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  1. Article ; Online: The author replies.

    Drewry, Anne M

    Critical care medicine

    2022  Volume 50, Issue 9, Page(s) e735–e736

    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The author replies.

    Drewry, Anne M

    Critical care medicine

    2022  Volume 50, Issue 12, Page(s) e812–e813

    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Temperature Management in the ICU.

    Drewry, Anne / Mohr, Nicholas M

    Critical care medicine

    2022  Volume 50, Issue 7, Page(s) 1138–1147

    Abstract: Objective: Temperature abnormalities are recognized as a marker of human disease, and the therapeutic value of temperature is an attractive treatment target. The objective of this synthetic review is to summarize and critically appraise evidence for ... ...

    Abstract Objective: Temperature abnormalities are recognized as a marker of human disease, and the therapeutic value of temperature is an attractive treatment target. The objective of this synthetic review is to summarize and critically appraise evidence for active temperature management in critically ill patients.
    Data sources: We searched MEDLINE for publications relevant to body temperature management (including targeted temperature management and antipyretic therapy) in cardiac arrest, acute ischemic and hemorrhagic stroke, traumatic brain injury, and sepsis. Bibliographies of included articles were also searched to identify additional relevant studies.
    Study selection: English-language systematic reviews, meta-analyses, randomized trials, observational studies, and nonhuman data were reviewed, with a focus on the most recent randomized control trial evidence.
    Data extraction: Data regarding study methodology, patient population, temperature management strategy, and clinical outcomes were qualitatively assessed.
    Data synthesis: Temperature management is common in critically ill patients, and multiple large trials have been conducted to elucidate temperature targets, management strategies, and timing. The strongest data concerning the use of therapeutic hypothermia exist in comatose survivors of cardiac arrest, and recent trials suggest that appropriate postarrest temperature targets between 33°C and 37.5°C are reasonable. Targeted temperature management in other critical illnesses, including acute stroke, traumatic brain injury, and sepsis, has not shown benefit in large clinical trials. Likewise, trials of pharmacologic antipyretic therapy have not demonstrated improved outcomes, although national guidelines do recommend treatment of fever in patients with stroke and traumatic brain injury based on observational evidence associating fever with worse outcomes.
    Conclusions: Body temperature management in critically ill patients remains an appealing therapy for several illnesses, and additional studies are needed to clarify management strategies and therapeutic pathways.
    MeSH term(s) Humans ; Intensive Care Units ; Temperature
    Language English
    Publishing date 2022-04-15
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Expanding Critical Care Delivery beyond the Intensive Care Unit: Determining the Design and Implementation Needs for a Tele-Critical Care Consultation Service.

    Abraham, Joanna / Kandasamy, Madhumitha / Fritz, Bradley / Konzen, Lisa / White, Jason / Drewry, Anne / Palmer, Christopher

    Applied clinical informatics

    2024  Volume 15, Issue 1, Page(s) 178–191

    Abstract: Background:  Unplanned intensive care unit (ICU) admissions from medical/surgical floors and increased boarding times of ICU patients in the emergency department (ED) are common; approximately half of these are associated with adverse events. We explore ...

    Abstract Background:  Unplanned intensive care unit (ICU) admissions from medical/surgical floors and increased boarding times of ICU patients in the emergency department (ED) are common; approximately half of these are associated with adverse events. We explore the potential role of a tele-critical care consult service (TC3) in managing critically ill patients outside of the ICU and potentially preventing low-acuity unplanned admissions and also investigate its design and implementation needs.
    Methods:  We conducted a qualitative study involving general observations of the units, shadowing of clinicians during patient transfers, and interviews with clinicians from the ED, medical/surgical floor units and their ICU counterparts, tele-ICU, and the rapid response team at a large academic medical center in St. Louis, Missouri, United States. We used a hybrid thematic analysis approach supported by open and structured coding using the Consolidated Framework for Implementation Research (CFIR).
    Results:  Over 165 hours of observations/shadowing and 26 clinician interviews were conducted. Our findings suggest that a tele-critical care consult (TC3) service can prevent avoidable, lower acuity ICU admissions by offering a second set of eyes via remote monitoring and providing guidance to bedside and rapid response teams in the care delivery of these patients on the floor/ED. CFIR-informed enablers impacting the successful implementation of the TC3 service included the optional and on-demand features of the TC3 service, around-the-clock availability, and continuous access to trained critical care clinicians for avoidable lower acuity (ALA) patients outside of the ICU, familiarity with tele-ICU staff, and a willingness to try alternative patient risk mitigation strategies for ALA patients (suggested by TC3), before transferring all unplanned admissions to ICUs. Conversely, the CFIR-informed barriers to implementation included a desire to uphold physician autonomy by floor/ED clinicians, potential role conflicts with rapid response teams, additional workload for floor/ED nurses, concerns about obstructing unavoidable, higher acuity admissions, and discomfort with audio-visual tools. To amplify these potential enablers and mitigate potential barriers to TC3 implementation, informed by this study, we propose
    Conclusion:  Tele-critical care represents an innovative strategy for delivering safe and high-quality critical care services to lower acuity borderline patients outside the ICU setting.
    MeSH term(s) Humans ; Telemedicine ; Critical Care ; Intensive Care Units ; Academic Medical Centers ; Emergency Service, Hospital
    Language English
    Publishing date 2024-03-06
    Publishing country Germany
    Document type Journal Article
    ISSN 1869-0327
    ISSN (online) 1869-0327
    DOI 10.1055/s-0044-1780508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Response to "Body temperature correlates with mortality in COVID-19 patients".

