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  1. Article: Measurement of the mass dependence of the transverse momentum of lepton pairs in Drell-Yan production in proton-proton collisions at

    Tumasyan, A / Adam, W / Andrejkovic, J W / Bergauer, T / Chatterjee, S / Dragicevic, M / Valle, A Escalante Del / Frühwirth, R / Jeitler, M / Krammer, N / Lechner, L / Liko, D / Mikulec, I / Paulitsch, P / Pitters, F M / Schieck, J / Schöfbeck, R / Spanring, M / Templ, S /
    Waltenberger, W / Wulz, C-E / Darwish, M R / De Wolf, E A / Janssen, T / Kello, T / Lelek, A / Sfar, H Rejeb / Mechelen, P Van / Putte, S Van / Remortel, N Van / Blekman, F / Bols, E S / D'Hondt, J / Delcourt, M / Faham, H El / Lowette, S / Moortgat, S / Morton, A / Müller, D / Sahasransu, A R / Tavernier, S / Doninck, W Van / Mulders, P Van / Beghin, D / Bilin, B / Clerbaux, B / De Lentdecker, G / Favart, L / Grebenyuk, A / Kalsi, A K / Lee, K / Mahdavikhorrami, M / Makarenko, I / Moureaux, L / Pétré, L / Popov, A / Postiau, N / Starling, E / Thomas, L / Bemden, M Vanden / Velde, C Vander / Vanlaer, P / Vannerom, D / Wezenbeek, L / Cornelis, T / Dobur, D / Knolle, J / Lambrecht, L / Mestdach, G / Niedziela, M / Roskas, C / Samalan, A / Skovpen, K / Tytgat, M / Vermassen, B / Vit, M / Bethani, A / Bruno, G / Bury, F / Caputo, C / David, P / Delaere, C / Donertas, I S / Giammanco, A / Jaffel, K / Jain, Sa / Lemaitre, V / Mondal, K / Prisciandaro, J / Taliercio, A / Teklishyn, M / Tran, T T / Vischia, P / Wertz, S / Alves, G A / Hensel, C / Moraes, A / Júnior, W L Aldá / Pereira, M Alves Gallo / Filho, M Barroso Ferreira / Malbouisson, H Brandao / Carvalho, W / Chinellato, J / Da Costa, E M / Da Silveira, G G / De Jesus Damiao, D / De Souza, S Fonseca / Figueiredo, D Matos / Herrera, C Mora / Amarilo, K Mota / Mundim, L / Nogima, H / Teles, P Rebello / Santoro, A / Amaral, S M Silva Do / Sznajder, A / Thiel, M / Da Silva De Araujo, F Torres / Pereira, A Vilela / Bernardes, C A / Calligaris, L / Tomei, T R Fernandez Perez / Gregores, E M / Lemos, D S / Mercadante, P G / Novaes, S F / Padula, Sandra S / Aleksandrov, A / Antchev, G / Hadjiiska, R / Iaydjiev, P / Misheva, M / Rodozov, M / Shopova, M / Sultanov, G / Dimitrov, A / Ivanov, T / Litov, L / Pavlov, B / Petkov, P / Petrov, A / Cheng, T / Guo, Q / Javaid, T / Mittal, M / Wang, H / Yuan, L / Ahmad, M / Bauer, G / Dozen, C / Hu, Z / Martins, J / Wang, Y / Yi, K / Chapon, E / Chen, G M / Chen, H S / Chen, M / Iemmi, F / Kapoor, A / Leggat, D / Liao, H / Liu, Z-A / Milosevic, V / Monti, F / Sharma, R / Tao, J / Thomas-Wilsker, J / Wang, J / Zhang, H / Zhang, S / Zhao, J / Agapitos, A / An, Y / Ban, Y / Chen, C / Levin, A / Li, Q / Lyu, X / Mao, Y / Qian, S J / Wang, D / Wang, Q / Xiao, J / Lu, M / You, Z / Gao, X / Okawa, H / Lin, Z / Xiao, M / Avila, C / Cabrera, A / Florez, C / Fraga, J / Guisao, J Mejia / Ramirez, F / Alvarez, J D Ruiz / González, C A Salazar / Giljanovic, D / Godinovic, N / Lelas, D / Puljak, I / Antunovic, Z / Kovac, M / Sculac, T / Brigljevic, V / Ferencek, D / Majumder, D / Roguljic, M / Starodumov, A / Susa, T / Attikis, A / Christoforou, K / Erodotou, E / Ioannou, A / Kole, G / Kolosova, M / Konstantinou, S / Mousa, J / Nicolaou, C / Ptochos, F / Razis, P A / Rykaczewski, H / Saka, H / Finger, M / Kveton, A / Ayala, E / Jarrin, E Carrera / Abdelalim, A A / Elgammal, S / Lotfy, A / Mahmoud, M A / Bhowmik, S / Dewanjee, R K / Ehataht, K / Kadastik, M / Nandan, S / Nielsen, C / Pata, J / Raidal, M / Tani, L / Veelken, C / Eerola, P / Forthomme, L / Kirschenmann, H / Osterberg, K / Voutilainen, M / Bharthuar, S / Brücken, E / Garcia, F / Havukainen, J / Kim, M S / Kinnunen, R / Lampén, T / Lassila-Perini, K / Lehti, S / Lindén, T / Lotti, M / Martikainen, L / Myllymäki, M / Ott, J / Siikonen, H / Tuominen, E / Tuominiemi, J / Luukka, P / Petrow, H / Tuuva, T / Amendola, C / Besancon, M / Couderc, F / Dejardin, M / Denegri, D / Faure, J L / Ferri, F / Ganjour, S / Givernaud, A / Gras, P / de Monchenault, G Hamel / Jarry, P / Lenzi, B / Locci, E / Malcles, J / Rander, J / Rosowsky, A / Sahin, M Ö / Savoy-Navarro, A / Titov, M / Yu, G B / Ahuja, S / Beaudette, F / Bonanomi, M / Perraguin, A Buchot / Busson, P / Cappati, A / Charlot, C / Davignon, O / Diab, B / Falmagne, G / Ghosh, S / de Cassagnac, R Granier / Hakimi, A / Kucher, I / Motta, J / Nguyen, M / Ochando, C / Paganini, P / Rembser, J / Salerno, R / Sauvan, J B / Sirois, Y / Tarabini, A / Zabi, A / Zghiche, A / Agram, J-L / Andrea, J / Apparu, D / Bloch, D / Bourgatte, G / Brom, J-M / Chabert, E C / Collard, C / Darej, D / Fontaine, J-C / Goerlach, U / Grimault, C / Bihan, A-C Le / Nibigira, E / Hove, P Van / Asilar, E / Beauceron, S / Bernet, C / Boudoul, G / Camen, C / Carle, A / Chanon, N / Contardo, D / Depasse, P / Mamouni, H El / Fay, J / Gascon, S / Gouzevitch, M / Ille, B / Laktineh, I B / Lattaud, H / Lesauvage, A / Lethuillier, M / Mirabito, L / Perries, S / Shchablo, K / Sordini, V / Torterotot, L / Touquet, G / Donckt, M Vander / Viret, S / Lomidze, I / Toriashvili, T / Tsamalaidze, Z / Botta, V / Feld, L / Klein, K / Lipinski, M / Meuser, D / Pauls, A / Rauch, M P / Röwert, N / Schulz, J / Teroerde, M / Dodonova, A / Eliseev, D / Erdmann, M / Fackeldey, P / Fischer, B / Hebbeker, T / Hoepfner, K / Ivone, F / Keller, H / Mastrolorenzo, L / Merschmeyer, M / Meyer, A / Mocellin, G / Mondal, S / Mukherjee, S / Noll, D / Novak, A / Pook, T / Pozdnyakov, A / Rath, Y / Reithler, H / Roemer, J / Schmidt, A / Schuler, S C / Sharma, A / Vigilante, L / Wiedenbeck, S / Zaleski, S / Dziwok, C / Flügge, G / Ahmad, W Haj / Hlushchenko, O / Kress, T / Nowack, A / Pistone, C / Pooth, O / Roy, D / Sert, H / Stahl, A / Ziemons, T / Petersen, H Aarup / Martin, M Aldaya / Asmuss, P / Babounikau, I / Baxter, S / Behnke, O / Martínez, A Bermúdez / Bhattacharya, S / Anuar, A A Bin / Borras, K / Brunner, D / Campbell, A / Cardini, A / Cheng, C / Colombina, F / Rodríguez, S Consuegra / Silva, G Correia / Danilov, V / De Silva, M / Didukh, L / Eckerlin, G / Eckstein, D / Banos, L I Estevez / Filatov, O / Gallo, E / Geiser, A / Giraldi, A / Grohsjean, A / Guthoff, M / Jafari, A / Jomhari, N Z / Kasem, A / Kasemann, M / Kaveh, H / Kleinwort, C / Krücker, D / Lange, W / Lidrych, J / Lipka, K / Lohmann, W / Mankel, R / Melzer-Pellmann, I-A / Morentin, M Mendizabal / Metwally, J / Meyer, A B / Meyer, M / Mnich, J / Mussgiller, A / Otarid, Y / Adán, D Pérez / Pitzl, D / Raspereza, A / Lopes, B Ribeiro / Rübenach, J / Saggio, A / Saibel, A / Savitskyi, M / Scham, M / Scheurer, V / Schütze, P / Schwanenberger, C / Singh, A / Ricardo, R E Sosa / Stafford, D / Tonon, N / Turkot, O / De Klundert, M Van / Walsh, R / Walter, D / Wen, Y / Wichmann, K / Wiens, L / Wissing, C / Wuchterl, S / Aggleton, R / Albrecht, S / Bein, S / Benato, L / Benecke, A / Connor, P / De Leo, K / Eich, M / Feindt, F / Fröhlich, A / Garbers, C / Garutti, E / Gunnellini, P / Haller, J / Hinzmann, A / Kasieczka, G / Klanner, R / Kogler, R / Kramer, T / Kutzner, V / Lange, J / Lange, T / Lobanov, A / Malara, A / Nigamova, A / Rodriguez, K J Pena / Rieger, O / Schleper, P / Schröder, M / Schwandt, J / Schwarz, D / Sonneveld, J / Stadie, H / Steinbrück, G / Tews, A / Vormwald, B / Zoi, I / Bechtel, J / Berger, T / Butz, E / Caspart, R / Chwalek, T / De Boer, W / Dierlamm, A / Droll, A / El Morabit, K / Faltermann, N / Giffels, M / Gosewisch, J O / Gottmann, A / Hartmann, F / Heidecker, C / Husemann, U / Keicher, P / Koppenhöfer, R / Maier, S / Metzler, M / Mitra, S / Müller, Th / Neukum, M / Nürnberg, A / Quast, G / Rabbertz, K / Rauser, J / Savoiu, D / Schnepf, M / Seith, D / Shvetsov, I / Simonis, H J / Ulrich, R / Van Der Linden, J / Cube, R F Von / Wassmer, M / Weber, M / Wieland, S / Wolf, R / Wozniewski, S / Wunsch, S / Anagnostou, G / Daskalakis, G / Geralis, T / Kyriakis, A / Stakia, A / Diamantopoulou, M / Karasavvas, D / Karathanasis, G / Kontaxakis, P / Koraka, C K / Manousakis-Katsikakis, A / Panagiotou, A / Papavergou, I / Saoulidou, N / Theofilatos, K / Tziaferi, E / Vellidis, K / Vourliotis, E / Bakas, G / Kousouris, K / Papakrivopoulos, I / Tsipolitis, G / Zacharopoulou, A / Adamidis, K / Bestintzanos, I / Evangelou, I / Foudas, C / Gianneios, P / Katsoulis, P / Kokkas, P / Manthos, N / Papadopoulos, I / Strologas, J / Csanád, M / Farkas, K / Gadallah, M M A / Lökös, S / Major, P / Mandal, K / Mehta, A / Pásztor, G / Rádl, A J / Surányi, O / Veres, G I / Bartók, M / Bencze, G / Hajdu, C / Horvath, D / Sikler, F / Veszpremi, V / Vesztergombi, G / Czellar, S / Karancsi, J / Molnar, J / Szillasi, Z / Teyssier, D / Raics, P / Trocsanyi, Z L / Ujvari, B / Csorgo, T / Nemes, F / Novak, T / Komaragiri, J R / Kumar, D / Panwar, L / Tiwari, P C / Bansal, S / Beri, S B / Bhatnagar, V / Chaudhary, G / Chauhan, S / Dhingra, N / Gupta, R / Kaur, A / Kaur, M / Kaur, S / Kumari, P / Meena, M / Sandeep, K / Singh, J B / Virdi, A K / Ahmed, A / Bhardwaj, A / Choudhary, B C / Gola, M / Keshri, S / Kumar, A / Naimuddin, M / Priyanka, P / Ranjan, K / Shah, A / Bharti, M / Bhattacharya, R / Bhowmik, D / Dutta, S / Gomber, B / Maity, M / Palit, P / Rout, P K / Saha, G / Sahu, B / Sarkar, S / Sharan, M / Singh, B / Thakur, S / Behera, P K / Behera, S C / Kalbhor, P / Muhammad, A / Pradhan, R / Pujahari, P R / Sikdar, A K / Dutta, D / Jha, V / Kumar, V / Mishra, D K / Naskar, K / Netrakanti, P K / Pant, L M / Shukla, P / Aziz, T / Dugad, S / Kumar, M / Mohanty, G B / Sarkar, U / Banerjee, S / Chudasama, R / Guchait, M / Karmakar, S / Kumar, S / Majumder, G / Mazumdar, K / Bahinipati, S / Kar, C / Mal, P / Mishra, T / Bindhu, V K Muraleedharan Nair / Nayak, A / Saha, P / Sur, N / Swain, S K / Vats, D / Alpana, K / Dube, S / Kansal, B / Laha, A / Pandey, S / Rane, A / Rastogi, A / Sharma, S / Bakhshiansohi, H / Khazaie, E / Zeinali, M / Chenarani, S / Etesami, S M / Khakzad, M / Najafabadi, M Mohammadi / Grunewald, M / Abbrescia, M / Aly, R / Aruta, C / Colaleo, A / Creanza, D / De Filippis, N / De Palma, M / Di Florio, A / Di Pilato, A / Elmetenawee, W / Fiore, L / Gelmi, A / Gul, M / Iaselli, G / Ince, M / Lezki, S / Maggi, G / Maggi, M / Margjeka, I / Mastrapasqua, V / Merlin, J A / My, S / Nuzzo, S / Pellecchia, A / Pompili, A / Pugliese, G / Ranieri, A / Selvaggi, G / Silvestris, L / Simone, F M / Venditti, R / Verwilligen, P / Abbiendi, G / Battilana, C / Bonacorsi, D / Borgonovi, L / Brigliadori, L / Campanini, R / Capiluppi, P / Castro, A / Cavallo, F R / Cuffiani, M / Dallavalle, G M / Diotalevi, T / Fabbri, F / Fanfani, A / Giacomelli, P / Giommi, L / Grandi, C / Guiducci, L / Meo, S Lo / Lunerti, L / Marcellini, S / Masetti, G / Navarria, F L / Perrotta, A / Primavera, F / Rossi, A M / Rovelli, T / Siroli, G P / Albergo, S / Costa, S / Di Mattia, A / Potenza, R / Tricomi, A / Tuve, C / Barbagli, G / Cassese, A / Ceccarelli, R / Ciulli, V / Civinini, C / D'Alessandro, R / Focardi, E / Latino, G / Lenzi, P / Lizzo, M / Meschini, M / Paoletti, S / Seidita, R / Sguazzoni, G / Viliani, L / Benussi, L / Bianco, S / Piccolo, D / Bozzo, M / Ferro, F / Mulargia, R / Robutti, E / Tosi, S / Benaglia, A / Boldrini, G / Brivio, F / Cetorelli, F / Ciriolo, V / De Guio, F / Dinardo, M E / Dini, P / Gennai, S / Ghezzi, A / Govoni, P / Guzzi, L / Malberti, M / Malvezzi, S / Massironi, A / Menasce, D / Moroni, L / Paganoni, M / Pedrini, D / Pinolini, B S / Ragazzi, S / Redaelli, N / de Fatis, T Tabarelli / Valsecchi, D / Zuolo, D / Buontempo, S / Carnevali, F / Cavallo, N / De Iorio, A / Fabozzi, F / Iorio, A O M / Lista, L / Meola, S / Paolucci, P / Rossi, B / Sciacca, C / Azzi, P / Bacchetta, N / Bisello, D / Bortignon, P / Bragagnolo, A / Carlin, R / Checchia, P / Dorigo, T / Dosselli, U / Gasparini, F / Gasparini, U / Grosso, G / Hoh, S Y / Layer, L / Lusiani, E / Margoni, M / Meneguzzo, A T / Pazzini, J / Presilla, M / Ronchese, P / Rossin, R / Simonetto, F / Strong, G / Tosi, M / Yarar, H / Zanetti, M / Zotto, P / Zucchetta, A / Zumerle, G / Aime', C / Braghieri, A / Calzaferri, S / Fiorina, D / Montagna, P / Ratti, S P / Re, V / Riccardi, C / Salvini, P / Vai, I / Vitulo, P / Asenov, P / Bilei, G M / Ciangottini, D / Fanò, L / Lariccia, P / Magherini, M / Mantovani, G / Mariani, V / Menichelli, M / Moscatelli, F / Piccinelli, A / Rossi, A / Santocchia, A / Spiga, D / Tedeschi, T / Azzurri, P / Bagliesi, G / Bertacchi, V / Bianchini, L / Boccali, T / Bossini, E / Castaldi, R / Ciocci, M A / D'Amante, V / Dell'Orso, R / Domenico, M R Di / Donato, S / Giassi, A / Ligabue, F / Manca, E / Mandorli, G / Messineo, A / Palla, F / Parolia, S / Ramirez-Sanchez, G / Rizzi, A / Rolandi, G / Chowdhury, S Roy / Scribano, A / Shafiei, N / Spagnolo, P / Tenchini, R / Tonelli, G / Turini, N / Venturi, A / Verdini, P G / Campana, M / Cavallari, F / Re, D Del / Di Marco, E / Diemoz, M / Longo, E / Meridiani, P / Organtini, G / Pandolfi, F / Paramatti, R / Quaranta, C / Rahatlou, S / Rovelli, C / Santanastasio, F / Soffi, L / Tramontano, R / Amapane, N / Arcidiacono, R / Argiro, S / Arneodo, M / Bartosik, N / Bellan, R / Bellora, A / Antequera, J Berenguer / Biino, C / Cartiglia, N / Cometti, S / Costa, M / Covarelli, R / Demaria, N / Kiani, B / Legger, F / Mariotti, C / Maselli, S / Migliore, E / Monteil, E / Monteno, M / Obertino, M M / Ortona, G / Pacher, L / Pastrone, N / Pelliccioni, M / Angioni, G L Pinna / Ruspa, M / Shchelina, K / Siviero, F / Sola, V / Solano, A / Soldi, D / Staiano, A / Tornago, M / Trocino, D / Vagnerini, A / Belforte, S / Candelise, V / Casarsa, M / Cossutti, F / Da Rold, A / Ricca, G Della / Sorrentino, G / Vazzoler, F / Dogra, S / Huh, C / Kim, B / Kim, D H / Kim, G N / Kim, J / Lee, J / Lee, S W / Moon, C S / Oh, Y D / Pak, S I / Radburn-Smith, B C / Sekmen, S / Yang, Y C / Kim, H / Moon, D H / Francois, B / Kim, T J / Park, J / Cho, S / Choi, S / Go, Y / Hong, B / Lee, K S / Lim, J / Park, S K / Yoo, J / Goh, J / Gurtu, A / Kim, H S / Kim, Y / Almond, J / Bhyun, J H / Choi, J / Jeon, S / Kim, J S / Ko, S / Kwon, H / Lee, H / Lee, S / Oh, B H / Oh, M / Oh, S B / Seo, H / Yang, U K / Yoon, I / Jang, W / Kang, D Y / Kang, Y / Kim, S / Ko, B / Lee, J S H / Lee, Y / Park, I C / Roh, Y / Ryu, M S / Song, D / I J, Watson / Yang, S / Ha, S / Yoo, H D / Choi, M / Jeong, Y / Yu, I / Beyrouthy, T / Maghrbi, Y / Torims, T / Veckalns, V / Ambrozas, M / De Oliveira, A Carvalho Antunes / Juodagalvis, A / Rinkevicius, A / Tamulaitis, G / Norjoharuddeen, N Bin / Abdullah, W A T Wan / Yusli, M N / Zolkapli, Z / Benitez, J F / Hernandez, A Castaneda / Coello, M León / Quijada, J A Murillo / Sehrawat, A / Palomo, L Valencia / Ayala, G / Castilla-Valdez, H / De La Cruz-Burelo, E / La Cruz, I Heredia-De / Lopez-Fernandez, R / Herrera, C A Mondragon / Navarro, D A Perez / Hernández, A Sánchez / Moreno, S Carrillo / Barrera, C Oropeza / Valencia, F Vazquez / Pedraza, I / Ibarguen, H A Salazar / Estrada, C Uribe / Bubanja, I / Mijuskovic, J / Raicevic, N / Krofcheck, D / Bheesette, S / Butler, P H / Ahmad, A / Asghar, M I / Awais, A / Awan, M I M / Hoorani, H R / Khan, W A / Shah, M A / Shoaib, M / Waqas, M / Avati, V / Grzanka, L / Malawski, M / Bialkowska, H / Bluj, M / Boimska, B / Górski, M / Kazana, M / Szleper, M / Zalewski, P / Bunkowski, K / Doroba, K / Kalinowski, A / Konecki, M / Krolikowski, J / Walczak, M / Araujo, M / Bargassa, P / Bastos, D / Boletti, A / Faccioli, P / Gallinaro, M / Hollar, J / Leonardo, N / Niknejad, T / Pisano, M / Seixas, J / Toldaiev, O / Varela, J / Adzic, P / Dordevic, M / Milenovic, P / Milosevic, J / Aguilar-Benitez, M / Maestre, J Alcaraz / Fernández, A Álvarez / Bachiller, I / Luna, M Barrio / Bedoya, Cristina F / Montoya, C A Carrillo / Cepeda, M / Cerrada, M / Colino, N / De La Cruz, B / Peris, A Delgado / Ramos, J P Fernández / Flix, J / Fouz, M C / Lopez, O Gonzalez / Lopez, S Goy / Hernandez, J M / Josa, M I / Holgado, J León / Moran, D / Tobar, Á Navarro / Dengra, C Perez / Yzquierdo, A Pérez-Calero / Pelayo, J Puerta / Redondo, I / Romero, L / Navas, S Sánchez / Gómez, L Urda / Willmott, C / de Trocóniz, J F / Reyes-Almanza, R / Gonzalez, B Alvarez / Cuevas, J / Erice, C / Menendez, J Fernandez / Folgueras, S / Caballero, I Gonzalez / Fernández, J R González / Cortezon, E Palencia / Álvarez, C Ramón / Bouza, V Rodríguez / Trapote, A / Trevisani, N / Cifuentes, J A Brochero / Cabrillo, I J / Calderon, A / Campderros, J Duarte / Fernandez, M / Madrazo, C Fernandez / Manteca, P J Fernández / Alonso, A García / Gomez, G / Rivero, C Martinez / Arbol, P Martinez Ruiz Del / Matorras, F / Cuevas, P Matorras / Gomez, J Piedra / Prieels, C / Rodrigo, T / Ruiz-Jimeno, A / Scodellaro, L / Vila, I / Garcia, J M Vizan / Jayananda, M K / Kailasapathy, B / Sonnadara, D U J / Wickramarathna, D D C / Dharmaratna, W G D / Liyanage, K / Perera, N / Wickramage, N / Aarrestad, T K / Abbaneo, D / Alimena, J / Auffray, E / Auzinger, G / Baechler, J / Baillon, P / Barney, D / Bendavid, J / Bianco, M / Bocci, A / Camporesi, T / Garrido, M Capeans / Cerminara, G / Chhibra, S S / Cipriani, M / Cristella, L / d'Enterria, D / Dabrowski, A / David, A / De Roeck, A / Defranchis, M M / Deile, M / Dobson, M / Dünser, M / Dupont, N / Elliott-Peisert, A / Emriskova, N / Fallavollita, F / Fasanella, D / Florent, A / Franzoni, G / Funk, W / Giani, S / Gigi, D / Gill, K / Glege, F / Gouskos, L / Haranko, M / Hegeman, J / Iiyama, Y / Innocente, V / James, T / Janot, P / Kaspar, J / Kieseler, J / Komm, M / Kratochwil, N / Lange, C / Laurila, S / Lecoq, P / Long, K / Lourenço, C / Malgeri, L / Mallios, S / Mannelli, M / Marini, A C / Meijers, F / Mersi, S / Meschi, E / Moortgat, F / Mulders, M / Orfanelli, S / Orsini, L / Pantaleo, F / Pape, L / Perez, E / Peruzzi, M / Petrilli, A / Petrucciani, G / Pfeiffer, A / Pierini, M / Piparo, D / Pitt, M / Qu, H / Quast, T / Rabady, D / Racz, A / Gutiérrez, G Reales / Rieger, M / Rovere, M / Sakulin, H / Salfeld-Nebgen, J / Scarfi, S / Schäfer, C / Selvaggi, M / Silva, P / Snoeys, W / Sphicas, P / Summers, S / Tatar, K / Tavolaro, V R / Treille, D / Tsirou, A / Onsem, G P Van / Wanczyk, J / Wozniak, K A / Zeuner, W D / Caminada, L / Ebrahimi, A / Erdmann, W / Horisberger, R / Ingram, Q / Kaestli, H C / Kotlinski, D / Missiroli, M / Rohe, T / Androsov, K / Backhaus, M / Berger, P / Calandri, A / Chernyavskaya, N / De Cosa, A / Dissertori, G / Dittmar, M / Donegà, M / Dorfer, C / Eble, F / Gedia, K / Glessgen, F / 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Zhang, Y / Branson, J G / Chang, P / Cittolin, S / Cooperstein, S / Deelen, N / Diaz, D / Duarte, J / Gerosa, R / Giannini, L / Gilbert, D / Guiang, J / Kansal, R / Krutelyov, V / Lee, R / Letts, J / Masciovecchio, M / May, S / Pieri, M / Narayanan, B V Sathia / Sharma, V / Tadel, M / Vartak, A / Würthwein, F / Xiang, Y / Yagil, A / Amin, N / Campagnari, C / Citron, M / Dorsett, A / Dutta, V / Incandela, J / Kilpatrick, M / Marsh, B / Mei, H / Oshiro, M / Quinnan, M / Richman, J / Sarica, U / Setti, F / Sheplock, J / Stuart, D / Wang, S / Bornheim, A / Cerri, O / Dutta, I / Lawhorn, J M / Lu, N / Mao, J / Newman, H B / Nguyen, T Q / Spiropulu, M / Vlimant, J R / Wang, C / Xie, S / Zhang, Z / Zhu, R Y / Alison, J / An, S / Andrews, M B / Bryant, P / Ferguson, T / Harilal, A / Liu, C / Mudholkar, T / Paulini, M / Sanchez, A / Terrill, W / Cumalat, J P / Ford, W T / Hassani, A / MacDonald, E / Patel, R / Perloff, A / Savard, C / Stenson, K / Ulmer, K A / Wagner, S R / Alexander, J / Bright-Thonney, S / Cheng, Y / Cranshaw, D J / Hogan, S / Monroy, J / Patterson, J R / Quach, D / Reichert, J / Reid, M / Ryd, A / Sun, W / Thom, J / Wittich, P / Zou, R / Albrow, M / Alyari, M / Apollinari, G / Apresyan, A / Apyan, A / Bauerdick, L A T / Berry, D / Berryhill, J / Bhat, P C / Burkett, K / Butler, J N / Canepa, A / Cerati, G B / Cheung, H W K / Chlebana, F / Cremonesi, M / Di Petrillo, K F / Elvira, V D / Feng, Y / Freeman, J / Gecse, Z / Gray, L / Green, D / Grünendahl, S / Gutsche, O / Harris, R M / Heller, R / Herwig, T C / Hirschauer, J / Jayatilaka, B / Jindariani, S / Johnson, M / Joshi, U / Klijnsma, T / Klima, B / Kwok, K H M / Lammel, S / Lincoln, D / Lipton, R / Liu, T / Madrid, C / Maeshima, K / Mantilla, C / Mason, D / McBride, P / Merkel, P / Mrenna, S / Nahn, S / Ngadiuba, J / O'Dell, V / Papadimitriou, V / Pedro, K / Pena, C / Prokofyev, O / Ravera, F / Hall, A Reinsvold / Ristori, L / Schneider, B / Sexton-Kennedy, E / Smith, N / Soha, A / Spalding, W J / Spiegel, L / Strait, J / Taylor, L / Tkaczyk, S / Tran, N V / Uplegger, L / Vaandering, E W / Weber, H A / Acosta, D / Avery, P / Bourilkov, D / Cadamuro, L / Cherepanov, V / Errico, F / Field, R D / Guerrero, D / Joshi, B M / Kim, M / Koenig, E / Konigsberg, J / Korytov, A / Lo, K H / Matchev, K / Menendez, N / Mitselmakher, G / Madhu, A Muthirakalayil / Rawal, N / Rosenzweig, D / Rosenzweig, S / Shi, K / Sturdy, J / Yigitbasi, E / Zuo, X / Adams, T / Askew, A / Habibullah, R / Hagopian, V / Johnson, K F / Khurana, R / Kolberg, T / Martinez, G / Prosper, H / Schiber, C / Viazlo, O / Yohay, R / Zhang, J / Baarmand, M M / Butalla, S / Elkafrawy, T / Hohlmann, M / Verma, R Kumar / Noonan, D / Rahmani, M / Yumiceva, F / Adams, M R / Gonzalez, H Becerril / Cavanaugh, R / Chen, X / Dittmer, S / Evdokimov, O / Gerber, C E / Hangal, D A / Hofman, D J / Merrit, A H / Mills, C / Oh, G / Roy, T / Rudrabhatla, S / Tonjes, M B / Varelas, N / Viinikainen, J / Wang, X / Wu, Z / Ye, Z / Alhusseini, M / Dilsiz, K / Gandrajula, R P / Köseyan, O K / Merlo, J-P / Mestvirishvili, A / Nachtman, J / Ogul, H / Onel, Y / Penzo, A / Snyder, C / Tiras, E / Amram, O / Blumenfeld, B / Corcodilos, L / Davis, J / Eminizer, M / Gritsan, A V / Kyriacou, S / Maksimovic, P / Roskes, J / Swartz, M / Vámi, T Á / Abreu, A / Anguiano, J / Barrera, C Baldenegro / Baringer, P / Bean, A / Bylinkin, A / Flowers, Z / Isidori, T / Khalil, S / King, J / Krintiras, G / Kropivnitskaya, A / Lazarovits, M / Lindsey, C / Marquez, J / Minafra, N / Murray, M / Nickel, M / Rogan, C / Royon, C / Salvatico, R / Sanders, S / Schmitz, E / Smith, C / Takaki, J D Tapia / Warner, Z / Williams, J / Wilson, G / Duric, S / Ivanov, A / Kaadze, K / Kim, D / Maravin, Y / Mitchell, T / Modak, A / Nam, K / Rebassoo, F / Wright, D / Adams, E / Baden, A / Baron, O / Belloni, A / Eno, S C / Hadley, N J / Jabeen, S / Kellogg, R G / Koeth, T / Mignerey, A C / Nabili, S / Palmer, C / Seidel, M / Skuja, A / Wang, L / Wong, K / 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    The European physical journal. C, Particles and fields

