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  1. Article ; Online: A shadow in the GOLD ABCD classification system: measurement of perception of symptoms in COPD.

    Crisafulli, Ernesto / Sartori, Giulia

    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

    2021  Volume 47, Issue 5, Page(s) e20210389

    MeSH term(s) Humans ; Perception ; Pulmonary Disease, Chronic Obstructive ; Spirometry
    Language Portuguese
    Publishing date 2021-12-01
    Publishing country Brazil
    Document type Editorial ; Comment
    ZDB-ID 2223157-2
    ISSN 1806-3756 ; 1806-3713
    ISSN (online) 1806-3756
    ISSN 1806-3713
    DOI 10.36416/1806-3756/e20210389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bronchodilator reversibility in patients with asthma and persistent airflow limitation.

    Crisafulli, Ernesto / Sartori, Giulia / Patruno, Vincenzo / Fantin, Alberto

    The Lancet. Respiratory medicine

    2022  Volume 10, Issue 11, Page(s) e94–e95

    MeSH term(s) Humans ; Bronchodilator Agents/therapeutic use ; Asthma/drug therapy ; Lung ; Forced Expiratory Volume
    Chemical Substances Bronchodilator Agents
    Language English
    Publishing date 2022-10-21
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(22)00363-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Autonomic nervous system alterations in patients with mild-to-moderate asthma: do not forget airflow obstruction! a lesson from COPD.

    Fantin, Alberto / Patruno, Vincenzo / Sartori, Giulia / Crisafulli, Ernesto

    The Journal of asthma : official journal of the Association for the Care of Asthma

    2022  Volume 60, Issue 5, Page(s) 1054–1055

    MeSH term(s) Humans ; Asthma ; Lung ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Autonomic Nervous System ; Forced Expiratory Volume ; Airway Obstruction
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603816-5
    ISSN 1532-4303 ; 0277-0903
    ISSN (online) 1532-4303
    ISSN 0277-0903
    DOI 10.1080/02770903.2022.2114085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Efficacy of Respiratory Muscle Training in the Immediate Postoperative Period of Cardiac Surgery: A Systematic Review and Meta-Analysis.

    Aquino, Tarcísio Nema de / Prado, João Paulo / Crisafulli, Ernesto / Clini, Enrico Maria / Galdino, Giovane

    Brazilian journal of cardiovascular surgery

    2024  Volume 39, Issue 1, Page(s) e20220165

    Abstract: Introduction: This study aimed to evaluate the efficacy of respiratory muscle training during the immediate postoperative period of cardiac surgery on respiratory muscle strength, pulmonary function, functional capacity, and length of hospital stay.: ... ...

    Abstract Introduction: This study aimed to evaluate the efficacy of respiratory muscle training during the immediate postoperative period of cardiac surgery on respiratory muscle strength, pulmonary function, functional capacity, and length of hospital stay.
    Methods: This is a systematic review and meta-analysis. A comprehensive search on PubMed®, Excerpta Medica Database (or Embase), Cumulative Index of Nursing and Allied Health Literature (or CINAHL), Latin American and Caribbean Health Sciences Literature (or LILACS), Scientific Electronic Library Online (or SciELO), Physiotherapy Evidence Database (or PEDro), and Cochrane Central Register of Controlled Trials databases was performed. A combination of free-text words and indexed terms referring to cardiac surgery, coronary artery bypass grafting, respiratory muscle training, and clinical trials was used. A total of 792 studies were identified; after careful selection, six studies were evaluated.
    Results: The studies found significant improvement after inspiratory muscle training (IMT) (n = 165, 95% confidence interval [CI] 9.68, 21.99) and expiratory muscle training (EMT) (n = 135, 95% CI 8.59, 27.07) of maximal inspiratory pressure and maximal expiratory pressure, respectively. Also, IMT increased significantly (95% CI 19.59, 349.82, n = 85) the tidal volume. However, no differences were found in the peak expiratory flow, functional capacity, and length of hospital stay after EMT and IMT.
    Conclusion: IMT and EMT demonstrated efficacy in improving respiratory muscle strength during the immediate postoperative period of cardiac surgery. There was no evidence indicating the efficacy of IMT for pulmonary function and length of hospital stay and the efficacy of EMT for functional capacity.
    MeSH term(s) Humans ; Cardiac Surgical Procedures ; Breathing Exercises ; Lung ; Coronary Artery Bypass ; Respiratory Muscles/physiology ; Muscle Strength/physiology
    Language English
    Publishing date 2024-02-05
    Publishing country Brazil
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2031026-2
    ISSN 1678-9741 ; 1678-9741
    ISSN (online) 1678-9741
    ISSN 1678-9741
    DOI 10.21470/1678-9741-2022-0165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The intriguing possibility of using probiotics in allergen-specific immunotherapy.

