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Article ; Online: DIBAL-H-mediated

Shukla, Pushpendra Mani / Pratap, Aniruddh / Maji, Biswajit

2024 Volume 22, Issue 3, Page(s) 501–505

Abstract: A rapid DIBAL-H-mediated ...

Abstract	A rapid DIBAL-H-mediated
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d3ob01660a
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Article ; Online: Novel role of xanthine oxidase-dependent H

Govatati, Suresh / Pichavaram, Prahalathan / Mani, Arul M / Kumar, Raj / Sharma, Deepti / Dienel, Ari / Meena, Sunita / Puchowicz, Michelle A / Park, Edwards A / Rao, Gadiparthi N

Redox biology

2021 Volume 47, Page(s) 102163

Abstract: ... expansion and weight gain via xanthine oxidase (XO)-dependent production of H ...

Abstract	12/15-lipoxygenase (12/15-LOX) plays an essential role in oxidative conversion of polyunsaturated fatty acids into various bioactive lipid molecules. Although 12/15-LOX's role in the pathophysiology of various human diseases has been well studied, its role in weight gain is controversial and poorly clarified. Here, we demonstrated the role of 12/15-LOX in high-fat diet (HFD)-induced weight gain in a mouse model. We found that 12/15-LOX mediates HFD-induced de novo lipogenesis (DNL), triglyceride (TG) biosynthesis and the transport of TGs from the liver to adipose tissue leading to white adipose tissue (WAT) expansion and weight gain via xanthine oxidase (XO)-dependent production of H
MeSH term(s)	Animals ; Arachidonate 15-Lipoxygenase/genetics ; Arachidonate 15-Lipoxygenase/metabolism ; Diet, High-Fat/adverse effects ; Hydrogen Peroxide/metabolism ; Lipogenesis ; Liver/metabolism ; Mice ; Triglycerides/metabolism ; Weight Gain ; Xanthine Oxidase/metabolism
Chemical Substances	Triglycerides ; Hydrogen Peroxide (BBX060AN9V) ; Arachidonate 15-Lipoxygenase (EC 1.13.11.33) ; Xanthine Oxidase (EC 1.17.3.2)
Language	English
Publishing date	2021-10-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2021.102163
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Article ; Online: Resolvin D1 blocks H

Chattopadhyay, Rima / Mani, Arul M / Singh, Nikhlesh K / Rao, Gadiparthi N

Free radical biology & medicine

2018 Volume 117, Page(s) 119–131

Abstract: ... monocyte interactions via blocking H ...

Abstract	In recent years, various studies have demonstrated a role for endogenously derived specialized proresolving mediators such as resolvins in the resolution of inflammation. In exploring the signaling mechanisms, in the present study we show that Resolvin D1 (RvD1) reduces LPS-induced endothelial cell (EC)-monocyte interactions via blocking H
MeSH term(s)	Docosahexaenoic Acids/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Hydrogen Peroxide/metabolism ; Inflammation/metabolism ; Inflammation Mediators/metabolism ; Monocytes/metabolism ; Oxidants/metabolism ; Protein Phosphatase 2/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism ; Receptor Cross-Talk/physiology ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction/physiology
Chemical Substances	GPR32 protein, human ; Inflammation Mediators ; Oxidants ; Receptors, G-Protein-Coupled ; resolvin D1 ; Docosahexaenoic Acids (25167-62-8) ; Hydrogen Peroxide (BBX060AN9V) ; Protein Phosphatase 2 (EC 3.1.3.16) ; Protein Tyrosine Phosphatase, Non-Receptor Type 11 (EC 3.1.3.48)
Language	English
Publishing date	2018-02-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2018.01.034
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Zs.A 2109: Show issues

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Article ; Online: The interaction of estrogen and CSE/H

Li, Hongzhu / Mani, Sarathi / Wu, Lingyun / Fu, Ming / Shuang, Tian / Xu, Changqing / Wang, Rui

American journal of physiology. Heart and circulatory physiology

2016 Volume 312, Issue 3, Page(s) H406–H414

Abstract: Both estrogen and hydrogen sulfide (H ...

