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  1. Article ; Online: Invited Commentary: A Step Toward Safer and More Precise Management of Osteoarthritis Pain.

    Baker, Joshua F

    American journal of epidemiology

    2023  Volume 192, Issue 9, Page(s) 1449–1451

    Abstract: In this issue of the Journal, Wei et al. (Am J Epidemiol. 2023;192(9):1432-1448); demonstrate the modification of effect of nonselective nonsteroidal antiinflammatory drugs in the setting of aspirin use for the outcome of cardiovascular events. This ... ...

    Abstract In this issue of the Journal, Wei et al. (Am J Epidemiol. 2023;192(9):1432-1448); demonstrate the modification of effect of nonselective nonsteroidal antiinflammatory drugs in the setting of aspirin use for the outcome of cardiovascular events. This study is distinctive in its aim to compare 2 similar therapies in the setting of 2 clinical scenarios (aspirin use vs. not) based on some mechanistic rationale. The use of an active comparator design with a prehypothesized evaluation of treatment heterogeneity can provide compelling evidence to support relevant clinical decisions for which clinical trial evidence is not likely or possible.
    MeSH term(s) Humans ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Osteoarthritis/complications ; Osteoarthritis/drug therapy ; Aspirin/therapeutic use ; Pain/drug therapy
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2937-3
    ISSN 1476-6256 ; 0002-9262
    ISSN (online) 1476-6256
    ISSN 0002-9262
    DOI 10.1093/aje/kwad092
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  2. Article ; Online: H. Ralph Schumacher.

    Baker, Joshua F / Baker, Daniel G

    Rheumatic diseases clinics of North America

    2023  Volume 50, Issue 1, Page(s) 103–111

    Abstract: Dr Schumacher was a force in rheumatology for more than half a century through his multiple roles as a researcher, clinician, mentor, and educator. He is not likely to be soon forgotten by the rheumatology community; however, it is hoped that this ... ...

    Abstract Dr Schumacher was a force in rheumatology for more than half a century through his multiple roles as a researcher, clinician, mentor, and educator. He is not likely to be soon forgotten by the rheumatology community; however, it is hoped that this chapter can provide a faithful recollection that will help bring his memory to life for some and that rings true to those who knew him and learned from him.
    MeSH term(s) Male ; Humans ; Rheumatology ; Mentors
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2023.08.008
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  3. Article ; Online: Reply.

    Baker, Joshua F / Reed, George / Kremer, Joel

    Arthritis care & research

    2023  Volume 75, Issue 6, Page(s) 1384–1385

    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.25041
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  4. Article ; Online: All differential on the splicing front: Host alternative splicing alters the landscape of virus-host conflict.

    Mann, Joshua T / Riley, Brent A / Baker, Steven F

    Seminars in cell & developmental biology

    2023  Volume 146, Page(s) 40–56

    Abstract: Alternative RNA splicing is a co-transcriptional process that richly increases proteome diversity, and is dynamically regulated based on cell species, lineage, and activation state. Virus infection in vertebrate hosts results in rapid host transcriptome- ... ...

    Abstract Alternative RNA splicing is a co-transcriptional process that richly increases proteome diversity, and is dynamically regulated based on cell species, lineage, and activation state. Virus infection in vertebrate hosts results in rapid host transcriptome-wide changes, and regulation of alternative splicing can direct a combinatorial effect on the host transcriptome. There has been a recent increase in genome-wide studies evaluating host alternative splicing during viral infection, which integrates well with prior knowledge on viral interactions with host splicing proteins. A critical challenge remains in linking how these individual events direct global changes, and whether alternative splicing is an overall favorable pathway for fending off or supporting viral infection. Here, we introduce the process of alternative splicing, discuss how to analyze splice regulation, and detail studies on genome-wide and splice factor changes during viral infection. We seek to highlight where the field can focus on moving forward, and how incorporation of a virus-host co-evolutionary perspective can benefit this burgeoning subject.
    MeSH term(s) Alternative Splicing/genetics ; Viruses/genetics ; Genome ; Transcriptome ; Proteome/genetics
    Chemical Substances Proteome
    Language English
    Publishing date 2023-02-02
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2023.01.013
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  5. Article: 18

    Reddy, Natasha / Raynor, William Y / Werner, Thomas J / Baker, Joshua F / Alavi, Abass / Revheim, Mona-Elisabeth

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 13

    Abstract: Rheumatoid arthritis (RA) involves chronic inflammation of synovial joints, causing pain, stiffness, and limited mobility. ...

    Abstract Rheumatoid arthritis (RA) involves chronic inflammation of synovial joints, causing pain, stiffness, and limited mobility.
    Language English
    Publishing date 2023-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13132149
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  6. Article ; Online: Osteoporosis and fractures in rheumatoid arthritis - risk factors.

    Wysham, Katherine D / Baker, Joshua F / Narla, Radhika

    Best practice & research. Clinical rheumatology

    2022  Volume 36, Issue 3, Page(s) 101757

    Abstract: In this chapter, we emphasize among rheumatoid arthritis (RA) patients, whom and how to screen for osteoporosis. We highlight certain modalities, advancements in technology, secondary osteoporosis workup, and laboratory testing as well as their caveats. ... ...

    Abstract In this chapter, we emphasize among rheumatoid arthritis (RA) patients, whom and how to screen for osteoporosis. We highlight certain modalities, advancements in technology, secondary osteoporosis workup, and laboratory testing as well as their caveats. Finally, we discuss current guidance on how to direct the laboratory and radiology testing in the context of the individual patient with RA to guide and select from the osteoporosis treatment options currently available.
    Language English
    Publishing date 2022-06-21
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2022.101757
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  7. Article ; Online: Risk factors for osteoporosis and fractures in rheumatoid arthritis.

