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  1. Article ; Online: The Romanian Journal of Cardiology on the path to becoming an international journal

    Ginghina Carmen

    Romanian Journal of Cardiology, Vol 32, Iss 1, Pp 1-

    2022  Volume 1

    Keywords Internal medicine ; RC31-1245
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: An extended tenure, new expectations and aspirations. A welcome editorial

    Carmen Ginghina

    Romanian Journal of Cardiology, Vol 31, Iss 1, Pp 1-

    2021  Volume 2

    Keywords Internal medicine ; RC31-1245
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Blood Rheology Alterations in Patients with Cardiovascular Diseases.

    Valeanu, Liana / Ginghina, Carmen / Bubenek-Turconi, Serban

    Romanian journal of anaesthesia and intensive care

    2022  Volume 28, Issue 2, Page(s) 41–46

    Abstract: Blood rheology is an important determinant of blood flow but is probably one of the most neglected areas in clinical literature and practice. Blood viscosity changes according to shear rates and depends on cellular and plasma factors. RBCs' aggregability ...

    Abstract Blood rheology is an important determinant of blood flow but is probably one of the most neglected areas in clinical literature and practice. Blood viscosity changes according to shear rates and depends on cellular and plasma factors. RBCs' aggregability and deformability are the main determinants of local flow characteristics in areas with lower and higher shear rates, but plasma viscosity is the main regulatory factor of flow resistance in the microcirculation. In individuals with altered blood rheology, the mechanical stress to vascular walls induces endothelial injury and vascular remodelling, and promotes atherosclerosis. Increased values of whole blood viscosity and plasma viscosity are correlated with cardiovascular risk factors and adverse cardiovascular events. The long-term effects of physical exercise can produce a hemorheological fitness that protects against cardiovascular diseases.
    Language English
    Publishing date 2022-12-29
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2977912-1
    ISSN 2502-0307 ; 2392-7518
    ISSN (online) 2502-0307
    ISSN 2392-7518
    DOI 10.2478/rjaic-2021-0007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Liquid biopsy in lung cancer management.

    Irofei Zamfir, Maria Anca / Buburuzan, Laura / Hudiţă, Ariana / Gălăţeanu, Bianca / Ginghină, Octav / Ion, Daniel / Motaş, Natalia / Ardeleanu, Carmen Maria / Costache, Marieta

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

    2022  Volume 63, Issue 1, Page(s) 31–38

    Abstract: Liquid biopsy is a promising tool for a better cancer management and currently opens perspectives for several clinical applications, such as detection of mutations when the analysis from tissue is not available, monitoring tumor mutational burden and ... ...

    Abstract Liquid biopsy is a promising tool for a better cancer management and currently opens perspectives for several clinical applications, such as detection of mutations when the analysis from tissue is not available, monitoring tumor mutational burden and prediction of targeted therapy response. These characteristics validate liquid biopsy analysis as a strong cancer biomarkers source with high potential for improving cancer patient's evolution. Compared to classical biopsy, liquid biopsy is a minimal invasive procedure, and it allows the real-time monitoring of treatment response. Considering that lung cancer is the most common cause of cancer-associated death worldwide and that only 15-19% of the lung cancer patients survive five years after diagnosis, there is an important interest in improving its management. Like in other types of solid cancers, lung cancer could benefit from liquid biopsy through a simple peripheral blood sample as tumor-related biomarkers, such as circulating tumor cells (CTCs), cell-free nucleic acids (cfNA) [cell-free ribonucleic acid (cfRNA) and cell-free deoxyribonucleic acid (cfDNA)], exosomes and tumor-educated platelets (TEPs) may shed into circulation because of necrosis or in an active manner. More, the detection and analysis of these biomarkers could lead to a better understanding of oncological diseases like lung cancer. The better the tumor profile is established; the better management is possible. However, this approach has currently some limitations, such as low cfNA concentration or low count of CTCs that might be overcome by improving the actual methods and technologies.
    MeSH term(s) Biomarkers, Tumor/genetics ; Cell-Free Nucleic Acids/genetics ; Humans ; Liquid Biopsy/methods ; Lung Neoplasms/pathology ; Neoplastic Cells, Circulating/pathology
    Chemical Substances Biomarkers, Tumor ; Cell-Free Nucleic Acids
    Language English
    Publishing date 2022-09-26
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 1062519-7
    ISSN 2066-8279 ; 1220-0522 ; 0035-4007
    ISSN (online) 2066-8279
    ISSN 1220-0522 ; 0035-4007
    DOI 10.47162/RJME.63.1.02
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1105: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: The Coandă effect in cardiology.