    2023  Volume 83, Issue 7, Page(s) 628

    Abstract: The double differential cross sections of the Drell-Yan lepton pair ( ...

    Abstract The double differential cross sections of the Drell-Yan lepton pair (
    Language English
    Publishing date 2023-07-17
    Publishing country France
    Document type Journal Article
    ZDB-ID 1459069-4
    ISSN 1434-6052 ; 1434-6044
    ISSN (online) 1434-6052
    ISSN 1434-6044
    DOI 10.1140/epjc/s10052-023-11631-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Forensic Validation and Application Evaluation of IDentifier DNA Typing Kit (Yan-Huang34).

    Gao, Lin-Lin / Xie, Wei / Zhu, Su-Juan / Li, Da / Wang, Qin / Hong, Liang / Li, You-Ying

    Fa yi xue za zhi

    2024  Volume 39, Issue 6, Page(s) 579–585

    Abstract: Objectives: To investigate the technical performance of IDentifier DNA typing kit (YanHuang34) and evaluate its forensic application value.: Methods: Following the : Results: IDentifier DNA typing kit (YanHuang34) had good species specificity, ... ...

    Abstract Objectives: To investigate the technical performance of IDentifier DNA typing kit (YanHuang34) and evaluate its forensic application value.
    Methods: Following the
    Results: IDentifier DNA typing kit (YanHuang34) had good species specificity, veracity, adaptability, inhibitor tolerance and balance. The sensibility was up to 0.062 5 ng. It was able to detect different types of samples, degraded samples and inhibitor mixed samples. Complete DNA typing could be obtained for samples with the mixture ratio less than 4∶1. The system efficiency of IDentifier DNA typing kit (YanHuang34) was very high, with TDP up to 1-1.08×10
    Conclusions: The IDentifier DNA typing kit (YanHuang34) is adaptive to the GB/T 37226-2018 requirements. It can be used for individual identification and paternity identification, and is suitable for application in the field of forensic science.
    MeSH term(s) Humans ; DNA Fingerprinting ; Polymerase Chain Reaction ; Microsatellite Repeats ; Paternity ; Species Specificity
    Language Chinese
    Publishing date 2024-01-16
    Publishing country China
    Document type Journal Article
    ISSN 1004-5619
    ISSN 1004-5619
    DOI 10.12116/j.issn.1004-5619.2022.520902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reply to Yan et al.: Quercetin possesses a fluorescence quenching effect but is a weak inhibitor against SARS-CoV-2 main protease.

    Xu, Haiyu / Zhong, Yute / Yang, Jinyue / Fu, Lifeng / Shi, Yi / Huang, Luqi / Gao, George F

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 37, Page(s) e2309870120

    MeSH term(s) Humans ; Quercetin ; Fluorescence ; COVID-19 ; SARS-CoV-2
    Chemical Substances 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Quercetin (9IKM0I5T1E)
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2309870120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Spatio-temporal variation in leaf area index in the Yan Mountains over the past 40 years and its relationship to hydrothermal conditions

    Da Guo / Xiaoning Song / Ronghai Hu / Rui Ma / Yanan Zhang / Liang Gao / Xinming Zhu / Paul Kardol

    Ecological Indicators, Vol 157, Iss , Pp 111291- (2023)

    2023  

    Abstract: ... the trends of leaf area index (LAI) in the Yan Mountains over the last four decades using Global Land Surface ...

    Abstract Changes in hydrothermal conditions have significant effects on vegetation, but there is still a lack of understanding of how vegetation responds to land surface (surface temperature and soil moisture) and meteorological (temperature and precipitation) conditions in mountain regions. This study examined the trends of leaf area index (LAI) in the Yan Mountains over the last four decades using Global Land Surface Satellite (GLASS) data. The results showed a persistent increase of LAI (greening) over 20 % to 80 % of the study area in growing season, spring, summer and autumn. Anthropogenic activities caused the greening trend by crop management before 2000 and afforestation after 2000. The increasing rate of LAI varied with elevation, and the most significant increase occurred in areas between 300 and 900 m, and the lowest increase occurred in areas below 300 m. Moreover, we found that LAI was negatively correlated with land surface temperature and soil moisture, but positively correlated with precipitation and air temperature. The time-lag effect was found between hydrothermal factors and LAI in the past four decades. There was a time lag of 2–3 months between LAI changes and temperature/precipitation during the early and late stages of the growing season, and a time lag of 0–1 month during the middle stage. Specifically, there was no time lag in vegetation response to surface soil moisture, and a time lag of 2–3 months in vegetation response to land surface temperature from July to October. Our findings provide insights into how vegetation adapts to land surface and climatic hydrothermal conditions in mountain regions and can be used by governments to develop policies for ecological protection.
    Keywords Mountains ; Climate change ; Leaf area index ; Vegetation greening ; Global warming ; Precipitation ; Ecology ; QH540-549.5
    Subject code 910 ; 550
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  5. Article ; Online: The anti-MDR efficacy of YAN against A549/Taxol cells is associated with its inhibition on glycolysis and is further enhanced by 2-deoxy-d-glucose.

    Gao, Minghuan / Yang, Yuying / Gao, Ying / Liu, Tong / Guan, Qi / Zhou, Tianhao / Shi, Yani / Hao, Mingjing / Li, Zengqiang / Zuo, Daiying / Zhang, Weige / Wu, Yingliang

    Chemico-biological interactions

    2022  Volume 354, Page(s) 109843

    Abstract: ... drug resistance. 5-(4-ethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazol-3-amine (YAN), a newly synthesized ... related with the apoptosis resistance. The effects of YAN above were relevant to the down-regulation ... of PI3K-Akt-c-Myc/HIF-1α pathway. Moreover, YAN induced the reactive oxygen species generation in A549 and ...

