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Article: Oncostatin M is a Master Regulator of an Inflammatory Network in

Schwartz, Logan S / Young, Kira A / Stearns, Timothy M / Boyer, Nathan / Mujica, Kristina D / Trowbridge, Jennifer J

bioRxiv : the preprint server for biology

2023

Abstract: ... transcriptomic approaches, we identify Oncostatin M (OSM) signaling as a candidate contributor to aging-driven ...

Abstract	Age-associated clonal hematopoiesis (CH) occurs due to somatic mutations accrued in hematopoietic stem cells (HSCs) that confer a selective advantage in the context of aging. The mechanisms by which CH-mutant HSCs gain this advantage with aging are not comprehensively understood. Using unbiased transcriptomic approaches, we identify Oncostatin M (OSM) signaling as a candidate contributor to aging-driven
Language	English
Publishing date	2023-07-12
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.12.548764
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Article ; Online: Muscarinic (M

Huff, Andrew E / McGraw, Shelby D / Winters, Boyer D

Hippocampus

2021 Volume 32, Issue 1, Page(s) 55–66

Abstract: ... the neurotransmitter acetylcholine, acting at M ...

Abstract	Following the initial consolidation process, memories can become reactivated by exposure to a reminder of the original learning event. This can lead to the memory becoming destabilized and vulnerable to disruption or other forms of modification. The memory must then undergo the protein-synthesis dependent process of reconsolidation in order to be retained. However, older and/or stronger memories resist destabilization, but can become labile when reactivated in the presence of salient novelty. We have implicated the neurotransmitter acetylcholine, acting at M
MeSH term(s)	Animals ; Cholinergic Agents/metabolism ; Hippocampus/metabolism ; Humans ; Perirhinal Cortex/metabolism ; Rats ; Rats, Long-Evans ; Receptor, Muscarinic M1/metabolism ; Receptors, Cholinergic/metabolism
Chemical Substances	Cholinergic Agents ; Receptor, Muscarinic M1 ; Receptors, Cholinergic
Language	English
Publishing date	2021-12-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1074352-2
ISSN	1098-1063 ; 1050-9631
ISSN (online)	1098-1063
ISSN	1050-9631
DOI	10.1002/hipo.23396
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Zs.A 3227: Show issues

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Article ; Online: Transcriptional and functional consequences of Oncostatin M signaling on young Dnmt3a-mutant hematopoietic stem cells.

Schwartz, Logan S / Young, Kira A / Stearns, Timothy M / Boyer, Nathan / Mujica, Kristina D / Trowbridge, Jennifer J

Experimental hematology

2023 Volume 130, Page(s) 104131

Abstract: ... transcriptomic approaches, we identified Oncostatin M (OSM) signaling as a candidate contributor to age-related ...

Abstract	Age-associated clonal hematopoiesis (CH) occurs due to somatic mutations accrued in hematopoietic stem cells (HSCs) that confer a selective growth advantage in the context of aging. The mechanisms by which CH-mutant HSCs gain this advantage with aging are not comprehensively understood. Using unbiased transcriptomic approaches, we identified Oncostatin M (OSM) signaling as a candidate contributor to age-related Dnmt3a-mutant CH. We found that Dnmt3a-mutant HSCs from young adult mice (3-6 months old) subjected to acute OSM stimulation do not demonstrate altered proliferation, apoptosis, hematopoietic engraftment, or myeloid differentiation. Dnmt3a-mutant HSCs from young mice do transcriptionally upregulate an inflammatory cytokine network in response to acute in vitro OSM stimulation as evidenced by significant upregulation of the genes encoding IL-6, IL-1β, and TNFα. OSM-stimulated Dnmt3a-mutant HSCs also demonstrate upregulation of the anti-inflammatory genes Socs3, Atf3, and Nr4a1. In the context of an aged bone marrow (BM) microenvironment, Dnmt3a-mutant HSCs upregulate proinflammatory genes but not the anti-inflammatory genes Socs3, Atf3, and Nr4a1. The results from our studies suggest that aging may exhaust the regulatory mechanisms that HSCs employ to resolve inflammatory states in response to factors such as OSM.
MeSH term(s)	Animals ; Mice ; Anti-Inflammatory Agents ; Bone Marrow ; Hematopoiesis/genetics ; Hematopoietic Stem Cells ; Oncostatin M/genetics
Chemical Substances	Anti-Inflammatory Agents ; Oncostatin M (106956-32-5) ; Dnmt3a protein, mouse
Language	English
Publishing date	2023-11-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	185107-x
ISSN	1873-2399 ; 0531-5573 ; 0301-472X
ISSN (online)	1873-2399
ISSN	0531-5573 ; 0301-472X
DOI	10.1016/j.exphem.2023.11.005
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Zs.A 922: Show issues

