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Article ; Online: Protective effects of Re-yan-ning mixture on

Han, Lizhu / Kou, Jing / Hu, Kunxia / Wang, Yunlan / Tang, Zhishu / Wu, Zhisheng / Song, Xiao

2021 Volume 59, Issue 1, Page(s) 209–221

Abstract: Context: Re-yan-ning mixture (RYNM) is a new national drug approved by China's State ...

Abstract	Context: Re-yan-ning mixture (RYNM) is a new national drug approved by China's State Food and Drug Administration for the treatment of colds, simple pneumonia and acute bronchitis. Objective: To determine the mechanism of action of RYNM in the treatment of bacterial pneumonia. Materials and methods: Using the network pharmacology approach, the multiple components, component candidate targets and multiple therapeutic targets of RYNM were screened and functionally enriched. Also, we established a rat Results: The network pharmacology approach successfully identified 48 bioactive components in RYNM, and 65 potential targets and 138 signal pathways involved in the treatment of Discussion and conclusions: The present study demonstrated the protective effects of RYNM on
MeSH term(s)	Animals ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Inflammation/drug therapy ; Inflammation/microbiology ; Male ; NF-kappa B/metabolism ; Pneumonia, Pneumococcal/microbiology ; Pneumonia, Pneumococcal/prevention & control ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Streptococcus pneumoniae/drug effects ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Drugs, Chinese Herbal ; NF-kappa B ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2021-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2021.1872653
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Article ; Online: Liao ning virus in China.

Lu, Zhi / Liu, Hong / Fu, Shihong / Lu, Xinjun / Dong, Qiang / Zhang, Song / Tong, Suxiang / Li, Minghua / Li, Wenjuan / Tang, Qing / Liang, Guodong

Virology journal

2011 Volume 8, Page(s) 282

Abstract: Background: Liao ning virus is in the genus Seadornavirus within the family Reoviridae and has ...

Abstract	Background: Liao ning virus is in the genus Seadornavirus within the family Reoviridae and has a genome composed of 12 segments of double-stranded RNA (dsRNA). It is transmitted by mosquitoes and only isolated in China to date and it is the only species within the genus Seadornavirus which was reported to have been propagated in mammalian cell lines. In the study, we report 41 new isolates from northern and southern Xinjiang Uygur autonomous region in China and describe the phylogenetic relationships among all 46 Chinese LNV isolates. Findings: The phylogenetic analysis indicated that all the isolates evaluated in this study can be divided into 3 different groups that appear to be related to geographic origin based on partial nucleotide sequence of the 10th segment which is predicted to encode outer coat proteins of LNV. Bayesian coalescent analysis estimated the date of the most recent common ancestor for the current Chinese LNV isolates to be 318 (with a 95% confidence interval of 30-719) and the estimated evolutionary rates is 1.993 × 10-3 substitutions per site per year. Conclusions: The results indicated that LNV may be an emerging virus at a stage that evaluated rapidly and has been widely distributed in the north part of China.
MeSH term(s)	Animals ; China ; Cluster Analysis ; Culicidae/virology ; Evolution, Molecular ; Genotype ; Phylogeny ; Phylogeography ; Polymorphism, Genetic ; RNA, Viral/genetics ; Reoviridae/classification ; Reoviridae/genetics ; Reoviridae/isolation & purification
Chemical Substances	RNA, Viral
Language	English
Publishing date	2011-06-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2160640-7
ISSN	1743-422X ; 1743-422X
ISSN (online)	1743-422X
ISSN	1743-422X
DOI	10.1186/1743-422X-8-282
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Article ; Online: Protective effects of Re-yan-ning mixture on Streptococcus pneumonia in rats based on network pharmacology

Lizhu Han / Jing Kou / Kunxia Hu / Yunlan Wang / Zhishu Tang / Zhisheng Wu / Xiao Song

Pharmaceutical Biology, Vol 59, Iss 1, Pp 209-

2021 Volume 221

Abstract: Context Re-yan-ning mixture (RYNM) is a new national drug approved by China's State ...

