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  1. Article ; Online: WHO hepatitis C elimination targets: the global equity challenge.

    Heath, Katherine / Hill, Andrew

    The lancet. Gastroenterology & hepatology

    2024  Volume 9, Issue 4, Page(s) 286–288

    MeSH term(s) Humans ; Hepatitis C/epidemiology ; Hepatitis C/prevention & control ; Hepacivirus ; World Health Organization
    Language English
    Publishing date 2024-02-15
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(23)00408-9
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  2. Article ; Online: Effects of chirality and side chain length in C

    Heath, Shelby L / Horne, W Seth / Lengyel, George A

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 31, Page(s) 6320–6324

    Abstract: Strategic incorporation of achiral C ...

    Abstract Strategic incorporation of achiral C
    MeSH term(s) Protein Structure, Secondary ; Peptides/chemistry ; Amino Acids/chemistry ; Glycine ; Thermodynamics ; Protein Folding
    Chemical Substances Peptides ; Amino Acids ; Glycine (TE7660XO1C)
    Language English
    Publishing date 2023-08-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob00963g
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  3. Article ; Online: Acclimation of C

    Dohl, Jacob / Foldi, Jonathan / Heller, Julian / Gasier, Heath G / Deuster, Patricia A / Yu, Tianzheng

    Life sciences

    2018  Volume 211, Page(s) 238–244

    Abstract: ... conditions in vitro.: Materials and methods: We acclimated the C: Key findings: Acclimated cells ... mitogen-activated protein kinase kinase MEK 1/2 protein expression, upregulated the early pro-apoptotic transcription factor C/EBP ...

    Abstract Aims: The interplay between hyper-glycemia and -lipidemia in diabetes mellitus (DM) is important in simulating diabetic conditions. However, cell culture media typically contain supraphysiological levels of glucose to stimulate cellular growth, which also desensitizes cells to elevated glucose levels. Moreover, creating hyperlipidemic conditions in vitro requires specialized carriers because unbound lipids form micelles when introduced to liquid media. This study sought to develop a novel method for simulating DM conditions in vitro.
    Materials and methods: We acclimated the C
    Key findings: Acclimated cells exposed to these hyper-glycemic (15 mM glucose) and/or -lipidemic (0.25 mM palmitate) conditions for 2 h showed increased mitochondrial fragmentation and membrane potential as well as elevated reactive oxygen species production compared to control cells. These findings suggest altered mitochondrial morphology and function, which have been confirmed using isolated rat flexor digitorum brevis myofibers. Hyper-glycemic and/or -lipidemic stimulations for 24 h significantly increased mitogen-activated protein kinase kinase MEK 1/2 protein expression, upregulated the early pro-apoptotic transcription factor C/EBP homologous protein (CHOP), and induced apoptosis.
    Significance: Our results further support and confirm the utility of this method which will allow for subsequent investigations studying the effects of hyper-glycemia and/or -lipidemia in vitro.
    MeSH term(s) Acclimatization ; Animals ; Cells, Cultured ; Diabetes Mellitus/physiopathology ; Glucose/pharmacology ; Mice ; Mitochondria/drug effects ; Mitochondria/pathology ; Myoblasts/drug effects ; Myoblasts/pathology ; Palmitic Acid/pharmacology ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Sweetening Agents/pharmacology
    Chemical Substances Reactive Oxygen Species ; Sweetening Agents ; Palmitic Acid (2V16EO95H1) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2018-09-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2018.09.041
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  4. Article ; Online: Progressive sector retinitis pigmentosa due to c.440G>T mutation in

    Pappalardo, Juanita / Heath Jeffery, Rachael C / Thompson, Jennifer A / Charng, Jason / Chelva, Enid S / Constable, Ian J / McLaren, Terri L / Lamey, Tina M / De Roach, John N / Chen, Fred K

    Ophthalmic genetics

    2020  Volume 42, Issue 1, Page(s) 62–70

    Abstract: Background: Heterozygous c.440 G > T mutation in the S-antigen visual arrestin : Materials and ...

    Abstract Background: Heterozygous c.440 G > T mutation in the S-antigen visual arrestin
    Materials and methods: An observational case series of four family members with adRP. They were examined clinically, with multi-modal retinal imaging and electroretinography (ERG) to ascertain phenotype. Disease progression rate was measured using optical coherence tomography (OCT) and fundus autofluorescence (FAF). A retinal dystrophy panel was used for the proband and cascade testing with targeted Sanger sequencing was conducted in other available family members.
    Results: The proband presented at 36 years of age with profoundly reduced full-field ERG responses despite a sector RP phenotype. This progressed to a classic RP pattern over several decades leaving a small residual island of central visual field. The horizontal span of the residual outer nuclear layer and the area of hyperautofluorescent ring contracted at a rate of 8-11% and 9-14% per year, respectively. DNA sequencing confirmed the segregation of
    Conclusion: SAG
    MeSH term(s) Adult ; Aged ; Australia ; Calcium-Binding Proteins/genetics ; DNA-Binding Proteins/genetics ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Mutation ; Pedigree ; Retinitis Pigmentosa/etiology ; Retinitis Pigmentosa/metabolism ; Retinitis Pigmentosa/pathology ; Tumor Suppressor Proteins/genetics ; Visual Fields
    Chemical Substances Calcium-Binding Proteins ; DMBT1 protein, human ; DNA-Binding Proteins ; Tumor Suppressor Proteins
    Language English
    Publishing date 2020-10-13
    Publishing country England
    Document type Case Reports ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1199279-7
    ISSN 1744-5094 ; 0167-6784 ; 1381-6810
    ISSN (online) 1744-5094
    ISSN 0167-6784 ; 1381-6810
    DOI 10.1080/13816810.2020.1832533
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    Zs.A 1708: Show issues Location:
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  5. Article ; Online: A novel phenotype in a family with autosomal dominant retinal dystrophy due to c.1430A > G in retinoid isomerohydrolase (RPE65) and c.37C > T in bestrophin 1 (BEST1).

