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  1. Article ; Online: Medical Industry Contributions to the Climate Crisis: Behind the Green Drapes.

    Downey, Gregory P

    Canadian journal of respiratory, critical care, and sleep medicine

    2023  Volume 7, Issue 5, Page(s) 228–231

    Abstract: The climate crisis is rapidly unfolding with immediate, disastrous consequences including rising surface temperatures, melting of icecaps and glaciers, rising of sea levels, and destructive wildfires spanning the globe. The impact of these climate ... ...

    Abstract The climate crisis is rapidly unfolding with immediate, disastrous consequences including rising surface temperatures, melting of icecaps and glaciers, rising of sea levels, and destructive wildfires spanning the globe. The impact of these climate changes on human health is broad, ranging from immediate heat-related deaths to acute and chronic respiratory and cardiovascular illness. Ironically, the healthcare industry itself contributes to climate change in many ways including waste generation, energy consumption, pharmaceutical production, equipment manufacturing, transportation, and infrastructure. In addition to these obvious ways, the use of HFA-propelled MDIs contributes significantly to the climate footprint of healthcare and is easily addressed immediately by changing to DPIs and soft mist inhalers where feasible and appropriate based on patient needs, safety, and availability of inhalers. Implementing carbon offset programs, investing in research and development, and raising awareness among healthcare professionals are crucial components to reform. The healthcare industry must lead by example and commit to long term sustainable practices that not only mitigate the environmental footprint of the healthcare industry but also improve patient outcomes.
    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Journal Article
    ISSN 2474-5340
    ISSN (online) 2474-5340
    DOI 10.1080/24745332.2023.2268075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Proteinases in the pathogenesis of lymphangioleiomyomatosis lung disease: nibbling or chewing up the lung?

    Aschner, Yael / Downey, Gregory P

    The European respiratory journal

    2022  Volume 59, Issue 4

    MeSH term(s) Humans ; Lung/pathology ; Lung Diseases ; Lymphangioleiomyomatosis/pathology ; Mastication ; Peptide Hydrolases
    Chemical Substances Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2022-04-14
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00405-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2322: Show issues Location:
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  3. Article ; Online: Considerations in Selecting Venues for the American Thoracic Society International Conference: Balancing Competing Priorities of the Society's Diverse Membership.

    Downey, Gregory P / Rivera, M Patricia / Schnapp, Lynn M / Petrache, Irina / Roman, Jesse / Collishaw, Karen J

    Annals of the American Thoracic Society

    2023  Volume 20, Issue 6, Page(s) 929–930

    MeSH term(s) Humans ; Societies, Medical/ethics ; United States ; Congresses as Topic/ethics ; Supreme Court Decisions
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202302-179LE
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    Zs.A 5828: Show issues Location:
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  4. Article ; Online: Lymphangioleiomyomatosis and Other Cystic Lung Diseases.

    Koslow, Matthew / Lynch, David A / Cool, Carlyne D / Groshong, Steve D / Downey, Gregory P

    Immunology and allergy clinics of North America

    2023  Volume 43, Issue 2, Page(s) 359–377

    Abstract: Cysts and cavities in the lung are commonly encountered on chest imaging. It is necessary to distinguish thin-walled lung cysts (≤2 mm) from cavities and characterize their distribution as focal or multifocal versus diffuse. Focal cavitary lesions are ... ...

    Abstract Cysts and cavities in the lung are commonly encountered on chest imaging. It is necessary to distinguish thin-walled lung cysts (≤2 mm) from cavities and characterize their distribution as focal or multifocal versus diffuse. Focal cavitary lesions are often caused by inflammatory, infectious, or neoplastic processes in contrast to diffuse cystic lung diseases. An algorithmic approach to diffuse cystic lung disease can help narrow the differential diagnosis, and additional testing such as skin biopsy, serum biomarkers, and genetic testing can be confirmatory. An accurate diagnosis is essential for the management and disease surveillance of extrapulmonary complications.
    MeSH term(s) Humans ; Lymphangioleiomyomatosis/diagnosis ; Lymphangioleiomyomatosis/etiology ; Lymphangioleiomyomatosis/therapy ; Histiocytosis, Langerhans-Cell/complications ; Histiocytosis, Langerhans-Cell/diagnosis ; Histiocytosis, Langerhans-Cell/pathology ; Birt-Hogg-Dube Syndrome/complications ; Birt-Hogg-Dube Syndrome/diagnosis ; Birt-Hogg-Dube Syndrome/pathology ; Tomography, X-Ray Computed/methods ; Lung Diseases/diagnosis ; Lung Diseases/etiology ; Lung/pathology ; Cysts/diagnosis ; Cysts/complications ; Cysts/pathology ; Diagnosis, Differential
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92606-1
    ISSN 1557-8607 ; 0889-8561
    ISSN (online) 1557-8607
    ISSN 0889-8561
    DOI 10.1016/j.iac.2023.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 710: Show issues Location:
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  5. Article: Desert particulate matter from Afghanistan increases airway obstruction in human distal lungs exposed to type 2 cytokine IL-13.

