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  1. Book: Mammakarzinom

    Avril, Norbert / Tiling, Reinhold

    nuklearmedizinische und radiologische Diagnostik

    1998  

    Author's details Reinhold Tiling (Hrsg.). Mit Beitr. von N. Avril
    Keywords Brustkrebs ; Nuklearmedizin ; Radiologische Diagnostik
    Subject Diagnostische Radiologie ; Strahlendiagnostik ; Brustdrüsenkrebs ; Carcinoma mammae ; Mammacarcinom ; Mammakarzinom ; Nuklearmedizinische Diagnostik
    Language German
    Size XVI, 216 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book
    HBZ-ID HT008511784
    ISBN 3-540-63147-X ; 978-3-540-63147-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 5996 order for loan Magazin

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  2. Book ; Thesis: Adhärenz von Candida albicans an Epithelzellen der Mundschleimhaut von Diabetikern und gesunden Probanden

    Avril, Norbert

    Beeinflussung der Adhärenz durch Glucose und Oxoferin ("Tetrachlordecaoxid-TCDO")

    1989  

    Author's details vorgelegt von Norbert Avril
    Size 82 Bl. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 1989
    HBZ-ID HT003757449
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: PET/CT Variants and Pitfalls in Breast Cancers.

    Kikano, Elias George / Avril, Stefanie / Marshall, Holly / Jones, Robert Stanley / Montero, Alberto J / Avril, Norbert

    Seminars in nuclear medicine

    2021  Volume 51, Issue 5, Page(s) 474–484

    Abstract: There are a number of normal variants and pitfalls which are important to consider when evaluating F-18 Fluorodeoxyglucose (FDG) with Positron Emission Tomography (PET) in breast cancer patients. Although FDG-PET is not indicated for the initial ... ...

    Abstract There are a number of normal variants and pitfalls which are important to consider when evaluating F-18 Fluorodeoxyglucose (FDG) with Positron Emission Tomography (PET) in breast cancer patients. Although FDG-PET is not indicated for the initial diagnosis of breast cancer, focally increased glucose metabolism within breast tissue represents a high likelihood for a neoplastic process and requires further evaluation. Focally increased glucose metabolism is not unique to breast cancer. Other malignancies such as lymphoma, metastases from solid tumors as well as inflammatory changes also may demonstrate increased glucose metabolism either within the breast or at other sites throughout the body. Importantly, benign breast disease may also exhibit increased glucose metabolism, limiting the specificity of FDG-PET. Breast cancer has a wide range of metabolic activity attributed to tumor heterogeneity and breast cancer subtype. Intracellular signaling pathways regulating tumor glucose utilization contribute to these pitfalls of PET/CT in breast cancer. The evaluation of axillary lymph nodes by FDG-PET is less accurate than sentinel lymph node procedure, however is very accurate in identifying level II and III axillary lymph node metastases or retropectoral metastases. It is important to note that non-malignant inflammation in lymph nodes are often detected by modern PET/CT technology. Therefore, particular consideration should be given to recent vaccinations, particularly to COVID-19, which can commonly result in increased metabolic activity of axillary nodes. Whole body FDG-PET for staging of breast cancer requires specific attention to physiologic variants of FDG distribution and a careful comparison with co-registered anatomical imaging. The most important pitfalls are related to inflammatory changes including sarcoidosis, sarcoid like reactions, and other granulomatous diseases as well as secondary neoplastic processes.
    MeSH term(s) Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Fluorodeoxyglucose F18 ; Humans ; Neoplasm Metastasis ; Neoplasm Staging ; Positron Emission Tomography Computed Tomography/methods
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-06-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120248-0
    ISSN 1558-4623 ; 0001-2998
    ISSN (online) 1558-4623
    ISSN 0001-2998
    DOI 10.1053/j.semnuclmed.2021.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Pretreatment and Posttreatment Tumor Metabolic Activity Assessed by FDG-PET/CT as Predictors of Tumor Recurrence and Survival Outcomes in Early-Stage Non-Small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy.

