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  1. Article ; Online: Reply: pineal parenchymal tumors of intermediate differentiation: in need of a stringent definition to avoid confusion.

    Rahmanzade, Ramin / Sahm, Felix

    Acta neuropathologica

    2024  Volume 147, Issue 1, Page(s) 35

    MeSH term(s) Humans ; Pinealoma/pathology ; Pineal Gland/pathology ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology
    Language English
    Publishing date 2024-02-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1079-0
    ISSN 1432-0533 ; 0001-6322
    ISSN (online) 1432-0533
    ISSN 0001-6322
    DOI 10.1007/s00401-024-02685-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.188: Show issues Location:
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  2. Article ; Online: Redefinition of tumor capsule: Rho-dependent clustering of cancer-associated fibroblasts in favor of tensional homeostasis.

    Rahmanzade, Ramin

    Medical hypotheses

    2019  Volume 135, Page(s) 109425

    Abstract: Fibroblasts are the most frequent cells of the connective tissues. Having the ability to sense and respond to mechanical stimuli in addition to the biochemical ones makes them crucial for such a composite-like and tension-preserving tissue. Over the last ...

    Abstract Fibroblasts are the most frequent cells of the connective tissues. Having the ability to sense and respond to mechanical stimuli in addition to the biochemical ones makes them crucial for such a composite-like and tension-preserving tissue. Over the last decade, the investigation of the role of these cells in tumor progression was a hot topic of research in tumor biology. Literatures almost unanimously describe the re-education of stromal fibroblasts by tumor cells in favor of tumor progression, which resulted in the birth of a new nomenclature, the cancer-associated fibroblasts. On the other hand, some studies reported anti-tumor roles for these cells. Herein, author suggests that the previously described pro-migratory and pro-contractile contexts, which respectively results in divergent and convergent distribution of fibroblasts by changing Rho-Rac1 balance, could be applied for cancer-associated fibroblasts as well. Based on this proposed concept, stromal fibroblasts could represent different roles, either pro-tumor or anti-tumor, during the course of tumor progression. In the earlier phases, they tend to assemble along tumor-stroma interface in the form of tumor capsules in order to resist tumor growth and to maintain tensional homeostasis in stroma. But in later phases, after being chronically subjected to tumor-induced chemical and mechanical stimuli, they will gradually lose their substantial abilities to oppose tumor expansion and, in contrary, will promote tumorigenesis. In summary, this paper redefines tumor capsule from chemical and mechanical standpoints as Rho-dependent clustering of cancer-associated fibroblasts in favor of tensional homeostasis. Furthermore, it proposes that stromal fibroblasts will undergo some irreversible epigenetic changes in Rac1- and Rho-related proteins through tumor-stroma crosstalk, which irreversibly diminish their ability of capsule formation. Finally, the author discusses the possible researches helping us to assess the proposed concept and its clinical implications.
    MeSH term(s) Cancer-Associated Fibroblasts ; Cells, Cultured ; Fibroblasts/metabolism ; Homeostasis ; Humans ; Models, Theoretical ; Neoplasms/metabolism ; Stress, Mechanical ; Tumor Microenvironment ; rac1 GTP-Binding Protein/metabolism ; rho-Associated Kinases/metabolism
    Chemical Substances RAC1 protein, human ; rho-Associated Kinases (EC 2.7.11.1) ; rac1 GTP-Binding Protein (EC 3.6.5.2)
    Language English
    Publishing date 2019-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2019.109425
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    Zs.A 1132: Show issues Location:
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  3. Article ; Online: Mini-surgical Percutaneous Dilatational Tracheostomy (msPDT): Our Experience during the COVID-19 Pandemic.

    Rahmanzade, Ramin / Hashemian, Seyed MohammadReza

    The British journal of surgery

    2020  Volume 107, Issue 10, Page(s) e363

    MeSH term(s) COVID-19/epidemiology ; Contraindications, Procedure ; Dilatation/adverse effects ; Dilatation/methods ; Humans ; Minimally Invasive Surgical Procedures ; Pandemics ; SARS-CoV-2 ; Tracheostomy/adverse effects ; Tracheostomy/methods
    Keywords covid19
    Language English
    Publishing date 2020-08-05
    Publishing country England
    Document type Letter
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.11799
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  5. Article ; Online: Mini-surgical Percutaneous Dilatational Tracheostomy (msPDT)

    Rahmanzade, Ramin / Hashemian, Seyed MohammadReza

    British Journal of Surgery ; ISSN 0007-1323

    Our Experience during the COVID-19 Pandemic ; msPDT during COVID-19 Pandemic

    2020  

    Keywords Surgery ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/bjs.11799
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Accessory nerve schwannoma extending into the fourth ventricle: case report and review of literature.

    Naser, Paul Vincent / Haux-Nettesheim, Daniel / Rahmanzade, Ramin / Lenga, Pavlina / Reuss, David / Unterberg, Andreas W / Beynon, Christopher

    British journal of neurosurgery

    2023  , Page(s) 1–4

    Abstract: Accessory nerve schwannoma is a rare entity in patients presenting with cranial nerve (CN) deficits. Most of these tumours arise from the cisternal segment of the eleventh CN and extend caudally. Herein, we report the third case of an accessory ... ...

