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Article ; Online: New insight into atomic-level interpretation of interactions in molecules and reacting systems.

Lefebvre, Corentin / Khartabil, Hassan / Hénon, Eric

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 16, Page(s) 11398–11409

Abstract: We hereby introduce the atomic degree of interaction (DOI), a new concept rooted in the electron density-based independent gradient model (IGM). Capturing any manifestation of electron density sharing around an atom, including covalent and non-covalent ... ...

Abstract	We hereby introduce the atomic degree of interaction (DOI), a new concept rooted in the electron density-based independent gradient model (IGM). Capturing any manifestation of electron density sharing around an atom, including covalent and non-covalent situations, this index reflects the attachment strength of an atom to its molecular neighbourhood. It is shown to be very sensitive to the local chemical environment of the atom. No significant correlation could be found between the atomic DOI and various other atomic properties, making this index a specific source of information. However, examining the simple H
Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d2cp02839e
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Diagnostic de mort encéphalique et réanimation du donneur en vue de prélèvements.

Bretagnol, Anne / Barrier, Damien / Brunet, Carine / Lefebvre, Isabelle / Messi, Lydia / Narcisse, Éric / Vanacker, Ludivine

Soins; la revue de reference infirmiere

2023 Volume 68, Issue 878, Page(s) 25–28

Abstract: Encephalic death is a rare and unique pathophysiological process. Its diagnosis and management in the intensive care unit, which are well codified, determine the possibility and short- and long-term outcome of organ and tissue transplants. ...

Title translation	Diagnosis of encephalic death and donor resuscitation for harvesting purposes.
Abstract	Encephalic death is a rare and unique pathophysiological process. Its diagnosis and management in the intensive care unit, which are well codified, determine the possibility and short- and long-term outcome of organ and tissue transplants.
Language	French
Publishing date	2023-08-17
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	604655-1
ISSN	0038-0814
ISSN	0038-0814
DOI	10.1016/j.soin.2023.07.006
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Article: Optimization of a Mass Trapping Method against the Striped Cucumber Beetle

Tinslay, Jessee / Fournier, Marc / Couture, Isabelle / Lafontaine, Pierre J / Lefebvre, Maxime / Lucas, Eric

Insects

2022 Volume 13, Issue 5

Abstract: The striped cucumber beetle (SCB) ...

Abstract	The striped cucumber beetle (SCB)
Language	English
Publishing date	2022-05-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662247-6
ISSN	2075-4450
ISSN	2075-4450
DOI	10.3390/insects13050465
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Article ; Online: New design of microchip for in-situ DLS measurement of colloidal suspensions

Claire Marliere / Sylvie Perrin / Didier Frot / Xavier Lefebvre / Eric Lécolier

JCIS Open, Vol 11, Iss , Pp 100086- (2023)

2023

Abstract: Stability of dispersed materials remains an important question in a wide variety of fields such as cosmetics, catalysis, food or energy and the environment. As stability is directly linked to the size of the dispersed colloids it is essential to assess ... ...

Abstract	Stability of dispersed materials remains an important question in a wide variety of fields such as cosmetics, catalysis, food or energy and the environment. As stability is directly linked to the size of the dispersed colloids it is essential to assess the size distribution of colloidal suspensions. Nowadays, microfluidic-based approaches generate increasing interest as they represent flexible and fast measurements allowing high throughput experimentations. However, characterization of colloidal dispersions is usually performed by dynamic light scattering (DLS), that requires static measurements as well as significant volumes, that are not compatible with on-line analysis and microfluidics. Moreover, due to flow-induced decorrelation terms, DLS measurements in microfluidic channels are only accurate at very low shear rates.This work aimed at developing an on-line microfluidic device for dispersed materials characterization using DLS. The main challenges of this project were i) to adapt the microfabrication of the PDMS device in order to combine microchannels of hundreds of microns with a milli-fluidic cavity to perform the DLS measurements, and ii) to downsize the DLS set up. A PDMS microchip, consisting in a millimeter cavity for DLS measurements in parallel with a microchannel, was designed to perform the measurement on the sample without stopping the suspension flow during the microfluidic experiment. The cavity geometry was then optimized thanks to numerical simulation to ensure a good sweep efficiency and to downscale as much as possible without impairing the DLS signal.By adapting the microfabrication process, a PDMS microfluidic chip was designed allowing the size measurements of successive suspensions containing 100 and 12 nm diameter particles. This work is a first step towards the implementation of a new technological building block for online microfluidic characterization.© 2017 Elsevier Inc. All rights reserved.
Keywords	Colloidal suspension ; Microfluidics ; Dynamic light scattering ; DLS ; Physical and theoretical chemistry ; QD450-801 ; Chemical technology ; TP1-1185
Subject code	600
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Population Genomic Evidence of Adaptive Response during the Invasion History of Plasmodium falciparum in the Americas.