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Article ; Online: Activation of cortical M

Jardine, Kristen H / Wideman, Cassidy E / MacGregor, Chelsea / Sgarbossa, Cassandra / Orr, Dean / Mitchnick, Krista A / Winters, Boyer D

Scientific reports

2020 Volume 10, Issue 1, Page(s) 9209

Abstract: ... blocked by interference with M ...

Abstract	Reactivated long-term memories can become labile and sensitive to modification. Memories in this destabilized state can be weakened or strengthened, but there is limited research characterizing the mechanisms underlying retrieval-induced qualitative updates (i.e., information integration). We have previously implicated cholinergic transmission in object memory destabilization. Here we present a novel rodent paradigm developed to assess the role of this cholinergic mechanism in qualitative object memory updating. The post-reactivation object memory modification (PROMM) task exposes rats to contextual information following object memory reactivation. Subsequent object exploratory performance suggests that the contextual information is integrated with the original memory in a reactivation- and time-dependent manner. This effect is blocked by interference with M
MeSH term(s)	Animals ; Benzylamines/pharmacology ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/antagonists & inhibitors ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Inositol 1,4,5-Trisphosphate Receptors/antagonists & inhibitors ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Lactones/pharmacology ; Male ; Memory/drug effects ; Perirhinal Cortex/metabolism ; Perirhinal Cortex/surgery ; Pirenzepine/pharmacology ; Proteasome Inhibitors/pharmacology ; Rats ; Rats, Long-Evans ; Receptor, Muscarinic M1/agonists ; Receptor, Muscarinic M1/antagonists & inhibitors ; Receptor, Muscarinic M1/metabolism ; Scopolamine/pharmacology ; Sulfonamides/pharmacology
Chemical Substances	Benzylamines ; Inositol 1,4,5-Trisphosphate Receptors ; Lactones ; Proteasome Inhibitors ; Receptor, Muscarinic M1 ; Sulfonamides ; KN 93 (139298-40-1) ; Pirenzepine (3G0285N20N) ; Scopolamine (DL48G20X8X) ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17)
Language	English
Publishing date	2020-06-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-65836-x
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Article ; Online: Harold J. Fallon, M.D. (1931-2018).

Boyer, James L

Hepatology (Baltimore, Md.)

2019 Volume 69, Issue 5, Page(s) 2308–2309

Language	English
Publishing date	2019-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.30585
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Zs.A 1660: Show issues

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Article ; Online: Red Cell Depletion of Major ABO Incompatible Bone Marrow Hematopoietic Progenitor Cells HPC(M) with the Spectra Optia®.

Christensen, Austin / Hsieh, FenFen / Boyer, Michael / Couriel, Daniel / Reems, Jo-Anna

Annals of clinical and laboratory science

2020 Volume 50, Issue 6, Page(s) 781–789

Abstract: Objective: Major ABO incompatible hematopoietic progenitors from bone marrow (HPC(M)) donor ... of HPC(M)) with the Spectra Optia® were determined for volume, RBC content, viable total nucleated cells ... RBC depletions with Spectra Optia® were then performed with 10 BMP cycles on additional HPC(M ...