Abstract	Both estrogen and hydrogen sulfide (H
MeSH term(s)	Animals ; Aorta, Thoracic/pathology ; Atherosclerosis/genetics ; Atherosclerosis/pathology ; Atherosclerosis/physiopathology ; Cystathionine gamma-Lyase ; Diet, Atherogenic ; Estrogens/blood ; Female ; Homocysteine/blood ; Hydrogen Sulfide ; I-kappa B Proteins/blood ; Intercellular Adhesion Molecule-1/metabolism ; Lipids/blood ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction ; Transcription Factor RelA/metabolism
Chemical Substances	Estrogens ; I-kappa B Proteins ; Lipids ; Transcription Factor RelA ; Homocysteine (0LVT1QZ0BA) ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Cystathionine gamma-Lyase (EC 4.4.1.1) ; Hydrogen Sulfide (YY9FVM7NSN)
Language	English
Publishing date	2016-12-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00245.2016
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Article ; Online: N-Heterocyclic carbene-catalysed homoenolate addition reaction to 3-cyano-2-imino-2H-chromenes: synthesis of C4-functionalized 2-amino-3-cyano-4H-chromene.

Shukla, Pushpendra Mani / Pratap, Aniruddh / Maji, Biswajit

Organic & biomolecular chemistry

2022 Volume 20, Issue 42, Page(s) 8203–8208

Abstract: ... H-chromene is described for accessing a new type of C₄-functionalized 2-amino-3-cyano ... 4H-chromene. A wide variety of enals and iminochromenes afforded the desired homoenolate ... addition product 2-amino-4H-chromenes in good yields and with moderate to good ...

Abstract	A diastereoselective N-heterocyclic carbene-catalysed reaction between enal and 3-cyano-2-imino-2H-chromene is described for accessing a new type of C<sub>4</sub>-functionalized 2-amino-3-cyano-4H-chromene. A wide variety of enals and iminochromenes afforded the desired homoenolate addition product 2-amino-4H-chromenes in good yields and with moderate to good diastereoselectivities.
MeSH term(s)	Benzopyrans ; Catalysis ; Methane
Chemical Substances	carbene (2465-56-7) ; Benzopyrans ; Methane (OP0UW79H66)
Language	English
Publishing date	2022-11-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d2ob01447e
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Article ; Online: Cholesterol crystals promote endothelial cell and monocyte interactions via H

Pichavaram, Prahalathan / Mani, Arul M / Singh, Nikhlesh K / Rao, Gadiparthi N

Redox biology

2019 Volume 24, Page(s) 101180

Abstract: ... expression via xanthine oxidase-mediated H ...

Abstract	In the present study, we show that cholesterol crystals induce NFκB activation, and ICAM1 and VCAM1 expression via xanthine oxidase-mediated H
MeSH term(s)	Animals ; Cholesterol/chemistry ; Cholesterol/metabolism ; Docosahexaenoic Acids/pharmacology ; Endothelial Cells/metabolism ; Humans ; Hydrogen Peroxide/pharmacology ; Intercellular Adhesion Molecule-1/metabolism ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Mice ; Monocytes/metabolism ; NF-kappa B/metabolism ; Oxidants/metabolism ; Vascular Cell Adhesion Molecule-1/metabolism
Chemical Substances	ICAM1 protein, human ; NF-kappa B ; Oxidants ; Vascular Cell Adhesion Molecule-1 ; resolvin D1 ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Docosahexaenoic Acids (25167-62-8) ; Cholesterol (97C5T2UQ7J) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2019-04-03
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2213-2317
ISSN (online)	2213-2317
DOI	10.1016/j.redox.2019.101180
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Book ; Online: Max-Cut in Degenerate $H$-Free Graphs

Li, Ray / Mani, Nitya

2019

Abstract: ... m,d,H)$ denote the smallest $\textsf{Max-Cut}$ of an $H$-free $d$-degenerate graph on $m$ edges ... of Carlson, Kolla, and Trevisan. We also give bounds on $f(m,d,H)$ when $H$ is a cycle, odd wheel, or ... We obtain several lower bounds on the $\textsf{Max-Cut}$ of $d$-degenerate $H$-free graphs. Let $f ...