    Cervantes, Diana / Schaunaman, Niccolette / Downey, Gregory P / Chu, Hong Wei / Day, Brian J

    Frontiers in medicine

    2023  Volume 10, Page(s) 1177665

    Abstract: Introduction: Deployment related asthma-like symptoms including distal airway obstruction have been described in U.S. military personnel who served in Iraq and Afghanistan. The mechanisms responsible for the development of distal airway obstruction in ... ...

    Abstract Introduction: Deployment related asthma-like symptoms including distal airway obstruction have been described in U.S. military personnel who served in Iraq and Afghanistan. The mechanisms responsible for the development of distal airway obstruction in deployers exposed to desert particulate matter (PM) is not well understood. We sought to determine if respiratory exposure to PM from Afghanistan (PMa) increases human distal airway hyperresponsiveness (AHR) with or without exposures to IL-13, a type 2 cytokine. We further tested whether mitochondrial dysfunction, such as ATP signaling and oxidative stress, may contribute to PMa- mediated AHR.
    Methods: Precision-cut lung slices from donors without a history of lung disease, tobacco smoking, or vaping were pre-treated with IL-13 for 24 h. This was followed by exposure to PMa or PM from California (PMc, control for PMa) for up to 72 h. The role of hydrogen peroxide and ATP in AHR was assessed using the antioxidant enzyme catalase or an ATP receptor P2Y13 antagonist MRS2211. AHR in response to methacholine challenges as well as cytokine IL-8 production were measured.
    Results: PMa alone, but not PMc alone, trended to increase AHR. Importantly, the combination of PMa and IL-13 significantly amplified AHR compared to control or PMc+IL-13. PMa alone and in combination with IL-13 increased IL-8 as compared to the control. PMa increased H2O2 and ATP. MRS211 and catalase reduced AHR in PCLS exposed to both PMa and IL-13.
    Discussion: Our data suggests that PMa in a type 2 inflammation-high lung increased AHR in part through oxidative stress and ATP signaling.
    Language English
    Publishing date 2023-06-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1177665
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  6. Article ; Online: Reply: Experimental Acute Lung Injury in Animals: With Age Comes Knowledge.

    Kulkarni, Hrishikesh S / Lee, Janet S / Downey, Gregory P / Matute-Bello, Gustavo

    American journal of respiratory cell and molecular biology

    2022  Volume 67, Issue 2, Page(s) 267

    MeSH term(s) Acute Lung Injury ; Animals ; Disease Models, Animal ; Lung
    Language English
    Publishing date 2022-05-14
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2022-0091LE
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2851: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Be the Change: Advancing Lung Health and Closing the Global Healthcare Gap.

    Downey, Gregory P / Rivera, M Patricia / Schnapp, Lynn / Petrache, Irina / Roman, Jesse / Collishaw, Karen

    American journal of respiratory and critical care medicine

    2022  Volume 206, Issue 6, Page(s) 667–669

    MeSH term(s) Delivery of Health Care ; Humans ; Lung ; Thorax
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202207-1423ED
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    Uh II Zs.80: Show issues Location:
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  8. Article ; Online: Desert particulate matter from Afghanistan increases airway obstruction in human distal lungs exposed to type 2 cytokine IL-13

    Diana Cervantes / Niccolette Schaunaman / Gregory P. Downey / Hong Wei Chu / Brian J. Day

    Frontiers in Medicine, Vol

    2023  Volume 10

    Abstract: IntroductionDeployment related asthma-like symptoms including distal airway obstruction have been described in U.S. military personnel who served in Iraq and Afghanistan. The mechanisms responsible for the development of distal airway obstruction in ... ...