    Furci, Fabiana / Caminati, Marco / Crisafulli, Ernesto / Senna, Gianenrico / Gangemi, Sebastiano

    The World Allergy Organization journal

    2023  Volume 16, Issue 2, Page(s) 100751

    Abstract: Allergen immunotherapy (AIT) can be considered the etiological therapy for allergic rhinitis and hymenoptera venom allergy. Its role is increasingly emerging in the context of IgE mediated food allergy, where the achievement of tolerance, or the ... ...

    Abstract Allergen immunotherapy (AIT) can be considered the etiological therapy for allergic rhinitis and hymenoptera venom allergy. Its role is increasingly emerging in the context of IgE mediated food allergy, where the achievement of tolerance, or the permanent resolution of an allergy, represents the optimal goal of AIT. AIT treatment, indicated in adults and children with allergic rhinitis, has a preventative effect on the development of asthma and can also be used when asthma is associated to rhinitis; however, it is not the first choice for treatment of isolated asthma. While knowledge on immunological mechanisms, efficacy, and safety of AIT is known, an intriguing line of investigation has arisen on how the action of AIT is modulated by the use of probiotics, starting from awareness that the microbiome is altered in allergic conditions: the use of probiotics in inducing the stimulation of innate immunity via toll-like receptor activation, thus acting as adjuvants in AIT, is hereby examined. Therefore, by analyzing literature on AIT and probiotics, we intend to draw attention to how the role and use of AIT are emerging as being increasingly important for both the short- and long-term management of allergic diseases and how recourse probiotics may represent an additional therapeutic strategy to modulate the effectiveness of AIT. However, further investigations are needed to better identify which probiotics to use, the dosage, and the optimal duration to obtain correct immunomodulation, and how to best customize their use, including a "AIT + probiotics" strategy in the field of precision medicine.
    Language English
    Publishing date 2023-02-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2581968-9
    ISSN 1939-4551
    ISSN 1939-4551
    DOI 10.1016/j.waojou.2023.100751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Hospitalized acute exacerbations of chronic obstructive pulmonary disease: which patients may have a negative clinical outcome?

    Crisafulli, Ernesto / Torres, Antoni

    Expert review of respiratory medicine

    2019  Volume 13, Issue 8, Page(s) 691–693

    Language English
    Publishing date 2019-07-03
    Publishing country England
    Document type Editorial
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2019.1635459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Predicting poor prognosis in COPD patients: looking for a lamp lit in the darkness of the night.

    Crisafulli, Ernesto

    The European respiratory journal

    2014  Volume 43, Issue 6, Page(s) 1560–1562

    MeSH term(s) Dyspnea/complications ; Dyspnea/epidemiology ; Female ; Humans ; Male ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/epidemiology
    Language English
    Publishing date 2014-06
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/09031936.00045614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Endoscopic Technologies for Peripheral Pulmonary Lesions: From Diagnosis to Therapy.

    Fantin, Alberto / Manera, Massimiliano / Patruno, Vincenzo / Sartori, Giulia / Castaldo, Nadia / Crisafulli, Ernesto

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 2

    Abstract: Peripheral pulmonary lesions (PPLs) are frequent incidental findings in subjects when performing chest radiographs or chest computed tomography (CT) scans. When a PPL is identified, it is necessary to proceed with a risk stratification based on the ... ...

    Abstract Peripheral pulmonary lesions (PPLs) are frequent incidental findings in subjects when performing chest radiographs or chest computed tomography (CT) scans. When a PPL is identified, it is necessary to proceed with a risk stratification based on the patient profile and the characteristics found on chest CT. In order to proceed with a diagnostic procedure, the first-line examination is often a bronchoscopy with tissue sampling. Many guidance technologies have recently been developed to facilitate PPLs sampling. Through bronchoscopy, it is currently possible to ascertain the PPL's benign or malignant nature, delaying the therapy's second phase with radical, supportive, or palliative intent. In this review, we describe all the new tools available: from the innovation of bronchoscopic instrumentation (e.g., ultrathin bronchoscopy and robotic bronchoscopy) to the advances in navigation technology (e.g., radial-probe endobronchial ultrasound, virtual navigation, electromagnetic navigation, shape-sensing navigation, cone-beam computed tomography). In addition, we summarize all the PPLs ablation techniques currently under experimentation. Interventional pulmonology may be a discipline aiming at adopting increasingly innovative and disruptive technologies.
    Language English
    Publishing date 2023-01-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13020254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Do Patients with Bronchiectasis Have an Increased Risk of Developing Lung Cancer? A Systematic Review.

