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  1. Article ; Online: Recurrent Neuralgic Amyotrophy With Bilateral Diaphragm Paralysis: A Case Report.

    Tankere, Pierre / Georges, Marjolaine / Bonniaud, Philippe / Rabec, Claudio

    Archivos de bronconeumologia

    2023  Volume 59, Issue 9, Page(s) 595–596

    MeSH term(s) Humans ; Brachial Plexus Neuritis/complications ; Diaphragm/diagnostic imaging ; Paralysis/etiology ; Respiratory Paralysis/etiology
    Language Spanish
    Publishing date 2023-07-04
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2023.06.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Is COVID-19 Infection a Multiorganic Disease? Focus on Extrapulmonary Involvement of SARS-CoV-2.

    Duloquin, Gauthier / Pommier, Thibaut / Georges, Marjolaine / Giroud, Maurice / Guenancia, Charles / Béjot, Yannick / Laurent, Gabriel / Rabec, Claudio

    Journal of clinical medicine

    2024  Volume 13, Issue 5

    Abstract: First described in December 2019 in Wuhan (China), COVID-19 disease rapidly spread worldwide, constituting the biggest pandemic in the last 100 years. Even if SARS-CoV-2, the agent responsible for COVID-19, is mainly associated with pulmonary injury, ... ...

    Abstract First described in December 2019 in Wuhan (China), COVID-19 disease rapidly spread worldwide, constituting the biggest pandemic in the last 100 years. Even if SARS-CoV-2, the agent responsible for COVID-19, is mainly associated with pulmonary injury, evidence is growing that this virus can affect many organs, including the heart and vascular endothelial cells, and cause haemostasis, CNS, and kidney and gastrointestinal tract abnormalities that can impact in the disease course and prognosis. In fact, COVID-19 may affect almost all the organs. Hence, SARS-CoV-2 is essentially a systemic infection that can present a large number of clinical manifestations, and it is variable in distribution and severity, which means it is potentially life-threatening. The goal of this comprehensive review paper in the series is to give an overview of non-pulmonary involvement in COVID-19, with a special focus on underlying pathophysiological mechanisms and clinical presentation.
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13051397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Respiratory support in patients with COVID-19 (outside ICU)

    Rabec, Claudio / Gonzalez-Bermejo, Jesus

    Respir Med Res

    Abstract: Abstract With first cases noted towards the end of 2019 in China, COVID19 infection was rapidly become a devastating pandemic. Even if most patients present with a mild to moderate form of the disease, the estimated prevalence of COVID19-related severe ... ...

    Abstract Abstract With first cases noted towards the end of 2019 in China, COVID19 infection was rapidly become a devastating pandemic. Even if most patients present with a mild to moderate form of the disease, the estimated prevalence of COVID19-related severe acute respiratory failure (ARF) is 15-20% and 2-12% needed intubation and mechanical ventilation. In addition to mechanical ventilation some other techniques of respiratory support could be used in some forms of COVID19 related ARF. This position paper of the Respiratory Support and Chronic Care Group of the French Society of Respiratory Diseases is intended to help respiratory clinicians involved in care of COVID19 pandemic in the rational use of non-invasive techniques such as oxygen therapy, CPAP, non-invasive ventilation and high flow oxygen therapy in managing patients outside ICU. The aims are: 1) to focus both on the place of each technique and in describing practical tips (types of devices and circuit assemblies) aimed to limit the risk of caregivers when using those techniques at high risk spreading of viral particles. 2) to propose a step-by-step strategy to manage ARF outside ICU
    Keywords covid19
    Publisher Elsevier; PMC; WHO
    Document type Article ; Online
    Note WHO #Covidence: #401399
    DOI 10.1016/j.resmer.2020.100768
    Database COVID19

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  4. Article: Monitoring Long Term Noninvasive Ventilation: Benefits, Caveats and Perspectives.

    Janssens, Jean-Paul / Cantero, Chloé / Pasquina, Patrick / Georges, Marjolaine / Rabec, Claudio

    Frontiers in medicine

    2022  Volume 9, Page(s) 874523

    Abstract: Long term noninvasive ventilation (LTNIV) is a recognized treatment for chronic hypercapnic respiratory failure (CHRF). COPD, obesity-hypoventilation syndrome, neuromuscular disorders, various restrictive disorders, and patients with sleep-disordered ... ...