    Abstract IntroductionDeployment related asthma-like symptoms including distal airway obstruction have been described in U.S. military personnel who served in Iraq and Afghanistan. The mechanisms responsible for the development of distal airway obstruction in deployers exposed to desert particulate matter (PM) is not well understood. We sought to determine if respiratory exposure to PM from Afghanistan (PMa) increases human distal airway hyperresponsiveness (AHR) with or without exposures to IL-13, a type 2 cytokine. We further tested whether mitochondrial dysfunction, such as ATP signaling and oxidative stress, may contribute to PMa- mediated AHR.MethodsPrecision-cut lung slices from donors without a history of lung disease, tobacco smoking, or vaping were pre-treated with IL-13 for 24 h. This was followed by exposure to PMa or PM from California (PMc, control for PMa) for up to 72 h. The role of hydrogen peroxide and ATP in AHR was assessed using the antioxidant enzyme catalase or an ATP receptor P2Y13 antagonist MRS2211. AHR in response to methacholine challenges as well as cytokine IL-8 production were measured.ResultsPMa alone, but not PMc alone, trended to increase AHR. Importantly, the combination of PMa and IL-13 significantly amplified AHR compared to control or PMc+IL-13. PMa alone and in combination with IL-13 increased IL-8 as compared to the control. PMa increased H2O2 and ATP. MRS211 and catalase reduced AHR in PCLS exposed to both PMa and IL-13.DiscussionOur data suggests that PMa in a type 2 inflammation-high lung increased AHR in part through oxidative stress and ATP signaling.
    Keywords particulate matter ; human lung ; IL-13 ; airway hyperresponsiveness ; oxidative stress ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Cryopreservation of 13 Commercial

    Downey, Cassandra D / Golenia, Gregory / Boudko, Ekaterina A / Jones, Andrew Maxwell P

    Plants (Basel, Switzerland)

    2021  Volume 10, Issue 9

    Abstract: Cannabis has developed into a multi-billion-dollar industry that relies on clonal propagation of elite genetics with desirable agronomic and chemical phenotypes. While the goal of clonal propagation is to produce genetically uniform plants, somatic ... ...

    Abstract Cannabis has developed into a multi-billion-dollar industry that relies on clonal propagation of elite genetics with desirable agronomic and chemical phenotypes. While the goal of clonal propagation is to produce genetically uniform plants, somatic mutations can accumulate during growth and compromise long-term genetic fidelity. Cryopreservation is a process in which tissues are stored at cryogenic temperatures, halting cell division and metabolic processes to facilitate high fidelity germplasm preservation. In this study, a series of experiments were conducted to optimize various stages of cryopreservation and develop a protocol for long-term germplasm storage of
    Language English
    Publishing date 2021-08-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10091794
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  10. Article ; Online: The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not.

    Aschner, Yael / Downey, Gregory P

    American journal of respiratory cell and molecular biology

    2018  Volume 59, Issue 5, Page(s) 535–547

    Abstract: Reversible phosphorylation of proteins on tyrosine residues is an essential signaling mechanism by which diverse cellular processes are closely regulated. The tight temporal and spatial control of the tyrosine phosphorylation status of proteins by ... ...

    Abstract Reversible phosphorylation of proteins on tyrosine residues is an essential signaling mechanism by which diverse cellular processes are closely regulated. The tight temporal and spatial control of the tyrosine phosphorylation status of proteins by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) is critical to cellular homeostasis as well as to adaptations to the external environment. Via regulation of cellular signaling cascades involving other protein kinases and phosphatases, receptors, adaptor proteins, and transcription factors, PTKs and PTPs closely control diverse cellular processes such as proliferation, differentiation, migration, inflammation, and maintenance of cellular barrier function. Given these key regulatory roles, it is not surprising that dysfunction of PTKs and PTPs is important in the pathogenesis of human disease, including many pulmonary diseases. The roles of various PTKs and PTPs in acute lung injury and repair, pulmonary fibrosis, pulmonary vascular disease, and inflammatory airway disease are discussed in this review. It is important to note that although there is overlap among many of these proteins in various disease states, the mechanisms by which they influence the pathogenesis of these conditions differ, suggesting wide-ranging roles for these enzymes and their potential as therapeutic targets.
    MeSH term(s) Animals ; Humans ; Phosphorylation ; Protein Tyrosine Phosphatases/metabolism ; Protein-Tyrosine Kinases/metabolism ; Respiration Disorders/metabolism ; Respiration Disorders/physiopathology ; Signal Transduction
    Chemical Substances Protein-Tyrosine Kinases (EC 2.7.10.1) ; Protein Tyrosine Phosphatases (EC 3.1.3.48)
    Language English
    Publishing date 2018-05-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2018-0049TR
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