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Article ; Online: Longitudinal association of sleep duration with possible sarcopenia: evidence from CHARLS.

Lv, Xiaoling / Peng, Wenjia / Jia, Bingbing / Lin, Ping / Yang, Zhouxin

2024 Volume 14, Issue 3, Page(s) e079237

Abstract: Objectives: There are limited data on the relationship between sleep duration and possible sarcopenia. Hence, this study aimed to investigate the associations of sleep duration with possible sarcopenia and its defining components based on the China ... ...

Abstract	Objectives: There are limited data on the relationship between sleep duration and possible sarcopenia. Hence, this study aimed to investigate the associations of sleep duration with possible sarcopenia and its defining components based on the China Health and Retirement Longitudinal Study (CHARLS). Design: A retrospective cohort study. Setting: This study was conducted on participants aged over 45 years applying the 2011 baseline and 2015 follow-up survey from CHARLS covering 450 villages, 150 counties and 28 provinces. Participants: Data from 5036 individuals (2568 men and 2468 women) free of possible sarcopenia at baseline were analysed. Primary and secondary outcome measures: The dose-response relationship between sleep duration and possible sarcopenia. Results: During 4 years of follow-up, 964 (19.14%) participants developed possible sarcopenia. Compared with participants who slept 6-8 hours per night, those with shorter sleep duration (<6 hours per night) were independently associated with 22% (OR, 1.22; 95% CI, 1.04 to 1.44) increased risk of developing possible sarcopenia and 27% (OR, 1.27; 95% CI, 1.04 to 1.57) increased risk of developing low handgrip strength after controlling for potential confounders. Long sleep duration (>8 hours per night) was not significantly associated with incident possible sarcopenia. The plots of restricted cubic splines exhibited an atypical inverse J-shaped association between sleep duration and possible sarcopenia. Subgroup analysis showed a stronger association between sleep duration and possible sarcopenia in participants aged 45-59 years and composed of male populations. Conclusions: Short sleep duration was a potential risk factor for possible sarcopenia and low handgrip strength. The improvement of sleep duration should be considered a target in early preventive and administrative strategies against the development of handgrip strength decline and further reduced the occurrence of sarcopenia.
MeSH term(s)	Humans ; Male ; Female ; Longitudinal Studies ; Retirement ; Sarcopenia/epidemiology ; Sleep Duration ; Hand Strength/physiology ; Retrospective Studies ; Sleep/physiology ; Sleep Wake Disorders/epidemiology ; China/epidemiology
Language	English
Publishing date	2024-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-079237
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Improving Landscape Ecological Network Connectivity in Urbanizing Areas from Dual Dimensions of Structure and Function

SHEN, Jiake / ZHU, Wenjia / Peng, Zhenwei / Wang, Yuncai

Ecological Modelling. 2023, p.110380-

2023 , Page(s) 110380–

Abstract: By building connectivity between ecological spaces, the landscape ecology network (LEN) can effectively prevent further habitat fragmentation and loss in urbanizing areas. The existing LEN construction method fails to consider the multiple optimization ... ...

Abstract	By building connectivity between ecological spaces, the landscape ecology network (LEN) can effectively prevent further habitat fragmentation and loss in urbanizing areas. The existing LEN construction method fails to consider the multiple optimization goals of improving network structural and functional connectivity. This paper aimed to provide a novel method to improve connectivity for existing LENs in urbanizing areas. We took an urbanizing area in China as an example and extract existing LEN based on ecological priorities. On this basis, from the dimension of structural connectivity optimization, we used the network link additional technique based on "integral index of probable connection" to identify 50 optimal locations of additional corridors that could significantly improve the network structural connectivity. From the dimension of functional connectivity enhancement, we applied the greedy algorithm based on hierarchical rules with different priorities to search for corridor paths with maximum ecological function and low ecological and construction resistance. The optimized LEN contained 43 ecological sources and 74 ecological corridors. The dual dimension method proposed in this paper can improve the functional and structural connectivity of existing LEN, and greatly save the optimization time and efficiency of the network, to provide targeted ecological space protection schemes for urbanizing areas.
Keywords	Lens ; algorithms ; ecological function ; habitat fragmentation ; landscape ecology ; landscapes ; China ; Landscape ecological network ; optimization approach ; connectivity improvement ; structural and functional connectivity ; landscape graph theory ; greedy algorithm
Language	English
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	191971-4
ISSN	0304-3800
ISSN	0304-3800
DOI	10.1016/j.ecolmodel.2023.110380
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Moderating Role of Environmental Information Disclosure on the Impact of Environment Protection Investment on Firm Value

Kedan Wang / Wenjia Cui / Mei Mei / Benfu Lv / Geng Peng

Sustainability, Vol 15, Iss 9174, p

2023 Volume 9174

Abstract: The presence of a link between corporate environmental protection investment and firm value is essential for enterprises to have incentives to invest in environmental protection by themselves. How environmental information disclosure affects the ... ...