    Abstract Long term noninvasive ventilation (LTNIV) is a recognized treatment for chronic hypercapnic respiratory failure (CHRF). COPD, obesity-hypoventilation syndrome, neuromuscular disorders, various restrictive disorders, and patients with sleep-disordered breathing are the major groups concerned. The purpose of this narrative review is to summarize current knowledge in the field of monitoring during home ventilation. LTNIV improves symptoms related to CHRF, diurnal and nocturnal blood gases, survival, and health-related quality of life. Initially, patients with LTNIV were most often followed through elective short in-hospital stays to ensure patient comfort, correction of daytime blood gases and nocturnal oxygenation, and control of nocturnal respiratory events. Because of the widespread use of LTNIV, elective in-hospital monitoring has become logistically problematic, time consuming, and costly. LTNIV devices presently have a built-in software which records compliance, leaks, tidal volume, minute ventilation, cycles triggered and cycled by the patient and provides detailed pressure and flow curves. Although the engineering behind this information is remarkable, the quality and reliability of certain signals may vary. Interpretation of the curves provided requires a certain level of training. Coupling ventilator software with nocturnal pulse oximetry or transcutaneous capnography performed at the patient's home can however provide important information and allow adjustments of ventilator settings thus potentially avoiding hospital admissions. Strategies have been described to combine different tools for optimal detection of an inefficient ventilation. Recent devices also allow adapting certain parameters at a distance (pressure support, expiratory positive airway pressure, back-up respiratory rate), thus allowing progressive changes in these settings for increased patient comfort and tolerance, and reducing the requirement for in-hospital titration. Because we live in a connected world, analyzing large groups of patients through treatment of "big data" will probably improve our knowledge of clinical pathways of our patients, and factors associated with treatment success or failure, adherence and efficacy. This approach provides a useful add-on to randomized controlled studies and allows generating hypotheses for better management of HMV.
    Language English
    Publishing date 2022-05-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.874523
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  5. Article ; Online: Residual upper airway obstruction during nocturnal noninvasive ventilation despite high positive expiratory pressure. Impact of oronasal mask to nasal mask switch.

    Tankéré, Pierre / Georges, Marjolaine / Abdulmalak, Caroline / Schenesse, Deborah / Beltramo, Guillaume / Berrier, Amaury / Bonniaud, Philippe / Rabec, Claudio

    Respiratory medicine and research

    2023  Volume 85, Page(s) 101083

    Abstract: Background: Nasal mask (NM) and oronasal masks (OM) can be used to provide noninvasive ventilation (NIV). Recent studies suggested that OM is the most used interface and that there is no difference in efficacy or in tolerance between OM and NM for ... ...

    Abstract Background: Nasal mask (NM) and oronasal masks (OM) can be used to provide noninvasive ventilation (NIV). Recent studies suggested that OM is the most used interface and that there is no difference in efficacy or in tolerance between OM and NM for chronic use. However, studies focusing on video laryngoscopy underlined the impact of OM in residual upper airway obstruction (UAO) under NIV. We sought to assess the real-life practice of switching from OM to NM when UAO events persist despite high EPAP levels.
    Methods: In an open-label single center prospective cohort study, data from files and full night polysomnography on NM and OM were collected for patients wearing OM and presenting an UAO index ≥15/h despite an EPAP level ≥ 10 cmH20.
    Results: Forty-four patients were included in the study. In 31 patients (74 %), switching to a NM reduced UAOi to ≥10/h. Interestingly, 92 % of these patients still had NM at 3 to 12 months of follow-up. Switching to a NM was also associated with a trend in paCO2 reduction and significant improvements in Epworth, sleep quality and NIV compliance. Successful interface switching was significantly associated with female gender, and a trend was observed in non-smokers.
    Conclusion: As for CPAP, switching to a NM improved NIV efficacy in a selected group of patients presenting residual UAO events despite high EPAP levels. Additionally, this switch has an impact on compliance and subjective sleepiness. Thus, in patients with persisting UAO on OM, switching to a NM could be a first-line intervention before considering further investigation such as polygraphy or video laryngoscopy. We also derive an algorithm for mask allocation and adaptation in acute and chronic NIV use.
    Language English
    Publishing date 2023-12-25
    Publishing country France
    Document type Journal Article
    ISSN 2590-0412
    ISSN (online) 2590-0412
    DOI 10.1016/j.resmer.2023.101083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: One Plus One Might not make Two: Patient-Ventilator Interaction in Non-Invasive Ventilation. Who Does What?