    Deshpande, Saarang R / Podder, Tarun K / Grubb, William / Zhang, Yuxia / Zheng, Yiran / Towe, Christopher / Linden, Philip / Avril, Norbert / Biswas, Tithi

    Advances in radiation oncology

    2023  Volume 9, Issue 1, Page(s) 101313

    Abstract: Purpose: Stereotactic body radiation therapy (SBRT) is considered the standard of care for medically inoperable early-stage non-small cell lung cancer. There is mixed evidence on the prognostic significance of tumor metabolic activity assessed by ... ...

    Abstract Purpose: Stereotactic body radiation therapy (SBRT) is considered the standard of care for medically inoperable early-stage non-small cell lung cancer. There is mixed evidence on the prognostic significance of tumor metabolic activity assessed by positron emission tomography combined with computed tomography (PET/CT) using F-18 fluorodeoxyglucose (FDG). The objectives of this study were to evaluate the maximum standardized uptake value (SUV
    Methods and materials: Consecutive patients from a single institution with T12N0M0 non-small cell lung cancer receiving primary treatment with SBRT with pretreatment FDG-PET/CT (n = 163) and follow-up FDG-PET/CT at 3 or 6 months (n = 71) were included. Receiver operator characteristic analysis was performed to dichotomize variables for Kaplan-Meier survival analysis. Multivariate analysis was performed with Cox proportional hazards regression.
    Results: Median follow-up was 19 months. For the whole cohort, 1-year and 2-year local control, progression-free survival (PFS), and overall survival (OS) were 95.0% and 80.3%, 87.1% and 75.4%, and 67.0% and 49.6% respectively. The following pre-SBRT SUV
    Conclusions: Pre-SBRT SUV
    Language English
    Publishing date 2023-07-09
    Publishing country United States
    Document type Journal Article
    ISSN 2452-1094
    ISSN 2452-1094
    DOI 10.1016/j.adro.2023.101313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Breast Cancer.

    Avril, Norbert

    PET clinics

    2006  Volume 1, Issue 1, Page(s) xi

    Language English
    Publishing date 2006-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2764575-7
    ISSN 1879-9809 ; 1556-8598
    ISSN (online) 1879-9809
    ISSN 1556-8598
    DOI 10.1016/j.cpet.2005.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Metabolic FDG-PET imaging in breast cancer: implications for treatment stratification.

    Avril, Norbert

    Nature clinical practice. Oncology

    2007  Volume 4, Issue 6, Page(s) 336–337

    Language English
    Publishing date 2007-06
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2173301-6
    ISSN 1743-4262 ; 1743-4254
    ISSN (online) 1743-4262
    ISSN 1743-4254
    DOI 10.1038/ncponc0817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: PET Imaging of Hepatocellular Carcinoma Using ZD2-(

    Sergeeva, Olga / Zhang, Yifan / Gao, Songqi / Chan, E Ricky / Sergeev, Maxim / Iyer, Renuka / Sexton, Sandra / Avril, Norbert / Lu, Zheng-Rong / Lee, Zhenghong

    Journal of hepatocellular carcinoma

    2023  Volume 10, Page(s) 291–301

    Abstract: Purpose: We tested a recently developed short peptide radioligand for PET imaging of hepatocellular carcinoma (HCC) by targeting an oncoprotein, extra-domain B fibronectin (EDB-FN) in the tumor microenvironment.: Methods: The radioligand consists of ... ...