Abstract	We obtain several lower bounds on the $\textsf{Max-Cut}$ of $d$-degenerate $H$-free graphs. Let $f(m,d,H)$ denote the smallest $\textsf{Max-Cut}$ of an $H$-free $d$-degenerate graph on $m$ edges. We show that $f(m,d,K_r)\ge \left(\frac{1}{2} + d^{-1+\Omega(r^{-1})}\right)m$, generalizing a recent work of Carlson, Kolla, and Trevisan. We also give bounds on $f(m,d,H)$ when $H$ is a cycle, odd wheel, or a complete bipartite graph with at most 4 vertices on one side. We also show stronger bounds on $f(m,d,K_r)$ assuming a conjecture of Alon, Bollabas, Krivelevich, and Sudakov (2003). We conjecture that $f(m,d,K_r)= \left( \frac{1}{2} + \Theta_r(d^{-1/2}) \right)m$ for every $r\ge 3$, and show that this conjecture implies the ABKS conjecture. Comment: This paper has been superseded by arXiv:1810.10044
Keywords	Mathematics - Combinatorics ; Computer Science - Discrete Mathematics ; 05C35
Publishing date	2019-05-07
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Variable-Pitch Power Regulation of Tethered-Wing Systems Based on Robust Gain-Scheduling H-infinity Control

Kakavand, Mani / Nikoobin, Amin

2022

Abstract: ... limitation during high-speed wind. The controllers are synthesized using H-infinity method and are based ...

Abstract	In this paper, we deal with the power regulation of tethered-wing systems and demonstrate advantages of variable-pitch control in mitigating the dynamic mechanical loads and power fluctuations. The proposed scheme is based on a strategy that maximizes the energy capture during low-speed wind and prevents overloads during the high-speed wind. To realize this strategy, we use a tether reeling-speed controller to track the optimal generator speed during low-speed wind and a MIMO speed-force controller for power limitation during high-speed wind. The controllers are synthesized using H-infinity method and are based on a linear parameter varying (LPV) system that expresses the flexible dynamics of system as a function of the tether's length and force. Using this method, the controllers are made robust with respect to dynamic and parametric uncertainties and the wing's pitch angle activity is minimized during high-speed wind. We carry out extensive simulations to demonstrate the controllers' performance. These include the implementation of the scheme in a detailed 3-dimensional tethered-wing system simulator with a realistic turbulent wind field. Comment: 21 pages, 23 figures
Keywords	Electrical Engineering and Systems Science - Systems and Control
Subject code	621
Publishing date	2022-10-17
Publishing country	us
Document type	Book ; Online
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Article ; Online: High-Pressure Limit Rate Rules for α-H Isomerization of Hydroperoxyalkylperoxy Radicals.

Mohamed, Samah Y / Davis, Alexander C / Al Rashidi, Mariam J / Sarathy, S Mani

The journal of physical chemistry. A

2018 Volume 122, Issue 14, Page(s) 3626–3639

Abstract: ... reaction. Rate rules for H-migration reactions proceeding through 5-, 6-, 7-, and 8-membered ring ... atmospheric conditions) or when two chiral centers are present in the reactant. Regarding the effect of the H-migration ... ring size, it is found that in most cases, the 1,5 and 1,6 H-migration reactions have similar rates ...

