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  1. Article ; Online: Response to comment on "genetic variants and source of introduction of SARS-CoV-2 in South America".

    Poterico, Julio A / Mestanza, Orson

    Journal of medical virology

    2020  Volume 93, Issue 1, Page(s) 25–27

    Abstract: During a pandemic, science needs data to generate helpful evidence, and researchers assume this responsibility despite the risk of potential bias. This is the response to the comment made by Pedro Romero, who argued that our manuscript did not use ... ...

    Abstract During a pandemic, science needs data to generate helpful evidence, and researchers assume this responsibility despite the risk of potential bias. This is the response to the comment made by Pedro Romero, who argued that our manuscript did not use reassembling and mapping strategies for corroborating mutations, and lacked bootstrap support in the phylogenetic analysis.
    MeSH term(s) COVID-19 ; Humans ; Pandemics ; Phylogeny ; SARS-CoV-2 ; South America/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-08-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26359
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  2. Article ; Online: Genetic variants and source of introduction of SARS-CoV-2 in South America.

    Poterico, Julio A / Mestanza, Orson

    Journal of medical virology

    2020  Volume 92, Issue 10, Page(s) 2139–2145

    Abstract: After more than 4 months of the COVID-19 pandemics with genomic information of SARS-CoV-2 around the globe, there are more than 1000 complete genomes of this virus. We used 691 genomes from the GISAID database. Several studies have been reporting ... ...

    Abstract After more than 4 months of the COVID-19 pandemics with genomic information of SARS-CoV-2 around the globe, there are more than 1000 complete genomes of this virus. We used 691 genomes from the GISAID database. Several studies have been reporting mutations and hotspots according to viral evolution. Our work intends to show and compare positions that have variants in 30 complete viral genomes from South American countries. We classified strains according to point alterations and portray the source where strains came into this region. Most viruses entered South America from Europe, followed by Oceania. Only Chilean isolates demonstrated a relationship with Asian isolates. Some changes in South American genomes are near to specific domains related to viral replication or the S protein. Our work contributes to the global understanding of which sort of strains are spreading throughout South America, and the differences among them according to the first isolates introduced to this region.
    MeSH term(s) Asia/epidemiology ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/transmission ; COVID-19/virology ; Europe/epidemiology ; Evolution, Molecular ; Genome, Viral ; Humans ; Molecular Epidemiology ; Mutation ; Pandemics ; Phylogeny ; SARS-CoV-2/classification ; SARS-CoV-2/genetics ; South America/epidemiology ; Spike Glycoprotein, Coronavirus/genetics ; Travel ; Virus Replication
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26001
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  3. Article: Antigen-Induced IL-1RA Production Discriminates Active and Latent Tuberculosis Infection.

    Sanchez, Cesar / Jaramillo-Valverde, Luis / Capristano, Silvia / Solis, Gilmer / Soto, Alonso / Valdivia-Silva, Julio / Poterico, Julio A / Guio, Heinner

    Microorganisms

    2023  Volume 11, Issue 6

    Abstract: The IGRA (Interferon Gamma Release Assays) test is currently the standard specific test ... ...

    Abstract The IGRA (Interferon Gamma Release Assays) test is currently the standard specific test for
    Language English
    Publishing date 2023-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11061385
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  4. Article ; Online: Pharmacogenetic variability of tuberculosis biomarkers in native and mestizo Peruvian populations.

    Jaramillo-Valverde, Luis / Levano, Kelly S / Tarazona, David D / Capristano, Silvia / Sanchez, Cesar / Poterico, Julio A / Tarazona-Santos, Eduardo / Guio, Heinner

    Pharmacology research & perspectives

    2024  Volume 12, Issue 3, Page(s) e1179

    Abstract: In Peru, 29 292 people were diagnosed with tuberculosis in 2022. Although tuberculosis treatments are effective, 3.4%-13% are associated with significant adverse drug reactions, with drug-induced liver injury (DILI) considered the most predominant. Among ...