    Rabec, Claudio / Sayas, Javier / Luján, Manel

    Archivos de bronconeumologia

    2019  Volume 55, Issue 8, Page(s) 403–406

    Title translation Uno más uno pueden no ser dos: interacción paciente-ventilador en ventilación no invasiva. ¿Quién hace qué?
    MeSH term(s) Humans ; Noninvasive Ventilation ; Respiration ; Respiratory Muscles/physiology
    Language Spanish
    Publishing date 2019-03-04
    Document type Editorial
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2019.01.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Home NIV treatment quality in patients with chronic respiratory failure having participated to the French nationwide telemonitoring experimental program (The TELVENT study).

    Pontier-Marchandise, Sandrine / Texereau, Joelle / Prigent, Arnaud / Gonzalez-Bermejo, Jésus / Rabec, Claudio / Gagnadoux, Frédéric / Letierce, Alexia / Winck, Joao Carlos

    Respiratory medicine and research

    2023  Volume 84, Page(s) 101028

    Abstract: Background: The ETAPES program is a national telemedicine experiment conducted in France between 2018 and 2023 to investigate whether home non-invasive ventilation (NIV) telemonitoring improves healthcare pathways in patients with chronic respiratory ... ...

    Abstract Background: The ETAPES program is a national telemedicine experiment conducted in France between 2018 and 2023 to investigate whether home non-invasive ventilation (NIV) telemonitoring improves healthcare pathways in patients with chronic respiratory failure (CRF) and impacts healthcare organization. The program provides a combination of therapeutic education and NIV telemonitoring with data processed by an algorithm generating alerts. The TELVENT study objective was to analyze the evolution of ventilation quality in patients included in the ETAPES program.
    Methods: Multicentric cohort study on patients undergoing long-term NIV included in the ETAPES program between September 2018 and December 2020 and who did not refuse the use of their data for this research. Data were obtained from homecare provider databases. The primary endpoint was to attain successful NIV treatment, which was determined by a combination of daily NIV usage for > 4 h per day, low leaks, and a low apnea-hypopnea index (AHI) identified by the NIV device. Respiratory disability was assessed using the DIRECT questionnaire.
    Results: 329 patients were included in the study of which 145 had COPD and 83 had started NIV and ETAPES within one-month delay. Approximately 25% of patients did not achieve the criteria for successful NIV at ETAPES entry. The proportion of patients with successful NIV treatment increased to 86.8% at six months (p = 0.003, Cochran-Armitage trend test) regardless of NIV history and continued to increase at 12 months in newly equipped NIV patients (93.8%, at month 12, p = 0.0026 for trend test). Over time, a significant increase in NIV use and compliance was observed, while AHI significantly decreased in the overall population. No significant decrease was observed for non-intentional leaks. Approximately 4.9 alerts were generated per patient per 6 months. Their number and type (low NIV use, high AHI or leaks) differed among patients based on their NIV history. Respiratory disability score decreased over time compared with baseline.
    Conclusion: The TELVENT study highlights the importance of remote NIV monitoring to rapidly identify patients with unsuccessful ventilation. The combination of remote monitoring and therapeutic education may improve the quality of home NIV, especially in the first months of treatment.
    MeSH term(s) Humans ; Noninvasive Ventilation/adverse effects ; Cohort Studies ; Respiratory Insufficiency/therapy ; Respiratory Insufficiency/etiology ; Lung ; Acidosis, Respiratory/etiology
    Language English
    Publishing date 2023-05-25
    Publishing country France
    Document type Journal Article
    ISSN 2590-0412
    ISSN (online) 2590-0412
    DOI 10.1016/j.resmer.2023.101028
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  8. Article: Outcomes in Patients with Acute Myocardial Infarction and Known Sleep Apnea: A Nationwide Analysis.

