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Article: Osteoporosis Risk Calculators.

Edwards, Beatrice J

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

2017 Volume 20, Issue 3, Page(s) 379–388

Abstract: Osteoporosis is a silent disease until fractures occur, patient recognition is the greatest clinical challenge. Although more than 20 million women in the US are estimated to have established osteoporosis the majority are not appropriately identified. ... ...

Abstract	Osteoporosis is a silent disease until fractures occur, patient recognition is the greatest clinical challenge. Although more than 20 million women in the US are estimated to have established osteoporosis the majority are not appropriately identified. Bone densitometry is the current gold standard for diagnosis of osteoporosis; but may not be feasible or cost-effective to recommend for all postmenopausal women. Therefore, questionnaires incorporating risk factors have been developed to aid the clinician in identifying women with osteoporosis. We will review Qfracture, CAnadian Risk for Osteoporosis Calculator (CAROC), the Simple Calculated Osteoporosis Risk Index (SCORE), the Osteoporosis Risk Assessment Index (ORAI), the Osteoporotic Self-assessment Tool (OST), ABONE, and the United States Preventive Services Task Force recommendations.
MeSH term(s)	Algorithms ; Humans ; Osteoporosis/complications ; Osteoporosis/diagnosis ; Osteoporotic Fractures/etiology ; Risk Assessment/methods ; Risk Factors ; Surveys and Questionnaires
Language	English
Publishing date	2017-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2040951-5
ISSN	1094-6950
ISSN	1094-6950
DOI	10.1016/j.jocd.2017.06.024
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Article ; Online: Malnutrition in Older Adults with Cancer.

Zhang, Xiaotao / Edwards, Beatrice J

Current oncology reports

2019 Volume 21, Issue 9, Page(s) 80

Abstract: Purpose of review: Malnutrition is a common and under-recognized geriatric condition in older adults with cancer. This review describes the public health burden, malnutrition prevention, and the relationship among cancer cachexia, malnutrition, and ... ...

Abstract	Purpose of review: Malnutrition is a common and under-recognized geriatric condition in older adults with cancer. This review describes the public health burden, malnutrition prevention, and the relationship among cancer cachexia, malnutrition, and sarcopenia. Finally, clinical practice recommendations on malnutrition and prevention are presented. Recent findings: Advanced age and cancer stage, frailty, dementia, major depression, functional impairment, and physical performance are important risk factors for malnutrition in older adults with cancer. The Mini Nutrition Assessment (MNA), Malnutrition Universal Screening Tool (MUST), and Patient Generated Subjective Global Assessment (PG-SGA) are the most commonly used assessment tools in older adults with cancer. In addition, malnutrition is independently associated with poor overall survival and quality of life, longer hospital stays, greater hospital cost, and hospital readmission. Comprehensive malnutrition prevention is required for improving the nutrition status among older adults with cancer.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Frailty/etiology ; Frailty/metabolism ; Humans ; Malnutrition/etiology ; Malnutrition/metabolism ; Neoplasms/complications ; Neoplasms/metabolism ; Quality of Life ; Risk Factors
Language	English
Publishing date	2019-07-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2057359-5
ISSN	1534-6269 ; 1523-3790
ISSN (online)	1534-6269
ISSN	1523-3790
DOI	10.1007/s11912-019-0829-8
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Zs.A 5521: Show issues

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Article ; Online: Gesture Recognition in Robotic Surgery With Multimodal Attention.

van Amsterdam, Beatrice / Funke, Isabel / Edwards, Eddie / Speidel, Stefanie / Collins, Justin / Sridhar, Ashwin / Kelly, John / Clarkson, Matthew J / Stoyanov, Danail

IEEE transactions on medical imaging

2022 Volume 41, Issue 7, Page(s) 1677–1687

Abstract: Automatically recognising surgical gestures from surgical data is an important building block of automated activity recognition and analytics, technical skill assessment, intra-operative assistance and eventually robotic automation. The complexity of ... ...

