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  1. Article ; Online: The Role of Radiotherapy in the Contemporary Management of Patients With Sarcoma: Opportunities to Improve Patient Outcomes.

    Kirsch, David G

    Seminars in radiation oncology

    2024  Volume 34, Issue 2, Page(s) 145–146

    MeSH term(s) Humans ; Sarcoma/radiotherapy ; Soft Tissue Neoplasms/radiotherapy ; Radiotherapy, Adjuvant
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2024.02.004
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    Zs.A 3654: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Treating the Unknown: First Refine the Diagnosis.

    Kirsch, David G

    International journal of radiation oncology, biology, physics

    2021  Volume 112, Issue 1, Page(s) 37–38

    Language English
    Publishing date 2021-12-14
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2021.05.128
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    Zs.A 1218: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Radiation Therapy as a Treatment for COVID-19?

    Kirsch, David G

    International journal of radiation oncology, biology, physics

    2020  Volume 108, Issue 5, Page(s) 1140–1142

    MeSH term(s) COVID-19 ; Humans ; Lung ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2020.07.025
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    Zs.A 1218: Show issues Location:
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  4. Article: Relationship between the tumor microenvironment and the efficacy of the combination of radiotherapy and immunotherapy.

    Su, Chang / Himes, Jonathon E / Kirsch, David G

    International review of cell and molecular biology

    2023  Volume 378, Page(s) 201–232

    Abstract: Activating and recruiting the immune system is critical for successful cancer treatment. Since the discovery of immune checkpoint inhibitors, immunotherapy has become the standard of care for many types of cancers. However, many patients fail to respond ... ...

    Abstract Activating and recruiting the immune system is critical for successful cancer treatment. Since the discovery of immune checkpoint inhibitors, immunotherapy has become the standard of care for many types of cancers. However, many patients fail to respond to immunotherapy. Further research is needed to understand the mechanisms of resistance and adjuvant therapies that can help sensitize patients to immunotherapies. Here, we will discuss how radiotherapy can change the tumor microenvironment and work synergistically with immunotherapy. We will examine different pre-clinical models focusing on their limitations and their unique advantages in studying the efficacy of treatments and the tumor microenvironment. We will also describe emerging findings from clinical trials testing the combination of immunotherapy and radiotherapy.
    MeSH term(s) Humans ; Tumor Microenvironment ; Immunotherapy
    Language English
    Publishing date 2023-04-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2427220-6
    ISSN 1937-6448 ; 0074-7696
    ISSN 1937-6448 ; 0074-7696
    DOI 10.1016/bs.ircmb.2023.03.006
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  6. Article ; Online: Current Opportunities and Future Vision of Precision Medicine in Radiation Oncology.

    Kirsch, David G

    International journal of radiation oncology, biology, physics

    2018  Volume 101, Issue 2, Page(s) 267–270

    MeSH term(s) Forecasting ; Humans ; Mutation ; Neoplasms/genetics ; Neoplasms/radiotherapy ; Precision Medicine/methods ; Precision Medicine/trends ; Radiation Oncology/methods ; Radiation Oncology/trends ; Radiotherapy Dosage
    Language English
    Publishing date 2018-04-26
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2017.04.005
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    Zs.A 1218: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Radiation Therapy as a Treatment for COVID-19?

    Kirsch, David G.

    International Journal of Radiation Oncology*Biology*Physics ; ISSN 0360-3016

    2020  

    Keywords Cancer Research ; Oncology ; Radiation ; Radiology Nuclear Medicine and imaging ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.ijrobp.2020.07.025
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Radiotherapy Combined with Intralesional Immunostimulatory Agents for Soft Tissue Sarcomas.

    Su, Chang / Kim, Soo Kyoung / Wang, Charles X / Kirsch, David G / Monjazeb, Arta M

    Seminars in radiation oncology

    2024  Volume 34, Issue 2, Page(s) 243–257

    Abstract: Immunotherapy has shifted the treatment paradigm for many types of cancer. Unfortunately, the most commonly used immunotherapies, such as immune checkpoint inhibitors (ICI), have yielded limited benefit for most types of soft tissue sarcoma (STS). ... ...

    Abstract Immunotherapy has shifted the treatment paradigm for many types of cancer. Unfortunately, the most commonly used immunotherapies, such as immune checkpoint inhibitors (ICI), have yielded limited benefit for most types of soft tissue sarcoma (STS). Radiotherapy (RT) is a mainstay of sarcoma therapy and can induce immune modulatory effects. Combining immunotherapy and RT in STS may be a promising strategy to improve sarcoma response to RT and increase the efficacy of immunotherapy. Most combination strategies have employed immunotherapies, such as ICI, that derepress immune suppressive networks. These have yielded only modest results, possibly due to the limited immune stimulatory effects of RT. Combining RT with immune stimulatory agents has yielded promising preclinical and clinical results but can be limited by the toxic nature of systemic administration of immune stimulants. Using intralesional immune stimulants may generate stronger RT immune modulation and less systemic toxicity, which may be a feasible strategy in accessible tumors such as STS. In this review, we summarize the immune modulatory effects of RT, the mechanism of action of various immune stimulants, including toll-like receptor agonists, and data for combinatorial strategies utilizing these agents.
    MeSH term(s) Humans ; Sarcoma/drug therapy ; Sarcoma/radiotherapy ; Immunotherapy/methods ; Immune Checkpoint Inhibitors/therapeutic use
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2024.01.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3654: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer.

    Wisdom, Amy J / Kirsch, David G

    Cancer research

    2020  Volume 80, Issue 24, Page(s) 5459–5461

    Abstract: DNA polymerase mutations can cause hypermutant cancers, but the mechanisms of tumorigenesis and the impact of various DNA polymerase mutations on treatment response is poorly understood. In this issue ... ...

    Abstract DNA polymerase mutations can cause hypermutant cancers, but the mechanisms of tumorigenesis and the impact of various DNA polymerase mutations on treatment response is poorly understood. In this issue of
    MeSH term(s) Animals ; DNA Polymerase II/genetics ; Immune Checkpoint Inhibitors ; Immunotherapy ; Mice ; Mutation ; Neoplasms/genetics ; Neoplasms/therapy ; Tumor Microenvironment
    Chemical Substances Immune Checkpoint Inhibitors ; DNA Polymerase II (EC 2.7.7.7)
    Language English
    Publishing date 2020-11-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-20-3241
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    Uh III Zs.135/5: Show issues Location:
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  10. Article ; Online: Safely combining trabectedin with radiotherapy to treat myxoid liposarcoma.

    Chen, Mark / Kirsch, David G

    EClinicalMedicine

    2019  Volume 9, Page(s) 5–6

    Language English
    Publishing date 2019-03-31
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2019.03.015
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