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Article ; Online: High Tibial Osteotomy versus Proximal Fibular Osteotomy in Medial Compartmental Osteoarthritis of Knee

Tanmay Datta / Kunal Mondal / Avijit Basak / Pinaki Das

Journal of Clinical and Diagnostic Research, Vol 16, Iss 7, Pp RC06-RC

A Longitudinal Study

2022 Volume 09

Abstract: Introduction: Osteoarthritis (OA) is a chronic degenerative intra-articular disorder of cartilage and bone. Knee joint is most commonly involved due to its pivotal role in weight bearing as it is constantly exposed to wear and tear. Osteotomy procedures ... ...

Abstract	Introduction: Osteoarthritis (OA) is a chronic degenerative intra-articular disorder of cartilage and bone. Knee joint is most commonly involved due to its pivotal role in weight bearing as it is constantly exposed to wear and tear. Osteotomy procedures can achieve normal alignment of the weight bearing axis of the lower limbs. Aim: To evaluate and compare the functional outcome of High Tibial Osteotomy (HTO) and Proximal Fibular Osteotomy (PFO) in medial compartmental osteoarthritis of knee joint. Materials and Methods: This prospective longitudinal study was conducted in a tertiary healthcare centre, IPGMER and SSKMH, Kolkata, West Bengal, India from October 2019 to November 2021 for a duration of 26 months, in which 40 osteotomies were performed around the knee. Considering the inclusion and exclusion criteria 20 proximal fibular osteotomies and 20 high tibial osteotomies were operated avoiding the patients with advanced stage or tricompartmental OA. The scoring system considered for evaluation of the functional outcome was Oxford Knee Score (OKS) and Visual Analouge Scale (VAS) Score. The analysis was done through paired t-test with determining of p-value where value ≤0.05 was considered as statistically significant. Results: Majority of the patients in the present study were more than 45 years of age. The most frequent age group was 46-50 years followed by 51-55 years. The follow-up period was atleast 15 months where the OKS score was 39.35±3.51 and 41.20±4.50 with p-value of 0.1556 and VAS score was 5.50±1.10 and 3.80±1.10 with p-value of <0.0001 for PFO and HTO, respectively. Only two of the patients developed surgical site infection in both cases. Conclusion: In long term follow-up the final functional status of both treatment modalities were comparable although HTO was considered superior with significant improvement in pain relief perspective than PTO.
Keywords	knee osteoarthritis ; kellgren lawrence score ; oxford knee score ; visual analouge scale score ; Medicine ; R
Subject code	616
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
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Article ; Online: Authors' reply.

Patra, Aparesh Chandra / Sil, Amrita / Ahmed, Sk Shahriar / Rahaman, Sufiur / Mondal, Nasiruddin / Roy, Sudipta / Datta, Adrija / Kaliyadan, Feroze / Panda, Saumya / Setia, Maninder Singh / Dogra, Sunil / Khandpur, Sujay / Hazra, Avijit / Das, Nilay Kanti

Indian journal of dermatology, venereology and leprology

2022 Volume 89, Issue 1, Page(s) 77–78

Language	English
Publishing date	2022-12-02
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	416068-x
ISSN	0973-3922 ; 0019-5162 ; 0378-6323
ISSN (online)	0973-3922
ISSN	0019-5162 ; 0378-6323
DOI	10.25259/IJDVL_858_2022
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Article ; Online: Newborn joint mechanics.

Mondal, Rakesh / Nandy, Arnab / Datta, Debadyuti / Majumdar, Rahul / Hazra, Avijit / Das, Sankar Kumar

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2021 Volume 35, Issue 25, Page(s) 7259–7266

Abstract: Introduction: We aimed to evaluate joint mechanics in newborn by goniometric assessment of major joints in healthy babies born at different gestational ages (GAs).: Materials and methods: An institution based observational study was carried out on ... ...