Lefebvre, Margaux J M / Daron, Josquin / Legrand, Eric / Fontaine, Michael C / Rougeron, Virginie / Prugnolle, Franck

Molecular biology and evolution

2023 Volume 40, Issue 5

Abstract: Plasmodium falciparum, the most virulent agent of human malaria, spread from Africa to all continents following the out-of-Africa human migrations. During the transatlantic slave trade between the 16th and 19th centuries, it was introduced twice ... ...

Abstract	Plasmodium falciparum, the most virulent agent of human malaria, spread from Africa to all continents following the out-of-Africa human migrations. During the transatlantic slave trade between the 16th and 19th centuries, it was introduced twice independently to the Americas where it adapted to new environmental conditions (new human populations and mosquito species). Here, we analyzed the genome-wide polymorphisms of 2,635 isolates across the current P. falciparum distribution range in Africa, Asia, Oceania, and the Americas to investigate its genetic structure, invasion history, and selective pressures associated with its adaptation to the American environment. We confirmed that American populations originated from Africa with at least two independent introductions that led to two genetically distinct clusters, one in the North (Haiti and Colombia) and one in the South (French Guiana and Brazil), and an admixed Peruvian group. Genome scans revealed recent and more ancient signals of positive selection in the American populations. Particularly, we detected positive selection signals in genes involved in interactions with hosts (human and mosquito) cells and in genes involved in resistance to malaria drugs in both clusters. Analyses suggested that for five genes, adaptive introgression between clusters or selection on standing variation was at the origin of this repeated evolution. This study provides new genetic evidence on P. falciparum colonization history and on its local adaptation in the Americas.
MeSH term(s)	Humans ; Animals ; Plasmodium falciparum/genetics ; Metagenomics ; Malaria, Falciparum/genetics ; Americas ; Polymorphism, Genetic
Language	English
Publishing date	2023-04-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	998579-7
ISSN	1537-1719 ; 0737-4038
ISSN (online)	1537-1719
ISSN	0737-4038
DOI	10.1093/molbev/msad082
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Article ; Online: Flying the RNA Nest: Drosophila Reveals Novel Insights into the Transcriptome Dynamics of Early Development.

Lefebvre, Fabio Alexis / Lécuyer, Éric

Journal of developmental biology

2018 Volume 6, Issue 1

Abstract: Early development is punctuated by a series of pervasive and fast paced transitions. These events reshape a differentiated oocyte into a totipotent embryo and allow it to gradually mount a genetic program of its own, thereby framing a new organism. ... ...

Abstract	Early development is punctuated by a series of pervasive and fast paced transitions. These events reshape a differentiated oocyte into a totipotent embryo and allow it to gradually mount a genetic program of its own, thereby framing a new organism. Specifically, developmental transitions that ensure the maternal to embryonic control of developmental events entail a deep remodeling of transcriptional and transcriptomic landscapes.
Language	English
Publishing date	2018-03-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720870-9
ISSN	2221-3759 ; 2221-3759
ISSN (online)	2221-3759
ISSN	2221-3759
DOI	10.3390/jdb6010005
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Article ; Online: Molecular techniques drive cutting edge advancements in management of cutaneous T cell lymphoma.

