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  1. Article: A Comparative Analysis of Functional Recovery in Surgical Rotator Cuff Tear Repair: Mini-Open Versus All-Arthroscopic Techniques.

    Sharma, Dhruv / Tolani, Mohit / Pathan, Sohilkhan R / Soni, Sanjay / Patel, Dhruv R / Shroff, Manan R

    Cureus

    2024  Volume 16, Issue 4, Page(s) e57529

    Abstract: Introduction:  Rotator cuff tears frequently lead to shoulder pain and impaired function, often necessitating surgical intervention to achieve the best results. The choice between mini-open and all-arthroscopic techniques remains a subject of debate, ... ...

    Abstract Introduction:  Rotator cuff tears frequently lead to shoulder pain and impaired function, often necessitating surgical intervention to achieve the best results. The choice between mini-open and all-arthroscopic techniques remains a subject of debate, with each approach offering unique advantages and challenges. This study seeks to evaluate and compare the functional outcomes of surgical repair utilizing these two techniques, offering valuable insights into their relative effectiveness.
    Material and methods:  This retrospective observational study was conducted at Shree Krishna Hospital, Karamsad, involving patients treated surgically for rotator cuff tears over the past five years. Clinical records were reviewed to identify patients who underwent either mini-open or all-arthroscopic repair. Follow-up assessments were conducted using the Quick Disabilities of the Arm, Shoulder, and Hand (Quick DASH) score and the Visual Analog Scale (VAS) for pain. A statistical analysis was performed to compare outcomes between the two groups.
    Results:  A total of 33 patients were included, with 16 undergoing mini-open repair and 17 undergoing all-arthroscopic repair. The mean follow-up duration was 31.06 months for mini-open repair and 20.4 months for all-arthroscopic repair. No statistically significant variances were observed in the postoperative Quick Disabilities of the Arm, Shoulder, and Hand (Quick DASH) scores or Visual Analog Scale (VAS) scores between the two groups. Both techniques demonstrated satisfactory functional recovery and pain relief at long-term follow-up.
    Conclusion: Our study provides evidence of comparable outcomes between mini-open and all-arthroscopic techniques for rotator cuff repair. Despite limitations such as a small sample size and the subjective nature of Quick DASH scores, both approaches offer promising results in terms of functional improvement and pain reduction. Further research is needed to assess short-term outcomes, cost-effectiveness, and patient satisfaction, but our findings support the continued use of both techniques in clinical practice.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.57529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Corrective Efficacy of Calcaneal Lengthening Osteotomy for Planovalgus Deformity in Cerebral Palsy Patients.

    Dubey, Vinod / Pathan, Sohilkhan R / Sharma, Dhruv

    Cureus

    2024  Volume 16, Issue 3, Page(s) e57092

    Abstract: Introduction Planovalgus deformity is common in children with spastic cerebral palsy (CP), particularly spastic diplegia and spastic quadriplegia. It results from muscle imbalance over the immature foot skeleton, leading to hindfoot valgus, forefoot ... ...

    Abstract Introduction Planovalgus deformity is common in children with spastic cerebral palsy (CP), particularly spastic diplegia and spastic quadriplegia. It results from muscle imbalance over the immature foot skeleton, leading to hindfoot valgus, forefoot abduction, and joint subluxation. Surgical interventions, like calcaneal lengthening osteotomy (CLO), are frequently employed to correct this deformity, but objective guidelines for its use in CP patients are lacking. Material and methods This retrospective cohort study examined the efficacy of CLO in correcting plano valgus deformity in pediatric CP patients at the Pediatric Orthopedic Unit of Christian Medical College (CMC) in Vellore, India. Data from patient records and radiographs were collected, including demographics, pre- and postoperative angles, and surgical details. Statistical analysis was performed to assess changes in angles and associations with various factors. Results After the surgery, there was a notable enhancement in the calcaneal pitch, lateral talo-first metatarsal angle, and naviculocuboid overlap, as shown by the CLO results. However, tibiocalcaneal angles did not show significant changes. Associations were observed between age, Gross Motor Function Classification System (GMFCS) level, additional surgeries, and postoperative angle corrections. Conclusion CLO shows promise in correcting plano valgus deformity, with age, GMFCS level, and comorbidities influencing outcomes. Long-term follow-up is crucial to monitor correction durability. Specific radiographic angles provide insights into CLO's biomechanical effects, but study limitations warrant caution in interpretation. CLO effectively corrects plano valgus deformity in pediatric CP patients, with age, GMFCS level, and comorbidities influencing outcomes. Long-term follow-up and further research are needed to optimize management strategies and enhance understanding of surgical outcomes.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.57092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Brief Report: Evaluating the Impact of Perioperative Immune Checkpoint Inhibitor in the Treatment of Patients with Resectable Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.

