integrated approach with full-length 16S rRNA sequencing and different types of untargeted metabolomics was conducted to investigate the relationship between the gut microbiome at the species level, metabolic brain functions, and JWXYS. Results: We found that behavioral symptoms were associated with the relative abundance of Lactobacillus animalis. After JWXYS treatment, the relative abundance of Ileibacterium valens with enzymes potentially involved in purine metabolism was also described. The activation of astrocytes and microglia was negatively correlated with the relative abundance of L. animalis. Combined with network pharmacological analysis, several targets predicted based on JWXYS treatment focused on purine metabolism, which was also enriched from cerebral metabolites regulated by JWXYS. Conclusion: Our study suggests that L. animalis is involved in depression-like behaviors in mice. JWXYS increases the abundance of I. valens with potential enzymes in relation to cerebral purine metabolism, which is positively correlated with the activation of astrocytes in the amygdala.
Language	English
Publishing date	2022-01-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.153940
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4115: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Impacts of chemical weathering and human perturbations on dissolved loads of the Wei River, the Yellow River catchment

Jia, Hui / Qu, Wengang / Ren, Wenhao / Qian, Hui

Journal of hydrology. 2021 Dec., v. 603

2021

Abstract: As the largest tributary of the Yellow River, the Wei River drains a basin mainly comprising two ... from the Wei River to the Yellow River. The geochemical characteristics of the Wei River mainstream and ... Mountain area. The CO₂ consumption by the Wei River is 19.9 × 10⁹ mol/yr, accounting for 32.5% of the total CO₂ ...

Abstract	As the largest tributary of the Yellow River, the Wei River drains a basin mainly comprising two different geological settings, i.e., the Chinese Loess Plateau (CLP) in the north covered by Quaternary loess and the Qinling Mountains area in the south. Exploring the influence of natural weathering processes and human activities on river chemistry has high significance in understanding chemical transport from the Wei River to the Yellow River. The geochemical characteristics of the Wei River mainstream and its tributaries as well as chemical weathering were determined using a geochemistry and isotope dataset of high spatial resolution. The mainstream clearly exhibited a mixture of major elements and stable isotopes from tributaries on both the north and south banks, with values within the range of those of the tributaries. North-bank tributaries draining thick loess deposits showed higher contents of major elements and the enrichment of stable isotopes, reflecting the influence of geological setting on river chemistry. The dominant processes accounting for the water chemistry of the mainstream are evaporite (39–75%) and carbonate weathering (21–54%). Within the watershed, evaporite dissolution and silicate weathering are higher in the northern CLP area, whereas carbonate weathering is higher in the southern Qinling Mountain area. The CO₂ consumption by the Wei River is 19.9 × 10⁹ mol/yr, accounting for 32.5% of the total CO₂ consumption by the middle reaches of the Yellow River. During the high-flow period, the chemical weathering flux of the Wei River was found to be within the range of northern rivers in China, while the chemical weathering rate was relatively high in the semi-arid region. This suggests that chemical denudation is a significant factor for the river chemistry of the CLP at least in the high-flow period.
Keywords	basins ; carbon dioxide ; carbonates ; data collection ; geochemistry ; humans ; hydrochemistry ; loess ; rivers ; semiarid zones ; silicates ; watersheds ; China ; Yellow River
Language	English
Dates of publication	2021-12
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1473173-3
ISSN	1879-2707 ; 0022-1694
ISSN (online)	1879-2707
ISSN	0022-1694
DOI	10.1016/j.jhydrol.2021.126950
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: Spatial-temporal trends of rainfall erosivity and its implication for sustainable agriculture in the Wei River Basin of China

Zhang, Yan / Chao, Yang / Fan, Ruirui / Ren, Feier / Qi, Bin / Ji, Kai / Xu, Bin

Agricultural water management. 2021 Feb. 28, v. 245

2021

Abstract: ... in the Wei River Basin from 1969 to 2018 were collected, the spatial and temporal variation characteristics ... soil erosion prevention and sustainable agricultural development of the Wei River Basin. ...

Abstract	Water and soil are important natural resources for agricultural development. Soil erosion is a worldwide problem threatening sustainable agriculture development. Rainfall is one of the major natural factors that cause soil erosion. The study of the spatial distribution and temporal trends of rainfall erosivity is practical and important for the assessment of soil erosion hazards, the planning of soil and water conservation measures, and the sustainable agriculture development. In this study, the data of daily rainfall in the Wei River Basin from 1969 to 2018 were collected, the spatial and temporal variation characteristics of rainfall and rainfall erosivity were analyzed. The results show that the regional mean annual rainfall varies from 315.0 to 807.3 mm, which shows an increasing spatial trend from northwest to southeast. The mean annual rainfall erosivity in the basin ranges from 751.4 to 2600.0 MJ⋅mm⋅hm-2⋅h-1, which has a similar pattern of spatial distribution as the rainfall. The monthly rainfall erosivity changing pattern is a single-peak type. High erosivity of rainfall was mainly observed from July to September. The peaks mostly occur in July and August. The temporal trend of annual rainfall erosivity ranges from −6.6–10.1 MJ⋅mm⋅hm-2⋅h-1 per year, the Loess Plateau and the Qinling Mountains in the southern basin show an increasing trend, and the surroundings of Xifeng, Changwu and Huanxian have the statistical significance of P < 0.05. In the midstream and downstream of the basin and the Guanzhong Plain, the rainfall erosivity shows an insignificant decreasing trend. The North Atlantic Oscillation obviously influences the rainfall erosivity in the recent two decades. The study results may helpful for the scientific management, soil erosion prevention and sustainable agricultural development of the Wei River Basin.
Keywords	North Atlantic Oscillation ; agricultural development ; basins ; erosion control ; rain ; soil ; soil erosion ; sustainable agriculture ; temporal variation ; water conservation ; watersheds ; China
Language	English
Dates of publication	2021-0228
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	751144-9
ISSN	1873-2283 ; 0378-3774
ISSN (online)	1873-2283
ISSN	0378-3774
DOI	10.1016/j.agwat.2020.106557
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 3189: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Jia Wei Xiao Yao San ameliorates chronic stress-induced depression-like behaviors in mice by regulating the gut microbiome and brain metabolome in relation to purine metabolism

