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  1. Article ; Online: Flexible active-site loops fine-tune substrate specificity of hyperthermophilic metallo-oxidases.

    Brissos, Vânia / Borges, Patrícia T / Sancho, Ferran / Lucas, Maria Fátima / Frazão, Carlos / Conzuelo, Felipe / Martins, Lígia O

    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry

    2024  

    Abstract: ... and ferrous ions. In this work, directed evolution was used to expand the substrate specificity of P ...

    Abstract Hyperthermophilic ('superheat-loving') archaea found in high-temperature environments such as Pyrobaculum aerophilum contain multicopper oxidases (MCOs) with remarkable efficiency for oxidizing cuprous and ferrous ions. In this work, directed evolution was used to expand the substrate specificity of P. aerophilum McoP for organic substrates. Six rounds of error-prone PCR and DNA shuffling followed by high-throughput screening lead to the identification of a hit variant with a 220-fold increased efficiency (k
    Language English
    Publishing date 2024-01-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1464026-0
    ISSN 1432-1327 ; 0949-8257
    ISSN (online) 1432-1327
    ISSN 0949-8257
    DOI 10.1007/s00775-023-02040-y
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  2. Article ; Online: Peripheral and intestinal T lymphocyte subsets in dogs with chronic inflammatory enteropathy.

    Agulla, Beatriz / Villaescusa, Alejandra / Sainz, Ángel / Díaz-Regañón, David / Rodríguez-Franco, Fernando / Calleja-Bueno, Lydia / Olmeda, Patricia / García-Sancho, Mercedes

    Journal of veterinary internal medicine

    2024  

    Abstract: ... lymphocytes (87/μL [18-273] CIE, 44/μL [16-162] healthy control (HC, P = .013) and regulatory T cells (Treg ... 07-0.85] HC, P = .003). Conversely, higher percentage of activated T cytotoxic cells (20.24% [3.12-77 ... 12] CIE, 12.32% [1.21-39.22] HC, P = .04) and interferon-gamma (IFN-γ) producing T lymphocytes (7.36 ...

    Abstract Background: Dysregulated T lymphocyte response is thought to play a key role in chronic intestinal inflammation (CIE).
    Objectives: To evaluate the presence of changes in peripheral and intestinal T lymphocyte subsets and to describe potential immune and inflammatory biomarkers in dogs with CIE.
    Animals: Sixteen healthy dogs and 26 dogs were diagnosed with CIE.
    Methods: Prospective case-control study evaluating peripheral and intestinal T lymphocytes using flow cytometry and inflammatory markers obtained from complete blood cell counts.
    Results: Dogs with CIE had higher peripheral activated T helper (Th) lymphocytes (87/μL [18-273] CIE, 44/μL [16-162] healthy control (HC, P = .013) and regulatory T cells (Treg; 108/μL [2-257] CIE, 34/μL [1-114] HC, P = .004). In the intestinal epithelium, CIE dogs presented lower percentages of Th (4.55% [1.75-18.67] CIE, 8.77% [3.79-25.03] HC, P = .002), activated Th cells (0.16% [0.02-0.83] CIE, 0.33% [0.05-0.57] HC, P = .03) and CD4/CD8 ratio (0.08 [0.02-0.39] CIE, 0.21 [0.07-0.85] HC, P = .003). Conversely, higher percentage of activated T cytotoxic cells (20.24% [3.12-77.12] CIE, 12.32% [1.21-39.22] HC, P = .04) and interferon-gamma (IFN-γ) producing T lymphocytes (7.36% [0.63-55.83] CIE, 1.44% [0.00-10.56] HC, P = .01) within the epithelium was observed. In the lamina propria the percentage of Treg lymphocytes was higher (6.02% [1.00-21.48] CIE, 3.52% [0.18-10.52] HC, P = .02).
    Conclusions and clinical importance: Systemic and intestinal immune alterations occur in dogs with CIE suggesting that blood IFN-γ producing T lymphocytes and the systemic immune-inflamation index (SII) could potentially serve as biomarkers for the disease.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 92798-3
    ISSN 1939-1676 ; 0891-6640
    ISSN (online) 1939-1676
    ISSN 0891-6640
    DOI 10.1111/jvim.17036
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    Zs.A 4095: Show issues Location:
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  3. Article ; Online: Respiratory physiotherapy with Vibration belts in the critical patient Covid-19 in the prone position.