    Abstract In Peru, 29 292 people were diagnosed with tuberculosis in 2022. Although tuberculosis treatments are effective, 3.4%-13% are associated with significant adverse drug reactions, with drug-induced liver injury (DILI) considered the most predominant. Among the first-line antituberculosis drugs, isoniazid is the main drug responsible for the appearance of DILI. In liver, isoniazid (INH) is metabolized by N-acetyltransferase-2 (NAT2) and cytochrome P450 2E1 (CYP2E1). Limited information exists on genetic risk factors associated with the presence of DILI to antituberculosis drugs in Latin America, and even less is known about these factors in the native and mestizo Peruvian population. The aim of this study was to determine the prevalence of NAT2 and CYP2E1 genotypes in native and mestizo population. An analytical cross-sectional analysis was performed using genetic data from mestizo population in Lima and native participants from south of Peru. NAT2 metabolizer was determined as fast, intermediate and slow, and CYP2E1 genotypes were classified as c1/c1, c1/c2 and c2/c2, from molecular tests and bioinformatic analyses. Of the 472 participants, 36 and 6 NAT2 haplotypes were identified in the mestizo and native population, respectively. In mestizo population, the most frequent NAT2*5B and NAT2*7B haplotypes were associated with DILI risk; while in natives, NAT2*5G and NAT2*13A haplotypes were associated with decreased risk of DILI. For CYP2E1, c1/c1 and c1/c2 genotypes are the most frequent in natives and mestizos, respectively. The linkage disequilibrium of NAT2 single nucleotide polymorphisms (SNPs) was estimated, detecting a block between all SNPs natives. In addition, a block between rs1801280 and rs1799929 for NAT2 was detected in mestizos. Despite the limitations of a secondary study, it was possible to report associations between NAT2 and CYP2E alleles with Peruvian native and mestizo by prevalence ratios. The results of this study will help the development of new therapeutic strategies for a Tuberculosis efficient control between populations.
    MeSH term(s) Humans ; Peru ; Arylamine N-Acetyltransferase/genetics ; Antitubercular Agents/therapeutic use ; Antitubercular Agents/adverse effects ; Female ; Male ; Adult ; Middle Aged ; Tuberculosis/genetics ; Tuberculosis/drug therapy ; Isoniazid/adverse effects ; Isoniazid/therapeutic use ; Cytochrome P-450 CYP2E1/genetics ; Cross-Sectional Studies ; Chemical and Drug Induced Liver Injury/genetics ; Young Adult ; Genotype ; Indians, South American/genetics ; Biomarkers ; Adolescent ; Aged ; Pharmacogenetics
    Chemical Substances Arylamine N-Acetyltransferase (EC 2.3.1.5) ; Antitubercular Agents ; NAT2 protein, human (EC 2.3.1.5) ; Isoniazid (V83O1VOZ8L) ; Cytochrome P-450 CYP2E1 (EC 1.14.13.-) ; Biomarkers
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2740389-0
    ISSN 2052-1707 ; 2052-1707
    ISSN (online) 2052-1707
    ISSN 2052-1707
    DOI 10.1002/prp2.1179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Genetic variants and source of introduction of SARS‐CoV‐2 in South America

    Poterico, Julio A. / Mestanza, Orson

    Journal of Medical Virology

    2020  Volume 92, Issue 10, Page(s) 2139–2145

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26001
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Response to comment on “genetic variants and source of introduction of SARS‐CoV‐2 in South America”

    Poterico, Julio A. / Mestanza, Orson

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    2020  

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jmv.26359
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Response to comment on "genetic variants and source of introduction of SARS-CoV-2 in South America"

    Poterico, Julio A / Mestanza, Orson

    J. med. virol

    Abstract: During a pandemic, science needs data to generate helpful evidence, and researchers assume this responsibility despite the risk of potential bias. This is the response to the comment made by Pedro Romero, who argued that our manuscript did not use ... ...

    Abstract During a pandemic, science needs data to generate helpful evidence, and researchers assume this responsibility despite the risk of potential bias. This is the response to the comment made by Pedro Romero, who argued that our manuscript did not use reassembling and mapping strategies for corroborating mutations, and lacked bootstrap support in the phylogenetic analysis.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #676602
    Database COVID19

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  8. Article ; Online: Giant cavernous malformation of the posterior fossa with lymphangiomatous phenotype, associated with orbital venolymphatic anomaly in an 11-month-old patient: case report and literature review.