    Pappalardo, Juanita / Heath Jeffery, Rachael C / Thompson, Jennifer A / Chelva, Enid / Pham, Quang / Constable, Ian J / McLaren, Terri L / Lamey, Tina M / De Roach, John N / Chen, Fred K

    Documenta ophthalmologica. Advances in ophthalmology

    2021  Volume 143, Issue 1, Page(s) 61–73

    Abstract: Purpose: The c.1430A > G (Asp477Gly) variant in RPE65 has been reported in Irish and Scottish ... the natural history of a family harbouring this variant in combination with the BEST1 c.37C > T (Arg13Cys) variant ... of the pathogenic BEST1 c.37C > T variant may modify clinical features observed in RPE65 adRD. This study expands ...

    Abstract Purpose: The c.1430A > G (Asp477Gly) variant in RPE65 has been reported in Irish and Scottish families with either an autosomal dominant retinal dystrophy (adRD) that resembles choroideremia, a vitelliform macular dystrophy or an isolated macular atrophy. We report novel features on multimodal imaging and the natural history of a family harbouring this variant in combination with the BEST1 c.37C > T (Arg13Cys) variant.
    Methods: Members of a family with an adRD were examined clinically to ascertain phenotype and underwent genetic testing. Multimodal imaging included widefield colour fundus photography, quantitative autofluorescence (qAF) and spectral domain optical coherence tomography. Electrophysiology and microperimetry were also performed.
    Results: Vision loss was attributed to foveal atrophy in the proband and choroidal neovascularisation and a vitello-eruptive lesion in one affected son. Peripheral retinal white dots corresponding to subretinal deposits were seen in three patients. The median qAF
    Conclusions: The coexistence of the pathogenic BEST1 c.37C > T variant may modify clinical features observed in RPE65 adRD. This study expands our understanding of RPE65 adRD as a retinoid cycle disorder supported by the reduced qAF, fine white retinal dots and corresponding subretinal deposits on OCT in affected members.
    MeSH term(s) Aged ; Bestrophins/genetics ; Electroretinography ; Fluorescein Angiography ; Humans ; Male ; Middle Aged ; Mutation ; Pedigree ; Phenotype ; Retinal Dystrophies/diagnosis ; Retinal Dystrophies/genetics ; Tomography, Optical Coherence ; Vitelliform Macular Dystrophy ; cis-trans-Isomerases/genetics
    Chemical Substances BEST1 protein, human ; Bestrophins ; retinoid isomerohydrolase (EC 3.1.1.64) ; cis-trans-Isomerases (EC 5.2.-)
    Language English
    Publishing date 2021-01-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 212594-8
    ISSN 1573-2622 ; 0012-4486
    ISSN (online) 1573-2622
    ISSN 0012-4486
    DOI 10.1007/s10633-021-09819-x
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  6. Article ; Online: Observation of the B_{c}^{+} Meson in Pb-Pb and pp Collisions at sqrt[s_{NN}]=5.02  TeV and Measurement of its Nuclear Modification Factor.

