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  1. Article ; Online: Evolution of respiratory syncytial virus burden in young children following the COVID-19 pandemic: influence of concomitant changes in testing practices.

    Fafi, Inès / Assad, Zein / Lenglart, Léa / Valtuille, Zaba / Ouldali, Naïm

    The Lancet. Infectious diseases

    2024  Volume 24, Issue 4, Page(s) e216–e217

    MeSH term(s) Child ; Humans ; Infant ; Child, Preschool ; Pandemics ; COVID-19 ; Respiratory Syncytial Virus, Human ; Respiratory Syncytial Virus Infections/diagnosis ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Tract Infections
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Letter
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(24)00081-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: NT-proBNP course during MIS-C post-COVID-19: an observational study.

    Bichali, Saïd / Ouldali, Naïm / Godart, François / Maboudou, Patrice / Houeijeh, Ali / Leteurtre, Stéphane

    European journal of pediatrics

    2024  Volume 183, Issue 4, Page(s) 1667–1674

    Abstract: Multisystem inflammatory syndrome in children (MIS-C or PIMS-TS) is a severe disease. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is used for positive and differential diagnosis, diagnosis of complications and severity, and cardiogenic shock ... ...

    Abstract Multisystem inflammatory syndrome in children (MIS-C or PIMS-TS) is a severe disease. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is used for positive and differential diagnosis, diagnosis of complications and severity, and cardiogenic shock prediction. However, contrasting cut-offs have been suggested. The aims of the present study were to compare NT-proBNP values depending on the time of measurement and to describe the NT-proBNP course during the MIS-C episode. The data from a single-centre cohort observational study on the impact of time to diagnosis, defined as the time from first symptom to diagnosis of MIS-C, were used for the purpose of this study, with an extended period of inclusion from May 2020 to April 2023. The timing and level of all NT-proBNP samples available for each patient were retrospectively collected. Thirty-seven children (18 (49%) females, median age 8.8 years, 14 (38%) with shock) were included. Until diagnosis, NT-proBNP increased with time and was significantly higher at 6 days from first symptoms than at 3 days (median (interquartile range) 32,933 (7773-61,592) versus 1994 (1291-4190) pg/mL, respectively, p = 0.031). From diagnosis, NT-proBNP decreased by at least 50% after 3.0 (2.1-5.3) days (n = 12) when NT-proBNP at diagnosis was low ≤ 11,000 pg/mL versus 1.8 (0.7-3.4) days (n = 16) when NT-proBNP at diagnosis was high (p = 0.040), and after 3.6 (2.4-5.9) days (n = 7) when fever persisted after 48 h versus 1.8 (0.8-3.0) days (n = 21) when fever resolved before 48 h (p = 0.004).  Conclusions: During the MIS-C episode, NT-proBNP increased over time until diagnosis and treatment. It dropped faster thereafter in children with high NT-proBNP at diagnosis > 11,000 pg/mL and slower in case of persistent fever. What is Known: • NT-proBNP is useful in MIS-C for positive and differential diagnosis, diagnosis of complications and severity, and cardiogenic shock prediction. • Contrasting cut-offs for differential diagnosis and severity assessment have been suggested. What is New: • Before diagnosis, NT-proBNP increases with time and is significantly higher at 6 days from first symptoms than at 3 days suggesting different cut-offs depending on the timing of measurement. • From diagnosis and treatment initiation, the 50% NT-proBNP drop occurs earlier in children with high NT-proBNP at diagnosis > 11,000 pg/mL and later in children with persistent fever.
    MeSH term(s) Female ; Child ; Humans ; Male ; Natriuretic Peptide, Brain ; Heart Failure/complications ; Heart Failure/diagnosis ; Biomarkers ; Shock, Cardiogenic ; COVID-19/complications ; COVID-19/diagnosis ; Retrospective Studies ; Peptide Fragments ; Systemic Inflammatory Response Syndrome
    Chemical Substances pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0) ; Biomarkers ; Peptide Fragments
    Language English
    Publishing date 2024-01-11
    Publishing country Germany
    Document type Observational Study ; Journal Article
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-023-05353-x
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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.75: Show issues Location:
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  3. Article ; Online: Syndrome inflammatoire multisystémique associé au Covid chez l’enfant.