    Sancho, P T / Gandarias, P A / González, R S / Gurumeta, A A

    Revista espanola de anestesiologia y reanimacion

    2020  Volume 67, Issue 8, Page(s) 481–482

    Title translation Fisioterapia respiratoria con cinturones de vibración en el paciente crítico COVID-19 en posición de prono.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Critical Illness ; Humans ; Oxygen Inhalation Therapy/methods ; Pandemics ; Partial Pressure ; Patient Positioning ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; Prone Position/physiology ; Respiration, Artificial ; Respiratory Therapy/instrumentation ; Respiratory Therapy/methods ; SARS-CoV-2 ; Sputum ; Supine Position/physiology ; Vibration/therapeutic use
    Keywords covid19
    Language Spanish
    Publishing date 2020-07-09
    Document type Letter
    ISSN 2341-1929
    ISSN (online) 2341-1929
    DOI 10.1016/j.redar.2020.06.014
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  4. Article ; Online: Respiratory physiotherapy with vibration belts in the critical patient Covid-19 in the prone position

    Sancho, P.T. / Gandarias, P.A. / González, R.S. / Gurumeta, A.A.

    Revista Española de Anestesiología y Reanimación (English Edition)

    2020  Volume 67, Issue 8, Page(s) 481–482

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2341-1929
    DOI 10.1016/j.redare.2020.06.005
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Fisioterapia respiratoria con cinturones de vibración en el paciente crítico COVID-19 en posición de prono

    Sancho, P.T. / Gandarias, P.A. / González, R.S. / Gurumeta, A.A.

    Revista Española de Anestesiología y Reanimación

    2020  Volume 67, Issue 8, Page(s) 481–482

    Keywords Anesthesiology and Pain Medicine ; Critical Care and Intensive Care Medicine ; covid19
    Language Spanish
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 604162-0
    ISSN 2340-3284 ; 0034-9356 ; 1131-4044
    ISSN (online) 2340-3284
    ISSN 0034-9356 ; 1131-4044
    DOI 10.1016/j.redar.2020.06.014
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 445: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Peripheral T-cell lymphoma with a T follicular-helper phenotype: A different entity? Results of the Spanish Real-T study.

    Martín García-Sancho, Alejandro / Rodríguez-Pinilla, Socorro M / Domingo-Domenech, Eva / Climent, Fina / Sánchez-Garcia, Joaquín / López Jiménez, Javier / García-Cosío Piqueras, Mónica / Castellvi, Josep / González, Ana Julia / González de Villambrosia, Sonia / Gómez Codina, José / Navarro, Belén / Rodríguez, Guillermo / Borrero, Juan José / Fraga, Máximo / Naves, Andrea / Baeza, Lourdes / Córdoba, Raúl

    British journal of haematology

    2023  Volume 203, Issue 2, Page(s) 182–193

    Abstract: Nodal peripheral T-cell lymphoma (PTCL) with a T follicular helper phenotype (PTCL-TFH) is a new ... otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL). This retrospective ... months, respectively, p = 0.002; OS, 52.6 months vs. 10.0 and 19.3 months, respectively, p < 0.001 ...

    Abstract Nodal peripheral T-cell lymphoma (PTCL) with a T follicular helper phenotype (PTCL-TFH) is a new type of PTCL. We aimed to define its clinical characteristics and prognosis compared to PTCL not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL). This retrospective observational study included 175 patients diagnosed with PTCL between 2008 and 2013 in 13 Spanish sites. Patient diagnosis was centrally reviewed, and patients were reclassified according to the World Health Organization (WHO) 2016 criteria: 21 patients as PTCL-NOS, 55 as AITL and 23 as PTCL-TFH. Median follow-up was 56.07 months (95% CI 38.7-73.4). Progression-free survival (PFS) and overall survival (OS) were significantly higher in patients with PTCL-TFH than in those with PTCL-NOS and AITL (PFS, 24.6 months vs. 4.6 and 7.8 months, respectively, p = 0.002; OS, 52.6 months vs. 10.0 and 19.3 months, respectively, p < 0.001). Histological diagnosis maintained an independent influence on both PFS (hazard ratio [HR] 4.1 vs. PTCL-NOS, p = 0.008; HR 2.6 vs. AITL, p = 0.047) and OS (HR 5.7 vs. PTCL-NOS, p = 0.004; HR 2.6 vs. AITL, p = 0.096), regardless of the International Prognostic Index. These results suggest that PTCL-TFH could have more favourable features and prognosis than the other PTCL subtypes, although larger series are needed to corroborate these findings.
    MeSH term(s) Humans ; Lymphoma, T-Cell, Peripheral ; Immunoblastic Lymphadenopathy/genetics ; Prognosis ; Phenotype ; Retrospective Studies
    Language English
    Publishing date 2023-06-30
    Publishing country England
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18941
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    Uh III Zs.182: Show issues Location:
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  7. Article ; Online: Mechanistic insights into glycoside 3-oxidases involved in C-glycoside metabolism in soil microorganisms.