Ji, Shuai / Han, Shuangshuang / Yu, Lin / Du, Lijing / You, Yanting / Chen, Jieyu / Wang, Ming / Wu, Shengwei / Li, Shasha / Sun, Xiaomin / Luo, Ren / Zhao, Xiaoshan

Phytomedicine. 2022 Apr., v. 98

2022

Abstract: ... the existence of a complex relationship between gut microbiome composition and brain functions. Jia Wei Xiao Yao ...

Abstract	The pathogenesis of depression remains largely unknown. Accumulating evidence demonstrates the existence of a complex relationship between gut microbiome composition and brain functions. Jia Wei Xiao Yao San (JWXYS) is considered a potential antidepressant. However, the pharmacological mechanisms of JWXYS have not yet been clarified. This study aimed to explore the effects of JWXYS on chronic stress-induced depression-like behaviors in mice. A chronic restraint stress mouse model of depression was established. JWXYS was administered, and the responses of these mice to treatment were evaluated through several behavioral tests. The activity of astrocytes and microglia was detected by specific fluorescent labels. Inflammatory cytokines were quantified in intestinal and cerebral tissues. An integrated approach with full-length 16S rRNA sequencing and different types of untargeted metabolomics was conducted to investigate the relationship between the gut microbiome at the species level, metabolic brain functions, and JWXYS. We found that behavioral symptoms were associated with the relative abundance of Lactobacillus animalis. After JWXYS treatment, the relative abundance of Ileibacterium valens with enzymes potentially involved in purine metabolism was also described. The activation of astrocytes and microglia was negatively correlated with the relative abundance of L. animalis. Combined with network pharmacological analysis, several targets predicted based on JWXYS treatment focused on purine metabolism, which was also enriched from cerebral metabolites regulated by JWXYS. Our study suggests that L. animalis is involved in depression-like behaviors in mice. JWXYS increases the abundance of I. valens with potential enzymes in relation to cerebral purine metabolism, which is positively correlated with the activation of astrocytes in the amygdala.
Keywords	Lactobacillus animalis ; amygdala ; antidepressants ; astrocytes ; cytokines ; fluorescence ; intestinal microorganisms ; intestines ; metabolism ; metabolites ; metabolome ; metabolomics ; mice ; pathogenesis
Language	English
Dates of publication	2022-04
Publishing place	Elsevier GmbH
Document type	Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.153940
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 4115: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A comparative pharmacokinetic study of three flavonoids and three anthraquinones in normal and gastrointestinal motility disorders rat plasma after the oral administration of Wei-Chang-Shu tablet using high-performance liquid chromatography-tandem mass spectrometry.

Ren, Yan / Zhao, Weiwei / Zhao, Juanjuan / Chen, Xiangming / Yu, Chen / Liu, Mengan

Biomedical chromatography : BMC

2017 Volume 31, Issue 11

Abstract: ... aloe-emodin), which are the bioactive ingredients of Wei-Chang-Shu tablet found in rat plasma. After ...

Abstract	A simple, fast and reliable high-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous quantification and pharmacokinetic study of three flavonoids (liquiritigenin, isoliquiritigenin and formononetin) and three anthraquinones (emodin, rhein and aloe-emodin), which are the bioactive ingredients of Wei-Chang-Shu tablet found in rat plasma. After extraction by liquid-liquid extraction with ethyl acetate, chromatographic separation was achieved on an Agilent Zorbax SB-C
MeSH term(s)	Administration, Oral ; Animals ; Anthraquinones/blood ; Anthraquinones/chemistry ; Anthraquinones/pharmacokinetics ; Chromatography, High Pressure Liquid/methods ; Drug Stability ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacokinetics ; Flavonoids/blood ; Flavonoids/chemistry ; Flavonoids/pharmacokinetics ; Gastrointestinal Diseases/metabolism ; Gastrointestinal Motility ; Limit of Detection ; Linear Models ; Male ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Tandem Mass Spectrometry/methods
Chemical Substances	Anthraquinones ; Drugs, Chinese Herbal ; Flavonoids
Language	English
Publishing date	2017-11
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.3997
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2166: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito