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  1. Article ; Online: Respiratory syncytial virus Prefusion F vaccine.

    Falsey, Ann R / Walsh, Edward E

    Cell

    2023  Volume 186, Issue 15, Page(s) 3137–3137.e1

    Abstract: Respiratory syncytial virus (RSV) is the most common cause of serious respiratory infection in infants. Reinfections occur commonly, including in older adults. For six decades, effective vaccines remained elusive. Stabilization of the prefusion ... ...

    Abstract Respiratory syncytial virus (RSV) is the most common cause of serious respiratory infection in infants. Reinfections occur commonly, including in older adults. For six decades, effective vaccines remained elusive. Stabilization of the prefusion conformation of the RSV glycoprotein F was critical for development of effective vaccines to prevent RSV in older adults. To view this Bench to Bedside, open or download the PDF.
    MeSH term(s) Humans ; Aged ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Syncytial Virus Vaccines ; Antibodies, Neutralizing ; Antibodies, Viral ; Respiratory Syncytial Virus, Human ; Viral Fusion Proteins
    Chemical Substances Respiratory Syncytial Virus Vaccines ; Antibodies, Neutralizing ; Antibodies, Viral ; Viral Fusion Proteins
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2023.05.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: The Challenge of Respiratory Syncytial Virus Human Challenge Studies.

    Anderson, Larry J / Walsh, Edward E

    The New England journal of medicine

    2022  Volume 386, Issue 7, Page(s) 696–697

    MeSH term(s) Humans ; Respiratory Syncytial Virus Infections ; Respiratory Syncytial Virus, Human
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2118465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Early Life RSV: Can Vaccines Help Fix Societal Ills?

    Caserta, Mary T / Walsh, Edward E

    Pediatrics

    2021  Volume 147, Issue 4

    MeSH term(s) Child ; Humans ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus Infections/prevention & control ; Risk Factors ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2021-03-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2020-038356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Brain Glutamate Dynamics Predict Positive Agency in Healthy Women: Insights from Combined Application of Pharmacological Challenge, Comprehensive Affective Assessment, and Magnetic Resonance Spectroscopy.

    White, Tara L / Gonsalves, Meghan A / Harris, Ashley D / Walsh, Edward G / Joyce, Hannah E

    ACS chemical neuroscience

    2024  Volume 15, Issue 3, Page(s) 491–502

    Abstract: Contributions of brain glutamate (Glu) to conscious emotion are not well understood. Here, we evaluate the relationship of experimentally induced change in neocortical Glu (ΔGlu) and subjective states in well individuals, using combined application of ... ...

    Abstract Contributions of brain glutamate (Glu) to conscious emotion are not well understood. Here, we evaluate the relationship of experimentally induced change in neocortical Glu (ΔGlu) and subjective states in well individuals, using combined application of pharmacological challenge, magnetic resonance spectroscopy (MRS), and comprehensive affective assessment. Drug challenge with d-amphetamine (AMP) (20 mg oral), methamphetamine (MA) (Desoxyn, 20 mg oral), and placebo (PBO) was conducted on three separate test days in a within-subjects double blind design. Proton MRS quantified neurometabolites in the right dorsal anterior cingulate cortex 140-150 min post-drug and PBO. Subjective states were assessed at half hour intervals over 5.5 h on each session, yielding 3792 responses per participant (91,008 responses overall,
    MeSH term(s) Female ; Humans ; Brain ; Glutamic Acid ; Glutamine ; Magnetic Resonance Spectroscopy/methods ; Methamphetamine ; Double-Blind Method
    Chemical Substances Glutamic Acid (3KX376GY7L) ; Glutamine (0RH81L854J) ; Methamphetamine (44RAL3456C)
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.3c00521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Respiratory Syncytial Virus: An Old Foe in a New Era.

    Falsey, Ann R / Walsh, Edward E

    The Journal of infectious diseases

    2020  Volume 222, Issue 8, Page(s) 1245–1246

    MeSH term(s) Aged ; Humans ; Morbidity ; Palivizumab ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus, Human
    Chemical Substances Palivizumab (DQ448MW7KS)
    Language English
    Publishing date 2020-06-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiaa362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Respiratory syncytial virus Prefusion F vaccine

    Falsey, Ann R. / Walsh, Edward E.

    Cell. 2023 July, v. 186, no. 15 p.3137-3137.e1

    2023  

    Abstract: Respiratory syncytial virus (RSV) is the most common cause of serious respiratory infection in infants. Reinfections occur commonly, including in older adults. For six decades, effective vaccines remained elusive. Stabilization of the prefusion ... ...