    Tumasyan, A / Adam, W / Andrejkovic, J W / Bergauer, T / Chatterjee, S / Dragicevic, M / Del Valle, A Escalante / Frühwirth, R / Jeitler, M / Krammer, N / Lechner, L / Liko, D / Mikulec, I / Paulitsch, P / Pitters, F M / Schieck, J / Schöfbeck, R / Schwarz, D / Templ, S /
    Waltenberger, W / Wulz, C-E / Chekhovsky, V / Litomin, A / Makarenko, V / Darwish, M R / De Wolf, E A / Janssen, T / Kello, T / Lelek, A / Sfar, H Rejeb / Van Mechelen, P / Van Putte, S / Van Remortel, N / Blekman, F / Bols, E S / D'Hondt, J / Delcourt, M / Faham, H El / Lowette, S / Moortgat, S / Morton, A / Müller, D / Sahasransu, A R / Tavernier, S / Van Doninck, W / Van Mulders, P / Beghin, D / Bilin, B / Clerbaux, B / De Lentdecker, G / Favart, L / Grebenyuk, A / Kalsi, A K / Lee, K / Mahdavikhorrami, M / Makarenko, I / Moureaux, L / Pétré, L / Popov, A / Postiau, N / Starling, E / Thomas, L / Vanden Bemden, M / Vander Velde, C / Vanlaer, P / Wezenbeek, L / Cornelis, T / Dobur, D / Knolle, J / Lambrecht, L / Mestdach, G / Niedziela, M / Roskas, C / Samalan, A / Skovpen, K / Tytgat, M / Vermassen, B / Vit, M / Benecke, A / Bethani, A / Bruno, G / Bury, F / Caputo, C / David, P / Delaere, C / Donertas, I S / Giammanco, A / Jaffel, K / Jain, Sa / Lemaitre, V / Mondal, K / Prisciandaro, J / Taliercio, A / Teklishyn, M / Tran, T T / Vischia, P / Wertz, S / Alves, G A / Hensel, C / Moraes, A / Júnior, W L Aldá / Pereira, M Alves Gallo / Filho, M Barroso Ferreira / Malbouisson, H Brandao / Carvalho, W / Chinellato, J / Da Costa, E M / Da Silveira, G G / Damiao, D De Jesus / De Souza, S Fonseca / Figueiredo, D Matos / Herrera, C Mora / Amarilo, K Mota / Mundim, L / Nogima, H / Teles, P Rebello / Santoro, A / Amaral, S M Silva Do / Sznajder, A / Thiel, M / De Araujo, F Torres Da Silva / Pereira, A Vilela / Bernardes, C A / Calligaris, L / Tomei, T R Fernandez Perez / Gregores, E M / Lemos, D S / Mercadante, P G / Novaes, S F / Padula, Sandra S / Aleksandrov, A / Antchev, G / Hadjiiska, R / Iaydjiev, P / Misheva, M / Rodozov, M / Shopova, M / Sultanov, G / Dimitrov, A / Ivanov, T / Litov, L / Pavlov, B / Petkov, P / Petrov, A / Cheng, T / Javaid, T / Mittal, M / Yuan, L / Ahmad, M / Bauer, G / Dozen, C / Hu, Z / Martins, J / Wang, Y / Yi, K / Chapon, E / Chen, G M / Chen, H S / Chen, M / Iemmi, F / Kapoor, A / Leggat, D / Liao, H / Liu, Z-A / Milosevic, V / Monti, F / Sharma, R / Tao, J / Thomas-Wilsker, J / Wang, J / Zhang, H / Zhao, J / Agapitos, A / An, Y / Ban, Y / Chen, C / Levin, A / Li, Q / Lyu, X / Mao, Y / Qian, S J / Wang, D / Wang, Q / Xiao, J / Lu, M / You, Z / Gao, X / Okawa, H / Lin, Z / Xiao, M / Avila, C / Cabrera, A / Florez, C / Fraga, J / Guisao, J Mejia / Ramirez, F / Alvarez, J D Ruiz / González, C A Salazar / Giljanovic, D / Godinovic, N / Lelas, D / Puljak, I / Antunovic, Z / Kovac, M / Sculac, T / Brigljevic, V / Ferencek, D / Majumder, D / Roguljic, M / Starodumov, A / Susa, T / Attikis, A / Christoforou, K / Erodotou, E / Ioannou, A / Kole, G / Kolosova, M / Konstantinou, S / Mousa, J / Nicolaou, C / Ptochos, F / Razis, P A / Rykaczewski, H / Saka, H / Finger, M / Kveton, A / Ayala, E / Jarrin, E Carrera / Elgammal, S / Kamel, A Ellithi / Mahmoud, M A / Mohammed, Y / Bhowmik, S / Dewanjee, R K / Ehataht, K / Kadastik, M / Nandan, S / Nielsen, C / Pata, J / Raidal, M / Tani, L / Veelken, C / Eerola, P / Forthomme, L / Kirschenmann, H / Osterberg, K / Voutilainen, M / Bharthuar, S / Brücken, E / Garcia, F / Havukainen, J / Kim, M S / Kinnunen, R / Lampén, T / Lassila-Perini, K / Lehti, S / Lindén, T / Lotti, M / Martikainen, L / Myllymäki, M / Ott, J / Siikonen, H / Tuominen, E / Tuominiemi, J / Luukka, P / Petrow, H / Tuuva, T / Amendola, C / Besancon, M / Couderc, F / Dejardin, M / Denegri, D / Faure, J L / Ferri, F / Ganjour, S / Givernaud, A / Gras, P / de Monchenault, G Hamel / Jarry, P / Lenzi, B / Locci, E / Malcles, J / Rander, J / Rosowsky, A / Sahin, M Ö / Savoy-Navarro, A / Titov, M / Yu, G B / Ahuja, S / Arleo, F / Beaudette, F / Bonanomi, M / Perraguin, A Buchot / Busson, P / Cappati, A / Charlot, C / Davignon, O / Diab, B / Falmagne, G / Ghosh, S / de Cassagnac, R Granier / Hakimi, A / Kucher, I / Motta, J / Nguyen, M / Ochando, C / Paganini, P / Rembser, J / Salerno, R / Sarkar, U / Sauvan, J B / Sirois, Y / Tarabini, A / Zabi, A / Zghiche, A / Agram, J-L / Andrea, J / Apparu, D / Bloch, D / Bourgatte, G / Brom, J-M / Chabert, E C / Collard, C / Darej, D / Fontaine, J-C / Goerlach, U / Grimault, C / Le Bihan, A-C / Nibigira, E / Van Hove, P / Asilar, E / Beauceron, S / Bernet, C / Boudoul, G / Camen, C / Carle, A / Chanon, N / Contardo, D / Depasse, P / Mamouni, H El / Fay, J / Gascon, S / Gouzevitch, M / Ille, B / Laktineh, I B / Lattaud, H / Lesauvage, A / Lethuillier, M / Mirabito, L / Perries, S / Shchablo, K / Sordini, V / Torterotot, L / Touquet, G / Vander Donckt, M / Viret, S / Lomidze, I / Toriashvili, T / Tsamalaidze, Z / Botta, V / Feld, L / Klein, K / Lipinski, M / Meuser, D / Pauls, A / Röwert, N / Schulz, J / Teroerde, M / Dodonova, A / Eliseev, D / Erdmann, M / Fackeldey, P / Fischer, B / Hebbeker, T / Hoepfner, K / Ivone, F / Mastrolorenzo, L / Merschmeyer, M / Meyer, A / Mocellin, G / Mondal, S / Mukherjee, S / Noll, D / Novak, A / Pook, T / Pozdnyakov, A / Rath, Y / Reithler, H / Roemer, J / Schmidt, A / Schuler, S C / Sharma, A / Vigilante, L / Wiedenbeck, S / Zaleski, S / Dziwok, C / Flügge, G / Ahmad, W Haj / Hlushchenko, O / Kress, T / Nowack, A / Pistone, C / Pooth, O / Roy, D / Sert, H / Stahl, A / Ziemons, T / Zotz, A / Petersen, H Aarup / Martin, M Aldaya / Asmuss, P / Baxter, S / Bayatmakou, M / Behnke, O / Martínez, A Bermúdez / Bhattacharya, S / Anuar, A A Bin / Borras, K / Brunner, D / Campbell, A / Cardini, A / Cheng, C / Colombina, F / Rodríguez, S Consuegra / Silva, G Correia / Danilov, V / De Silva, M / Didukh, L / Eckerlin, G / Eckstein, D / Banos, L I Estevez / Filatov, O / Gallo, E / Geiser, A / Giraldi, A / Grohsjean, A / Guthoff, M / Jafari, A / Jomhari, N Z / Jung, H / Kasem, A / Kasemann, M / Kaveh, H / Kleinwort, C / Krücker, D / Lange, W / Lidrych, J / Lipka, K / Lohmann, W / Mankel, R / Melzer-Pellmann, I-A / Morentin, M Mendizabal / Metwally, J / Meyer, A B / Meyer, M / Mnich, J / Mussgiller, A / Otarid, Y / Adán, D Pérez / Pitzl, D / Raspereza, A / Lopes, B Ribeiro / Rübenach, J / Saggio, A / Saibel, A / Savitskyi, M / Scham, M / Scheurer, V / Schütze, P / Schwanenberger, C / Singh, A / Ricardo, R E Sosa / Stafford, D / Tonon, N / Van De Klundert, M / Walsh, R / Walter, D / Wen, Y / Wichmann, K / Wiens, L / Wissing, C / Wuchterl, S / Aggleton, R / Albrecht, S / Bein, S / Benato, L / Connor, P / De Leo, K / Eich, M / Feindt, F / Fröhlich, A / Garbers, C / Garutti, E / Gunnellini, P / Hajheidari, M / Haller, J / Hinzmann, A / Kasieczka, G / Klanner, R / Kogler, R / Kramer, T / Kutzner, V / Lange, J / Lange, T / Lobanov, A / Malara, A / Nigamova, A / Rodriguez, K J Pena / Rieger, O / Schleper, P / Schröder, M / Schwandt, J / Sonneveld, J / Stadie, H / Steinbrück, G / Tews, A / Zoi, I / Bechtel, J / Brommer, S / Butz, E / Caspart, R / Chwalek, T / De Boer, W / Dierlamm, A / Droll, A / Morabit, K El / Faltermann, N / Giffels, M / Gosewisch, J O / Gottmann, A / Hartmann, F / Heidecker, C / Husemann, U / Keicher, P / Koppenhöfer, R / Maier, S / Metzler, M / Mitra, S / Müller, Th / Neukum, M / Nürnberg, A / Quast, G / Rabbertz, K / Rauser, J / Savoiu, D / Schnepf, M / Seith, D / Shvetsov, I / Simonis, H J / Ulrich, R / Van Der Linden, J / Von Cube, R F / Wassmer, M / Weber, M / Wieland, S / Wolf, R / Wozniewski, S / Wunsch, S / Anagnostou, G / Daskalakis, G / Geralis, T / Kyriakis, A / Loukas, D / Stakia, A / Diamantopoulou, M / Karasavvas, D / Karathanasis, G / Kontaxakis, P / Koraka, C K / Manousakis-Katsikakis, A / Panagiotou, A / Papavergou, I / Saoulidou, N / Theofilatos, K / Tziaferi, E / Vellidis, K / Vourliotis, E / Bakas, G / Kousouris, K / Papakrivopoulos, I / Tsipolitis, G / Zacharopoulou, A / Adamidis, K / Bestintzanos, I / Evangelou, I / Foudas, C / Gianneios, P / Katsoulis, P / Kokkas, P / Manthos, N / Papadopoulos, I / Strologas, J / Csanad, M / Farkas, K / Gadallah, M M A / Lökös, S / Major, P / Mandal, K / Mehta, A / Pasztor, G / Rádl, A J / Surányi, O / Veres, G I / Bartók, M / Bencze, G / Hajdu, C / Horvath, D / Sikler, F / Veszpremi, V / Czellar, S / Karancsi, J / Molnar, J / Szillasi, Z / Teyssier, D / Raics, P / Trocsanyi, Z L / Ujvari, B / Csorgo, T / Nemes, F / Novak, T / Komaragiri, J R / Kumar, D / Panwar, L / Tiwari, P C / Bahinipati, S / Kar, C / Mal, P / Mishra, T / Bindhu, V K Muraleedharan Nair / Nayak, A / Saha, P / Sur, N / Swain, S K / Vats, D / Bansal, S / Beri, S B / Bhatnagar, V / Chaudhary, G / Chauhan, S / Dhingra, N / Gupta, R / Kaur, A / Kaur, M / Kaur, S / Kumari, P / Meena, M / Sandeep, K / Singh, J B / Virdi, A K / Ahmed, A / Bhardwaj, A / Choudhary, B C / Gola, M / Keshri, S / Kumar, A / Naimuddin, M / Priyanka, P / Ranjan, K / Shah, A / Bharti, M / Bhattacharya, R / Bhowmik, D / Dutta, S / Gomber, B / Maity, M / Palit, P / Rout, P K / Saha, G / Sahu, B / Sarkar, S / Sharan, M / Singh, B / Thakur, S / Behera, P K / Behera, S C / Kalbhor, P / Muhammad, A / Pradhan, R / Pujahari, P R / Sikdar, A K / Dutta, D / Jha, V / Kumar, V / Mishra, D K / Naskar, K / Netrakanti, P K / Pant, L M / Shukla, P / Aziz, T / Dugad, S / Kumar, M / Banerjee, S / Chudasama, R / Guchait, M / Karmakar, S / Kumar, S / Majumder, G / Mazumdar, K / Alpana, K / Dube, S / Kansal, B / Laha, A / Pandey, S / Rane, A / Rastogi, A / Sharma, S / Bakhshiansohi, H / Khazaie, E / Zeinali, M / Chenarani, S / Etesami, S M / Khakzad, M / Najafabadi, M Mohammadi / Grunewald, M / Abbrescia, M / Aly, R / Aruta, C / Colaleo, A / Creanza, D / De Filippis, N / De Palma, M / Di Florio, A / Di Pilato, A / Elmetenawee, W / Fiore, L / Gelmi, A / Gul, M / Iaselli, G / Ince, M / Lezki, S / Maggi, G / Maggi, M / Margjeka, I / Mastrapasqua, V / Merlin, J A / My, S / Nuzzo, S / Pellecchia, A / Pompili, A / Pugliese, G / Ramos, D / Ranieri, A / Selvaggi, G / Silvestris, L / Simone, F M / Venditti, R / Verwilligen, P / Abbiendi, G / Battilana, C / Bonacorsi, D / Borgonovi, L / Brigliadori, L / Campanini, R / Capiluppi, P / 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    Physical review letters