    Mercier, Jean-Christophe / Ouldali, Naïm / Basmaci, Romain

    La Revue du praticien

    2022  Volume 71, Issue 9, Page(s) 1009–1015

    Abstract: Multisystemic inflammatory syndrome in children (mis-c) Asociated with covid Although children are less susceptible to sars-cov-2 and less symptomatic than adults with low mortality, clusters of Septic shock associated with elevated cardiac biomarkers ... ...

    Title translation Multisystemic inflammatory syndrome in children (MIS-C) associated with Covid.
    Abstract Multisystemic inflammatory syndrome in children (mis-c) Asociated with covid Although children are less susceptible to sars-cov-2 and less symptomatic than adults with low mortality, clusters of Septic shock associated with elevated cardiac biomarkers and unusual vasoplegia have been recently described and Treated by inotropes, vasopressors, and fluid loading. Both clinical symptoms (i.e., high and persistent fever, gastrointestinal Disorders, skin rash, conjunctivitis and dry cracked lips) and biological signs (e.g., elevated crp/procalcitonin, high Levels of ferritinemia) resembled kawasaki disease. In most instances, intravenous immunoglobin therapy with glucosteroids Improved the cardiac function and led to full recovery within a few days. However, adjunctive biotherapy (e.g., Anti-il-1ra, anti-il-6 monoclonal antibodies) was sometimes necessary. Although almost all children fully recovered Within a few days, some of them developed late coronary artery dilation or aneurysm. Thus, a new "multisystem inflammatory Syndrome in children" (mis-c) associated with sars-cov-2 has been identified, and its pathophysiology better Understood.
    MeSH term(s) COVID-19/complications ; Child ; Humans ; Mucocutaneous Lymph Node Syndrome ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
    Language French
    Publishing date 2022-02-11
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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    Ua VI Zs.433: Show issues Location:
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  4. Article ; Online: Reducing the burden of paediatric pneumonia in the most affected populations.

    Ouldali, Naïm / Cohen, Robert

    The Lancet. Child & adolescent health

    2020  Volume 4, Issue 6, Page(s) 408–409

    MeSH term(s) Child ; Cohort Studies ; Humans ; Infant ; Northern Territory ; Pneumococcal Vaccines ; Pneumonia ; Respiratory Tract Infections
    Chemical Substances Pneumococcal Vaccines
    Language English
    Publishing date 2020-05-22
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-4650
    ISSN (online) 2352-4650
    DOI 10.1016/S2352-4642(20)30107-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Definitions and implications of the pharmacokinetic-pharmacodynamic parameters of antibiotics in pediatric clinical practice.

    Cohen, Robert / Tauzin, Manon / Rybak, Alexis / Ouldali, Naim / Grimprel, Emmanuel

    Infectious diseases now

    2023  Volume 53, Issue 8S, Page(s) 104781

    Abstract: Knowledge of infectious diseases and their treatments is constantly evolving. New infectious agents are regularly discovered, mainly due to improvement of identification techniques, especially the development of molecular biology and mass spectrometry. ... ...