Abstract	Introduction: We aimed to evaluate joint mechanics in newborn by goniometric assessment of major joints in healthy babies born at different gestational ages (GAs). Materials and methods: An institution based observational study was carried out on healthy newborn babies within two days of birth. Study subjects were born at 28-41 completed weeks of gestation. The major joints of upper and lower limbs were assessed with manual goniometer for joint angles in relation to specific passive movements and range of motion (ROM) calculated where applicable. All measurements were made by a single observer with careful consideration of plane of movement and axes involved. Strength of association between joint angles and GA was quantified by Pearson's Results: Six major joints (shoulder, elbow, wrist, hip, knee, and ankle) were evaluated on either side in 433 babies. No significant differences were found between male and female babies and left or right side of the body. For most joints, a secular declining trend of joint angle or ROM was noted with good to strong inverse correlation with GA. The strongest associations were for flexion-extension ROM and adduction-abduction ROM at shoulder, palmar flexion at wrist and dorsiflexion at ankle joint with Conclusions: The reading of a specific joint angle in the newborn infants was found to be dependent on GA. Precise calibration of gestation appropriate joint angles had laid down the foundation for functional assessment of multimodal joint mechanics.HighlightsEvaluation of newborn joint angles require stringent attention toward the plane and axis of the particular joint movement being assessed.Major joint angles and range of motion in newborn infants were observed to follow a secular declining trend according to the gestational age.Precise estimation of gestation appropriate joint angle will be helpful to understand the mechanics of musculoskeletal medicine in newborn.
MeSH term(s)	Infant ; Infant, Newborn ; Humans ; Male ; Female ; Range of Motion, Articular ; Lower Extremity ; Upper Extremity
Language	English
Publishing date	2021-08-10
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2021.1946784
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Article ; Online: Blood Pressure Variation with Altitudes in Children: A Cross-Sectional Observational Study from Himalayan Hills.

Rajashekar, Bhukya / Sarkar, Uttam Kumar / Datta, Debadyuti / Mondal, Tanushree / Sarkar, Mihir / Sengupta, Tapti / Hazra, Avijit / Mondal, Rakesh

Journal of tropical pediatrics

2022 Volume 68, Issue 2

Abstract: Objectives: We aimed to evaluate blood pressure (BP) in Indian children who had similar demographic characteristics but hailed from different altitudes.: Methods: BP of school going children, aged 5 to 12 years, at five different locations varying in ...

Abstract	Objectives: We aimed to evaluate blood pressure (BP) in Indian children who had similar demographic characteristics but hailed from different altitudes. Methods: BP of school going children, aged 5 to 12 years, at five different locations varying in altitude (near sea level: n = 425; 2000 feet: n = 244; 4000 feet: n = 248; 6000 feet: n = 242 and 8000 feet: n = 250) was measured in a mountainous district in Himalaya. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded by aneroid sphygmomanometer in the sitting posture using a calibrated instrument and four trained resident doctors. The average of three readings was taken. Results: Of the 1229 children whose data were analyzed, 50.4% were boys. SBP showed a progressive rise from 99.5 (4.00) mmHg [mean (standard deviation)] at near sea level to 106.7 (4.17) mmHg at 8000 feet. Similarly, DBP showed a rise from 60.1 (3.67) mmHg to 66.8 (4.58) mmHg over the same altitude range. Analysis of covariance for BP variation with altitude, with age as covariate, indicated a modest but statistically significant rise in both SBP and DBP with altitude. Higher BP values was noted among children residing at higher than at lower altitude (0.8% at sea level to 18.8% at 8000 feet). Correlations between SBP and DBP values and height and weight, though positive and significant at p < 0.01 level, were weak. Conclusions: These data will help in correct interpretation of BP readings in children residing at high altitude.
MeSH term(s)	Altitude ; Blood Pressure/physiology ; Blood Pressure Determination ; Body Height ; Child ; Child, Preschool ; Humans ; Hypertension ; Male
Language	English
Publishing date	2022-02-04
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	800065-7
ISSN	1465-3664 ; 0449-3281 ; 0142-6338
ISSN (online)	1465-3664
ISSN	0449-3281 ; 0142-6338
DOI	10.1093/tropej/fmac010
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Article ; Online: One- and Two-Photon Uncaging of Carbon Monoxide (CO) with Real-Time Monitoring: On-Demand Carbazole-Based Dual CO-Releasing Platform to Test over Single and Combinatorial Approaches for the Efficient Regression of Orthotopic Murine Melanoma

