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Article ; Online: The effect of inhibition of the Na + /H + exchanger on the development of hypertrophy in hypertrophic cardiomyopathy

van der Velden Jolanda / Pasterkamp Gerard / van Borren Marcel M / Germans Tjeerd / Nederhoff Marcel G / Houweling Arjan C / Brouwer Wessel P / van Rossum Albert C

Journal of Cardiovascular Magnetic Resonance, Vol 13, Iss Suppl 1, p P

2011 Volume 290

Keywords	Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2011-02-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The highs and lows of wheezing: A review of the most popular adventitious lung sound.

Pasterkamp, Hans

Pediatric pulmonology

2017 Volume 53, Issue 2, Page(s) 243–254

Abstract: Wheezing is the most widely reported adventitious lung sound in the English language. It is recognized by health professionals as well as by lay people, although often with a different meaning. Wheezing is an indicator of airway obstruction and therefore ...

Abstract	Wheezing is the most widely reported adventitious lung sound in the English language. It is recognized by health professionals as well as by lay people, although often with a different meaning. Wheezing is an indicator of airway obstruction and therefore of interest particularly for the assessment of young children and in other situations where objective documentation of lung function is not generally available. This review summarizes our current understanding of mechanisms producing wheeze, its subjective perception and description, its objective measurement, and visualization, and its relevance in clinical practice.
MeSH term(s)	Airway Obstruction/diagnosis ; Airway Obstruction/physiopathology ; Asthma/diagnosis ; Asthma/physiopathology ; Child ; Humans ; Respiratory Sounds/physiopathology ; Terminology as Topic
Language	English
Publishing date	2017-12-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.23930
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Article ; Online: Smart Devices Are Poised to Revolutionize the Usefulness of Respiratory Sounds.

Kraman, Steve S / Pasterkamp, Hans / Wodicka, George R

Chest

2023 Volume 163, Issue 6, Page(s) 1519–1528

Abstract: The association between breathing sounds and respiratory health or disease has been exceptionally useful in the practice of medicine since the advent of the stethoscope. Remote patient monitoring technology and artificial intelligence offer the potential ...

Abstract	The association between breathing sounds and respiratory health or disease has been exceptionally useful in the practice of medicine since the advent of the stethoscope. Remote patient monitoring technology and artificial intelligence offer the potential to develop practical means of assessing respiratory function or dysfunction through continuous assessment of breathing sounds when patients are at home, at work, or even asleep. Automated reports such as cough counts or the percentage of the breathing cycles containing wheezes can be delivered to a practitioner via secure electronic means or returned to the clinical office at the first opportunity. This has not previously been possible. The four respiratory sounds that most lend themselves to this technology are wheezes, to detect breakthrough asthma at night and even occupational asthma when a patient is at work; snoring as an indicator of OSA or adequacy of CPAP settings; cough in which long-term recording can objectively assess treatment adequacy; and crackles, which, although subtle and often overlooked, can contain important clinical information when appearing in a home recording. In recent years, a flurry of publications in the engineering literature described construction, usage, and testing outcomes of such devices. Little of this has appeared in the medical literature. The potential value of this technology for pulmonary medicine is compelling. We expect that these tiny, smart devices soon will allow us to address clinical questions that occur away from the clinic.
MeSH term(s)	Humans ; Respiratory Sounds/diagnosis ; Auscultation ; Cough/diagnosis ; Artificial Intelligence ; Stethoscopes
Language	English
Publishing date	2023-01-25
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2023.01.024
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Article ; Online: A critical appreciation of pathway analysis in atherosclerotic disease. Cellular phenotypic plasticity as an illustrative example.

Wesseling, M / Diez-Benavente, E / Mokry, M / den Ruijter, H M / Pasterkamp, G

Vascular pharmacology

2024 Volume 154, Page(s) 107286

Abstract: The rapid advancements in genome-scale (omics) techniques has created significant opportunities to investigate complex disease mechanisms in tissues and cells. Nevertheless, interpreting -omics data can be challenging, and pathway enrichment analysis is ... ...

Abstract	The rapid advancements in genome-scale (omics) techniques has created significant opportunities to investigate complex disease mechanisms in tissues and cells. Nevertheless, interpreting -omics data can be challenging, and pathway enrichment analysis is a frequently used method to identify candidate molecular pathways that drive gene expression changes. With a growing number of -omics studies dedicated to atherosclerosis, there has been a significant increase in studies and hypotheses relying on enrichment analysis. This brief review discusses the benefits and limitations of pathway enrichment analysis within atherosclerosis research. We highlight the challenges of identifying complex biological processes, such as cell phenotypic switching, within -omics data. Additionally, we emphasize the need for more comprehensive and curated gene sets that reflect the biological complexity of atherosclerosis. Pathway enrichment analysis is a valuable tool for gaining insights into the molecular mechanisms of atherosclerosis. Nevertheless, it is crucial to remain aware of the intrinsic limitations of this approach. By addressing these weaknesses, enrichment analysis in atherosclerosis can lead to breakthroughs in identifying the mechanisms of disease progresses, the identification of key driver genes, and consequently, advance personalized patient care.
MeSH term(s)	Humans ; Atherosclerosis/genetics
Language	English
Publishing date	2024-02-24
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2082846-9
ISSN	1879-3649 ; 1537-1891 ; 1879-3649
ISSN (online)	1879-3649 ; 1537-1891
ISSN	1879-3649
DOI	10.1016/j.vph.2024.107286
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Article ; Online: Inspiratory crackles-early and late-revisited: identifying COPD by crackle characteristics.