    2022  Volume 128, Issue 25, Page(s) 252301

    Abstract: The B_{c}^{+} meson is observed for the first time in heavy ion collisions. Data from the CMS ... detector are used to study the production of the B_{c}^{+} meson in lead-lead (Pb-Pb) and proton-proton (pp ... collisions at a center-of-mass energy per nucleon pair of sqrt[s_{NN}]=5.02  TeV, via the B_{c}^{+}→(J/ψ→μ^ ...

    Abstract The B_{c}^{+} meson is observed for the first time in heavy ion collisions. Data from the CMS detector are used to study the production of the B_{c}^{+} meson in lead-lead (Pb-Pb) and proton-proton (pp) collisions at a center-of-mass energy per nucleon pair of sqrt[s_{NN}]=5.02  TeV, via the B_{c}^{+}→(J/ψ→μ^{+}μ^{-})μ^{+}ν_{μ} decay. The B_{c}^{+} nuclear modification factor, derived from the Pb-Pb-to-pp ratio of production cross sections, is measured in two bins of the trimuon transverse momentum and of the Pb-Pb collision centrality. The B_{c}^{+} meson is shown to be less suppressed than quarkonia and most of the open heavy-flavor mesons, suggesting that effects of the hot and dense nuclear matter created in heavy ion collisions contribute to its production. This measurement sets forth a promising new probe of the interplay of suppression and enhancement mechanisms in the production of heavy-flavor mesons in the quark-gluon plasma.
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.128.252301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Observation of Two Excited B_{c}^{+} States and Measurement of the B_{c}^{+}(2S) Mass in pp Collisions at sqrt[s]=13  TeV.