    Abstract Accessory nerve schwannoma is a rare entity in patients presenting with cranial nerve (CN) deficits. Most of these tumours arise from the cisternal segment of the eleventh CN and extend caudally. Herein, we report the third case of an accessory schwannoma extending cranially into the fourth ventricle. A 61-year-old female presented with a history of variable headaches. Cerebral magnetic resonance imaging (cMRI) revealed a large inhomogeneous contrast-enhancing lesion at the craniocervical junction extending through the foramen of Magendi and concomitant hydrocephalus due to obstruction of the foramina of Luschkae. Microsurgical tumour resection was performed in the half-sitting position. Intraoperatively, the tumour arose from a vestigial fascicle of the spinal accessory nerve. At three month follow-up, neither radiological tumour recurrence nor neurological deficits were observed.
    Language English
    Publishing date 2023-02-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2023.2179598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2210: Show issues Location:
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  7. Article ; Online: Respiratory Distress in Postanesthesia Care Unit: First Presentation of Coronavirus Disease 2019 in a 17-Year-Old Girl: A Case Report.

    Rahmanzade, Ramin / Rahmanzadeh, Reza / Hashemian, Seyed MohammadReza

    A&A practice

    2020  Volume 14, Issue 7, Page(s) e01227

    Abstract: A 17-year-old healthy girl underwent an uneventful esthetic septorhinoplasty. She was easily extubated and transferred to the postanesthesia care unit (PACU) with oxygen saturation (SpO2) of 96%. About 30 minutes after arrival in the PACU, she developed ... ...

    Abstract A 17-year-old healthy girl underwent an uneventful esthetic septorhinoplasty. She was easily extubated and transferred to the postanesthesia care unit (PACU) with oxygen saturation (SpO2) of 96%. About 30 minutes after arrival in the PACU, she developed dyspnea with SpO2 of 84% and promptly received oxygen with bilevel positive airway pressure in conjunction with low-dose corticosteroid. The subsequent chest computed tomography (CT) revealed bilateral patchy infiltrates similar to the radiologic findings of Coronavirus Disease 2019 (COVID-19). Finally, a reverse transcriptase polymerase chain reaction (RT-PCR) of a pharyngeal specimen confirmed the diagnosis of COVID-19.
    MeSH term(s) Adolescent ; Airway Extubation ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus/genetics ; Coronavirus/isolation & purification ; Coronavirus Infections/diagnosis ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/drug therapy ; Dyspnea/diagnostic imaging ; Dyspnea/etiology ; Female ; Humans ; Hydroxychloroquine/administration & dosage ; Hydroxychloroquine/therapeutic use ; Lung/diagnostic imaging ; Oxygen/therapeutic use ; Pandemics ; Pharynx/virology ; Pneumonia, Viral/diagnostic imaging ; Postoperative Care ; Respiratory Distress Syndrome/complications ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Tomography, X-Ray Computed/methods ; Treatment Outcome
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Oxygen (S88TT14065)
    Keywords covid19
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2575-3126
    ISSN (online) 2575-3126
    DOI 10.1213/XAA.0000000000001227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Noninvasive Versus Invasive Ventilation in COVID-19: One Size Does Not Fit All!

    Rahmanzade, Ramin / Rahmanzadeh, Reza / Tabarsi, Payam / Hashemian, Seyed MohammadReza

    Anesthesia and analgesia

    2020  Volume 131, Issue 2, Page(s) e114–e115

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Humans ; Intubation, Intratracheal/methods ; Intubation, Intratracheal/standards ; Noninvasive Ventilation/methods ; Noninvasive Ventilation/standards ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Respiration, Artificial/methods ; Respiration, Artificial/standards ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-08
    Publishing country United States
    Document type Comparative Study ; Letter
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000004943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.78: Show issues Location:
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    Zs.MO 149: Show issues

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  9. Article: Iran's Approach to COVID-19: Evolving Treatment Protocols and Ongoing Clinical Trials.

    Rahmanzade, Ramin / Rahmanzadeh, Reza / Hashemian, Seyed MohammadReza / Tabarsi, Payam

    Frontiers in public health

    2020  Volume 8, Page(s) 551889

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic is challenging the health care systems around the world and compelling them to timely share their strategies, tactics and experiences. Since mid-January, a huge volume of instructions has been released by ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic is challenging the health care systems around the world and compelling them to timely share their strategies, tactics and experiences. Since mid-January, a huge volume of instructions has been released by Iran's Ministry of Health and Medical Education (MOHME) covering diverse aspects of disease control and prevention. In this study, we aimed to review the instructions published either before or after COVID-19's transmission to Iran to depict the clinical approach and therapeutics used in Iran to battle the current pandemic. We retrospectively gathered and critically reviewed all official situation reports, guidelines, guidance, flowcharts, protocols, recommendations and advice released by Iranian scientific, or administrative arms of action against COVID-19. The ongoing clinical trials approved by MOHME and registered to the Iranian Registry of Clinical Trials (IRCT) have been reviewed as well. Our study resulted in the following mainstays of Iran's approach to COVID-19: (i) active clinical screening; preferably on-line or on-phone, (ii) management of limited paraclinical resources; by using them as diagnostic tools rather than epidemiological, (iii) a trend toward outpatient care of mild-to-moderate cases; either confirmed or suspicious, with active scheduled follow-up, and (iv) avoidance of pharmacotherapy, as far as possible. The therapeutic and administrative instructions are still being actively updated with some recommendations different from the previous ones. Nevertheless, a common approach in the background could be detected, It seems that the instructions are conceptually in line with the first "National Guideline for 2019-nCoV" published on 20 January 2020. The screening has mainly been clinically oriented rather than being based on laboratory tests and MOHME seems to be following the approach of "early detection of symptomatic cases followed by early source control."
    MeSH term(s) COVID-19 ; Clinical Protocols ; Humans ; Iran/epidemiology ; Retrospective Studies ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.551889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Iran's Approach to COVID-19

    Rahmanzade, Ramin / Rahmanzadeh, Reza / Hashemian, Seyed MohammadReza / Tabarsi, Payam

    Frontiers in Public Health

    Evolving Treatment Protocols and Ongoing Clinical Trials

    2020  Volume 8

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.551889
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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