Abstract	Context Re-yan-ning mixture (RYNM) is a new national drug approved by China's State Food and Drug Administration for the treatment of colds, simple pneumonia and acute bronchitis. Objective To determine the mechanism of action of RYNM in the treatment of bacterial pneumonia. Materials and methods Using the network pharmacology approach, the multiple components, component candidate targets and multiple therapeutic targets of RYNM were screened and functionally enriched. Also, we established a rat Streptococcus pneumonia model to verify the results of network pharmacology enrichment analysis. Forty male SPF Sprague Dawley rats were divided into four groups of 10 rats: control (normal saline), model (normal saline), levofloxacin-intervened and RYNM-intervened groups. IL-10, NOS2, COX-1, IL-6, TNF-α and NF-κB in serum and BALF were detected by ELISA. Western blot detected IL-17, IL-6, TNF-α, COX-2 and Bcl-2. Results The network pharmacology approach successfully identified 48 bioactive components in RYNM, and 65 potential targets and 138 signal pathways involved in the treatment of Streptococcus pneumonia with RYNM. The in vivo experiments indicated that model group has visible inflammation and lesions while RYNM and levofloxacin groups have not. The RYNM exhibited its therapeutic effects on Streptococcus pneumonia mainly via the regulation of cell proliferation and survival through the IL-6/IL-10/IL-17, Bax/Bcl-2, COX-1/COX-2, NF-κB and TNF-α signalling pathways. Discussion and conclusions The present study demonstrated the protective effects of RYNM on Streptococcus pneumonia, providing a potential mechanism for the treatment of bacterial pneumonia with RYNM.
Keywords	traditional chinese medicine ; pneumonia ; signal pathway ; Therapeutics. Pharmacology ; RM1-950
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Protective effects of Re-yan-ning mixture on Streptococcus pneumonia in rats based on network pharmacology

Han, Lizhu / Kou, Jing / Hu, Kunxia / Wang, Yunlan / Tang, Zhishu / Wu, Zhisheng / Song, Xiao

Pharmaceutical Biology. 2021 Jan. 1, v. 59, no. 1 p.207-219

2021

Abstract: Re-yan-ning mixture (RYNM) is a new national drug approved by China's State ...

Abstract	Re-yan-ning mixture (RYNM) is a new national drug approved by China's State Food and Drug Administration for the treatment of colds, simple pneumonia and acute bronchitis. To determine the mechanism of action of RYNM in the treatment of bacterial pneumonia. Using the network pharmacology approach, the multiple components, component candidate targets and multiple therapeutic targets of RYNM were screened and functionally enriched. Also, we established a rat Streptococcus pneumonia model to verify the results of network pharmacology enrichment analysis. Forty male SPF Sprague Dawley rats were divided into four groups of 10 rats: control (normal saline), model (normal saline), levofloxacin-intervened and RYNM-intervened groups. IL-10, NOS2, COX-1, IL-6, TNF-α and NF-κB in serum and BALF were detected by ELISA. Western blot detected IL-17, IL-6, TNF-α, COX-2 and Bcl-2. The network pharmacology approach successfully identified 48 bioactive components in RYNM, and 65 potential targets and 138 signal pathways involved in the treatment of Streptococcus pneumonia with RYNM. The in vivo experiments indicated that model group has visible inflammation and lesions while RYNM and levofloxacin groups have not. The RYNM exhibited its therapeutic effects on Streptococcus pneumonia mainly via the regulation of cell proliferation and survival through the IL-6/IL-10/IL-17, Bax/Bcl-2, COX-1/COX-2, NF-κB and TNF-α signalling pathways. The present study demonstrated the protective effects of RYNM on Streptococcus pneumonia, providing a potential mechanism for the treatment of bacterial pneumonia with RYNM.
Keywords	Food and Drug Administration ; Streptococcus ; Western blotting ; bacterial pneumonia ; blood serum ; bronchitis ; cell proliferation ; inflammation ; interleukin-10 ; interleukin-17 ; interleukin-6 ; levofloxacin ; males ; mechanism of action ; models ; pharmacology ; rats ; therapeutics ; China ; Traditional Chinese medicine ; pneumonia ; signal pathway
Language	English
Dates of publication	2021-0101
Size	p. 207-219.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2021.1872653
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Article ; Online: Effect of Sheng Xue Ning Tablets on Renal Anemia in Patients Subject to Maintenance Hemodialysis and Safety Evaluation: A Multi-setting Prospective Randomized Study.