Venkatesh, Yarra / Vangala, Venugopal / Mengji, Rakesh / Chaudhuri, Amrita / Bhattacharya, Sayantan / Datta, Prasanta Kumar / Banerjee, Rajkumar / Jana, Avijit / Singh, N D Pradeep

Journal of medicinal chemistry

2022 Volume 65, Issue 3, Page(s) 1822–1834

Abstract: Herein, we report three new metal-free, photochemically active single, dual, and combinatorial CORMs (photoCORMs) based on a carbazole-fused 1,3-dioxol-2-one moiety which released one equivalent of CO, two equivalent of CO, and a combination of one ... ...

Abstract	Herein, we report three new metal-free, photochemically active single, dual, and combinatorial CORMs (photoCORMs) based on a carbazole-fused 1,3-dioxol-2-one moiety which released one equivalent of CO, two equivalent of CO, and a combination of one equivalent of each CO and anticancer drug upon one- and two-photon excitation, respectively. The photoCORMs exhibited good cellular uptake and real-time monitoring ability of CO uncaging by a color change approach in cancerous B16F10 cells. Interestingly, the cytotoxicity assay on B16F10 cells indicated that the dual photoCORM has increased anticancer activity over the single and combinatorial photoCORMs upon irradiation. Our results also showed that CO could accelerate the effectiveness of the well-known anticancer drug (chlorambucil). Finally, the
MeSH term(s)	Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/radiation effects ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Carbazoles/chemical synthesis ; Carbazoles/radiation effects ; Carbazoles/therapeutic use ; Carbon Monoxide/metabolism ; Cell Line, Tumor ; Dioxoles/chemical synthesis ; Dioxoles/radiation effects ; Dioxoles/therapeutic use ; Female ; Infrared Rays ; Melanoma/drug therapy ; Mice, Inbred C57BL ; Photons ; Mice
Chemical Substances	Antineoplastic Agents ; Carbazoles ; Dioxoles ; Carbon Monoxide (7U1EE4V452)
Language	English
Publishing date	2022-01-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.1c00750
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Article: Integral approach of sorption coupled with biodegradation for treatment of azo dye using

Roy, Uttariya / Sengupta, Shubhalakshmi / Das, Papita / Bhowal, Avijit / Datta, Siddhartha

3 Biotech

2018 Volume 8, Issue 4, Page(s) 192

Abstract: The present study investigated the removal of azo dye (crystal violet) by adsorption (using a low-cost adsorbent fly ash), biodegradation (using bacterial species, ...

Abstract	The present study investigated the removal of azo dye (crystal violet) by adsorption (using a low-cost adsorbent fly ash), biodegradation (using bacterial species,
Language	English
Publishing date	2018-03-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-018-1215-1
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Article ; Online: Economic Burden of Juvenile Idiopathic Arthritis in India.

Khatun, Moksuda / Datta, Debadyuti / Hazra, Avijit / Ghosh, Pramit / Selim, Muhammad Bin / Mondal, Rakesh

Indian pediatrics

2020 Volume 58, Issue 1, Page(s) 38–40

Abstract: Background: Published Indian studies on the economic burden of juvenile idiopathic arthritis (JIA) are lacking.: Methods: A prospective observational study recruited pediatric patients aged from 1 to 12 years with JIA in the pediatric rheumatology ... ...

