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  1. Article ; Online: Necrotizing fasciitis following an arthroscopic shoulder surgery: a case report and literature review.

    Delgado, Cristina / Erice, Alejo / García Navlet, Miguel

    JSES reviews, reports, and techniques

    2023  Volume 3, Issue 4, Page(s) 548–552

    Language English
    Publishing date 2023-05-27
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-6391
    ISSN (online) 2666-6391
    DOI 10.1016/j.xrrt.2023.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Long-Term Analyses of SARS-CoV-2 Humoral and T Cell Responses and Breakthrough SARS-CoV-2 Infections after Two Doses of BNT162b2 Followed by mRNA-1273 and Bivalent Omicron-Adapted BNT162b2 Vaccines: A Prospective Study over 2 Years in Non-Immunocompromised Individuals.

    Erice, Alejo / Prieto, Lola / Caballero, Cristina

    Vaccines

    2023  Volume 11, Issue 12

    Abstract: Long-term analyses of the immune response following SARS-CoV-2 mRNA vaccines are essential to determining its characteristics and providing the basis for vaccination strategies. We conducted a prospective study in a cohort of 268 healthy adults followed ... ...

    Abstract Long-term analyses of the immune response following SARS-CoV-2 mRNA vaccines are essential to determining its characteristics and providing the basis for vaccination strategies. We conducted a prospective study in a cohort of 268 healthy adults followed for >2 years after two doses of BNT162b2. Antibodies targeting the receptor-binding domain of the S1 subunit of the spike of SARS-CoV-2 (anti-RBD) were measured at eight time points; T cell response was analyzed using an interferon-γ release assay. A total of 248 (93%) subjects received mRNA-1273 on month 9; 93 (35%) received the bivalent Omicron-adapted BNT162b2 vaccine between months 19 and 26. Breakthrough infections occurred in 215 (80%) participants, with frequencies unaffected by the additional vaccines. Anti-RBD declined over the initial 9 months, increased after mRNA-1273, and declined gradually thereafter. In 50 (17%) previously infected subjects, anti-RBD levels were significantly higher up to month 9 (
    Language English
    Publishing date 2023-12-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11121835
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  3. Article ; Online: Pneumomediastinum and subcutaneous emphysema in COVID-19's spontaneous ventilation.

    Orera Pérez, Ángel / Barber Ansón, María / Erice Azparren, Edurne

    Medicina clinica (English ed.)

    2022  Volume 158, Issue 8, Page(s) 400

    Language English
    Publishing date 2022-04-18
    Publishing country Spain
    Document type Journal Article
    ISSN 2387-0206
    ISSN (online) 2387-0206
    DOI 10.1016/j.medcle.2021.11.007
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  4. Article ; Online: Decline of antibody titres 3 months after two doses of BNT162b2 in non-immunocompromised adults.

    Erice, Alejo / Varillas-Delgado, David / Caballero, Cristina

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2021  Volume 28, Issue 1, Page(s) 139.e1–139.e4

    Abstract: Objective: To assess the antibody response in non-immunocompromised adults after two doses of BNT162b2.: Methods: Prospective, single-centre observational study in non-immunocompromised adults aged 18 years or more who received two doses of BNT162b2. ...

    Abstract Objective: To assess the antibody response in non-immunocompromised adults after two doses of BNT162b2.
    Methods: Prospective, single-centre observational study in non-immunocompromised adults aged 18 years or more who received two doses of BNT162b2. The study contemplates analyses of serum samples collected 1.5, 3, 6, 9 and 12 months after the second dose of BNT162b2; results of the 1.5- and 3-month time-points are presented in this report. Antibodies against the receptor binding domain of the S1 subunit of the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (anti-RBD antibodies) were measured using a commercial quantitative immunoassay. A threshold of 4160 AU/mL (corresponding to an ID
    Results: Of 273 hospital workers who received two doses of BNT162b2, 260 (95%) agreed to participate in the study; 2/260 (0.8%) were excluded because of immunocompromised conditions. At the time of this report, 230/258 (89%) participants (mean age 46.0 years (SD 11.4 years); 143/230 (62%) female; 87/230 (38%) male) had completed 3 months of follow up after the second dose of BNT162b2. Thirty-six (16%) of the 230 had documented mild SARS-CoV-2 infection before receiving the first dose of BNT162b2. Median (interquartile range (IQR)) anti-RBD titres 1.5 months after vaccination were 9356 (5844-16 876) AU/mL; 3 months after vaccination, median anti-RBD titres had declined to 3952 (2190-8561) AU/mL (p < 0.001). Of 199/230 (86.5%) participants who had anti-RBD titres above 4160 AU/mL 1.5 months after the second dose of BNT162b2, only 95/230 (41%) maintained anti-RBD titres above this level 3 months after vaccination (p < 0.001).
    Conclusions: The decline of anti-RBD antibodies 3 months after the second dose of BNT162b2 is of concern because it raises the possibility of a short-lived humoral immunity after vaccination. Booster doses of BNT162b2 might be required to maintain high titres of anti-RBD antibodies over time.
    MeSH term(s) Adult ; Antibodies, Viral/blood ; BNT162 Vaccine/immunology ; COVID-19/immunology ; Female ; Humans ; Immunization, Secondary ; Male ; Middle Aged ; Prospective Studies ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-09-09
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2021.08.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 284: Show issues