Abstract	The presence of a link between corporate environmental protection investment and firm value is essential for enterprises to have incentives to invest in environmental protection by themselves. How environmental information disclosure affects the relationship between environmental protection investment and firm value is also an issue worth exploring. This paper uses the regression model with the industry and time-fixed effects to examine the relationship between environmental protection investment and firm value of China’s A-share heavily and non-heavily polluting enterprises from 2010–2020, as well as the moderating role of environmental information disclosure. The empirical results show that (1) there is a significant U-shaped relationship between environmental protection investment and firm value, and (2) corporate environmental information disclosure has a moderating effect. Specifically, it has an “amplifying” effect on the relationship between environmental protection investment and firm value. If a company’s environmental protection investment is insufficient, overly transparent corporate environmental disclosure will exacerbate the decline in firm value. Once environmental protection investment is up to standard, adequate disclosure can contribute to an increase in firm value.
Keywords	environment protection investment ; corporate information disclosure ; firm value ; moderating effect ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	650 ; 333
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Transcription Factor TFAP2B Exerts Neuroprotective Effects Targeting BNIP3-Mediated Mitophagy in Ischemia/Reperfusion Injury.

Peng, Yong / Jia, Jiaoying / Zhang, Mingming / Ma, Wenjia / Cui, Yan / Yu, Mengqiang

Molecular neurobiology

2024

Abstract: Cerebral ischemia-reperfusion injury (CIRI) leads to malignant brain edema, blood-brain barrier destruction, and neuronal apoptosis. N6-methyladenosine (m6A) RNA modification in CIRI was still limited explored. In this study, MeRIP- and RNA-sequencing ... ...

Abstract	Cerebral ischemia-reperfusion injury (CIRI) leads to malignant brain edema, blood-brain barrier destruction, and neuronal apoptosis. N6-methyladenosine (m6A) RNA modification in CIRI was still limited explored. In this study, MeRIP- and RNA-sequencing were performed of middle cerebral artery occlusion and reperfusion (MCAO/R) rats to find novel potential molecular targets. Transcription factor TFAP2B stood out of which its m6A abundance decreased associated with a marked reduction of its mRNA based on cojoint interactive bioinformatics analysis of the MeRIP- and RNA-sequencing data. It was suggested TFAP2B could have a role in CIRI. Functionally, overexpression of TFAP2B in cultured primary neurons could effectively improve the cell survival and pro-survival autophagy in parallel with reduced cell apoptosis during OGD/R in vitro. Through the RNA-sequencing of TFAP2B overexpressed primary neurons and subsequent validation experiments, it was found that mitophagy receptor BNIP3 was one of the important targets of TFAP2B in OGD/R neurons through which TFAP2B could bind to its promoter region for transcriptional activation of BNIP3, thereby enhancing BNIP3-mediated mitophagy to protect against OGD/R injury of neurons. Lastly, TFAP2B was demonstrated to alleviate the MCAO/R damage to a certain extent in vivo. Although it failed to confirm TFAP2B dysregulation was m6A dependent in current research, this is the first research of TFAP2B in CIRI field with important guiding significance.
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-024-04004-y
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Article: Diabetes and two kinds of primary tumors in a patient with thalassemia: a case report and literature review.

Yu, Xiaoyan / Peng, Yi / Nie, Tingting / Sun, Wenjia / Zhou, Yajuan

Frontiers in oncology

2023 Volume 13, Page(s) 1207336

Abstract: Background: Thalassemia is a group of common genetic hematologic disorders characterized by deficient synthesis of the hemoglobin chain. Due to effective blood transfusion and optimization of chelate therapy, the survival of thalassemia patients and ... ...