Abstract	Objective: Major ABO incompatible hematopoietic progenitors from bone marrow (HPC(M)) donor collections that are destined for clinical transplantation are typically processed to deplete products of red blood cells (RBCs). The purpose of this study was to compare RBC depletion when using the Spectra Optia® relative to a 2-step method involving a COBE2991 instrument to obtain a buffy coat followed by a hydroxyethyl starch (HES) density gradient (COBE+HES) of the buffy coat. Methods: Post-processing recoveries of products undergoing 4, 8, and 10 bone marrow processing (BMP) cycles (i.e. 1 cycle=1 volume of HPC(M)) with the Spectra Optia® were determined for volume, RBC content, viable total nucleated cells (vTNC), viable CD34+ cells (vCD34), viable CD3+ cells (vCD3) and colony-forming-cells (CFC). Subsequent RBC depletions with Spectra Optia® were then performed with 10 BMP cycles on additional HPC(M) collections and were compared against a retrospective analysis of historical COBE+HES post-processing data. Results: Ten BMP cycles of HPC(M) (n=6) products were identified as optimal with volume reductions of 81.3±1.6 % and RBC reductions of 97.0±0.6 % with the Spectra Optia®. This also resulted in an average of 0.28 ±0.14 mL of RBC/kg (mean±SD; n=6) with vTNC yields of 65.0±10.9%, vCD34+ yields of 98.5±12.7%, and vCD3+ yields of 90.6±10.0%. Recoveries with the COBE+HES methodology resulted in vTNC recoveries of 62.9±20.5% (mean±SD; n=30) and 0.63±0.71 mL of RBC/kg (mean±SD; n=30). Conclusions: The Spectra Optia® is a viable option for depleting HPC(M) harvests of contaminating RBC in situations of ABO incompatibility. Target cells from a MNC rich fractionation were preserved through processing while eliminating RBC contaminants.
MeSH term(s)	ABO Blood-Group System/metabolism ; Blood Component Removal/methods ; Bone Marrow/immunology ; Bone Marrow/metabolism ; Bone Marrow Transplantation/methods ; Cell Separation/methods ; Erythrocytes/immunology ; Healthy Volunteers ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cells/immunology ; Hematopoietic Stem Cells/metabolism ; Hematopoietic Stem Cells/pathology ; Humans ; Retrospective Studies ; Tissue Donors
Chemical Substances	ABO Blood-Group System
Language	English
Publishing date	2020-12-17
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	193092-8
ISSN	1550-8080 ; 0091-7370 ; 0095-8905
ISSN (online)	1550-8080
ISSN	0091-7370 ; 0095-8905
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Zs.A 942: Show issues

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Article ; Online: What future for Lévy walks in animal movement research?: Comment on "Liberating Lévy walk research from the shackles of optimal foraging", by A.M. Reynolds.

Boyer, Denis

Physics of life reviews

2015 Volume 14, Page(s) 87–89

MeSH term(s)	Animals ; Behavior, Animal ; Humans ; Movement
Language	English
Publishing date	2015-09
Publishing country	Netherlands
Document type	Comment ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2148883-6
ISSN	1873-1457 ; 1571-0645
ISSN (online)	1873-1457
ISSN	1571-0645
DOI	10.1016/j.plrev.2015.07.001
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Article ; Online: How does wearable robotic exoskeleton affect overground walking performance measured with the 10-m and six-minute walk tests after a basic locomotor training in healthy individuals?

Gagnon, Dany H / Cunha, Jérémie Da / Boyer-Delestre, Mael / Bosquet, Laurent / Duclos, Cyril

Gait & posture

2017 Volume 58, Page(s) 340–345

Abstract: ... overground walking without a WRE. Hence, the interpretability of the 10-m (10MWT) and six-minute (6MWT) walk ...