Abstract	Hydroperoxyalkylperoxy (OOQOOH) radical isomerization is an important low-temperature chain branching reaction within the mechanism of hydrocarbon oxidation. This isomerization may proceed via the migration of the α-hydrogen to the hydroperoxide group. In this work, a combination of high level composite methods-CBS-QB3, G3, and G4-is used to determine the high-pressure-limit rate parameters for the title reaction. Rate rules for H-migration reactions proceeding through 5-, 6-, 7-, and 8-membered ring transitions states are determined. Migrations from primary, secondary and tertiary carbon sites to the peroxy group are considered. Chirality is also investigated by considering two diastereomers for reactants and transition states with two chiral centers. This is important since chirality may influence the energy barrier of the reaction as well as the rotational energy barriers of hindered rotors in chemical species and transition states. The effect of chirality and hydrogen bonding interactions in the investigated energies and rate constants is studied. The results show that while the energy difference between two diastereomers ranges from 0.1-3.2 kcal/mol, chirality hardly affects the kinetics, except at low temperatures (atmospheric conditions) or when two chiral centers are present in the reactant. Regarding the effect of the H-migration ring size, it is found that in most cases, the 1,5 and 1,6 H-migration reactions have similar rates at low temperatures (below ∼830 K) since the 1,6 H-migration proceeds via a cyclohexane-like transition state similar to that of the 1,5 H-migration.
Language	English
Publishing date	2018-04-12
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.7b11955
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Article ; Online: Inhibition of HBV replication by N-hydroxyisoquinolinedione and N-hydroxypyridinedione ribonuclease H inhibitors.

Edwards, Tiffany C / Mani, Nagraj / Dorsey, Bruce / Kakarla, Ramesh / Rijnbrand, Rene / Sofia, Michael J / Tavis, John E

Antiviral research

2019 Volume 164, Page(s) 70–80

Abstract: ... of the Hepatitis B virus (HBV) ribonuclease H (RNaseH), which is the only HBV enzyme not targeted by current anti-HBV ...

Abstract	We recently developed a screening system capable of identifying and evaluating inhibitors of the Hepatitis B virus (HBV) ribonuclease H (RNaseH), which is the only HBV enzyme not targeted by current anti-HBV therapies. Inhibiting the HBV RNaseH blocks synthesis of the positive-polarity DNA strand, causing early termination of negative-polarity DNA synthesis and accumulation of RNA:DNA heteroduplexes. We previously reported inhibition of HBV replication by N-hydroxyisoquinolinediones (HID) and N-hydroxypyridinediones (HPD) in human hepatoma cells. Here, we report results from our ongoing efforts to develop more potent anti-HBV RNaseH inhibitors in the HID/HPD compound classes. We synthesized and screened additional HIDs and HPDs for preferential suppression of positive-polarity DNA in cells replicating HBV. Three of seven new HIDs inhibited HBV replication, however, the therapeutic indexes (TI = CC
MeSH term(s)	Antiviral Agents/chemical synthesis ; Antiviral Agents/pharmacology ; DNA Replication/drug effects ; Hepatitis B virus/drug effects ; Hepatitis B virus/enzymology ; Hepatitis B virus/physiology ; Humans ; Isoquinolines/chemical synthesis ; Isoquinolines/pharmacology ; Pyridines/chemistry ; Pyridines/pharmacology ; Pyridones/chemical synthesis ; Pyridones/pharmacology ; Ribonuclease H/antagonists & inhibitors ; Viral Proteins/antagonists & inhibitors ; Virus Replication/drug effects
Chemical Substances	Antiviral Agents ; Isoquinolines ; N-hydroxyisoquinolinedione ; N-hydroxypyridinedione ; Pyridines ; Pyridones ; Viral Proteins ; hydroxypyridines ; Ribonuclease H (EC 3.1.26.4)
Language	English
Publishing date	2019-02-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	306628-9
ISSN	1872-9096 ; 0166-3542
ISSN (online)	1872-9096
ISSN	0166-3542
DOI	10.1016/j.antiviral.2019.02.005
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Zs.A 1627: Show issues

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