Abstract	Background: Thalassemia is a group of common genetic hematologic disorders characterized by deficient synthesis of the hemoglobin chain. Due to effective blood transfusion and optimization of chelate therapy, the survival of thalassemia patients and their overall quality of life have improved noticeably in the past few decades. As a consequence, the longer life expectancy has led to the manifestation of several concomitant morbidities, including heart disease, infections, cirrhosis, endocrine abnormalities, various malignancies, and so on. In this context, the probability and updated literature about some malignancy cases in patients with thalassemia build new scenarios for the next few years. We describe the first report of a thalassemic patient developing diabetes and head and neck cancer and try to summarize the possible predisposing factors and mechanisms behind their phenomenon. Case presentation: The current case report describes a 50-year-old Asian man who has been diagnosed with thalassemia since childhood. In early 2017, he was also diagnosed with diabetes and started on insulin-hypoglycemic treatment. The patient was then diagnosed with primary non-keratinizing undifferentiated carcinoma of the nasopharynx in late February 2013. A biopsy of the left tongue revealed squamous cell carcinoma (SCC) in late March 2019. Conclusions: We report the first case of a thalassemic patient developing diabetes and squamous cell carcinoma of the head and neck and discuss the possibility of a link between the three diseases. This specific case should alert physicians to the possibility of endocrinopathy and malignancy in thalassemic patients.
Language	English
Publishing date	2023-08-11
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1207336
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Article ; Online: Mechanism of Interaction between hsa_circ_0002854 and MAPK1 Protein in PM

Hong, Jinchang / Tan, Yi / Wang, Yuyu / Wang, Hongjie / Li, Caixia / Jin, Wenjia / Wu, Yi / Ni, Dechun / Peng, Xiaowu

Toxics

2023 Volume 11, Issue 11

Abstract: Fine particulate matter ( ... ...

Abstract	Fine particulate matter (PM
Language	English
Publishing date	2023-11-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics11110906
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Article ; Online: Residential greenness is associated with disease severity among COVID-19 patients aged over 45 years in Wuhan, China

Wenjia Peng / Haidong Kan / Lian Zhou / Weibing Wang

Ecotoxicology and Environmental Safety, Vol 232, Iss , Pp 113245- (2022)

2022

Abstract: Evidence regarding environmental factors associated with disease severity of COVID-19 remained scarce. This study aimed to investigate the association of residential greenness exposure with COVID-19 severity applying a retrospective cross-sectional study ...

Abstract	Evidence regarding environmental factors associated with disease severity of COVID-19 remained scarce. This study aimed to investigate the association of residential greenness exposure with COVID-19 severity applying a retrospective cross-sectional study in Wuhan, China. We included 30,253 COVID-19 cases aged over 45 years from January 1 to February 27, 2020. Residential greenness was quantitatively assessed using normalized difference vegetation index (NDVI) and enhanced vegetation index (EVI). A multilevel generalized linear model using Poisson regression was implemented to analyze the association between greenness exposure and disease severity of COVID-19, after adjusting for potential covariates. A linear exposure-response relationship was found between greenness and COVID-19 severity. In the adjusted model, one 0.1 unit increase of NDVI and EVI in the 1000-m buffer radius was significantly associated with a 7.6% (95% confidence interval (CI): 4.0%, 11.1%) and 10.0% (95% CI: 5.1%, 14.7%) reduction of the prevalence of COVID-19 severity, respectively. The effect of residential greenness seemed to be more pronounced among participants with lower population density and economic levels. Air pollutants mediated 0.82~12.08% of the greenness and COVID-19 severity association, particularly to nitrogen dioxide. Sensitivity analyses suggested the robustness of the results. Our findings suggested that residential greenness exposure was beneficial to reduce the prevalence of COVID-19 severity.
Keywords	COVID-19 ; Greenness ; Air pollutant ; Disease severity ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Focus on health for global adaptation to climate change.

Zhang, Shihui / Cai, Wenjia / Zhang, Chi / Chan Fung Fu-Chun, Margaret / Gong, Peng

Nature

2023 Volume 618, Issue 7965, Page(s) 457

MeSH term(s)	Humans ; Acclimatization ; Climate Change ; Global Health/trends ; Global Warming ; Goals ; Public Health/trends
Language	English
Publishing date	2023-06-13
Publishing country	England
Document type	Letter
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/d41586-023-01913-1
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Article ; Online: Residential greenness is associated with disease severity among COVID-19 patients aged over 45 years in Wuhan, China.