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/ Joshi, U / Klima, B / Kortelainen, M J / Kreis, B / Lammel, S / Lewis, J / Lincoln, D / Lipton, R / Liu, M / Liu, T / Lykken, J / Maeshima, K / Marraffino, J M / Mason, D / McBride, P / Merkel, P / Mrenna, S / Nahn, S / O'Dell, V / Papadimitriou, V / Pedro, K / Pena, C / Rakness, G / Ravera, F / Ristori, L / Schneider, B / Sexton-Kennedy, E / Smith, N / Soha, A / Spalding, W J / Spiegel, L / Stoynev, S / Strait, J / Strobbe, N / Taylor, L / Tkaczyk, S / Tran, N V / Uplegger, L / Vaandering, E W / Vernieri, C / Verzocchi, M / Vidal, R / Wang, M / Weber, H A / Acosta, D / Avery, P / Bortignon, P / Bourilkov, D / Brinkerhoff, A / Cadamuro, L / Carnes, A / Cherepanov, V / Curry, D / Errico, F / Field, R D / Gleyzer, S V / Joshi, B M / Kim, M / Konigsberg, J / Korytov, A / Lo, K H / Ma, P / Matchev, K / Menendez, N / Mitselmakher, G / Rosenzweig, D / Shi, K / Wang, J / Zuo, X / Joshi, Y R / Linn, S / Adams, T / Askew, A / Hagopian, S / Hagopian, V / Johnson, K F / Kolberg, T / Martinez, G 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C / Sanders, S / Schmitz, E / Tapia Takaki, J D / Williams, J / Duric, S / Ivanov, A / Kaadze, K / Kim, D / Maravin, Y / Mendis, D R / Mitchell, T / Mohammadi, A / Rebassoo, F / Wright, D / Baden, A / Baron, O / Belloni, A / Eno, S C / Feng, Y / Ferraioli, C / Hadley, N J / Jabeen, S / Jeng, G Y / Kellogg, R G / Kunkle, J / Mignerey, A C / Nabili, S / Ricci-Tam, F / Seidel, M / Shin, Y H / Skuja, A / Tonwar, S C / Wong, K / Abercrombie, D / Allen, B / Baty, A / Bi, R / Brandt, S / Busza, W / Cali, I A / D'Alfonso, M / Gomez Ceballos, G / Goncharov, M / Harris, P / Hsu, D / Hu, M / Klute, M / Kovalskyi, D / Lee, Y-J / Luckey, P D / Maier, B / Marini, A C / Mcginn, C / Mironov, C / Narayanan, S / Niu, X / Paus, C / Rankin, D / Roland, C / Roland, G / Shi, Z / Stephans, G S F / Sumorok, K / Tatar, K / Velicanu, D / Wang, T W / Wyslouch, B / Benvenuti, A C / Chatterjee, R M / Evans, A / Hansen, P / Hiltbrand, J / Kalafut, S / Kubota, Y / Lesko, Z / Mans, J / Rusack, R / Wadud, M A / Acosta, J G / Oliveros, S / Avdeeva, E / Bloom, K / Claes, D R / Fangmeier, C / Finco, L / Golf, F / Gonzalez Suarez, R / Kamalieddin, R / Kravchenko, I / Siado, J E / Snow, G R / Stieger, B / Godshalk, A / Harrington, C / Iashvili, I / Kharchilava, A / Mclean, C / Nguyen, D / Parker, A / Rappoccio, S / Roozbahani, B / Alverson, G / Barberis, E / Freer, C / Haddad, Y / Hortiangtham, A / Madigan, G / Morse, D M / Orimoto, T / Skinnari, L / Tishelman-Charny, A / Wamorkar, T / Wang, B / Wisecarver, A / Wood, D / Bueghly, J / Gunter, T / Hahn, K A / Schmitt, M H / Sung, K / Trovato, M / Velasco, M / Bucci, R / Dev, N / Goldouzian, R / Hildreth, M / Hurtado Anampa, K / Jessop, C / Karmgard, D J / Lannon, K / Li, W / Loukas, N / Marinelli, N / Mcalister, I / Meng, F / Mueller, C / Musienko, Y / Planer, M / Ruchti, R / Siddireddy, P / Smith, G / Taroni, S / Wayne, M / Wightman, A / Wolf, M / Woodard, A / Alimena, J / Bylsma, B / Durkin, L S / Flowers, S / Francis, B / Hill, C / Ji, W / 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Caillol, C / Carlsmith, D / Dasu, S / De Bruyn, I / Dodd, L / Gomber, B / Grothe, M / Herndon, M / Hervé, A / Hussain, U / Klabbers, P / Lanaro, A / Long, K / Loveless, R / Ruggles, T / Savin, A / Smith, W H / Woods, N

    Physical review letters

    2019  Volume 122, Issue 13, Page(s) 132001

    Abstract: Signals consistent with the B_{c}^{+}(2S) and B_{c}^{*+}(2S) states are observed in proton-proton ... collected by the CMS experiment during the 2015-2018 LHC running periods. These excited b[over ¯]c states ... are observed in the B_{c}^{+}π^{+}π^{-} invariant mass spectrum, with the ground state B_{c ...