    Baker, Rahaf / Narla, Radhika / Baker, Joshua F / Wysham, Katherine D

    Best practice & research. Clinical rheumatology

    2022  Volume 36, Issue 3, Page(s) 101773

    Abstract: People with rheumatoid arthritis (RA) have both disease-specific risk factors for osteoporosis and fractures in addition to those that affect the general population. Disease specific risks include directly pathogenic auto-antibodies, chronic exposure to ... ...

    Abstract People with rheumatoid arthritis (RA) have both disease-specific risk factors for osteoporosis and fractures in addition to those that affect the general population. Disease specific risks include directly pathogenic auto-antibodies, chronic exposure to systemic inflammation, and joint damage causing early disability. Risk factors that affect the general population which may have a higher prevalence in RA include smoking, calcium and vitamin D deficiency as well as hypogonadism. Additionally, chronic exposure to glucocorticoids results in reduced bone mineral density and body composition changes which can further increase fracture risk. In this review we discuss these risk-factors for osteoporosis as well as factors that may impact fall and fracture risk in people with RA.
    Language English
    Publishing date 2022-10-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2022.101773
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  8. Article ; Online: Lifestyle, Hormonal, and Metabolic Environmental Risks for Rheumatoid Arthritis.

    Desai, Nancy / Federico, Lydia / Baker, Joshua F

    Rheumatic diseases clinics of North America

    2022  Volume 48, Issue 4, Page(s) 799–811

    Abstract: Although there is a substantial body of literature focused on understanding noninhalational risk-factors for rheumatoid arthritis, the data are mixed and often conflicting. Given the other health benefits for certain lifestyle modifications, it seems ... ...

    Abstract Although there is a substantial body of literature focused on understanding noninhalational risk-factors for rheumatoid arthritis, the data are mixed and often conflicting. Given the other health benefits for certain lifestyle modifications, it seems reasonable for clinicians to promote healthy lifestyle habits related to diet, exercise, maintenance of health weight, and maintenance of good dental hygiene. Overall, however, these lifestyle modifications may be expected to have modest benefit, and other strategies to prevent rheumatoid arthritis in high-risk patients are needed.
    MeSH term(s) Humans ; Life Style ; Exercise ; Arthritis, Rheumatoid/etiology ; Arthritis, Rheumatoid/prevention & control ; Diet ; Risk Factors
    Language English
    Publishing date 2022-10-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2022.06.003
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  9. Article ; Online: Weight variability, physical functioning and incident disability in older adults.

    McMenamin, Katie J / Harris, Tamara B / Baker, Joshua F

    Journal of cachexia, sarcopenia and muscle

    2023  Volume 14, Issue 4, Page(s) 1648–1656

    Abstract: Background: This study aimed to determine if greater variability in body mass index (BMI) is associated with declines in physical functioning and incident disability in older adults.: Methods: Included were participants from the Health, Aging and ... ...

    Abstract Background: This study aimed to determine if greater variability in body mass index (BMI) is associated with declines in physical functioning and incident disability in older adults.
    Methods: Included were participants from the Health, Aging and Body Composition Study who had semi-annual BMI data during the first 3 years of follow-up. Participants were categorized into quintiles of BMI variability, using two methods. The first method used average successive variability, whereas the second method adjusted these values to remove the variability due to net change in BMI over the 3-year period. Linear regression was used to assess the relationship between the two measures of BMI variability and net changes in BMI, fat mass index, appendicular lean mass index, and Health, Aging and Body Composition Physical Performance Score during the first 3 years of the study. Cox proportional hazard models were used to assess the relationship of BMI variability with the subsequent incidence of new disability, adjusting for confounding factors.
    Results: Among 2121 participants, those in the highest BMI variability quintile were more likely to lose both body mass (β: -0.086 [95% confidence interval, CI: -0.133, -0.040], P < 0.01) and fat mass (β: -0.059 [95% CI: -0.117, -0.002], P = 0.04) and had greater declines in physical performance score (β: -0.094 [95% CI: -0.162, -0.026], P < 0.01) compared to participants with the least variability in BMI. Participants with high BMI variability also had higher rates of incident disability (hazard ratio: 1.36 [95% CI: 1.07, 1.72], P = 0.01), independent of net BMI change.
    Conclusions: BMI variability in older adults is associated with decline in physical performance and incident disability. This relationship cannot be explained by net weight loss alone, supporting it as an independent feature of frailty.
    MeSH term(s) Humans ; Aged ; Aging ; Body Mass Index ; Disabled Persons ; Body Composition ; Frailty
    Language English
    Publishing date 2023-05-30
    Publishing country Germany
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2586864-0
    ISSN 2190-6009 ; 2190-5991
    ISSN (online) 2190-6009
    ISSN 2190-5991
    DOI 10.1002/jcsm.13239
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  10. Article ; Online: Response to: 'Correspondence on 'Disease activity, cytokines, chemokines and the risk of incident diabetes in rheumatoid arthritis'' by Ruscitti

    Baker, Joshua F / England, Bryant R / Mikuls, Ted R

    Annals of the rheumatic diseases

    2021  Volume 82, Issue 5, Page(s) e120

    MeSH term(s) Humans ; Cytokines ; Chemokines ; Arthritis, Rheumatoid/epidemiology ; Diabetes Mellitus
    Chemical Substances Cytokines ; Chemokines
    Language English
    Publishing date 2021-02-22
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2021-220114
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