    Abstract Respiratory syncytial virus (RSV) is the most common cause of serious respiratory infection in infants. Reinfections occur commonly, including in older adults. For six decades, effective vaccines remained elusive. Stabilization of the prefusion conformation of the RSV glycoprotein F was critical for development of effective vaccines to prevent RSV in older adults. To view this Bench to Bedside, open or download the PDF.
    Keywords Respiratory syncytial virus ; glycoproteins ; respiratory tract diseases ; vaccines
    Language English
    Dates of publication 2023-07
    Size p. 3137-3137.e1.
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2023.05.048
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Brain Glutamate Dynamics Predict Positive Agency in Healthy Women.

    White, Tara L / Gonsalves, Meghan A / Harris, Ashley D / Walsh, Edward G / Joyce, Hannah E

    Research square

    2023  

    Abstract: Contributions of brain glutamate to conscious emotion are not well understood. Here we evaluate the relationship of experimentally-induced change in neocortical glutamate (ΔGlu) and subjective states in well individuals. Drug challenge ... ...

    Abstract Contributions of brain glutamate to conscious emotion are not well understood. Here we evaluate the relationship of experimentally-induced change in neocortical glutamate (ΔGlu) and subjective states in well individuals. Drug challenge with
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3021527/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Perturbations in Respiratory Syncytial Virus (RSV) Activity During the SARS-CoV-2 Pandemic.

    Falsey, Ann R / Cameron, Andrew / Branche, Angela R / Walsh, Edward E

    The Journal of infectious diseases

    2022  

    Abstract: Respiratory Syncytial Virus (RSV) is a common cause of respiratory disease in all age groups with young children and older adults experiencing the most severe illness. The COVID-19 pandemic resulted in striking changes in the activity of seasonal ... ...

    Abstract Respiratory Syncytial Virus (RSV) is a common cause of respiratory disease in all age groups with young children and older adults experiencing the most severe illness. The COVID-19 pandemic resulted in striking changes in the activity of seasonal respiratory viruses including RSV. After a period of suppression early in the pandemic, an inter-seasonal surge of RSV occurred in 2021. Viral activity was detected primarily in children and young adults after relaxation of public health measures, but without the usual proportional increases in infections and hospitalizations in older adults who were likely still adhering to stricter public health measures.
    Language English
    Publishing date 2022-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiac434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Respiratory Syncytial Virus Infection: An Illness for All Ages.

    Walsh, Edward E

    Clinics in chest medicine

    2016  Volume 38, Issue 1, Page(s) 29–36

    Abstract: Respiratory syncytial virus (RSV) is the single most important cause of severe respiratory infection in very young infants. It has also been recently recognized as a significant cause of severe illness in elderly adults, those with underlying ... ...

    Abstract Respiratory syncytial virus (RSV) is the single most important cause of severe respiratory infection in very young infants. It has also been recently recognized as a significant cause of severe illness in elderly adults, those with underlying cardiopulmonary disease, and the immunocompromised. RSV is suspected of playing a major role in the development of asthma. Prophylaxis in high-risk infants using a monoclonal antibody is the only effective specific therapy available but recent breakthroughs in vaccine design and antiviral drugs offer the promise of effective prophylactic and therapeutic agents against RSV.
    MeSH term(s) Adolescent ; Adult ; Antiviral Agents/therapeutic use ; Child ; Child, Preschool ; Humans ; Infant ; Infant, Newborn ; Respiratory Syncytial Virus Infections/diagnosis ; Respiratory Syncytial Virus Infections/pathology ; Young Adult
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2016-12-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2016.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Predicting anterior cruciate ligament failure load with T

    Flannery, Sean W / Beveridge, Jillian E / Proffen, Benedikt L / Walsh, Edward G / Kramer, Dennis E / Murray, Martha M / Kiapour, Ata M / Fleming, Braden C

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 3524

    Abstract: Non-invasive methods to document healing anterior cruciate ligament (ACL) structural properties could potentially identify patients at risk for revision surgery. The objective was to evaluate machine learning models to predict ACL failure load from ... ...

    Abstract Non-invasive methods to document healing anterior cruciate ligament (ACL) structural properties could potentially identify patients at risk for revision surgery. The objective was to evaluate machine learning models to predict ACL failure load from magnetic resonance images (MRI) and to determine if those predictions were related to revision surgery incidence. It was hypothesized that the optimal model would demonstrate a lower mean absolute error (MAE) than the benchmark linear regression model, and that patients with a lower estimated failure load would have higher revision incidence 2 years post-surgery. Support vector machine, random forest, AdaBoost, XGBoost, and linear regression models were trained using MRI T
    MeSH term(s) Animals ; Humans ; Swine ; Anterior Cruciate Ligament/diagnostic imaging ; Anterior Cruciate Ligament/surgery ; Prospective Studies ; Reoperation ; Swine, Miniature ; Machine Learning ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-03-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-30637-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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