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  1. Article ; Online: Evidence-based medicine: Friend and foe.

    Funck-Brentano, Christian

    Therapie

    2022  Volume 78, Issue 4, Page(s) 345–348

    Language English
    Publishing date 2022-09-16
    Publishing country France
    Document type Editorial
    ZDB-ID 603474-3
    ISSN 1958-5578 ; 0040-5957
    ISSN (online) 1958-5578
    ISSN 0040-5957
    DOI 10.1016/j.therap.2022.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Considerations for Generic-to-Generic Levothyroxine Switching.

    Funck-Brentano, Christian

    JAMA internal medicine

    2022  Volume 182, Issue 8, Page(s) 886–887

    MeSH term(s) Drug Substitution ; Drugs, Generic ; Humans ; Therapeutic Equivalency ; Thyroxine/therapeutic use
    Chemical Substances Drugs, Generic ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2022-06-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2022.1987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Assessment of the Change of a Continuous Variable as a Function of its Initial Value.

    Funck-Brentano, Christian

    JAMA cardiology

    2021  Volume 6, Issue 11, Page(s) 1342

    MeSH term(s) Humans ; Risk Assessment
    Language English
    Publishing date 2021-08-24
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2021.3025
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  4. Article ; Online: Indispensable but deceptive evidence-based medicine.

    Funck-Brentano, Christian

    Diabetes & metabolism

    2020  Volume 46, Issue 6, Page(s) 415–422

    MeSH term(s) Data Interpretation, Statistical ; Evidence-Based Medicine ; Humans ; Observational Studies as Topic ; Peer Review, Research ; Randomized Controlled Trials as Topic ; Reproducibility of Results ; Research Design
    Language English
    Publishing date 2020-10-10
    Publishing country France
    Document type Editorial
    ZDB-ID 1315751-6
    ISSN 1878-1780 ; 1262-3636 ; 0338-1684
    ISSN (online) 1878-1780
    ISSN 1262-3636 ; 0338-1684
    DOI 10.1016/j.diabet.2020.09.006
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  5. Article ; Online: Les phases précoces du développement clinique d’un médicament.

    Funck-Brentano, Christian

    La Revue du praticien

    2019  Volume 69, Issue 6, Page(s) 607–611

    Abstract: The first administrations of a molecule to humans, so-called phase I studies of drug development, follow experimental animal studies which allow to have a first assessment of the pharmacological effects and toxicity of the molecule under development. ... ...

    Title translation Early clinical drug development.
    Abstract The first administrations of a molecule to humans, so-called phase I studies of drug development, follow experimental animal studies which allow to have a first assessment of the pharmacological effects and toxicity of the molecule under development. Typically, these studies are performed in "healthy" subjects or in relapsing patients with cancer. Participants' safety is a priority. Trained professionals administer single doses, followed by repeated doses, in authorized medical centres. They allow to study the pharmacokinetic and pharmacodynamic profile of tested molecules in humans and to explore some sources of variability of these parameters. These studies are highly regulated and their methodology is fairly standardized.
    MeSH term(s) Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Drug Development/legislation & jurisprudence ; Drug Industry/legislation & jurisprudence ; Guidelines as Topic ; Humans
    Language French
    Publishing date 2019-10-18
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  6. Article ; Online: Influence of baseline QTc on sotalol-induced prolongation of ventricular repolarization in men and women.

    Funck-Brentano, Christian / Salem, Joe-Elie

    British journal of clinical pharmacology

    2022  Volume 88, Issue 7, Page(s) 3510–3515

    Abstract: The extent of sotalol-induced QTc prolongation on the electrocardiogram, is variable among subjects and influenced by sex. However, the influence of baseline QTc on the extent of drug-induced QTc prolongation remains unclear. This was studied around peak ...

    Abstract The extent of sotalol-induced QTc prolongation on the electrocardiogram, is variable among subjects and influenced by sex. However, the influence of baseline QTc on the extent of drug-induced QTc prolongation remains unclear. This was studied around peak plasma concentration in a large cohort of 376 healthy male and 614 healthy female subjects who received 80 mg of sotalol orally. Baseline QTc was 379 ± 16 ms in men and 393 ± 15 ms in women (P < .0001). The change in QTc from baseline was highly variable among both sexes and was greater in women than in men (26.5 ± 13.2 vs.13.0 ± 10.8 ms; P < .0001). The slope of the regression line between QTc on sotalol and baseline QTc did not significantly differ from unity in men and in women, indicating that the extent of QTc prolongation with sotalol was not influenced by baseline QTc. Assessing QTc after administration of an I
    MeSH term(s) Anti-Arrhythmia Agents/adverse effects ; Cohort Studies ; Electrocardiography ; Female ; Humans ; Long QT Syndrome/chemically induced ; Male ; Sotalol/adverse effects
    Chemical Substances Anti-Arrhythmia Agents ; Sotalol (A6D97U294I)
    Language English
    Publishing date 2022-02-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous?

    Funck-Brentano, Christian / Salem, Joe-Elie

    publication RETRACTED

    Lancet (London, England)

    2020  

    Keywords covid19
    Language English
    Publishing date 2020-05-22
    Publishing country England
    Document type Journal Article ; Retracted Publication
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)31174-0
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  8. Article ; Online: Retraction and republication: cardiac toxicity of hydroxychloroquine in COVID-19.

    Funck-Brentano, Christian / Nguyen, Lee S / Salem, Joe-Elie

    Lancet (London, England)

    2020  Volume 396, Issue 10245, Page(s) e2–e3

    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country England
    Document type Journal Article ; Retraction of Publication ; Published Erratum
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)31528-2
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  9. Article ; Online: About fundamentals and sermonizers. Author's response to the letter on the article "The BIAL/Biotrial case of death of a human volunteer in the first-in-human study of BIA 10-2474: Are we missing the fundamentals?"

    Funck-Brentano, Christian / Ménard, Joël

    Presse medicale (Paris, France : 1983)

    2017  Volume 46, Issue 3, Page(s) 352–353

    Language English
    Publishing date 2017-03
    Publishing country France
    Document type Letter
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2017.01.008
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  10. Article ; Online: Inhibitor of Fatty Acid Amide Hydrolase — Learning from Tragic Failures

    Funck-Brentano, Christian / Ménard, Joël

    The New England journal of medicine

    2017  Volume 376, Issue 4, Page(s) 292–293

    MeSH term(s) Amidohydrolases ; Enzyme Inhibitors/pharmacology ; Humans
    Chemical Substances Enzyme Inhibitors ; Amidohydrolases (EC 3.5.-)
    Language English
    Publishing date 2017--26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1615417
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