Abstract	Background: Published Indian studies on the economic burden of juvenile idiopathic arthritis (JIA) are lacking. Methods: A prospective observational study recruited pediatric patients aged from 1 to 12 years with JIA in the pediatric rheumatology clinic of a public sector tertiary care hospital. Direct healthcare costs and indirect costs for transportation, accommodation of the caregivers, and productivity loss for work absenteeism were assessed. Results: The proportions of direct annualized cost assessed in 60 patients (mean (SD) age 8.46 (2.24) year) spent on outpatient visits, blood tests, imaging investigations, other tests, medications and hospitalization were 0.85%, 12.8%, 9.0%, 2.9%, 41.7% and 32.7%, respectively. Direct healthcare costs for blood tests and medicine were lowest in oligoarticular JIA and highest in systemic onset JIA and (P=0.043 and 0.001 respectively). The direct and indirect costs were higher with the use of biologic agents (n=9) than in those without (n=51). Conclusion: JIA imposes considerable economic burden with the largest share attributable to medicines, and maximum in those with systemic onset JIA.
MeSH term(s)	Arthritis, Juvenile/drug therapy ; Arthritis, Juvenile/epidemiology ; Caregivers ; Child ; Cost of Illness ; Health Care Costs ; Humans ; India/epidemiology
Language	English
Publishing date	2020-09-16
Publishing country	India
Document type	Journal Article ; Observational Study
ZDB-ID	402594-5
ISSN	0974-7559 ; 0019-6061
ISSN (online)	0974-7559
ISSN	0019-6061
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Article ; Online: COVID-19 and Co-infection in Children: The Indian Perspectives.

Raychaudhuri, Dibyendu / Sarkar, Mihir / Roy, Aniket / Roy, Debapriya / Datta, Kalpana / Sengupta, Tapti / Hazra, Avijit / Mondal, Rakesh

Journal of tropical pediatrics

2021 Volume 67, Issue 4

Abstract: Background and objectives: Assessing the co-infections with COVID-19 is crucial to delineate its true clinical impact. Pediatric information in this aspect is limited. Our study aims to analyze the spectrum of co-infections in pediatric COVID-19 ... ...

Abstract	Background and objectives: Assessing the co-infections with COVID-19 is crucial to delineate its true clinical impact. Pediatric information in this aspect is limited. Our study aims to analyze the spectrum of co-infections in pediatric COVID-19 patients and determine the clinical as well as laboratory parameters predicting co-infection. Methodology: In this prospective observational study conducted from June to December 2020 in a single tertiary care institution, data pertaining to demographic, illness and treatment-related variables were analyzed among two subsets of pediatric patients of age 1 month-12 years with RT-PCR-confirmed COVID-19 infection-Group A: those with confirmed co-infection and Group B: moderate to severe disease without co-infection. Among Group A, etiology of co-infection was characterized through relevant microbiological examination within 48 h admission. Result: Among our study population, 15.03% and 20.6% had co-infections and moderate to severe disease respectively. Among those with confirmed co-infection, 32.5%, 11.6% and 6.97% recorded blood culture, respiratory secretion and CSF growth, respectively, the picture being dominated by Methicillin resistant and sensitive Staphylococcus aureus. Serum serology demonstrated Scrub typhus infection to be most prevalent. Concurrent respiratory viral infections were seen in 11.6%. Children with co-infection had significantly higher morbidity and need for supportive therapy. Predictors of co-infection were localization of infection, Neutrophil count ≥10×109, age-specific lymphopenia, CRP > 100 mg/dl and hyperferritinemia. Conclusion: Co-infections are an important factor prognosticating pediatric COVID infection. Their early detection, prompt and appropriate treatment is of paramount importance.
MeSH term(s)	COVID-19 ; Child ; Coinfection/epidemiology ; Humans ; Prospective Studies ; SARS-CoV-2 ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/epidemiology
Language	English
Publishing date	2021-09-03
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	800065-7
ISSN	1465-3664 ; 0449-3281 ; 0142-6338
ISSN (online)	1465-3664
ISSN	0449-3281 ; 0142-6338
DOI	10.1093/tropej/fmab073
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Article ; Online: Serum Ferritin as a Diagnostic Biomarker for Severity of Childhood Sepsis.