    Taborda, André / Frazão, Tomás / Rodrigues, Miguel V / Fernández-Luengo, Xavier / Sancho, Ferran / Lucas, Maria Fátima / Frazão, Carlos / Melo, Eduardo P / Ventura, M Rita / Masgrau, Laura / Borges, Patrícia T / Martins, Lígia O

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 7289

    Abstract: C-glycosides are natural products with important biological activities but are recalcitrant to degradation. Glycoside 3-oxidases (G3Oxs) are recently identified bacterial flavo-oxidases from the glucose-methanol-coline (GMC) superfamily that catalyze the ...

    Abstract C-glycosides are natural products with important biological activities but are recalcitrant to degradation. Glycoside 3-oxidases (G3Oxs) are recently identified bacterial flavo-oxidases from the glucose-methanol-coline (GMC) superfamily that catalyze the oxidation of C-glycosides with the concomitant reduction of O
    MeSH term(s) Oxidoreductases/metabolism ; Hydrogen Peroxide ; Glycosides/metabolism ; Glucose/metabolism ; Cardiac Glycosides ; Substrate Specificity ; Glycoside Hydrolases/metabolism
    Chemical Substances Oxidoreductases (EC 1.-) ; C-glycoside ; Hydrogen Peroxide (BBX060AN9V) ; Glycosides ; Glucose (IY9XDZ35W2) ; Cardiac Glycosides ; Glycoside Hydrolases (EC 3.2.1.-)
    Language English
    Publishing date 2023-11-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42000-3
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  8. Article: Fisioterapia respiratoria con cinturones de vibración en el paciente crítico COVID-19 en posición de prono./ Fisioterapia respiratoria con cinturones de vibración en el paciente crítico COVID-19 en posición de prono./ Respiratory physiotherapy with Vibration belts in the critical patient Covid-19 in the prone position

    Sancho, P T / Gandarias, P A / González, R S / Gurumeta, A A

    Rev Esp Anestesiol Reanim

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #725476
    Database COVID19

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  9. Article ; Online: Corrigendum: Personalized monitoring of circulating tumor DNA with a specific signature of trackable mutations after chimeric antigen receptor T-cell therapy in follicular lymphoma patients.

    Jiménez-Ubieto, Ana / Martín-Muñoz, Alejandro / Poza, María / Dorado, Sara / García-Ortiz, Almudena / Revilla, Enrique / Sarandeses, Pilar / Ruiz-Heredia, Yanira / Baumann, Tycho / Rodríguez, Antonia / Calbacho, María / Sánchez, Pilar Martínez / Pina, José María Sánchez / García-Sancho, Alejandro Martín / Figaredo, Gloria / Gil-Alós, Daniel / Rufián, Laura / Rodríguez, Margarita / Carneros, Laura /
    Martínez-Laperche, Carolina / Bastos-Oreiro, Mariana / Wang, Chongwu / Cedena, María-Teresa / Rapado, Inmaculada / de Toledo, Paula / Gallardo, Miguel / Valeri, Antonio / Ayala, Rosa / Martínez-López, Joaquín / Barrio, Santiago

    Frontiers in immunology

    2024  Volume 14, Page(s) 1349296

    Abstract: This corrects the article DOI: 10.3389/fimmu.2023.1188818.]. ...

    Abstract [This corrects the article DOI: 10.3389/fimmu.2023.1188818.].
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1349296
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  10. Article: Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma: New Approved Options.

    García-Sancho, Alejandro Martín / Cabero, Almudena / Gutiérrez, Norma C

    Journal of clinical medicine

    2023  Volume 13, Issue 1

    Abstract: ... and that have manageable toxicity profiles. CAR-T cell therapy has become the new standard treatment ... TRANSFORM clinical trials. This review addresses the role of CAR-T therapy and autologous ...

    Abstract Overall, around 40% of patients with diffuse large B-cell lymphoma (DLBCL) have refractory disease or relapse after the first line of treatment. Until relatively recently, the prognosis of patients with relapsed or refractory DLBCL was very poor and treatment options were very limited. In recent years, several novel therapies have been approved that provide more effective options than conventional chemotherapy and that have manageable toxicity profiles. CAR-T cell therapy has become the new standard treatment for patients with refractory or early relapsed DLBCL, based on the positive results of the phase 3 ZUMA-7 and TRANSFORM clinical trials. This review addresses the role of CAR-T therapy and autologous stem cell transplantation in the treatment of these patients and other approved options for patients who are not candidates for transplant, such as the combinations of polatuzumab vedotin with bendamustine and rituximab, and tafasitamab with lenalidomide.
    Language English
    Publishing date 2023-12-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13010070
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