Abstract	It is still unknown to what extent overground walking with a WRE is equivalent to natural overground walking without a WRE. Hence, the interpretability of the 10-m (10MWT) and six-minute (6MWT) walk tests during overground walking with a WRE against reference values collected during natural overground walking without a WRE is challenging. This study aimed to 1) compare walking performance across three different overground walking conditions: natural walking without a WRE, walking with a WRE providing minimal assistance (active walking), and walking with a WRE proving complete assistance (passive walking) and 2) assess the association and the agreement between the 10MWT and the 6MWT during passive and active walking with a WRE. Seventeen healthy individuals who underwent basic locomotor training with a WRE performed the 10MWT (preferred and maximal speeds) and the 6MWT under the three conditions. For the 10MWT, the speed progressively and significantly decreased from natural walking without a WRE (preferred: 1.40±0.18m/s; maximal: 2.16±0.19m/s), to active walking with a WRE (preferred: 0.48±0.10m/s; maximal: 0.61±0.14m/s), and to passive walking with a WRE (preferred: 0.38±0.09m/s; maximal: 0.42±0.10m/s). For the 6MWT, total distances decreased from walking without a WRE (609±53.9m), to active walking with a WRE (196.6±42.6m), and to passive walking with a WRE (144.3±33.3m). The 10MWT and 6MWT provide distinct information and can't be used interchangeably to document speed only during active walking with the WRE. Speed and distance drastically decrease during active and, even more so, passive walking with the WRE in comparison to walking without a WRE. Selection of walking tests should depend on the level of assistance provided by the WRE.
MeSH term(s)	Adult ; Equipment Design ; Exoskeleton Device ; Female ; Healthy Volunteers ; Humans ; Locomotion/physiology ; Male ; Physical Therapy Modalities/instrumentation ; Robotics/instrumentation ; Spinal Cord Injuries/rehabilitation ; Time Factors ; Walk Test/instrumentation ; Walking/physiology
Language	English
Publishing date	2017
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1162323-8
ISSN	1879-2219 ; 0966-6362
ISSN (online)	1879-2219
ISSN	0966-6362
DOI	10.1016/j.gaitpost.2017.08.027
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Zs.A 3804: Show issues

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Article: CTX-M-1, CTX-M-3, and CTX-M-14 beta-lactamases from Enterobacteriaceae isolated in France.

Dutour, C / Bonnet, R / Marchandin, H / Boyer, M / Chanal, C / Sirot, D / Sirot, J

Antimicrobial agents and chemotherapy

2001 Volume 46, Issue 2, Page(s) 534–537

Abstract: Six clinical CTX-M-producing isolates of the family Enterobacteriaceae were detected between 1999 ... and 2000 in different French hospitals. Two strains produced CTX-M-1 and CTX-M-3 and four strains ... produced CTX-M-14, a mutant Ala-231-->Val of CTX-M-9. A putative transposable element, ISEcp-1, was located ...

Abstract	Six clinical CTX-M-producing isolates of the family Enterobacteriaceae were detected between 1999 and 2000 in different French hospitals. Two strains produced CTX-M-1 and CTX-M-3 and four strains produced CTX-M-14, a mutant Ala-231-->Val of CTX-M-9. A putative transposable element, ISEcp-1, was located 43 bp upstream of all the bla(CTX-M) genes. Two CTX-M-14-encoding plasmids exhibited similar restriction patterns. The CTX-M-1- and CTX-M-3-encoding plasmids were related to the CTX-M-1- and CTX-M-3-encoding plasmids previously reported in 1990 in France and in 1998 in Poland, respectively.
MeSH term(s)	DNA Transposable Elements/genetics ; Enterobacteriaceae/enzymology ; Enterobacteriaceae/genetics ; Escherichia coli Proteins ; France ; Humans ; beta-Lactamases/genetics ; beta-Lactamases/metabolism
Chemical Substances	DNA Transposable Elements ; Escherichia coli Proteins ; CTX-M-9 protein, E coli (EC 3.5.2.-) ; beta-lactamase CTX-M-3 (EC 3.5.2.-) ; beta-lactamase TEM-3 (EC 3.5.2.-) ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2001-10-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.46.2.534-537.2002
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Einzelsignatur: Show issues

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Article: Instrumentation of the M. I. T. cyclotron for the study of nuclear reactions.

BOYER, K / GOVE, H E / HARVEY, J A / DEUTSCH, M / LIVINGSTON, M S

The Review of scientific instruments

2004 Volume 22, Issue 5, Page(s) 310–320

MeSH term(s)	Cyclotrons ; Humans ; Nuclear Physics
Language	English
Publishing date	2004-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/1.1745918
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