Peng, Wenjia / Kan, Haidong / Zhou, Lian / Wang, Weibing

Ecotoxicology and environmental safety

2022 Volume 232, Page(s) 113245

Abstract	Evidence regarding environmental factors associated with disease severity of COVID-19 remained scarce. This study aimed to investigate the association of residential greenness exposure with COVID-19 severity applying a retrospective cross-sectional study in Wuhan, China. We included 30,253 COVID-19 cases aged over 45 years from January 1 to February 27, 2020. Residential greenness was quantitatively assessed using normalized difference vegetation index (NDVI) and enhanced vegetation index (EVI). A multilevel generalized linear model using Poisson regression was implemented to analyze the association between greenness exposure and disease severity of COVID-19, after adjusting for potential covariates. A linear exposure-response relationship was found between greenness and COVID-19 severity. In the adjusted model, one 0.1 unit increase of NDVI and EVI in the 1000-m buffer radius was significantly associated with a 7.6% (95% confidence interval (CI): 4.0%, 11.1%) and 10.0% (95% CI: 5.1%, 14.7%) reduction of the prevalence of COVID-19 severity, respectively. The effect of residential greenness seemed to be more pronounced among participants with lower population density and economic levels. Air pollutants mediated 0.82~12.08% of the greenness and COVID-19 severity association, particularly to nitrogen dioxide. Sensitivity analyses suggested the robustness of the results. Our findings suggested that residential greenness exposure was beneficial to reduce the prevalence of COVID-19 severity.
MeSH term(s)	Air Pollution/analysis ; COVID-19/epidemiology ; China/epidemiology ; Cross-Sectional Studies ; Humans ; Middle Aged ; Parks, Recreational ; Residence Characteristics ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index
Language	English
Publishing date	2022-01-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2022.113245
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Article ; Online: Design, development and evaluation of an ergonomically designed dual-use mechanism for robot-assisted cardiovascular intervention.

Peng, Wenjia / Wang, Zehua / Xie, Hongzhi / Gu, Lixu

International journal of computer assisted radiology and surgery

2022 Volume 18, Issue 2, Page(s) 205–216

Abstract: Purpose: Robot-assisted cardiovascular intervention has been recently developed, which enables interventionists to avoid x-ray radiation and improve their comfort. However, there are still some challenges in the robotic design, such as the inability of ... ...

Abstract	Purpose: Robot-assisted cardiovascular intervention has been recently developed, which enables interventionists to avoid x-ray radiation and improve their comfort. However, there are still some challenges in the robotic design, such as the inability of the interventionist to freely perform natural clinical techniques and the limited motion travel of the interventional tool. To overcome these challenges, this paper proposes an ergonomically designed dual-use mechanism for cardiovascular intervention (DMCI). Methods: DMCI can work as an ergonomic interface or a compact slave robot with unlimited motion travel. Our kinematic analysis of DMCI includes motion decoupling and coupling. Motion decoupling decomposes the translation and rotation from the interventionist's natural clinical actions at the master side. Motion coupling can calculate the input pulses of motors according to the desired rotation and translation, thus composing the motion of the intervention tool at the slave side. Results: Our kinematic analysis of DMCI has been experimentally verified, where the overall mean rotational errors are all less than 1° and translational errors are all less than 1 mm. We also evaluated the performance of the DMCI-based master-slave system, where the overall rotational and translational errors are 0.821 ± 0.753° and 0.608 ± 0.512 mm. Moreover, operators were found to be generally more efficient when using the DMCI-based interface compared to the conventional joystick. Conclusion: We have validated our kinematic analysis of DMCI. The master-slave teleoperation experiment demonstrated that operators can freely perform natural clinical techniques through the DMCI-based interface, and the slave robot can replicate the operators' manipulation at the master side well.
MeSH term(s)	Humans ; Robotics ; Robotic Surgical Procedures/methods ; Equipment Design ; Biomechanical Phenomena ; Rotation
Language	English
Publishing date	2022-10-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2365628-1
ISSN	1861-6429 ; 1861-6410
ISSN (online)	1861-6429
ISSN	1861-6410
DOI	10.1007/s11548-022-02755-4
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