Tang, Xiao-Jing / Rong, Shu / Mei, Chang-Lin / Ni, Zhao-Hui / Jiang, Geng-Ru / Yuan, Wei-Jie / Wang, Nian-Song / Guo, Zhi-Yong / Ma, Jun / Yan, Hai-Dong / ZHang, Li-Ming

Current medical science

2020 Volume 40, Issue 2, Page(s) 327–331

Abstract: This study compared Sheng Xue Ning (SXN) tablets with ferrous succinate (FS) tablets in terms ...

Abstract	This study compared Sheng Xue Ning (SXN) tablets with ferrous succinate (FS) tablets in terms of their efficacy for the treatment of iron-deficient renal anemia and safety in patients subject to maintenance hemodialysis (MHD). A total of 94 patients undergoing MHD were randomly assigned to an experiment group (receiving oral SXN tablets, SXN group) and a control group (orally given FS tablets, FS group) and followed up for 12 weeks. Erythropoietin (EPO) was used in both groups. The efficacy was assessed by detecting the subsequent changes in hemoglobin (Hb), serum iron (SI), SF and transferrin saturation (TSAT). At the 12th week, Hb and TSAT levels in both groups were significantly increased compared to those in the screening period (P<0.05). However, no significant difference in Hb and TSAT was found between the two groups. The average weekly EPO dosage used was lower in SXN group than in FS group (P<0.05) at the 10th week and the 12th week. Our study showed that SXN tablets can effectively ameliorate renal anemia and keep iron metabolism stable in MHD patients, and its efficacy is virtually close to that of FS tablets. Meanwhile, SXN tablets can reduce the dosage of EPO and have a good safety profile.
MeSH term(s)	Administration, Oral ; Adult ; Aged ; Anemia/drug therapy ; Anemia/etiology ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/therapeutic use ; Female ; Ferrous Compounds/administration & dosage ; Ferrous Compounds/therapeutic use ; Hemoglobins/analysis ; Humans ; Iron/blood ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Prospective Studies ; Renal Dialysis/adverse effects ; Tablets ; Treatment Outcome ; Young Adult
Chemical Substances	Drugs, Chinese Herbal ; Ferrous Compounds ; Hemoglobins ; Tablets ; shengxuening ; ferrous succinate (818ZYK7N91) ; Iron (E1UOL152H7)
Language	English
Publishing date	2020-04-26
Publishing country	China
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2931065-9
ISSN	2523-899X ; 2096-5230
ISSN (online)	2523-899X
ISSN	2096-5230
DOI	10.1007/s11596-020-2179-z
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Article ; Online: Bu‑Shen‑Ning‑Xin decoction suppresses osteoclastogenesis by modulating RANKL/OPG imbalance in the CD4+ T lymphocytes of ovariectomized mice.

Zhang, Jia-Li / Qiu, Xue-Min / Zhang, Na / Tang, Wei / Gober, Hans-Jürgen / Li, Da-Jin / Wang, Ling

International journal of molecular medicine

2018 Volume 42, Issue 1, Page(s) 299–308

Abstract: ... serve a key role in the interaction between bone metabolism and the immune system. Bu‑Shen‑Ning‑Xin ...