Abstract	Automatically recognising surgical gestures from surgical data is an important building block of automated activity recognition and analytics, technical skill assessment, intra-operative assistance and eventually robotic automation. The complexity of articulated instrument trajectories and the inherent variability due to surgical style and patient anatomy make analysis and fine-grained segmentation of surgical motion patterns from robot kinematics alone very difficult. Surgical video provides crucial information from the surgical site with context for the kinematic data and the interaction between the instruments and tissue. Yet sensor fusion between the robot data and surgical video stream is non-trivial because the data have different frequency, dimensions and discriminative capability. In this paper, we integrate multimodal attention mechanisms in a two-stream temporal convolutional network to compute relevance scores and weight kinematic and visual feature representations dynamically in time, aiming to aid multimodal network training and achieve effective sensor fusion. We report the results of our system on the JIGSAWS benchmark dataset and on a new in vivo dataset of suturing segments from robotic prostatectomy procedures. Our results are promising and obtain multimodal prediction sequences with higher accuracy and better temporal structure than corresponding unimodal solutions. Visualization of attention scores also gives physically interpretable insights on network understanding of strengths and weaknesses of each sensor.
MeSH term(s)	Biomechanical Phenomena ; Gestures ; Humans ; Motion ; Robotic Surgical Procedures ; Robotics/methods
Language	English
Publishing date	2022-06-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	622531-7
ISSN	1558-254X ; 0278-0062
ISSN (online)	1558-254X
ISSN	0278-0062
DOI	10.1109/TMI.2022.3147640
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Zs.A 2546: Show issues

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Article ; Online: Structure-Based Stabilization of SOSIP Env Enhances Recombinant Ectodomain Durability and Yield.

Wrapp, Daniel / Mu, Zekun / Thakur, Bhishem / Janowska, Katarzyna / Ajayi, Oluwatobi / Barr, Maggie / Parks, Robert / Mansouri, Katayoun / Edwards, Robert J / Hahn, Beatrice H / Acharya, Priyamvada / Saunders, Kevin O / Haynes, Barton F

Journal of virology

2023 Volume 97, Issue 1, Page(s) e0167322

Abstract: The envelope glycoprotein (Env) is the main focus of human immunodeficiency virus type 1 (HIV-1) vaccine development due to its critical role in viral entry. Despite advances in protein engineering, many Env proteins remain recalcitrant to recombinant ... ...

Abstract	The envelope glycoprotein (Env) is the main focus of human immunodeficiency virus type 1 (HIV-1) vaccine development due to its critical role in viral entry. Despite advances in protein engineering, many Env proteins remain recalcitrant to recombinant expression due to their inherent metastability, making biochemical and immunological experiments impractical or impossible. Here, we report a novel proline stabilization strategy to facilitate the production of prefusion Env trimers. This approach, termed "2P," works synergistically with previously described SOSIP mutations and dramatically increases the yield of recombinantly expressed Env ectodomains without altering the antigenic or conformational properties of near-native Env. We determined that the 2P mutations function by enhancing the durability of the prefusion conformation and that this stabilization strategy is broadly applicable to evolutionarily and antigenically diverse Env constructs. These findings provide a new Env stabilization platform to facilitate biochemical research and expand the number of Env variants that can be developed as future HIV-1 vaccine candidates.
MeSH term(s)	Humans ; env Gene Products, Human Immunodeficiency Virus/genetics ; Glycoproteins/genetics ; HIV Infections ; Molecular Conformation ; Protein Engineering ; Protein Multimerization ; Recombinant Proteins/genetics ; HIV-1/genetics
Chemical Substances	env Gene Products, Human Immunodeficiency Virus ; Glycoproteins ; Recombinant Proteins
Language	English
Publishing date	2023-01-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01673-22
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Zs.A 609: Show issues

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Article ; Online: The Pain in Dystonia Scale (PIDS)-Development and Validation in Cervical Dystonia.