    Abstract Purpose: We tested a recently developed short peptide radioligand for PET imaging of hepatocellular carcinoma (HCC) by targeting an oncoprotein, extra-domain B fibronectin (EDB-FN) in the tumor microenvironment.
    Methods: The radioligand consists of a small linear peptide ZD2 with
    Results: For ZD2 avid liver tumors, the radioligand accumulation plateaued a few minutes after injection, while the liver background uptake stabilized 20 min post-injection. The status of EDB-FN in woodchuck HCC was confirmed by histology and validated by PCR and western blocking.
    Conclusion: We have showed the viability of using the ZD2 short peptide radioligand targeting EDB-FN in liver tumor tissue for PET imaging of HCC, which can potentially impact the clinical care for HCC patients.
    Language English
    Publishing date 2023-02-22
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2780784-8
    ISSN 2253-5969
    ISSN 2253-5969
    DOI 10.2147/JHC.S390939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Letter from the guest editors.

    Avril, Norbert / Ros, Pablo R

    Seminars in roentgenology

    2014  Volume 49, Issue 3, Page(s) 236–237

    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Multimodal Imaging ; Positron-Emission Tomography
    Language English
    Publishing date 2014-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 80310-8
    ISSN 1558-4658 ; 0037-198X
    ISSN (online) 1558-4658
    ISSN 0037-198X
    DOI 10.1053/j.ro.2014.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 28: Show issues Location:
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  9. Article ; Online: In vitro histomechanical effects of enzymatic degradation in carotid arteries during inflation tests with pulsatile loading.

    Trabelsi, Olfa / Dumas, Virginie / Breysse, Edouard / Laroche, Norbert / Avril, Stephane

    Journal of the mechanical behavior of biomedical materials

    2019  Volume 103, Page(s) 103550

    Abstract: In this paper, the objective is to assess the histomechanical effects of collagen proteolysis in arteries under loading conditions reproducing in vivo environment. Thirteen segments of common porcine carotid arteries (8 proximal and 5 distal) were ... ...

    Abstract In this paper, the objective is to assess the histomechanical effects of collagen proteolysis in arteries under loading conditions reproducing in vivo environment. Thirteen segments of common porcine carotid arteries (8 proximal and 5 distal) were immersed in a bath of bacterial collagenase and tested with a pulsatile tension/inflation machine. Diameter, pressure and axial load were monitored throughout the tests and used to derive the stress-stretch curves and to determine the secant circumferential stiffness. Results were analysed separately for proximal and distal segments, before and after 1, 2 and 3 h of enzymatic degradation. A histological analysis was performed to relate the arterial microstructure to its mechanical behavior under collagen proteolysis. Control (before enzymatic degradation) and treated populations (after 1, 2 or 3 h of enzymatic degradation) were found statistically incomparable, and histology confirmed the alteration of the fibrous structure of collagen bundles induced by the collagenase treatment. A decrease of the secant circumferential stiffness of the arterial wall was noticed mostly at the beginning of the treatment, and was less pronounced after 1 h. These results constitute an important set of enzymatically damaged arteries that can be used to validate biomechanical computational models correlating structure and properties of blood vessels.
    MeSH term(s) Animals ; Biomechanical Phenomena ; Carotid Arteries ; Collagen ; Collagenases ; Stress, Mechanical ; Sus scrofa ; Swine
    Chemical Substances Collagen (9007-34-5) ; Collagenases (EC 3.4.24.-)
    Language English
    Publishing date 2019-11-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2378381-3
    ISSN 1878-0180 ; 1751-6161
    ISSN (online) 1878-0180
    ISSN 1751-6161
    DOI 10.1016/j.jmbbm.2019.103550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: 18F-FDG PET after radiofrequency ablation: Is timing everything?

    Avril, Norbert

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2006  Volume 47, Issue 8, Page(s) 1235–1237

    MeSH term(s) Animals ; Catheter Ablation/methods ; Disease Models, Animal ; Fluorodeoxyglucose F18 ; Humans ; Positron-Emission Tomography/methods ; Radiopharmaceuticals ; Time Factors ; Tomography, X-Ray Computed/methods
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2006-08
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0161-5505 ; 0097-9058 ; 0022-3123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 328: Show issues

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