Nandy, Arnab / Mondal, Tanushree / Datta, Debadyuti / Ray, Somosri / Kumar, Nitis / Ivan, M Divyoshanu / Hazra, Avijit / Mondal, Rakesh

Indian pediatrics

2021 Volume 58, Issue 12, Page(s) 1143–1146

Abstract: Objective: To explore association between serum ferritin and severity of sepsis among children, and relate levels to the final outcome.: Methods: This observational study was conducted in a tertiary care hospital between I February and 30 July, 2019. ...

Abstract	Objective: To explore association between serum ferritin and severity of sepsis among children, and relate levels to the final outcome. Methods: This observational study was conducted in a tertiary care hospital between I February and 30 July, 2019. Serum ferritin level was estimated in children (age 6 months to 12 years) suffering from sepsis, irrespective of the probable etiology. Children with hemoglobinopathies, autoimmune diseases, previous blood transfusion, severe acute malnutrition, hemophagocytic lymphohistiocytosis and chronic hepatitis were excluded. The ferritin level was measured sequentially at pre-defined stages of illness viz., sepsis, severe sepsis, septic shock and multiorgan dysfunction syndrome (MODS). Association between serum ferritin and severity of sepsis was analyzed, and ferritin level was related to the final outcome of death or recovery by receiver operating characteristic (ROC) curve analysis. Results: The study group included 47 children with sepsis who progressed to a state of MODS; 32 recovered from MODS. Significant differences in serum ferritin level were observed with severity of sepsis. There was clear demarcation of ferritin levels between sepsis severity stages. The proportion of death among the 47 MODS cases was 31.9% (95% CI 18.6 - 45.2%). ROC analysis in the MODS group indicated that serum ferritin >1994.3 ng/mL predicts mortality (AUC 0.73 [95% CI 0.58-0.85]) with sensitivity 66.7% [95% CI 38.4-88%] and specificity 100.0% [95% CI 89.1-100%]. Conclusions: There is clear demarcation of serum ferritin levels that can help differentiation of sepsis severity stages in children with sepsis. There is no such demarcation between survivors and non-survivors in MODS cases.
MeSH term(s)	Biomarkers ; Child ; Ferritins ; Humans ; Multiple Organ Failure/diagnosis ; Prognosis ; ROC Curve ; Retrospective Studies ; Sepsis/diagnosis ; Shock, Septic/diagnosis
Chemical Substances	Biomarkers ; Ferritins (9007-73-2)
Language	English
Publishing date	2021-05-28
Publishing country	India
Document type	Journal Article ; Observational Study
ZDB-ID	402594-5
ISSN	0974-7559 ; 0019-6061
ISSN (online)	0974-7559
ISSN	0019-6061
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Article ; Online: Extraction of dye from aqueous solution in rotating packed bed.

Modak, Jayant B / Bhowal, Avijit / Datta, Siddhartha

Journal of hazardous materials

2016 Volume 304, Page(s) 337–342

Abstract: The influence of centrifugal acceleration on mass transfer rates in liquid-liquid extraction was investigated experimentally in rotating packed bed (RPB) contactor. The extraction of methyl red using xylene was studied in the equipment. The effect of ... ...

Abstract	The influence of centrifugal acceleration on mass transfer rates in liquid-liquid extraction was investigated experimentally in rotating packed bed (RPB) contactor. The extraction of methyl red using xylene was studied in the equipment. The effect of rotational speed (300-900rpm), flow rate of the aqueous (4.17-20.8×10(-6)m(3)/s), and organic phase (0.83-2.5×10(-6)m(3)/s) on the mass transfer performance was examined. The maximum stage efficiency attained was ∼0.98 at aqueous to organic flow rate ratio of 10. The results suggest that contactor volume required to carry out a given separation can be reduced by an order of magnitude with RPB in comparison to conventional extractors.
Language	English
Publishing date	2016-03-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2015.10.062
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