Bruno, Veronica / Achen, Beatrice / Morgante, Francesca / Erro, Roberto / Fox, Susan H / Edwards, Mark J / Schrag, Anette / Stamelou, Maria / Appel-Cresswell, Silke / Defazio, Giovanni / Chaudhuri, K Ray / Pirio Richardson, Sarah / Jinnah, Hyder A / Martino, Davide

Movement disorders : official journal of the Movement Disorder Society

2023 Volume 38, Issue 7, Page(s) 1175–1186

Abstract: Background: A better understanding of pain in adult-onset idiopathic dystonia (AOID) is needed to implement effective therapeutic strategies.: Objective: To develop a new rating instrument for pain in AOID and validate it in cervical dystonia (CD).!## ...

Abstract	Background: A better understanding of pain in adult-onset idiopathic dystonia (AOID) is needed to implement effective therapeutic strategies. Objective: To develop a new rating instrument for pain in AOID and validate it in cervical dystonia (CD). Methods: Development and validation of the Pain in Dystonia Scale (PIDS) comprised three phases. In phase 1, international experts and participants with AOID generated and evaluated the preliminary items for content validity. In phase 2, the PIDS was drafted and revised by the experts, followed by cognitive interviews to ensure self-administration suitability. In phase 3, the PIDS psychometric properties were assessed in 85 participants with CD and retested in 40 participants. Results: The final version of PIDS evaluates pain severity (by body-part), functional impact, and external modulating factors. Test-retest reliability showed a high-correlation coefficient for the total score (0.9, P < 0.001), and intraclass correlation coefficients were 0.7 or higher for all items in all body-parts subscores. The overall PIDS severity score showed high internal consistency (Cronbach's α, 0.9). Convergent validity analysis revealed a strong correlation between the PIDS severity score and the Toronto Western Spasmodic Torticollis Rating Scale pain subscale (0.8, P < 0.001) and the Brief Pain Inventory-short form items related to pain at time of the assessment (0.7, P < 0.001) and impact of pain on daily functioning (0.7, P < 0.001). Conclusion: The PIDS is the first specific questionnaire developed to evaluate pain in all patients with AOID, here, demonstrating high-level psychometric properties in people with CD. Future work will validate PIDS in other forms of AOID. © 2023 International Parkinson and Movement Disorder Society.
MeSH term(s)	Adult ; Humans ; Torticollis/complications ; Pain Measurement ; Reproducibility of Results ; Dystonic Disorders ; Pain ; Psychometrics ; Surveys and Questionnaires
Language	English
Publishing date	2023-05-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.29452
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Zs.A 2555: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Malnutrition and overall survival in older patients with cancer.

Zhang, Xiaotao / Pang, Linda / Sharma, Shreela V / Li, Ruosha / Nyitray, Alan G / Edwards, Beatrice J

Clinical nutrition (Edinburgh, Scotland)

2020 Volume 40, Issue 3, Page(s) 966–977

Abstract: Background & aims: In this study, we assessed the prevalence of malnutrition and its association with overall survival among patients with cancer aged 65 years and older.: Methods: In this retrospective cohort study, patients receiving cancer care ... ...

Abstract	Background & aims: In this study, we assessed the prevalence of malnutrition and its association with overall survival among patients with cancer aged 65 years and older. Methods: In this retrospective cohort study, patients receiving cancer care underwent a comprehensive geriatric assessment (CGA). Malnutrition status was determined through the CGA. We used univariate and multivariable Cox regression survival analyses to assess the association between baseline malnutrition and survival. Results: A total of 454 patients with cancers were included in the analysis. The median age was 78 years and men and women were equally represented. Forty-two percent (n = 190) were malnourished at baseline, and 33% died during the follow-up (range 0.2-51.1 month). Univariate analysis showed that malnutrition increased the risk of all-cause mortality in older patients with cancer (HR, 1.49; 95% CI, 1.08-2.05; p = 0.01). In the multivariate Cox regression model, malnutrition increased the risk of all-cause mortality (HR, 1.87; 95% CI, 1.10-3.17; p = 0.02) in older patients with solid tumors. However, malnutrition did not increase the risk of all-cause mortality for hematologic malignancies. Conclusions: In our study, we found that malnutrition was a risk factor for mortality in older cancer patients, especially in older patients with solid tumors. Prospective inter ventional studies are recommended.
MeSH term(s)	Aged ; Aged, 80 and over ; Cause of Death ; Female ; Geriatric Assessment ; Humans ; Male ; Malnutrition/etiology ; Malnutrition/mortality ; Neoplasms/complications ; Neoplasms/mortality ; Nutrition Assessment ; Nutritional Status ; Prevalence ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Survival Analysis
Language	English
Publishing date	2020-07-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2020.06.026
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Article ; Online: Endocrinology of menopause.