    Drewry, Anne M / Hotchkiss, Richard / Kulstad, Erik

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 460

    MeSH term(s) Betacoronavirus ; Body Temperature ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-24
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03186-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Response to "COVID-19: room for treating T cell exhaustion?"

    Drewry, Anne M / Hotchkiss, Richard / Kulstad, Erik

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 345

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-15
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03068-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Core Warming of Coronavirus Disease 2019 Patients Undergoing Mechanical Ventilation: A Pilot Study.

    Bonfanti, Nathaniel P / Mohr, Nicholas M / Willms, David C / Bedimo, Roger J / Gundert, Emily / Goff, Kristina L / Kulstad, Erik B / Drewry, Anne M

    Therapeutic hypothermia and temperature management

    2023  Volume 13, Issue 4, Page(s) 225–229

    Abstract: ... 5) years, 37% female, mean weight 95.1 (±18.6) kg, and mean body mass index 34.5 (±5.9) kg/m ...

    Abstract Fever is a recognized protective factor in patients with sepsis, and growing data suggest beneficial effects on outcomes in sepsis with elevated temperature, with a recent pilot randomized controlled trial (RCT) showing lower mortality by warming afebrile sepsis patients in the intensive care unit (ICU). The objective of this prospective single-site RCT was to determine if core warming improves respiratory physiology of mechanically ventilated patients with coronavirus disease 2019 (COVID-19), allowing earlier weaning from ventilation, and greater overall survival. A total of 19 patients with mean age of 60.5 (±12.5) years, 37% female, mean weight 95.1 (±18.6) kg, and mean body mass index 34.5 (±5.9) kg/m
    MeSH term(s) Female ; Humans ; Middle Aged ; Male ; COVID-19/therapy ; Respiration, Artificial ; Pilot Projects ; Hypothermia, Induced ; Oxygen ; Sepsis
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2609342-X
    ISSN 2153-7933 ; 2153-7658
    ISSN (online) 2153-7933
    ISSN 2153-7658
    DOI 10.1089/ther.2023.0030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Response to “Body temperature correlates with mortality in COVID-19 patients”

    Anne M. Drewry / Richard Hotchkiss / Erik Kulstad

    Critical Care, Vol 24, Iss 1, Pp 1-

    2020  Volume 2

    Keywords Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Response to “COVID-19

    Anne M. Drewry / Richard Hotchkiss / Erik Kulstad

    Critical Care, Vol 24, Iss 1, Pp 1-

    room for treating T cell exhaustion?”

    2020  Volume 2

    Keywords Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Expanding Critical Care Delivery beyond the Intensive Care Unit: Determining the Design and Implementation Needs for a Tele-Critical Care Consultation Service

    Abraham, Joanna / Kandasamy, Madhumitha / Fritz, Bradley / Konzen, Lisa / White, Jason / Drewry, Anne / Palmer, Christopher

    Applied Clinical Informatics

    2024  Volume 15, Issue 01, Page(s) 178–191

    Abstract: Background: Unplanned intensive care unit (ICU) admissions from medical/surgical floors and increased boarding times of ICU patients in the emergency department (ED) are common; approximately half of these are associated with adverse events. We explore ... ...

    Abstract Background: Unplanned intensive care unit (ICU) admissions from medical/surgical floors and increased boarding times of ICU patients in the emergency department (ED) are common; approximately half of these are associated with adverse events. We explore the potential role of a tele-critical care consult service (TC3) in managing critically ill patients outside of the ICU and potentially preventing low-acuity unplanned admissions and also investigate its design and implementation needs.
    Methods: We conducted a qualitative study involving general observations of the units, shadowing of clinicians during patient transfers, and interviews with clinicians from the ED, medical/surgical floor units and their ICU counterparts, tele-ICU, and the rapid response team at a large academic medical center in St. Louis, Missouri, United States. We used a hybrid thematic analysis approach supported by open and structured coding using the Consolidated Framework for Implementation Research (CFIR).
    Results: Over 165 hours of observations/shadowing and 26 clinician interviews were conducted. Our findings suggest that a tele-critical care consult (TC3) service can prevent avoidable, lower acuity ICU admissions by offering a second set of eyes via remote monitoring and providing guidance to bedside and rapid response teams in the care delivery of these patients on the floor/ED. CFIR-informed enablers impacting the successful implementation of the TC3 service included the optional and on-demand features of the TC3 service, around-the-clock availability, and continuous access to trained critical care clinicians for avoidable lower acuity (ALA) patients outside of the ICU, familiarity with tele-ICU staff, and a willingness to try alternative patient risk mitigation strategies for ALA patients (suggested by TC3), before transferring all unplanned admissions to ICUs. Conversely, the CFIR-informed barriers to implementation included a desire to uphold physician autonomy by floor/ED clinicians, potential role conflicts with rapid response teams, additional workload for floor/ED nurses, concerns about obstructing unavoidable, higher acuity admissions, and discomfort with audio-visual tools. To amplify these potential enablers and mitigate potential barriers to TC3 implementation, informed by this study, we propose two key characteristics— essential for extending the delivery of critical care services beyond the ICU underlying a telemedicine critical care consultation model including its virtual footprint and on-demand and optional service features.
    Conclusion: Tele-critical care represents an innovative strategy for delivering safe and high-quality critical care services to lower acuity borderline patients outside the ICU setting.
    Keywords ICU ; admissions ; transfers ; rapid response teams ; acute care ; eICU ; tele-ICU ; telemedicine ; early warning system ; on-demand
    Language English
    Publishing date 2024-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 1869-0327
    ISSN (online) 1869-0327
    DOI 10.1055/s-0044-1780508
    Database Thieme publisher's database

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