    Abstract Signals consistent with the B_{c}^{+}(2S) and B_{c}^{*+}(2S) states are observed in proton-proton collisions at sqrt[s]=13  TeV, in an event sample corresponding to an integrated luminosity of 143  fb^{-1}, collected by the CMS experiment during the 2015-2018 LHC running periods. These excited b[over ¯]c states are observed in the B_{c}^{+}π^{+}π^{-} invariant mass spectrum, with the ground state B_{c}^{+} reconstructed through its decay to J/ψπ^{+}. The two states are reconstructed as two well-resolved peaks, separated in mass by 29.1±1.5(stat)±0.7(syst)  MeV. The observation of two peaks, rather than one, is established with a significance exceeding five standard deviations. The mass of the B_{c}^{+}(2S) meson is measured to be 6871.0±1.2(stat)±0.8(syst)±0.8(B_{c}^{+})  MeV, where the last term corresponds to the uncertainty in the world-average B_{c}^{+} mass.
    Language English
    Publishing date 2019-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.122.132001
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  8. Article ; Online: Prevalence of hepatitis C in sexual assault survivors presenting to a SANE clinic: A descriptive analysis.

    Ward, Erin / Carlisle, Nicholas / Williams, Ebony / Heath, Sonya L / Meloun, Kellie / Walter, Lauren A

    Journal of viral hepatitis

    2022  Volume 29, Issue 6, Page(s) 487–492

    Abstract: ... at disproportionate risk for exposure to Hepatitis C (HCV), HCV screening in SAS is not addressed in current post ...

    Abstract While previous epidemiologic research has demonstrated that sexual assault survivors (SAS) may be at disproportionate risk for exposure to Hepatitis C (HCV), HCV screening in SAS is not addressed in current post-sexual assault testing recommendations. We sought to identify the prevalence of HCV among a SAS cohort along with associated basic demographics. Opt-out HCV antibody screening and RNA confirmatory testing was provided for all SAS at a Sexual Assault Nurse Examiner (SANE) clinic in Birmingham, Alabama, from April 2020 through March 2021. A retrospective chart review was conducted using descriptive statistical and Chi-squared analyses. A total of 293 SAS presented to the clinic during the study timeframe. Two hundred forty-two (82.6%) were screened for HCV and 26 (8.9%) were found to be HCV antibody (Ab) positive [significantly higher than state (<1.0%) and national (1.0%) HCV incidence rates (p < 0.0001)]. SAS age groups 25-34 and 35-44 were more likely to screen HCV Ab-positive (15.2% and 14.9% respectively; p = 0.02). Female SAS were more likely to be tested for HCV then males (p = 0.02), although male SAS were more likely to be found HCV Ab-positive when screened (24.4%, p < 0.0001). Overall, SAS demographics also demonstrate the presence of significant social vulnerabilities, specifically high rates of homelessness (4.4%) and incarceration (5.1%). This data highlight the potential impact of universal HCV screening and risk counselling in a high social risk population and suggests a potential for future focused interventions.
    MeSH term(s) Female ; Hepacivirus ; Hepatitis C/diagnosis ; Hepatitis C/epidemiology ; Humans ; Male ; Prevalence ; Retrospective Studies ; Sex Offenses ; Survivors
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212497-7
    ISSN 1365-2893 ; 1352-0504
    ISSN (online) 1365-2893
    ISSN 1352-0504
    DOI 10.1111/jvh.13675
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  9. Article ; Online: Lysine 53 Acetylation of Cytochrome c in Prostate Cancer

    Viktoriia Bazylianska / Hasini A. Kalpage / Junmei Wan / Asmita Vaishnav / Gargi Mahapatra / Alice A. Turner / Dipanwita Dutta Chowdhury / Katherine Kim / Paul T. Morse / Icksoo Lee / Joseph S. Brunzelle / Lisa Polin / Prabal Subedi / Elisabeth I. Heath / Izabela Podgorski / Katrin Marcus / Brian F.P. Edwards / Maik Hüttemann

    Cells, Vol 10, Iss 802, p

    Warburg Metabolism and Evasion of Apoptosis

    2021  Volume 802

    Abstract: ... effect, and resistance to cell death. Cytochrome c (Cyt c ) is at the intersection of both pathways ... show that Cyt c is acetylated on lysine 53 in both androgen hormone-resistant and -sensitive human ... to acetylmimetic glutamine (K53Q), and to arginine (K53R) and isoleucine (K53I) as controls. Cytochrome c ...