Edwards, Beatrice J / Li, Jin

Periodontology 2000

2013 Volume 61, Issue 1, Page(s) 177–194

Abstract: Menopause is a natural process that occurs in women's lives as part of normal aging. Many women go through the menopausal transition with few or no symptoms, while some have significant, or even disabling, symptoms. This manuscript reviews the ... ...

Abstract	Menopause is a natural process that occurs in women's lives as part of normal aging. Many women go through the menopausal transition with few or no symptoms, while some have significant, or even disabling, symptoms. This manuscript reviews the physiologic processes and symptoms connected with menopause and the diseases associated with menopause, as well as how menopausal symptoms are managed.
MeSH term(s)	Aging/physiology ; Endocrine System/physiology ; Female ; Gonadal Steroid Hormones/physiology ; Hormone Replacement Therapy ; Hot Flashes/physiopathology ; Humans ; Menopause/physiology ; Osteoporosis, Postmenopausal/etiology ; Perimenopause/physiology
Chemical Substances	Gonadal Steroid Hormones
Language	English
Publishing date	2013-02
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	1200504-6
ISSN	1600-0757 ; 0906-6713
ISSN (online)	1600-0757
ISSN	0906-6713
DOI	10.1111/j.1600-0757.2011.00407.x
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Article ; Online: The validity of three malnutrition screening markers among older patients with cancer.

Zhang, Xiaotao / Pang, Linda / Sharma, Shreela V / Li, Ruosha / Nyitray, Alan G / Edwards, Beatrice J

BMJ supportive & palliative care

2019 Volume 10, Issue 3, Page(s) 363–368

Abstract: Background: Malnutrition is common in older adults with cancer and is associated with adverse clinical outcomes. We assessed and compared the validity of three tools commonly used to screen for malnutrition: The Mini Nutritional Assessment (MNA), weight ...

Abstract	Background: Malnutrition is common in older adults with cancer and is associated with adverse clinical outcomes. We assessed and compared the validity of three tools commonly used to screen for malnutrition: The Mini Nutritional Assessment (MNA), weight loss and body mass index (BMI). Methods: In this retrospective study, we reviewed patients over age 65 with a diagnosis of cancer who were treated at the MD Anderson Cancer Center between 1 January 2013 and 31 March 2017. All patients in this study were evaluated by a trained geriatrician as part of a comprehensive geriatric assessment (CGA). Malnutrition was diagnosed by both CGA and clinical examination. The sensitivity, specificity and Cohen's κ of each tool was also compared with the clinical diagnosis. Results: A total of 454 older patients with cancer who had malnutrition information available were included in the analyses. The median age was 78%, and 42% (n=190) were clinically diagnosed with malnutrition at baseline. When the MNA was performed, 105 out of 352 patients (30%) were malnourished, and 122 (35%) at risk of malnutrition. Weight loss >3 kg was seen in 183 out of 359 (51%) patients, and BMI <20 kg/m Conclusions: For clinical practice, MNA should be incorporated for standard assessment/screening for these older patients with cancer.
MeSH term(s)	Aged ; Aged, 80 and over ; Biomarkers ; Body Mass Index ; Female ; Geriatric Assessment/methods ; Humans ; Male ; Malnutrition/diagnosis ; Malnutrition/etiology ; Mass Screening/methods ; Mass Screening/standards ; Neoplasms/complications ; Nutrition Assessment ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity ; Weight Loss
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-06-25
Publishing country	England
Document type	Comparative Study ; Journal Article ; Validation Study
ISSN	2045-4368
ISSN (online)	2045-4368
DOI	10.1136/bmjspcare-2018-001706
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Article ; Online: Prevalence and factors associated with malnutrition in older patients with cancer.