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  5. Article ; Online: Prevalence and characteristics of hepatitis C virus infection detected by extended screening of working-age adults in Madrid (Spain).

    Erice, Alejo / Varillas-Delgado, David / Caballero, Cristina

    Journal of viral hepatitis

    2021  Volume 28, Issue 10, Page(s) 1496–1499

    MeSH term(s) Adult ; Hepacivirus ; Hepatitis C/diagnosis ; Hepatitis C/epidemiology ; Hepatitis C Antibodies ; Humans ; Prevalence ; Spain/epidemiology
    Chemical Substances Hepatitis C Antibodies
    Language English
    Publishing date 2021-07-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1212497-7
    ISSN 1365-2893 ; 1352-0504
    ISSN (online) 1365-2893
    ISSN 1352-0504
    DOI 10.1111/jvh.13564
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4119: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Neumomediastino y enfisema subcutáneo en COVID-19 en ventilación espontánea.

    Orera Pérez, Ángel / Barber Ansón, María / Erice Azparren, Edurne

    Medicina clinica

    2021  Volume 158, Issue 8, Page(s) 400

    Title translation Pneumomediastinum and subcutaneous emphysema in COVID-19's spontaneous ventilation.
    MeSH term(s) COVID-19/complications ; Humans ; Mediastinal Emphysema/diagnostic imaging ; Mediastinal Emphysema/etiology ; Subcutaneous Emphysema/diagnostic imaging ; Subcutaneous Emphysema/etiology
    Language Spanish
    Publishing date 2021-12-15
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2021.11.006
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.279: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Downregulation of

    Erice, Phillip A / Huang, Xinyan / Seasock, Matthew J / Robertson, Matthew J / Tung, Hui-Ying / Perez-Negron, Melissa A / Lotlikar, Shivani L / Corry, David B / Kheradmand, Farrah / Rodriguez, Antony

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Environmental air irritants including nanosized carbon black (nCB) can drive systemic inflammation, promoting chronic obstructive pulmonary disease (COPD) and emphysema development. ... ...

    Abstract Environmental air irritants including nanosized carbon black (nCB) can drive systemic inflammation, promoting chronic obstructive pulmonary disease (COPD) and emphysema development. The
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.12.562059
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  8. Article: Plant biostimulants as natural alternatives to synthetic auxins in strawberry production: physiological and metabolic insights.

    Cardarelli, Mariateresa / El Chami, Antonio / Rouphael, Youssef / Ciriello, Michele / Bonini, Paolo / Erice, Gorka / Cirino, Veronica / Basile, Boris / Corrado, Giandomenico / Choi, Seunghyun / Kim, Hye-Ji / Colla, Giuseppe

    Frontiers in plant science

    2024  Volume 14, Page(s) 1337926

    Abstract: The demand for high-quality strawberries continues to grow, emphasizing the need for innovative agricultural practices to enhance both yield and fruit quality. In this context, the utilization of natural products, such as biostimulants, has emerged as a ... ...

    Abstract The demand for high-quality strawberries continues to grow, emphasizing the need for innovative agricultural practices to enhance both yield and fruit quality. In this context, the utilization of natural products, such as biostimulants, has emerged as a promising avenue for improving strawberry production while aligning with sustainable and eco-friendly agricultural approaches. This study explores the influence of a bacterial filtrate (BF), a vegetal-derived protein hydrolysate (PH), and a standard synthetic auxin (SA) on strawberry, investigating their effects on yield, fruit quality, mineral composition and metabolomics of leaves and fruits. Agronomic trial revealed that SA and BF significantly enhanced early fruit yield due to their positive influence on flowering and fruit set, while PH treatment favored a gradual and prolonged fruit set, associated with an increased shoot biomass and sustained production. Fruit quality analysis showed that PH-treated fruits exhibited an increase of firmness and soluble solids content, whereas SA-treated fruits displayed lower firmness and soluble solids content. The ionomic analysis of leaves and fruits indicated that all treatments provided sufficient nutrients, with heavy metals within regulatory limits. Metabolomics indicated that PH stimulated primary metabolites, while SA and BF directly affected flavonoid and anthocyanin biosynthesis, and PH increased fruit quality through enhanced production of beneficial metabolites. This research offers valuable insights for optimizing strawberry production and fruit quality by harnessing the potential of natural biostimulants as viable alternative to synthetic compounds.
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1337926
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  9. Article: The Evolving Concept of the Blood Brain Barrier (BBB): From a Single Static Barrier to a Heterogeneous and Dynamic Relay Center.