Melbye, Hasse / Aviles Solis, Juan Carlos / Jácome, Cristina / Pasterkamp, Hans

BMJ open respiratory research

2021 Volume 8, Issue 1

Abstract: Background: The significance of pulmonary crackles, by their timing during inspiration, was described by Nath and Capel in 1974, with early crackles associated with bronchial obstruction and late crackles with restrictive defects. Crackles are also ... ...

Abstract	Background: The significance of pulmonary crackles, by their timing during inspiration, was described by Nath and Capel in 1974, with early crackles associated with bronchial obstruction and late crackles with restrictive defects. Crackles are also described as 'fine' or 'coarse'. We aimed to evaluate the usefulness of crackle characteristics in the diagnosis of chronic obstructive pulmonary disease (COPD). Methods: In a population-based study, lung sounds were recorded at six auscultation sites and classified in participants aged 40 years or older. Inspiratory crackles were classified as 'early' or 'late and into the types' 'coarse' and 'fine' by two observers. A diagnosis of COPD was based on respiratory symptoms and forced expiratory volume in 1 s/forced inspiratory vital capacity below lower limit of normal, based on Global Lung Function Initiative 2012 reference. Associations between crackle characteristics and COPD were analysed by logistic regression. Kappa statistics was applied for evaluating interobserver agreement. Results: Of 3684 subjects included in the analysis, 52.9% were female, 50.1% were ≥65 years and 204 (5.5%) had COPD. Basal inspiratory crackles were heard in 306 participants by observer 1 and in 323 by observer 2. When heard bilaterally COPD could be predicted with ORs of 2.59 (95% CI 1.36 to 4.91) and 3.20 (95% CI 1.71 to 5.98), annotated by observer 1 and 2, respectively, adjusted for sex and age. If bilateral crackles were coarse the corresponding ORs were 2.65 (95% CI 1.28 to 5.49) and 3.67 (95% CI 1.58 to 8.52) and when heard early during inspiration the ORs were 6.88 (95% CI 2.59 to 18.29) and 7.63 (95%CI 3.73 to 15.62). The positive predictive value for COPD was 23% when early crackles were heard over one or both lungs. We observed higher kappa values when classifying timing than type. Conclusions: 'Early' inspiratory crackles predicted COPD more strongly than 'coarse' inspiratory crackles. Identification of early crackles at the lung bases should imply a strong attention to the possibility of COPD.
MeSH term(s)	Auscultation ; Female ; Forced Expiratory Volume ; Humans ; Lung ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Respiratory Sounds/diagnosis ; Respiratory Sounds/etiology
Language	English
Publishing date	2021-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2736454-9
ISSN	2052-4439 ; 2052-4439
ISSN (online)	2052-4439
ISSN	2052-4439
DOI	10.1136/bmjresp-2020-000852
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Chapter Genetics of Amyotrophic Lateral Sclerosis

Koppers, Max / Es, Michael van / Berg, Leonard H. van den / Veldink, Jan H. / Pasterkamp, R. Jeroen

2012

Keywords	Astronautics ; Technology, engineering, agriculture
Size	1 Online-Ressource
Publisher	InTechOpen
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021047423
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Of Microsoft and mycobacteria.

Pasterkamp, H

The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses

2007 Volume 12, Issue 2, Page(s) 72–73

Language	English
Publishing date	2007-12-24
Publishing country	Canada
Document type	Editorial
ZDB-ID	1057056-1
ISSN	1180-2332 ; 1712-9532
ISSN	1180-2332 ; 1712-9532
DOI	10.1155/2001/254935
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Article ; Online: Cystic fibrosis in Canadian Hutterites.

Pasterkamp, Hans / Menzies, Kathryn J / Bayomi, Dennis J

Pediatric pulmonology

2019 Volume 55, Issue 2, Page(s) 526–532

Abstract: Background: The Hutterite Brethren are a communal group of Anabaptists who live in the Western regions of North America, predominantly in the Western Canadian provinces. Due to a founder effect, Hutterites have a high rate of cystic fibrosis (CF) with ... ...