    Flores-Sanchez, Jose Daniel / Pregúntegui, Ivethe / Ugas, Carlos / Cruzado, Carla / Ramirez, Alberto / Poterico, Julio A

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2022  Volume 39, Issue 1, Page(s) 289–293

    Abstract: The synchronous presentation of venolymphatic anomalies of the orbit and noncontiguous intracranial cavernous malformations is uncommon. Herein, we present a case of an 11-month-old female patient diagnosed with orbital venolymphatic anomaly associated ... ...

    Abstract The synchronous presentation of venolymphatic anomalies of the orbit and noncontiguous intracranial cavernous malformations is uncommon. Herein, we present a case of an 11-month-old female patient diagnosed with orbital venolymphatic anomaly associated with a large cavernous malformation in the posterior fossa, who underwent complete surgical resection of the latter. The immunohistochemical analysis was positive for podoplanin, a marker expressed by lymphatic endothelial cells, but not vascular endothelium. This exceptional finding suggests lymphatic involvement in the etiology of the lesion. In our review of the literature, we did not find similar cases in patients under 1 year of age.
    MeSH term(s) Female ; Endothelial Cells ; Orbit ; Humans ; Infant
    Language English
    Publishing date 2022-07-29
    Publishing country Germany
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-022-05623-3
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    Zs.A 2036: Show issues Location:
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  9. Article: Genetic variants and source of introduction of SARS-CoV-2 in South America

    Poterico, Julio A / Mestanza, Orson

    J. med. virol

    Abstract: After more than 4 months of the COVID-19 pandemics with genomic information of SARS-CoV-2 around the globe, there are more than 1000 complete genomes of this virus. We used 691 genomes from the GISAID database. Several studies have been reporting ... ...

    Abstract After more than 4 months of the COVID-19 pandemics with genomic information of SARS-CoV-2 around the globe, there are more than 1000 complete genomes of this virus. We used 691 genomes from the GISAID database. Several studies have been reporting mutations and hotspots according to viral evolution. Our work intends to show and compare positions that have variants in 30 complete viral genomes from South American countries. We classified strains according to point alterations and portray the source where strains came into this region. Most viruses entered South America from Europe, followed by Oceania. Only Chilean isolates demonstrated a relationship with Asian isolates. Some changes in South American genomes are near to specific domains related to viral replication or the S protein. Our work contributes to the global understanding of which sort of strains are spreading throughout South America, and the differences among them according to the first isolates introduced to this region.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #245424
    Database COVID19

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  10. Article ; Online: Antigen-Induced IL-1RA Production Discriminates Active and Latent Tuberculosis Infection

    Cesar Sanchez / Luis Jaramillo-Valverde / Silvia Capristano / Gilmer Solis / Alonso Soto / Julio Valdivia-Silva / Julio A. Poterico / Heinner Guio

    Microorganisms, Vol 11, Iss 1385, p

    2023  Volume 1385

    Abstract: The IGRA (Interferon Gamma Release Assays) test is currently the standard specific test for Mycobacterium tuberculosis infection status. However, a positive test cannot distinguish between active tuberculosis disease (ATBD) and latent tuberculosis ... ...

    Abstract The IGRA (Interferon Gamma Release Assays) test is currently the standard specific test for Mycobacterium tuberculosis infection status. However, a positive test cannot distinguish between active tuberculosis disease (ATBD) and latent tuberculosis infection (LTBI). Developing a test with this characteristic is needed. We conducted longitudinal studies to identify a combination of antigen peptides and cytokines to discriminate between ATBD and LTBI. We studied 54 patients with ATBD disease and 51 with LTBI infection. Cell culture supernatant from cells stimulated with overlapping Mycobacterium tuberculosis novel peptides and 40 cytokines/chemokines were analyzed using the Luminex technology. To summarize longitudinal measurements of analyte levels, we calculated the area under the curve (AUC). Our results indicate that in vitro cell stimulation with a novel combination of peptides (Rv0849-12, Rv2031c-14, Rv2031c-5, and Rv2693-06) and IL-1RA detection in culture supernatants can discriminate between LTBI and ATBD.
    Keywords Mycobacterium tuberculosis ; biomarkers ; active tuberculosis ; latent tuberculosis ; immune response ; IL-1RA ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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