    Ponvilawan, Ben / Mahadevia, Himil / Qasim, Hana / Sharma, Parth / Bansal, Dhruv / Subramanian, Janakiraman

    Clinical lung cancer

    2024  Volume 25, Issue 3, Page(s) 254–261

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Immune Checkpoint Inhibitors/therapeutic use ; Lung Neoplasms/drug therapy ; Perioperative Care/methods
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Systematic Review ; Meta-Analysis ; Journal Article ; Case Reports
    ZDB-ID 2145146-1
    ISSN 1938-0690 ; 1525-7304
    ISSN (online) 1938-0690
    ISSN 1525-7304
    DOI 10.1016/j.cllc.2024.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Outcomes of Immunotherapy Versus Chemotherapy as First-Line Treatment in Advanced NSCLC: A Meta-Analysis of Randomized Clinical Trials.

    Ponvilawan, Ben / Sharma, Parth / Mahadevia, Himil / Subramanian, Janakiraman / Bansal, Dhruv

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2023  Volume 18, Issue 9, Page(s) e90–e93

    MeSH term(s) Humans ; Lung Neoplasms/drug therapy ; Randomized Controlled Trials as Topic ; Immunotherapy
    Language English
    Publishing date 2023-08-19
    Publishing country United States
    Document type Letter
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2023.05.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Outcome of forgotten biliary stents for more than five years-A two-decade experience.

    Sharma, Shyam Sunder / Maharshi, Sudhir / Sapra, Bharat / Nijhawan, Sandeep / Sharma, Dhruv

    Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

    2024  

    Abstract: Background and objectives: Prolonged biliary stenting may lead to complications such as cholangitis, stentolith and stent migration. There is limited data on forgotten biliary stents for more than five years in literature. The aim of this retrospective ... ...

    Abstract Background and objectives: Prolonged biliary stenting may lead to complications such as cholangitis, stentolith and stent migration. There is limited data on forgotten biliary stents for more than five years in literature. The aim of this retrospective study was to analyze the complications and outcomes in patients who forgot to get their biliary stents removed or exchanged for more than five years.
    Methods: The study population included patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) and plastic biliary stent placements in a tertiary care center from 1990 to 2022 for benign biliary diseases. Loss to follow-up and subsequent forgotten stent for more than five years were observed in 40 patients who underwent ERCP during this study period. We retrospectively analyzed the indications of stenting, present status of stent, complications and outcomes in the study patients.
    Results: The mean age of the study patients was 51.5 ± 11.5 years with 27 females. Indications of biliary stent placement were choledocholithiasis (33, 82.5%), bile leak (3, 7.5%), benign biliary stricture (2, 5%) and choledochal cyst (2, 5%). The mean duration of forgotten stent was 5.9 ± 3.6 years. Presenting symptoms were abdominal pain (37, 92.5%), fever (26, 65%) and jaundice (32, 80%). Most commonly placed stent was 7 French double pigtail of 10 cm length. Complications in the study patients were cholangitis (35, 87.5%), internal migration (2, 5%), pancreatitis (1, 2.5%) and portal hypertension (1, 2.5%). The outcomes were stone removal (30, 90.9%), stent removal (31, 77.5%), stent reinsertion (19, 47.5%), broken stent (3, 7.5%) and surgery (2, 5%).
    Conclusions: Prolonged duration (> 5 years) of forgotten stent is uncommon and is observed most commonly in patients with choledocholithiasis. The most common complication of long duration of forgotten stents was cholangitis followed by internal migration, pancreatitis and portal hypertension. Stone and stent removal was successful in a majority of patents, while surgery was required in less number of patients.
    Language English
    Publishing date 2024-01-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 632595-6
    ISSN 0975-0711 ; 0254-8860
    ISSN (online) 0975-0711
    ISSN 0254-8860
    DOI 10.1007/s12664-023-01493-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Wetland functional assessment and uncertainty analysis using fuzzy α-cut-based modified hydrogeomorphic approach.

    Sharma, Ashutosh / Kumar, Dhruv / Rallapalli, Srinivas / Singh, Ajit Pratap

    Environmental science and pollution research international

    2023  Volume 30, Issue 28, Page(s) 72900–72915

    Abstract: Wetlands are significant ecosystems which perform several functions such as ground water recharge, flood control, carbon sequestration, and pollution reduction. Accurate evaluation of wetland functions is challenging, due to uncertainty associated with ... ...