    Abstract Aerobic glycolysis is a hallmark of malignant tumor. Here, the hyperactive glycolysis in multidrug-resistant A549/Taxol cells was demonstrated to be essential for maintaining the vigorous cell viability and drug resistance. 5-(4-ethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazol-3-amine (YAN), a newly synthesized tubulin inhibitor, could not only inhibit the glycolysis in A549 and A549/Taxol cells through down-regulating the glycolysis-related proteins, but also disrupt the mitochondrial localization of hexokinase-2 (HK-2) which is related with the apoptosis resistance. The effects of YAN above were relevant to the down-regulation of PI3K-Akt-c-Myc/HIF-1α pathway. Moreover, YAN induced the reactive oxygen species generation in A549 and A549/Taxol cells, which only mediated the apoptosis in A549 cells. We also showed that 2-DG, the glycolysis inhibitor, synergistically enhanced YAN-triggered apoptosis in A549/Taxol cells via further suppressing glycolysis and reducing mitotic slippage. Collectively, we illustrate the inhibition effect of YAN on the glycolysis in A549 and A549/Taxol cells, and provide a fresh insight into the mechanism for the development of YAN as a candidate for multidrug resistant cancer treatment. The finding that 2-DG improved the anti-tumor efficacy of YAN against A549/Taxol cells, offers a reference for solving mitotic slippage-mediated drug resistance.
    MeSH term(s) Paclitaxel
    Chemical Substances Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2022-02-02
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 218799-1
    ISSN 1872-7786 ; 0009-2797
    ISSN (online) 1872-7786
    ISSN 0009-2797
    DOI 10.1016/j.cbi.2022.109843
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  6. Article ; Online: On the One-Point Model for the Productivity Evaluation in Jingbian Sector of Yan’an Gas Field

    Liu Er-hu / Liu Yang-yang / Gao Li-jun / Zhou De-sheng / Liu Xiong / Xu Jin-ze

    Frontiers in Earth Science, Vol

    2021  Volume 9

    Abstract: ... of the Yan’an gas field. The field experience formula and production data are used to verify ... for productivity analysis of gas wells in paleozoic reservoirs in the Jingbian sector of the Yan’an gas field ...

    Abstract The productivity equation of a gas well is, in the final analysis, an expression that describes the relationship between the production of a gas well and its bottom-hole flowing pressure. There are two kinds of productivity equations in common use at present: binomial productivity equation and exponential productivity equation. Combined with the modified isochronal well test, the test data are interpreted, and it is found that the open flow rates calculated by the two productivity equations are basically the same when the pressure difference at the test point is large, and the deviation of the exponential productivity equation is large when the pressure difference at the test point is small. Using binomial productivity equation and modifying isochronous well test, we established the single-point deliverability formula for the Jingbian sector of the Yan’an gas field. The field experience formula and production data are used to verify it. Their average errors are 2.59% and 7.12%, respectively; and the coincidence rate of productivity evaluation is 90%. The one-point productivity formula established has high precision and is suitable for productivity analysis of gas wells in paleozoic reservoirs in the Jingbian sector of the Yan’an gas field. This paper provides insights into the one-point productivity evaluation and its future application in the gas field.
    Keywords productivity equation ; gas field ; modified isochronal test ; one-point deliverability formula ; open flow ; Science ; Q
    Subject code 621
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
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  7. Article ; Online: YAN, a novel microtubule inhibitor, inhibits P-gp and MRP1 function and induces mitotic slippage followed by apoptosis in multidrug-resistant A549/Taxol cells.

    Gao, Minghuan / Liu, Tong / Li, Jingnan / Guan, Qi / Wang, Haoran / Yan, Shuqi / Li, Zengqiang / Zuo, Daiying / Zhang, Weige / Wu, Yingliang

    Toxicology in vitro : an international journal published in association with BIBRA

    2020  Volume 69, Page(s) 104971

    Abstract: ... 5-trimethoxyphenyl)-1H-1,2,4-triazol-3-amine (YAN) exhibited strong cytotoxicity towards A549 and ... MDR-phenotype A549/Taxol cells. We demonstrated that YAN was a poor substrate of P-glycoprotein (P-gp ... and YAN inhibited their expression and function. Moreover, YAN arrested cells at mitosis phase ...

    Abstract Lung cancer is the most common cause of cancer-related death worldwide. The occurrence of multidrug resistance (MDR) affects the therapeutic efficacy of chemotherapeutics. Therefore, to develop new anticarcinogen which can overcome MDR is urgent. Here, the novel microtubule inhibitor 5-(4-ethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazol-3-amine (YAN) exhibited strong cytotoxicity towards A549 and MDR-phenotype A549/Taxol cells. We demonstrated that YAN was a poor substrate of P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) which were over-expressed in A549/Taxol cells, and YAN inhibited their expression and function. Moreover, YAN arrested cells at mitosis phase by inhibiting microtubule polymerization. Further, YAN induced caspase-dependent apoptosis in A549 cells via mitochondria-mediated intrinsic pathway. In contrast, the multinucleation of A549/Taxol cells after YAN-treatment indicated the occurrence of mitotic catastrophe, and the subsequent apoptosis was mediated by apoptosis-inducing factor (AIF) nuclear translocation instead of p53- and caspase-dependent manner. Moreover, the inhibitory effect of YAN on PI3K/Akt activity was involved in the regulation of P-gp, MRP1 and AIF in A549/Taxol cells. Taken together, our finding indicates that YAN is a novel microtubule inhibitor and overcomes MDR by suppressing P-gp and MRP1 function and inducing cell death independent of p53 and caspase in A549/Taxol cells. Therefore, YAN possesses great potential for future development into an effective anticarcinogen especially for drug-resistant cancer.
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line ; Drug Resistance, Multiple/drug effects ; Drug Resistance, Neoplasm/drug effects ; Humans ; Mice ; Mitosis/drug effects ; Multidrug Resistance-Associated Proteins/genetics ; Multidrug Resistance-Associated Proteins/metabolism ; Paclitaxel/pharmacology ; Tubulin Modulators/pharmacology
    Chemical Substances ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Antineoplastic Agents ; Multidrug Resistance-Associated Proteins ; Tubulin Modulators ; Paclitaxel (P88XT4IS4D) ; multidrug resistance-associated protein 1 (Y49M64GZ4Q)
    Language English
    Publishing date 2020-08-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 639064-x
    ISSN 1879-3177 ; 0887-2333
    ISSN (online) 1879-3177
    ISSN 0887-2333
    DOI 10.1016/j.tiv.2020.104971
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  8. Article ; Online: Correction to: YAN, a novel microtubule inhibitor, inhibits P-gp and MRP1 function and induces mitotic slippage followed by apoptosis in multidrug-resistant A549/Taxol cells.