    Villabona-Rueda, Andres / Erice, Clara / Pardo, Carlos A / Stins, Monique F

    Frontiers in cellular neuroscience

    2019  Volume 13, Page(s) 405

    Abstract: The blood-brain barrier (BBB) helps maintain a tightly regulated microenvironment for optimal central nervous system (CNS) homeostasis and facilitates communications with the peripheral circulation. The brain endothelial cells, lining the brain's ... ...

    Abstract The blood-brain barrier (BBB) helps maintain a tightly regulated microenvironment for optimal central nervous system (CNS) homeostasis and facilitates communications with the peripheral circulation. The brain endothelial cells, lining the brain's vasculature, maintain close interactions with surrounding brain cells, e.g., astrocytes, pericytes and perivascular macrophages. This function facilitates critical intercellular crosstalk, giving rise to the concept of the neurovascular unit (NVU). The steady and appropriate communication between all components of the NVU is essential for normal CNS homeostasis and function, and dysregulation of one of its constituents can result in disease. Among the different brain regions, and along the vascular tree, the cellular composition of the NVU varies. Therefore, differential cues from the immediate vascular environment can affect BBB phenotype. To support the fluctuating metabolic and functional needs of the underlying neuropil, a specialized vascular heterogeneity is required. This is achieved by variances in barrier function, expression of transporters, receptors, and adhesion molecules. This mini-review will take you on a journey through evolving concepts surrounding the BBB, the NVU and beyond. Exploring classical experiments leading to new approaches will allow us to understand that the BBB is not merely a static separation between the brain and periphery but a closely regulated and interactive entity. We will discuss shifting paradigms, and ultimately aim to address the importance of BBB endothelial heterogeneity with regard to the function of the BBB within the NVU, and touch on its implications for different neuropathologies.
    Language English
    Publishing date 2019-09-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2019.00405
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  10. Article ; Online: Harvest index combined with impaired N availability constrains the responsiveness of durum wheat to elevated CO

    Erice, Gorka / Sanz-Sáez, Alvaro / Urdiain, Amadeo / Araus, Jose L / Irigoyen, Juan José / Aranjuelo, Iker

    Functional plant biology : FPB

    2020  Volume 41, Issue 11, Page(s) 1138–1147

    Abstract: Despite its relevance, few studies to date have analysed the role of harvest index (HI) in the responsiveness of wheat (Triticum spp.) to elevated CO2 concentration ([CO2]) under limited water availability. The goal of the present work was to ... ...

    Abstract Despite its relevance, few studies to date have analysed the role of harvest index (HI) in the responsiveness of wheat (Triticum spp.) to elevated CO2 concentration ([CO2]) under limited water availability. The goal of the present work was to characterise the role of HI in the physiological responsiveness of durum wheat (Triticum durum Desf.) exposed to elevated [CO2] and terminal (i.e. during grain filling) water stress. For this purpose, the performance of wheat plants with high versus low HI (cvv. Sula and Blanqueta, respectively) was assessed under elevated [CO2] (700μmolmol-1 vs 400μmolmol-1 CO2) and terminal water stress (imposed after ear emergence) in CO2 greenhouses. Leaf carbohydrate build-up combined with limitations in CO2 diffusion (in droughted plants) limited the responsiveness to elevated [CO2] in both cultivars. Elevated [CO2] only increased wheat yield in fully watered Sula plants, where its larger HI prevented an elevated accumulation of total nonstructural carbohydrates. It is likely that the putative shortened grain filling period in plants exposed to water stress also limited the responsiveness of plants to elevated [CO2]. In summary, our study showed that even under optimal water availability conditions, only plants with a high HI responded to elevated [CO2] with increased plant growth, and that terminal drought constrained the responsiveness of wheat plants to elevated [CO2].
    Language English
    Publishing date 2020-06-02
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2071582-1
    ISSN 1445-4416 ; 1445-4408
    ISSN (online) 1445-4416
    ISSN 1445-4408
    DOI 10.1071/FP14045
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    In stock of ZB MED Bonn / Germany

    Z 4753: Show issues

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