    Castaldo, Nadia / Fantin, Alberto / Manera, Massimiliano / Patruno, Vincenzo / Sartori, Giulia / Crisafulli, Ernesto

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 2

    Abstract: Background: Initial evidence supports the hypothesis that patients with non-cystic fibrosis bronchiectasis (NCFB) have a higher risk of lung cancer. We systematically reviewed the available literature to define the characteristics of lung malignancies ... ...

    Abstract Background: Initial evidence supports the hypothesis that patients with non-cystic fibrosis bronchiectasis (NCFB) have a higher risk of lung cancer. We systematically reviewed the available literature to define the characteristics of lung malignancies in patients with bronchiectasis and the characteristics of patients who develop bronchiectasis-associated lung cancer.
    Method: This study was performed based on the PRISMA guidelines. The review protocol was registered in PROSPERO.
    Results: The frequency rates of lung cancer in patients with NCFB ranged from 0.93% to 8.0%. The incidence rate was 3.96. Cancer more frequently occurred in the elderly and males. Three studies found an overall higher risk of developing lung cancer in the NCFB population compared to the non-bronchiectasis one, and adenocarcinoma was the most frequently reported histological type. The effect of the co-existence of NCFB and COPD was unclear.
    Conclusions: NCFB is associated with a higher risk of developing lung cancer than individuals without NCFB. This risk is higher for males, the elderly, and smokers, whereas concomitant COPD's effect is unclear.
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13020459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Association Between Rome Classification Among Hospitalized Patients With COPD Exacerbations and Short-Term and Intermediate-Term Outcomes.

    Crisafulli, Ernesto / Sartori, Giulia / Huerta, Arturo / Gabarrús, Albert / Fantin, Alberto / Soler, Néstor / Torres, Antoni

    Chest

    2023  Volume 164, Issue 6, Page(s) 1422–1433

    Abstract: Background: Recently, the Rome proposal updated the definition of exacerbation of COPD (ECOPD). However, such severity grade has not yet demonstrated intermediate-term clinical relevance.: Research question: What is the association between the Rome ... ...

    Abstract Background: Recently, the Rome proposal updated the definition of exacerbation of COPD (ECOPD). However, such severity grade has not yet demonstrated intermediate-term clinical relevance.
    Research question: What is the association between the Rome severity classification and short-term and intermediate-term clinical outcomes?
    Study design and methods: We retrospectively grouped hospitalized patients with ECOPD according to the Rome severity classification (ie, mild, moderate, severe). Baseline, clinical, microbiologic, gas analysis, and laboratory variables were collected. In addition, data about the length of hospital stay and mortality (in-hospital and a follow-up time line from 6 months until 3 years) were assessed.
    Results: Of the 347 hospitalized patients, 39% were categorized as mild, 31% were categorized as moderate, and 30% were categorized as severe. Overall, patients with severe ECOPD had an extended length of hospital stay. Although in-hospital mortality was similar among groups, patients with severe ECOPD presented a worse prognosis in all follow-up time points. The Kaplan-Meier curves show the role of the severe classification in the cumulative survival at 1 and 3 years (Gehan-Breslow-Wilcoxon test, P = .032 and P = .004, respectively). The multivariable Cox regression analysis showed a higher risk of death at 1 year when patients presented a severe (hazard ratio, 1.99; 95% CI, 1.49-2.65) or moderate grade (hazard ratio, 1.47; 95% CI, 1.10-1.97) compared with a mild grade. Older patients (aged ≥ 80 years), patients requiring long-term oxygen therapy, or patients reporting previous ECOPD episodes had a higher mortality risk. A BMI between 25 and 29 kg/m
    Interpretation: The Rome classification makes it possible to discriminate patients with a worse prognosis (severe or moderate) until a 3-year follow-up.
    MeSH term(s) Humans ; Retrospective Studies ; Rome/epidemiology ; Pulmonary Disease, Chronic Obstructive/complications ; Length of Stay ; Prognosis ; Disease Progression
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.07.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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