Lefebvre, Mitchell N / Borcherding, Nicholas / Reis, Ryan J / Mou, Eric / Liu, Vincent / Jabbari, Ali

Frontiers in immunology

2023 Volume 14, Page(s) 1228563

Abstract: Cutaneous 5T cell lymphoma (CTCL), characterized by malignant T cells infiltrating the skin with potential for dissemination, remains a challenging disease to diagnose and treat due to disease heterogeneity, treatment resistance, and lack of effective ... ...

Abstract	Cutaneous 5T cell lymphoma (CTCL), characterized by malignant T cells infiltrating the skin with potential for dissemination, remains a challenging disease to diagnose and treat due to disease heterogeneity, treatment resistance, and lack of effective and standardized diagnostic and prognostic clinical tools. Currently, diagnosis of CTCL practically relies on clinical presentation, histopathology, and immunohistochemistry. These methods are collectively fraught with limitations in sensitivity and specificity. Fortunately, recent advances in flow cytometry, polymerase chain reaction, high throughput sequencing, and other molecular techniques have shown promise in improving diagnosis and treatment of CTCL. Examples of these advances include T cell receptor clonotyping via sequencing to detect CTCL earlier in the disease course and single-cell RNA sequencing to identify gene expression patterns that commonly drive CTCL pathogenesis. Experience with these techniques has afforded novel insights which may translate into enhanced diagnostic and therapeutic approaches for CTCL.
MeSH term(s)	Humans ; Lymphoma, T-Cell, Cutaneous/diagnosis ; Lymphoma, T-Cell, Cutaneous/genetics ; Lymphoma, T-Cell, Cutaneous/therapy ; Skin ; Lymphoma, Non-Hodgkin ; Disease Progression ; Skin Neoplasms/diagnosis ; Skin Neoplasms/genetics ; Skin Neoplasms/therapy
Language	English
Publishing date	2023-08-15
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1228563
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Article: Usage of Genetic Panels in an Adult Epilepsy Clinic.

Li, Jimmy / Toffa, Dènahin Hinnoutondji / Lefèbvre, Maude / Tétreault, Martine / Cossette, Patrick / Samarut, Éric / Nguyen, Dang Khoa

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

2022 Volume 50, Issue 3, Page(s) 411–417

Abstract: Background: There is limited data on the utility, yield, and cost efficiency of genetic testing in adults with epilepsy. We aimed to describe the yield and utility of genetic panels in our adult epilepsy clinic.: Methods: We performed a retrospective, ...

Abstract	Background: There is limited data on the utility, yield, and cost efficiency of genetic testing in adults with epilepsy. We aimed to describe the yield and utility of genetic panels in our adult epilepsy clinic. Methods: We performed a retrospective, cross-sectional study of all patients followed by an epileptologist at a Canadian tertiary care centre's epilepsy clinic between January 2016 and August 2021 for whom a genetic panel was ordered. A panel was generally ordered when the etiology was unknown or in the presence of a malformation of cortical development. We determined the yield of panel positivity and of confirmed genetic diagnoses. We also estimated the proportion of these diagnoses that were clinically actionable. Results: In total, 164 panels were ordered in 164 patients. Most had refractory epilepsy (80%), and few had comorbid intellectual disability (10%) or a positive family history of epilepsy (11%). The yield of panel positivity was 11%. Panel results were uncertain 49% of the time and negative 40% of the time. Genetic diagnoses were confirmed in 7 (4.3%) patients. These genetic conditions involved the following genes: Conclusion: We report a lower diagnostic yield for genetic panels in adults with epilepsy than what has so far been reported. Although the field of the genetics of epilepsy is a fast-moving one and more data is required, our findings suggest that guidelines for genetic testing in adults are warranted.
MeSH term(s)	Humans ; Adult ; Retrospective Studies ; Cross-Sectional Studies ; Canada ; Epilepsy/diagnosis ; Epilepsy/genetics ; Genetic Testing/methods ; Protocadherins
Chemical Substances	PCDH19 protein, human ; Protocadherins
Language	English
Publishing date	2022-04-28
Publishing country	England
Document type	Journal Article
ZDB-ID	197622-9
ISSN	0317-1671
ISSN	0317-1671
DOI	10.1017/cjn.2022.49
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Article ; Online: Flying the RNA Nest