Abstract	Postmenopausal osteoporosis (PMO) has been recognized as an inflammatory condition. CD4+ T cells serve a key role in the interaction between bone metabolism and the immune system. Bu‑Shen‑Ning‑Xin decoction (BSNXD), a traditional Chinese medicine, has been ultilized as a remedy for PMO. In the present study, the aim was to investigate the immune modulatory effects of BSNXD on CD4+ T cells, receptor activation of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG) imbalance, skeletal parameters and osteoclastogenesis. Ovariectomized (OVX) mice were treated with a series of concentrations of BSNXD and then autopsied. The bone phenotype was analyzed by micro computed tomography. CD4+ T cells were isolated and their percentage was measured using flow cytometry (FCM). RANKL and OPG expression by the CD4+ T cells at the transcriptional and translational levels were quantified by reverse transcription-quantitative polymerase chain reaction, ELISA and FCM. CD4+ T cells were cultured with blood serum derived from BSNXD‑treated OVX mice (BSNXD‑derived serum) and the apoptosis rate was quantified by FCM. CD4+ T cells were co-cultured with bone marrow‑derived macrophages and exposed to BSNXD‑derived serum to whether CD4+ T cells are involved in BSNXD‑modulated osteoclastogenesis and the results were quantified via tartrate‑resistant acid phosphatase staining. The results revealed that BSNXD ameliorated OVX‑induced bone loss, prevented the expansion of CD4+ T cells and restored the RANKL/OPG imbalance in the CD4+ T cells of OVX mice. In vitro, BSNXD‑derived serum promoted the apoptosis of CD4+ T cells. The co‑culture system demonstrated that CD4+ T cells from OVX mice increase osteoclastogenesis, while this effect was suppressed by BSNXD administration. The findings of the study collectively suggest that BSNXD exerts an immunoprotective effect on the bone phenotype of OVX mice by ameliorating RANKL/OPG imbalance in CD4+ T cells and attenuating osteoclastogenesis.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Bone and Bones/drug effects ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/metabolism ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Female ; Mice, Inbred BALB C ; Models, Biological ; Osteoclasts/drug effects ; Osteoclasts/metabolism ; Osteogenesis/drug effects ; Osteoprotegerin/metabolism ; Ovariectomy ; Phenotype ; RANK Ligand/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Osteoprotegerin ; RANK Ligand ; bu-shen-ning-xin
Language	English
Publishing date	2018-04-26
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1444428-8
ISSN	1791-244X ; 1107-3756
ISSN (online)	1791-244X
ISSN	1107-3756
DOI	10.3892/ijmm.2018.3645
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Article ; Online: Liao ning virus in China

Tang Qing / Li Wenjuan / Tong Suxiang / Li Minghua / Zhang Song / Dong Qiang / Lu Xinjun / Fu Shihong / Liu Hong / Lu Zhi / Liang Guodong

Virology Journal, Vol 8, Iss 1, p

2011 Volume 282

Abstract: Abstract Background Liao ning virus is in the genus Seadornavirus within the family Reoviridae and ...

Abstract	Abstract Background Liao ning virus is in the genus Seadornavirus within the family Reoviridae and has a genome composed of 12 segments of double-stranded RNA (dsRNA). It is transmitted by mosquitoes and only isolated in China to date and it is the only species within the genus Seadornavirus which was reported to have been propagated in mammalian cell lines. In the study, we report 41 new isolates from northern and southern Xinjiang Uygur autonomous region in China and describe the phylogenetic relationships among all 46 Chinese LNV isolates. Findings The phylogenetic analysis indicated that all the isolates evaluated in this study can be divided into 3 different groups that appear to be related to geographic origin based on partial nucleotide sequence of the 10th segment which is predicted to encode outer coat proteins of LNV. Bayesian coalescent analysis estimated the date of the most recent common ancestor for the current Chinese LNV isolates to be 318 (with a 95% confidence interval of 30-719) and the estimated evolutionary rates is 1.993 × 10 -3 substitutions per site per year. Conclusions The results indicated that LNV may be an emerging virus at a stage that evaluated rapidly and has been widely distributed in the north part of China.
Keywords	Microbiology ; QR1-502 ; Science ; Q ; DOAJ:Microbiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	580
Language	English
Publishing date	2011-06-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Antidiarrheal properties of different extracts of Chinese herbal medicine formula Bao-Xie-Ning.

Li, Jing / Wu, Xin-lin / Chen, Yuling / Tang, Zhi / Xu, Yue-hong / Jiang, Jian-min / Gu, Yue-yu / Chen, Jian-ping / Yang, De-po / Wang, Dong-mei

Journal of integrative medicine

2013 Volume 11, Issue 2, Page(s) 125–134

Abstract: Objective: Bao-Xie-Ning (BXN), a traditional Chinese herbal medicine (CHM) formula composed ...