Zhang, Xiaotao / Pang, Linda / Sharma, Shreela V / Li, Ruosha / Nyitray, Alan G / Edwards, Beatrice J

Journal of geriatric oncology

2019 Volume 10, Issue 5, Page(s) 763–769

Abstract: Background: >60% of patients with cancer are 65 years of age and older, and malnutrition is commonly encountered in older adults.: Objective: To assess the prevalence and factors associated with malnutrition in older patients with cancer.: Methods!# ...

Abstract	Background: >60% of patients with cancer are 65 years of age and older, and malnutrition is commonly encountered in older adults. Objective: To assess the prevalence and factors associated with malnutrition in older patients with cancer. Methods: In this cross-sectional study, patients with cancer underwent a comprehensive geriatric assessment (CGA). Malnutrition status was diagnosed by clinical assessment including screening tools such as Mini Nutrition Assessment (MNA), weight loss, and BMI. Analysis: Descriptive statistics, chi-Square and logistic regression analysis were used to assess factors associated with malnutrition. Results: A total of 454 patients with malnutrition information available were included in analysis. The median age was 78, range 65-96 years and comorbid diagnoses included dementia, mild cognitive impairment, frailty, and functional impairment. A total of 41.9% (n = 190) were diagnosed with malnutrition during the CGA. In the multivariable analysis, major depression and frailty were significantly associated with malnutrition. After controlling for potential confounders, patients who had malnutrition were 2.53-times more likely to have major depression (OR = 2.53, 95% CI: 1.23-5.24, p = 0.01) and 3.82 times more likely to have frailty (OR = 3.82, 95% CI: 1.35-10.84, p = 0.01) than those without malnutrition. Conclusions: Despite significant advances in cancer and supportive care, malnutrition remains a significant and highly prevalent public health problem among older patients with cancer. Identifying factors associated with risk for malnutrition in this patient population can help develop preventive strategies as part of care. Prospective studies are recommended.
MeSH term(s)	Activities of Daily Living ; Aged ; Aged, 80 and over ; Cognitive Dysfunction/epidemiology ; Comorbidity ; Dementia/epidemiology ; Depressive Disorder, Major/epidemiology ; Female ; Frailty/epidemiology ; Frailty/physiopathology ; Geriatric Assessment ; Humans ; Male ; Malnutrition/epidemiology ; Neoplasms/epidemiology ; Nutrition Assessment ; Prevalence ; Risk Factors ; Vitamin D Deficiency/epidemiology ; Walking Speed
Language	English
Publishing date	2019-04-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2556813-9
ISSN	1879-4076 ; 1879-4068
ISSN (online)	1879-4076
ISSN	1879-4068
DOI	10.1016/j.jgo.2019.01.021
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Article: Solutions to the undertreatment of osteoporosis-related fractures.

Edwards, Beatrice J

Archives of internal medicine

2004 Volume 164, Issue 6, Page(s) 677

MeSH term(s)	Female ; Fractures, Bone/etiology ; Fractures, Bone/prevention & control ; Health Services Accessibility ; Humans ; Osteoporosis, Postmenopausal/complications ; Osteoporosis, Postmenopausal/diagnosis ; Osteoporosis, Postmenopausal/drug therapy ; Practice Patterns, Physicians'
Language	English
Publishing date	2004-03-22
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	211575-x
ISSN	1538-3679 ; 0003-9926 ; 0888-2479 ; 0730-188X
ISSN (online)	1538-3679
ISSN	0003-9926 ; 0888-2479 ; 0730-188X
DOI	10.1001/archinte.164.6.677-a
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