    Gao, Minghuan / Liu, Tong / Li, Jingnan / Guan, Qi / Wang, Haoran / Yan, Shuqi / Li, Zengqiang / Zuo, Daiying / Zhang, Weige / Wu, Yingliang

    Toxicology in vitro : an international journal published in association with BIBRA

    2020  Volume 72, Page(s) 105033

    Language English
    Publishing date 2020-10-29
    Publishing country England
    Document type Published Erratum
    ZDB-ID 639064-x
    ISSN 1879-3177 ; 0887-2333
    ISSN (online) 1879-3177
    ISSN 0887-2333
    DOI 10.1016/j.tiv.2020.105033
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  9. Article: Modulation of the Gut Microbiota by Shen-Yan-Fang-Shuai Formula Improves Obesity Induced by High-Fat Diets.

    Wang, Zhen / Lu, Junfeng / Zhou, Jingwei / Sun, Weiwei / Qiu, Yang / Chen, Weihong / Gao, Yabin / Yang, Ruibing / Ai, Sinan / Liu, Zhongjie / Guo, Yingbo / Liu, Wei Jing / Wang, Yaoxian / Peng, Liang

    Frontiers in microbiology

    2020  Volume 11, Page(s) 564376

    Abstract: ... disrupted intestinal barrier and chronic inflammation. Shen-Yan-Fang-Shuai formula (SYFSF) is a traditional ...

    Abstract Obesity and related metabolic disorders are associated with intestinal microbiota dysbiosis, disrupted intestinal barrier and chronic inflammation. Shen-Yan-Fang-Shuai formula (SYFSF) is a traditional Chinese herbal formula composed of Astragali Radix, Radix Angelicae Sinensis, Rheum Officinale Baill, and four other herbs. In this study, we identified that SYFSF treatment prevented weight gain, low-grade inflammation and insulin resistance in high-fat diet (HFD)-fed mice. SYFSF also substantially improved gut barrier function, reduced metabolic endotoxemia, as well as systemic inflammation. Sequencing of 16S rRNA genes obtained from fecal samples demonstrated that SYFSF attenuated HFD-induced gut dysbiosis, seen an decreased Firmicutes to Bacteroidetes ratios. Microbial richness and diversity were also higher in the SYFSF-treated HFD group. Furthermore, similar therapeutic effects and changes in gut microbiota profile caused by SYFSF could be replicated by fecal microbiota transfer (FMT). Taken together, our study highlights the efficacy of SYFSF in preventing obesity and related metabolic disorders. Its therapeutic effect is associated with the modulation of gut microbiota, as a prebiotic.
    Language English
    Publishing date 2020-12-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.564376
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  10. Article ; Online: Wu-Zi-Yan-Zong-Wan protects mouse blood-testis barrier from Tripterygium wilfordii Hook. f. multiglycoside-induced disruption by regulating proinflammatory cytokines.

    Pan, Zhenkun / Gao, Yunxiao / Liu, Shuang / Ke, Zhenghao / Guo, Jianqiang / Ma, Wenjing / Cui, Tianwei / Liu, Baoxing / Zhang, Xiuping

    Journal of ethnopharmacology

    2021  Volume 280, Page(s) 114440

    Abstract: Ethnopharmacological relevance: Wu-Zi-Yan-Zong-Wan (WZYZW) is a classical traditonal Chinese ...

    Abstract Ethnopharmacological relevance: Wu-Zi-Yan-Zong-Wan (WZYZW) is a classical traditonal Chinese herbal formula and a Chinese patent medicine used to treat male infertility. However, the chemical components of WZYZW and its mechanism are not yet fully clarified.
    Aim of the study: The purpose of this study is to observe the effect and underlying mechanism of WZYZW on ameliorating blood-testis barrier (BTB) dysfunction in mice with spermatogenic dysfunction induced by administration of Tripterygium wilfordii Hook. f. multiglycosides (GTW).
    Materials and methods: WZYZW was administered by gavage to mice with GTW-induced spermatogenic dysfunction (kidney essence deficiency pattern) for 40 days. Testis tissues were obtained for subsequent histopathological analysis. Biotin tracing was used to evaluate the permeability of Sertoli cell tight junctions. The levels of proinflammatory cytokines including interleukin (IL)-6, IL-17A, IL-1α and tumor necrosis factor (TNF)-α were analyzed by ELISA. The expression levels of proteins related to tight junction including ZO-1, JAM-A and occludin were analyzed by western blotting. The ultrastructures of tight junctions were observed by transmission electron microscopy.
    Results: WZYZW ameliorated GTW-induced testicular spermatogenic dysfunction. Levels of IL-6, IL-17A, IL-1α, and TNF-α in the groups receiving low, medium, and high doses of WZYZW decreased in a dose-dependent manner. WZYZW impeded a biotin tracer from permeating the BTB, protecting its integrity in GTW-treated mice. In addition, our results showed no significant changes in the protein expressions of ZO-1, JAM-A, and occludin after WZYZW administration compared with the GTW group. Meanwhile, WZYZW exhibited a linear arrangement and restored the typical "sandwich" structure of BTB. No acute poisoning incidences were observed in all groups during the experiment.
    Conclusions: Our findings demonstrate that WZYZW may ameliorate some GTW-induced BTB dysfunction, possibly by regulating proinflammatory cytokine levels. In vitro studies on the regulation of BTB permeability by WZYZW and its active components are further required.
    MeSH term(s) Animals ; Blood-Testis Barrier/drug effects ; Cytokines/genetics ; Cytokines/metabolism ; Drugs, Chinese Herbal/pharmacology ; Gene Expression Regulation/drug effects ; Glycosides/toxicity ; Inflammation/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Random Allocation ; Spermatogenesis/drug effects ; Testis/blood supply ; Testis/metabolism ; Tripterygium/chemistry
    Chemical Substances Cytokines ; Drugs, Chinese Herbal ; Glycosides ; wu-zi-yan-zong-wan
    Language English
    Publishing date 2021-07-19
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2021.114440
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