Abstract	Background: The Hutterite Brethren are a communal group of Anabaptists who live in the Western regions of North America, predominantly in the Western Canadian provinces. Due to a founder effect, Hutterites have a high rate of cystic fibrosis (CF) with genotypes limited to only two CFTR mutations. One-third of Hutterite patients with CF are pancreatic sufficient. Previously we found an unexplained younger age at death in Hutterites compared with nonHutterites homozygous for the common F508del mutation. The present study expanded the data collection and analysis for confirmation and further exploration. Methods: Anonymized information, based on Hutterite surnames, was extracted from the Canadian CF Registry. Summary data on nonHutterite patients with CF homozygous for F508del served as control. Statistical analyses explored the effects of genotype within Hutterites and compared nutritional status, lung function, and microbiologic findings between the groups. Results: The younger average age at death in Hutterites compared with controls was confirmed, but there was no suggestion of a generally shortened life expectancy. While the nutritional status in Hutterite children was better than that of controls, their lung function was slightly but significantly lower. Staphylococcus aureus was more frequent in Hutterites while there was no difference between the groups regarding Pseudomonas aeruginosa. Conclusions: Despite less pancreatic insufficiency, better nutrition, communal life in socioeconomic stability, and without exposure to environmental tobacco smoke, the clinical course of CF appears to be more severe in a significant number of Hutterites. Investigations of gene-environment interactions and of CF disease gene modifiers may help to explain this conundrum.
MeSH term(s)	Adolescent ; Canada/ethnology ; Child ; Child, Preschool ; Cystic Fibrosis/epidemiology ; Cystic Fibrosis/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Exocrine Pancreatic Insufficiency ; Female ; Genotype ; Humans ; Male ; Mutation ; North America ; Nutritional Status ; Pseudomonas aeruginosa ; Registries ; Staphylococcal Infections
Chemical Substances	Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
Language	English
Publishing date	2019-11-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.24590
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Article ; Online: Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder.

Prince, Naika / Peralta Marzal, Lucia N / Markidi, Anastasia / Ahmed, Sabbir / Adolfs, Youri / Pasterkamp, R Jeroen / Kumar, Himanshu / Roeselers, Guus / Garssen, Johan / Kraneveld, Aletta D / Perez-Pardo, Paula

Acta pharmacologica Sinica

2024

Abstract: Autism spectrum disorder (ASD) is a cluster of neurodevelopmental disorders characterized by deficits in communication and behavior. Increasing evidence suggests that the microbiota-gut-brain axis and the likely related immune imbalance may play a role ... ...

Abstract	Autism spectrum disorder (ASD) is a cluster of neurodevelopmental disorders characterized by deficits in communication and behavior. Increasing evidence suggests that the microbiota-gut-brain axis and the likely related immune imbalance may play a role in the development of this disorder. Gastrointestinal deficits and gut microbiota dysfunction have been linked to the development or severity of autistic behavior. Therefore, treatments that focus on specific diets may improve gastrointestinal function and aberrant behavior in individuals with ASD. In this study, we investigated whether a diet containing specific prebiotic fibers, namely, 3% galacto-oligosaccharide/fructo-oligosaccharide (GOS/FOS; 9:1), can mitigate the adverse effects of in utero exposure to valproic acid (VPA) in mice. Pregnant BALB/cByJ dams were injected with VPA (600 mg/kg, sc.) or phosphate-buffered saline (PBS) on gestational day 11 (G11). Male offspring were divided into four groups: (1) in utero PBS-exposed with a control diet, (2) in utero PBS-exposed with GOS/FOS diet, (3) in utero VPA-exposed with a control diet, and (4) in utero VPA-exposed with GOS/FOS diet. Dietary intervention started from birth and continued throughout the duration of the experiment. We showed that the prebiotic diet normalized VPA-induced alterations in male offspring, including restoration of key microbial taxa, intestinal permeability, peripheral immune homeostasis, reduction of neuroinflammation in the cerebellum, and impairments in social behavior and cognition in mice. Overall, our research provides valuable insights into the gut-brain axis involvement in ASD development. In addition, dietary interventions might correct the disbalance in gut microbiota and immune responses and, ultimately, might improve detrimental behavioral outcomes in ASD.
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1360774-1
ISSN	1745-7254 ; 0253-9756 ; 1671-4083
ISSN (online)	1745-7254
ISSN	0253-9756 ; 1671-4083
DOI	10.1038/s41401-024-01268-x
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Article: Wheeze detection in the pediatric intensive care unit.

Pasterkamp, Hans

Respiratory care

2008 Volume 53, Issue 10, Page(s) 1283–1284

MeSH term(s)	Asthma/complications ; Asthma/diagnosis ; Child ; Diagnosis, Computer-Assisted/methods ; Diagnosis, Differential ; Diagnostic Techniques, Respiratory System/instrumentation ; Humans ; Intensive Care Units, Pediatric ; Recurrence ; Reproducibility of Results ; Respiratory Sounds/diagnosis ; Respiratory Sounds/etiology
Language	English
Publishing date	2008-10
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	603252-7
ISSN	0020-1324 ; 0098-9142
ISSN	0020-1324 ; 0098-9142
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