    Rabec, Claudio / Sombrun, Chan / Bentounes, Sid Ahmed / Georges, Marjolaine / Bisson, Arnaud / Bichat, Florence / Bodin, Alexandre / Herbert, Julien / Zeller, Marianne / Cottin, Yves / Fauchier, Laurent

    Journal of clinical medicine

    2023  Volume 12, Issue 18

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2023-09-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12185924
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  9. Article ; Online: Monitoring Long Term Noninvasive Ventilation

    Jean-Paul Janssens / Chloé Cantero / Patrick Pasquina / Marjolaine Georges / Claudio Rabec

    Frontiers in Medicine, Vol

    Benefits, Caveats and Perspectives

    2022  Volume 9

    Abstract: Long term noninvasive ventilation (LTNIV) is a recognized treatment for chronic hypercapnic respiratory failure (CHRF). COPD, obesity-hypoventilation syndrome, neuromuscular disorders, various restrictive disorders, and patients with sleep-disordered ... ...

    Abstract Long term noninvasive ventilation (LTNIV) is a recognized treatment for chronic hypercapnic respiratory failure (CHRF). COPD, obesity-hypoventilation syndrome, neuromuscular disorders, various restrictive disorders, and patients with sleep-disordered breathing are the major groups concerned. The purpose of this narrative review is to summarize current knowledge in the field of monitoring during home ventilation. LTNIV improves symptoms related to CHRF, diurnal and nocturnal blood gases, survival, and health-related quality of life. Initially, patients with LTNIV were most often followed through elective short in-hospital stays to ensure patient comfort, correction of daytime blood gases and nocturnal oxygenation, and control of nocturnal respiratory events. Because of the widespread use of LTNIV, elective in-hospital monitoring has become logistically problematic, time consuming, and costly. LTNIV devices presently have a built-in software which records compliance, leaks, tidal volume, minute ventilation, cycles triggered and cycled by the patient and provides detailed pressure and flow curves. Although the engineering behind this information is remarkable, the quality and reliability of certain signals may vary. Interpretation of the curves provided requires a certain level of training. Coupling ventilator software with nocturnal pulse oximetry or transcutaneous capnography performed at the patient's home can however provide important information and allow adjustments of ventilator settings thus potentially avoiding hospital admissions. Strategies have been described to combine different tools for optimal detection of an inefficient ventilation. Recent devices also allow adapting certain parameters at a distance (pressure support, expiratory positive airway pressure, back-up respiratory rate), thus allowing progressive changes in these settings for increased patient comfort and tolerance, and reducing the requirement for in-hospital titration. Because we live in a connected world, analyzing large groups of ...
    Keywords non-invasive ventilation ; chronic hypercapnic respiratory failure ; monitoring ; home ventilation ; long term mechanical ventilation ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Growth of home respiratory equipment from 2006 to 2019 and cost control by health policies.

    Ribeiro Baptista, Bruno / Baptiste, Amandine / Granger, Benjamin / Villemain, Aurélie / Ohayon, Raphaëlle / Rabec, Claudio / Chabot, François / Gonzalez-Bermejo, Jésus

    Respiratory medicine and research

    2022  Volume 82, Page(s) 100930

    Abstract: Background: Home respiratory equipment (HRE) designed for the management of chronic respiratory failure includes oxygen therapy (O: Methods: The French open access national health insurance aggregated data was used to estimate the evolution of theses ...

    Abstract Background: Home respiratory equipment (HRE) designed for the management of chronic respiratory failure includes oxygen therapy (O
    Methods: The French open access national health insurance aggregated data was used to estimate the evolution of theses parameters from 2006 to 2019.
    Results: The number of patients treated by HRE increased by 117% between 2006 and 2019, reaching a total of 245,896 patients (367/100,000). Prescriptions for O
    Conclusion: Our results highlighted the high rate of HRE prescription, but with cost control as a result of adapted health policies.
    MeSH term(s) Humans ; Respiratory Insufficiency/epidemiology ; Respiratory Insufficiency/therapy ; Noninvasive Ventilation/methods ; Oxygen ; Cost Control ; Health Policy
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-06-11
    Publishing country France
    Document type Journal Article
    ISSN 2590-0412
    ISSN (online) 2590-0412
    DOI 10.1016/j.resmer.2022.100930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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