Abstract	Objective: Bao-Xie-Ning (BXN), a traditional Chinese herbal medicine (CHM) formula composed of Fructus Evodiae, Flos Caryophylli and Cortex Cinnamomi, and used for the treatment of infant diarrheal illness, was subject to systematic assessment for its putative multiple pharmacodynamic effects and pharmacological antidiarrheal mechanisms. Methods: High-performance liquid chromatography-diode array detector-electrospray ionization-mass spectrometric/mass spectrometry was developed and validated for identification and quantification of the main constituents in different extracts of BXN. Male Kunming mice weighing 20 to 25 g were used for detecting the antidiarrheal activity of the extracts. Ethanolic extract (EE), volatile oil extract (VOE), and aqueous extract (AE) of BXN were respectively subjected to pharmacodynamic and pharmacological comparison in assessing antidiarrheal effects with senna-induced diarrhea, castor oil-induced diarrhea, acetic acid-induced writhing assay, and isolated duodenum test. Results: The highest yields of three detected components of BXN, rutaecarpine, eugenol and cinnamaldehyde were observed in EE. EE showed the most remarkable antidiarrheal activity in dose-dependent and time-dependent manners in both senna- and castor oil-induced diarrhea models, and presented dose-dependent analgesic activity in acetic acid-induced algesthesia model. In addition, EE extract of BXN also exhibited strong antimobility action on the intestine and strongest depression on spontaneous contraction of isolated duodenum. Conclusion: Ethanol extraction is an efficient method to extract the active constituents of BXN. BXN extract demonstrated multiple pharmacological activities affecting the main mechanisms of diarrhea, which validated BXN's usage in the comprehensive clinical treatment of diarrhea.
MeSH term(s)	Animals ; Antidiarrheals/administration & dosage ; Antidiarrheals/analysis ; Chromatography, High Pressure Liquid ; Diarrhea/drug therapy ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/analysis ; Humans ; Male ; Mice ; Plants, Medicinal/chemistry
Chemical Substances	Antidiarrheals ; Drugs, Chinese Herbal
Language	English
Publishing date	2013-03
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2705612-0
ISSN	2095-4964
ISSN	2095-4964
DOI	10.3736/jintegrmed2013019
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Article: Insights into Chemical Structure-Based Modeling for New Sweetener Discovery.

Tang, Ning

Foods (Basel, Switzerland)

2023 Volume 12, Issue 13

Abstract: The search for novel, natural, high-sweetness, low-calorie sweeteners remains open and challenging. In the present study, the structure-based machine learning modeling and sweetness recognition mechanism were investigated to assist this process. It was ... ...

Abstract	The search for novel, natural, high-sweetness, low-calorie sweeteners remains open and challenging. In the present study, the structure-based machine learning modeling and sweetness recognition mechanism were investigated to assist this process. It was found that whether or not a compound was sweet was closely related to molecular connectivity and composition (the number of hydrogen bond acceptors and donors), tpsaEfficiency, structural complexity, and shape (nAtomP and Fsp3). While the relative sweetness of sweet compounds was more determined by the molecular properties (tpsaEfficiency and Log P), structural complexity and composition (nAtomP and ATSm 1). The built machine learning models exhibited very good performance for classifying the sweet/non-sweet compounds and predicting the relative sweetness of the compounds. Moreover, a specific binding pocket was found for sweet compounds, and the sweet compounds mainly interacted with the VFT domain of the T1R2-T1R3 through hydrogen bonds. In addition, the results indicated that among the sweet compounds, those that were sweeter bound to the VFT domain stronger than those that had low sweetness. This study provides very useful information for developing new sweeteners.
Language	English
Publishing date	2023-06-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12132563
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Article ; Online: Insights into Chemical Structure-Based Modeling for New Sweetener Discovery

Tang, Ning

Foods. 2023 June 30, v. 12, no. 13

2023

Abstract	The search for novel, natural, high-sweetness, low-calorie sweeteners remains open and challenging. In the present study, the structure-based machine learning modeling and sweetness recognition mechanism were investigated to assist this process. It was found that whether or not a compound was sweet was closely related to molecular connectivity and composition (the number of hydrogen bond acceptors and donors), tpsaEfficiency, structural complexity, and shape (nAtomP and Fsp3). While the relative sweetness of sweet compounds was more determined by the molecular properties (tpsaEfficiency and Log P), structural complexity and composition (nAtomP and ATSm 1). The built machine learning models exhibited very good performance for classifying the sweet/non-sweet compounds and predicting the relative sweetness of the compounds. Moreover, a specific binding pocket was found for sweet compounds, and the sweet compounds mainly interacted with the VFT domain of the T1R2-T1R3 through hydrogen bonds. In addition, the results indicated that among the sweet compounds, those that were sweeter bound to the VFT domain stronger than those that had low sweetness. This study provides very useful information for developing new sweeteners.
Keywords	hydrogen ; hydrogen bonding ; sweetness
Language	English
Dates of publication	2023-0630
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12132563
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