    Abstract Wetlands are significant ecosystems which perform several functions such as ground water recharge, flood control, carbon sequestration, and pollution reduction. Accurate evaluation of wetland functions is challenging, due to uncertainty associated with variables such as vegetation, soil, hydrology, land use, and landscape. Uncertainty is due to the factors such as the cost of evaluating quality parameters, measurement, and human errors. This study proposes an innovative framework based on modified hydrogeomorphic approach (HGMA) using fuzzy α-cut technique. HGMA has been used for wetland functional assessment and α-cut technique is used to characterize uncertainty corresponding to the input variables and wetland functions. The most uncertain variables were found to be the density of wetlands and basin count in the landscape assessment area with the scores of 4.38% and 3.614% respectively. Among the functions, the highest uncertainty is found in functional capacity index (FCI) corresponding to water storage (1.697%) and retain particulate (1.577%). The quantified uncertainty can help the practitioners to make informed decisions regarding planning best management practices for preserving and restoring the wetland functionality.
    MeSH term(s) Humans ; Wetlands ; Ecosystem ; Uncertainty ; Groundwater ; Soil
    Chemical Substances Soil
    Language English
    Publishing date 2023-05-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-27556-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A machine learning approach for predicting the nucleophilicity of organic molecules.

    Saini, Vaneet / Sharma, Aditya / Nivatia, Dhruv

    Physical chemistry chemical physics : PCCP

    2022  Volume 24, Issue 3, Page(s) 1821–1829

    Abstract: Nucleophilicity provides important information about the chemical reactivity of organic molecules. Experimental determination of the nucleophilicity parameter is a tedious and resource-intensive approach. Herein, we present a novel machine learning ... ...

    Abstract Nucleophilicity provides important information about the chemical reactivity of organic molecules. Experimental determination of the nucleophilicity parameter is a tedious and resource-intensive approach. Herein, we present a novel machine learning protocol that uses key structural descriptors to predict the nucleophilicities of organic molecules, which agree well with the experimental values. A data driven approach was used where quantum mechanical molecular and thermodynamic descriptors from a wide range of structurally diverse nucleophiles and relevant solvents were extracted and modelled using advanced algorithms against the experimentally available nucleophilicity values. Despite the structural diversity of nucleophiles, we are able to achieve statistically robust models with a high predictive power using tree-based and neural network algorithms trained on an in-house developed unique dataset consisting of 752 nucleophilicity values and 27 molecular descriptors.
    Language English
    Publishing date 2022-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d1cp05072a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Can thymosin β4 and soluble CD163 be used as biomarkers of the prognosis in acute on chronic liver failure?

    Sharma, Sushil Kumar / Karna, Rahul / Ahuja, Dhruv / Kar, Premashis

    Journal of gastrointestinal and liver diseases : JGLD

    2022  Volume 31, Issue 1, Page(s) 143–145

    MeSH term(s) Acute-On-Chronic Liver Failure ; Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; Humans ; Prognosis ; Receptors, Cell Surface ; Thymosin
    Chemical Substances Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; CD163 antigen ; Receptors, Cell Surface ; thymosin beta(4) (549LM7U24W) ; Thymosin (61512-21-8)
    Language English
    Publishing date 2022-03-20
    Publishing country Romania
    Document type Letter
    ZDB-ID 2427021-0
    ISSN 1842-1121 ; 1841-8724
    ISSN (online) 1842-1121
    ISSN 1841-8724
    DOI 10.15403/jgld-4161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Ocular pulse amplitude (OPA) in canine

    Raphtis, Vanessa A / Sharma, Dhruv / Wang, Sichao / Kim, Jae Y / Jacobson, Amanda L / Harman, Christine D / Komáromy, András M

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1242166

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-12-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1242166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Endobronchial tuberculosis

    Rachit Sharma / Rajendra Prasad / Harshita Rani / Rishabh Kacker / Anshita Chhabra / Dhruv Raj Singh

    Asian Journal of Medical Sciences, Vol 14, Iss 4, Pp 252-

    A case-based approach

    2023  Volume 256

    Abstract: Endobronchial tuberculosis (TB) or tracheobronchial TB is defined as tuberculous infection of the tracheobronchial tree with microbial and histopathological evidence. Here, in this article, we are reporting four surprising cases of endobronchial TB which ...

    Abstract Endobronchial tuberculosis (TB) or tracheobronchial TB is defined as tuberculous infection of the tracheobronchial tree with microbial and histopathological evidence. Here, in this article, we are reporting four surprising cases of endobronchial TB which came to our institution with clinical symptoms and signs suggestive of TB but chest X-rays were within normal limit and sputum microscopies were repeatedly negative. Bronchoscopy was performed which showed endobronchial lesions. Hence, early diagnosis and treatment were possible for these patients.
    Keywords endobronchial ; tuberculosis ; bronchoscopy ; sputum smear-negative ; Medicine ; R
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Manipal College of Medical Sciences, Pokhara
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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