    Ginghină, Carmen

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2007  Volume 8, Issue 6, Page(s) 411–413

    Abstract: Many of the current technologies used today in clinical practice owe their lives to physicians. Coandă effect was originally described by the romanian scientist as a phenomenon with application in aerodynamics, the main field of interest for Henri Coandă. ...

    Abstract Many of the current technologies used today in clinical practice owe their lives to physicians. Coandă effect was originally described by the romanian scientist as a phenomenon with application in aerodynamics, the main field of interest for Henri Coandă. He made the observation that a thin liquid jet, passing through a narrow channel which is followed by a curved surface, deviates according to the surface' shape, adhering to it. The description of the phenomenon and a possible explanation was found in a patent registrated in France, in 1934. It is interesting how a physical phenomenon described 70 years ago has found its clear demonstration and real time visualization on color Doppler flow mapping. Coandă effect influences jet size and color encoding, determining (for eccentric jets) smaller color Doppler jet areas, greater variance and reverse velocity encoding. The phenomenon may alter the interpretation of color Doppler images and needs to be taken into account for an appropriate echocardiography assessment of valvular regurgitation and other abnormal flows.
    MeSH term(s) Cardiovascular Diseases/diagnosis ; Echocardiography, Doppler, Color ; Hemorheology ; Humans
    Language English
    Publishing date 2007-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/01.JCM.0000269720.25812.55
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5210: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 559: Show issues

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  6. Article ; Online: A view from Bucharest.

    Ginghinã, Carmen

    Circulation

    2006  Volume 113, Issue 3, Page(s) f9–10

    MeSH term(s) Academic Medical Centers ; Cardiology/manpower ; Cardiology/trends ; Cardiovascular Diseases/therapy ; Humans ; Romania
    Language English
    Publishing date 2006-01-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.60: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Hemodynamic Monitoring in Sepsis-A Conceptual Framework of Macro- and Microcirculatory Alterations.

    Valeanu, Liana / Bubenek-Turconi, Serban-Ion / Ginghina, Carmen / Balan, Cosmin

    Diagnostics (Basel, Switzerland)

    2021  Volume 11, Issue 9

    Abstract: Circulatory failure in sepsis is common and places a considerable burden on healthcare systems. It is associated with an increased likelihood of mortality, and timely recognition is a prerequisite to ensure optimum results. While there is consensus that ... ...

    Abstract Circulatory failure in sepsis is common and places a considerable burden on healthcare systems. It is associated with an increased likelihood of mortality, and timely recognition is a prerequisite to ensure optimum results. While there is consensus that aggressive source control, adequate antimicrobial therapy and hemodynamic management constitute crucial determinants of outcome, discussion remains about the best way to achieve each of these core principles. Sound cardiovascular support rests on tailored fluid resuscitation and vasopressor therapy. To this end, an overarching framework to improve cardiovascular dynamics has been a recurring theme in modern critical care. The object of this review is to examine the nature of one such framework that acknowledges the growing importance of adaptive hemodynamic support combining macro- and microhemodynamic variables to produce adequate tissue perfusion.
    Language English
    Publishing date 2021-08-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics11091559
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  8. Article: Electrocardiographic and Echocardiographic Predictors of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy.

    Mandeş, Leonard / Roşca, Monica / Ciupercă, Daniela / Călin, Andreea / Beladan, Carmen C / Enache, Roxana / Cuculici, Andreea / Băicuş, Cristian / Jurcuţ, Ruxandra / Ginghină, Carmen / Popescu, Bogdan A

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 905128

    Abstract: Background: Patients with hypertrophic cardiomyopathy (HCM) have an increased prevalence of atrial fibrillation (AF) compared to the general population, and left atrium (LA) remodeling is strongly correlated with the risk of AF. This prospective, ... ...