Fabio Alexis Lefebvre / Éric Lécuyer

Journal of Developmental Biology, Vol 6, Iss 1, p

Drosophila Reveals Novel Insights into the Transcriptome Dynamics of Early Development

2018 Volume 5

Abstract	Early development is punctuated by a series of pervasive and fast paced transitions. These events reshape a differentiated oocyte into a totipotent embryo and allow it to gradually mount a genetic program of its own, thereby framing a new organism. Specifically, developmental transitions that ensure the maternal to embryonic control of developmental events entail a deep remodeling of transcriptional and transcriptomic landscapes. Drosophila provides an elegant and genetically tractable system to investigate these conserved changes at a dazzling developmental pace. Here, we review recent studies applying emerging technologies such as ribosome profiling, in situ Hi-C chromatin probing and live embryo RNA imaging to investigate the transcriptional dynamics at play during Drosophila embryogenesis. In light of this new literature, we revisit the main models of zygotic genome activation (ZGA). We also review the contributions played by zygotic transcription in shaping embryogenesis and explore emerging concepts of processes such as transcriptional bursting and transcriptional memory.
Keywords	embryogenesis ; Drosophila ; development ; RNA ; transcriptomics ; zygotic genome activation ; posttranscriptional regulation ; maternal-to-zygotic transition ; epigenetics ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2018-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Importance of Public Transport Networks for Reconciling the Spatial Distribution of Dengue and the Association of Socio-Economic Factors with Dengue Risk in Bangkok, Thailand.

Lefebvre, Bertrand / Karki, Rojina / Misslin, Renaud / Nakhapakorn, Kanchana / Daudé, Eric / Paul, Richard E

International journal of environmental research and public health

2022 Volume 19, Issue 16

Abstract: Dengue is the most widespread mosquito-borne viral disease of man and spreading at an alarming rate. Socio-economic inequality has long been thought to contribute to providing an environment for viral propagation. However, identifying socio-economic (SE) ...

Abstract	Dengue is the most widespread mosquito-borne viral disease of man and spreading at an alarming rate. Socio-economic inequality has long been thought to contribute to providing an environment for viral propagation. However, identifying socio-economic (SE) risk factors is confounded by intra-urban daily human mobility, with virus being ferried across cities. This study aimed to identify SE variables associated with dengue at a subdistrict level in Bangkok, analyse how they explain observed dengue hotspots and assess the impact of mobility networks on such associations. Using meteorological, dengue case, national statistics, and transport databases from the Bangkok authorities, we applied statistical association and spatial analyses to identify SE variables associated with dengue and spatial hotspots and the extent to which incorporating transport data impacts the observed associations. We identified three SE risk factors at the subdistrict level: lack of education, % of houses being cement/brick, and number of houses as being associated with increased risk of dengue. Spatial hotspots of dengue were found to occur consistently in the centre of the city, but which did not entirely have the socio-economic risk factor characteristics. Incorporation of the intra-urban transport network, however, much improved the overall statistical association of the socio-economic variables with dengue incidence and reconciled the incongruous difference between the spatial hotspots and the SE risk factors. Our study suggests that incorporating transport networks enables a more real-world analysis within urban areas and should enable improvements in the identification of risk factors.
MeSH term(s)	Animals ; Cities/epidemiology ; Dengue/epidemiology ; Economic Factors ; Humans ; Male ; Risk Factors ; Socioeconomic Factors ; Thailand/epidemiology
Language	English
Publishing date	2022-08-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph191610123
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