    Abstract Prostate cancer is the second leading cause of cancer-related death in men. Two classic cancer hallmarks are a metabolic switch from oxidative phosphorylation (OxPhos) to glycolysis, known as the Warburg effect, and resistance to cell death. Cytochrome c (Cyt c ) is at the intersection of both pathways, as it is essential for electron transport in mitochondrial respiration and a trigger of intrinsic apoptosis when released from the mitochondria. However, its functional role in cancer has never been studied. Our data show that Cyt c is acetylated on lysine 53 in both androgen hormone-resistant and -sensitive human prostate cancer xenografts. To characterize the functional effects of K53 modification in vitro, K53 was mutated to acetylmimetic glutamine (K53Q), and to arginine (K53R) and isoleucine (K53I) as controls. Cytochrome c oxidase (COX) activity analyzed with purified Cyt c variants showed reduced oxygen consumption with acetylmimetic Cyt c compared to the non-acetylated Cyt c (WT), supporting the Warburg effect. In contrast to WT, K53Q Cyt c had significantly lower caspase-3 activity, suggesting that modification of Cyt c K53 helps cancer cells evade apoptosis. Cardiolipin peroxidase activity, which is another proapoptotic function of the protein, was lower in acetylmimetic Cyt c . Acetylmimetic Cyt c also had a higher capacity to scavenge reactive oxygen species (ROS), another pro-survival feature. We discuss our experimental results in light of structural features of K53Q Cyt c , which we crystallized at a resolution of 1.31 Å, together with molecular dynamics simulations. In conclusion, we propose that K53 acetylation of Cyt c affects two hallmarks of cancer by regulating respiration and apoptosis in prostate cancer xenografts.
    Keywords cytochrome c ; prostate cancer ; acetylation ; Warburg effect ; cytochrome c oxidase ; apoptosis ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  10. Article ; Online: Randomized clinical trial of DTaP5-HB-IPV-Hib vaccine administered concomitantly with meningococcal serogroup C conjugate vaccines during the primary infant series.

    Oliver, Jennifer L / Sadorge, Christine / Boisnard, Florence / Snape, Matthew D / Tomlinson, Richard / Mann, Rebecca / Rudd, Peter / Bhakthavalsala, Shyam / Faust, Saul N / Heath, Paul T / Hughes, Stephen M / Borrow, Ray / Thomas, Stéphane / Finn, Adam

    Vaccine

    2020  Volume 38, Issue 35, Page(s) 5718–5725

    Abstract: ... IPV-Hib with 2 different meningococcus group C conjugate (MCC) vaccines in infants.: Methods ... to other studies of DTaP5-HB-IPV-Hib, with pyrexia ≥38 °C in 10.9% of participants following any dose ...

    Abstract Background: Concomitant administration of vaccines simplifies delivery. DTaP5-HB-IPV-Hib is a fully liquid, combination vaccine against 6 diseases. This study evaluated the compatibility of DTaP5-HB-IPV-Hib with 2 different meningococcus group C conjugate (MCC) vaccines in infants.
    Methods: In a phase 3, open-label study, 284 healthy infants from 11 UK centres received DTaP5-HB-IPV-Hib at age 2, 3, and 4 months; 13-valent pneumococcal conjugate vaccine (PCV13) at 2 and 4 months; a Haemophilus influenzae type b (Hib)-MCC vaccine and a measles/mumps/rubella vaccine at 12 months. Participants were randomised 1:1 to receive either an MCC-detoxified tetanus toxin vaccine (MCC-TT; n = 141) or an MCC-Corynebacterium diphtheriae CRM
    Results: Per protocol analysis, MCC SPRs were 100 and 96.4 one month after the first dose, 100 and 99.1 after the second dose, and 100 and 97.3 after the third (booster) dose of MCC in the MCC-TT and MCC-CRM groups, respectively. One month after all 3 doses of DTaP5-HB-IPV-Hib, immunoglobulin G anti-polyribosylribitol phosphate SPRs (% ≥0.15 µg/mL) were 97.8 in the MCC-TT group and 100 in the MCC-CRM group; anti-hepatitis B antigen SPRs (% ≥10 mIU/mL) were 96.8 and 96.3 in the MCC-TT and MCC-CRM groups, respectively. All participants were seroprotected against diphtheria and tetanus (≥0.01 IU/mL) and poliovirus types 1, 2, and 3 (≥8 dilution), and seroresponse rates to all pertussis antigens were ≥90.4%. Two vaccine-related serious adverse events (transient severe abdominal pain and crying) occurred concomitantly in 1 participant in the MCC-CRM group. Adverse event rates were similar to other studies of DTaP5-HB-IPV-Hib, with pyrexia ≥38 °C in 10.9% of participants following any dose.
    Conclusions: DTaP5-HB-IPV-Hib can be effectively used in a 2-, 3-, and 4-month infant priming schedule when given with 2 doses of MCC.
    MeSH term(s) Animals ; Antibodies, Bacterial ; Diphtheria-Tetanus-Pertussis Vaccine ; Haemophilus Vaccines ; Haemophilus influenzae type b ; Humans ; Infant ; Meningococcal Vaccines ; Poliovirus Vaccine, Inactivated ; Rabbits ; Serogroup ; Vaccines, Combined ; Vaccines, Conjugate
    Chemical Substances Antibodies, Bacterial ; Diphtheria-Tetanus-Pertussis Vaccine ; Haemophilus Vaccines ; Meningococcal Vaccines ; Poliovirus Vaccine, Inactivated ; Vaccines, Combined ; Vaccines, Conjugate
    Language English
    Publishing date 2020-07-10
    Publishing country Netherlands
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2020.06.015
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