    Abstract Background: Patients with hypertrophic cardiomyopathy (HCM) have an increased prevalence of atrial fibrillation (AF) compared to the general population, and left atrium (LA) remodeling is strongly correlated with the risk of AF. This prospective, monocentric study aimed to assess the role of LA electrocardiographic and echocardiographic (structural and functional) parameters in predicting the risk for incident AF in patients with HCM.
    Methods and results: The study population consisted of 126 HCM patients in sinus rhythm (52.6 ± 16.2 years, 54 men), 118 of them without documented AF. During a median follow-up of 56 (7-124) months, 39 (30.9%) developed a new episode of AF. Multivariable analysis showed that LA booster pump function (assessed by ASr, HR = 4.24, CI = 1.84-9.75, and
    Conclusion: Left atrium booster pump function (ASr) and electrical dispersion (Pd) are related to the risk of incident AF in HCM patients. These parameters can provide further stratification of the risk for AF in this setting, including in patients considered at lower risk for AF based on the conventional assessment of LA size.
    Language English
    Publishing date 2022-05-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.905128
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  9. Article ; Online: Hemodynamic Monitoring in Sepsis—A Conceptual Framework of Macro- and Microcirculatory Alterations

    Liana Valeanu / Serban-Ion Bubenek-Turconi / Carmen Ginghina / Cosmin Balan

    Diagnostics, Vol 11, Iss 1559, p

    2021  Volume 1559

    Abstract: Circulatory failure in sepsis is common and places a considerable burden on healthcare systems. It is associated with an increased likelihood of mortality, and timely recognition is a prerequisite to ensure optimum results. While there is consensus that ... ...

    Abstract Circulatory failure in sepsis is common and places a considerable burden on healthcare systems. It is associated with an increased likelihood of mortality, and timely recognition is a prerequisite to ensure optimum results. While there is consensus that aggressive source control, adequate antimicrobial therapy and hemodynamic management constitute crucial determinants of outcome, discussion remains about the best way to achieve each of these core principles. Sound cardiovascular support rests on tailored fluid resuscitation and vasopressor therapy. To this end, an overarching framework to improve cardiovascular dynamics has been a recurring theme in modern critical care. The object of this review is to examine the nature of one such framework that acknowledges the growing importance of adaptive hemodynamic support combining macro- and microhemodynamic variables to produce adequate tissue perfusion.
    Keywords sepsis ; shock ; hemodynamic ; monitoring ; macrocirculation ; microcirculation ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Right ventricle to pulmonary artery coupling after transcatheter aortic valve implantation-Determinant factors and prognostic impact.

    Parasca, Catalina A / Calin, Andreea / Cadil, Deniz / Mateescu, Anca / Rosca, Monica / Botezatu, Simona Beatrice / Enache, Roxana / Beladan, Carmen / Ginghina, Carmen / Deleanu, Dan / Chioncel, Ovidiu / Bubenek-Turconi, Serban / Iliescu, Vlad A / Popescu, Bogdan A

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1150039

    Abstract: Introduction: Right ventricular (RV) dysfunction and pulmonary hypertension (PH) have been previously associated with unfavorable outcomes in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI), but little ...

    Abstract Introduction: Right ventricular (RV) dysfunction and pulmonary hypertension (PH) have been previously associated with unfavorable outcomes in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI), but little is known about the effect of right ventricle (RV) to pulmonary artery (PA) coupling. Our study aimed to evaluate the determinant factors and the prognostic value of RV-PA coupling in patients undergoing TAVI.
    Methods: One hundred sixty consecutive patients with severe AS were prospectively enrolled, between September 2018 and May 2020. They underwent a comprehensive echocardiogram before and 30 days after TAVI, including speckle tracking echocardiography (STE) for myocardial deformation analysis of the left ventricle (LV), left atrium (LA), and RV function. Complete data on myocardial deformation was available in 132 patients (76.6 ± 7.5 years, 52.5% men) who formed the final study population. The ratio of RV free wall longitudinal strain (RV-FWLS) to PA systolic pressure (PASP) was used as an estimate of RV-PA coupling. Patients were analyzed according to baseline RV-FWLS/PASP cut-off point, determined through time-dependent ROC curve analysis, as follows: normal RV-PA coupling group (RV-FWLS/PASP ≥0.63,
    Results: A significant improvement of RV-PA coupling was observed early after TAVI (0.75 ± 0.3 vs. 0.64 ± 0.3 before TAVI,
    Conclusion: Our results confirm that relief of aortic valve obstruction has beneficial effects on the baseline RV-PA coupling, and they occur early after TAVI. Despite significant improvement in LV, LA, and RV function after TAVI, RV-PA coupling remains impaired in some patients, it is mainly related to persistent pulmonary hypertension and is associated with adverse outcomes.
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1150039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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