    Abstract Knowledge of infectious diseases and their treatments is constantly evolving. New infectious agents are regularly discovered, mainly due to improvement of identification techniques, especially the development of molecular biology and mass spectrometry. While changes in the epidemiology of infectious diseases are not always predictable or readily understood, several factors regularly enter into consideration, such as not only the natural history of diseases, the impact of vaccinations, but also the excessive and irrational use of antibiotics. Antibiotic resistance is now recognized as one of the major challenges for humanity, especially since few new molecules have been put on the market in recent years. These molecules are reserved for serious infections caused by bacteria resistant to other antibiotics and should only be prescribed by infectious diseases specialists trained in their use. Rationalization of antibiotic therapy is therefore one of the keys to reducing antibiotic resistance and the spread of resistant bacteria. In this guide, for each clinical situation, the bacterial target(s) of antibiotic treatment, the preferred antibiotic choice, and the therapeutic alternatives will be specified. Comments on the diagnosis and treatment of the infection will be added if necessary.
    MeSH term(s) Humans ; Child ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteria ; Drug Resistance, Microbial ; Communicable Diseases/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-09-14
    Publishing country France
    Document type Journal Article ; Review
    ISSN 2666-9919
    ISSN (online) 2666-9919
    DOI 10.1016/j.idnow.2023.104781
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  6. Article ; Online: Therapy for Multisystem Inflammatory Syndrome in Children.

    Ouldali, Naïm / Belot, Alexandre / Angoulvant, François

    The New England journal of medicine

    2021  Volume 385, Issue 13, Page(s) e42

    MeSH term(s) COVID-19/complications ; Child ; Humans ; SARS-CoV-2 ; Syndrome ; Systemic Inflammatory Response Syndrome
    Language English
    Publishing date 2021-08-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2111096
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    Ua VI Zs.34: Show issues Location:
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  7. Article ; Online: The principles of curative antibiotic treatments.

    Cohen, Robert / Grimprel, Emmanuel / Rybak, Alexis / Hau, Isabelle / Madhi, Fouad / Ouldali, Naim / Raymond, Josette

    Infectious diseases now

    2023  Volume 53, Issue 8S, Page(s) 104780

    Abstract: Knowledge of infectious diseases and their treatments is constantly evolving. New infectious agents are regularly discovered, due mainly to improvement of identification techniques, especially the development of molecular biology and mass spectrometry. ... ...

    Abstract Knowledge of infectious diseases and their treatments is constantly evolving. New infectious agents are regularly discovered, due mainly to improvement of identification techniques, especially the development of molecular biology and mass spectrometry. While changes in the epidemiology of infectious diseases are not always predictable or readily understood, several factors regularly enter into consideration, such as not only the natural history of diseases and the impact of vaccinations, but also the excessive and irrational use of antibiotics. Antibiotic resistance is now recognized as one of the major challenges for humanity, especially since few new molecules have been put on the market in recent years. These molecules are reserved for serious infections caused by bacteria resistant to other antibiotics and should be prescribed only by infectious disease specialists trained in their use. Rationalization of antibiotic therapy is therefore one of the keys to reducing antibiotic resistance and the spread of resistant bacteria. In this guide, with regard to each clinical situation, the bacterial target(s) of antibiotic treatment, the preferred antibiotic choice, and the therapeutic alternatives will be specified. Comments on diagnosis and treatment of the infection will be added if necessary.
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Bacteria ; Drug Resistance, Microbial ; Communicable Diseases/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-09-15
    Publishing country France
    Document type Journal Article ; Review
    ISSN 2666-9919
    ISSN (online) 2666-9919
    DOI 10.1016/j.idnow.2023.104780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Immune debt: Recrudescence of disease and confirmation of a contested concept.

    Cohen, Robert / Levy, Corinne / Rybak, Alexis / Angoulvant, François / Ouldali, Naim / Grimprel, Emmanuel

    Infectious diseases now

    2022  Volume 53, Issue 2, Page(s) 104638

    MeSH term(s) Humans ; Recurrence ; Immune System Phenomena
    Language English
    Publishing date 2022-12-16
    Publishing country France
    Document type Editorial ; Comment
    ISSN 2666-9919
    ISSN (online) 2666-9919
    DOI 10.1016/j.idnow.2022.12.003
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  9. Article ; Online: Analysis of COVID-19 Vaccination Status Among Parents of Hospitalized Children Younger Than 5 Years With SARS-CoV-2 Infection During the Delta and Omicron Waves.

    Solignac, Florie / Ouldali, Naïm / Aupiais, Camille / Casha, Paul / Cohen, Robert / Levy, Corinne / Angoulvant, François

    JAMA network open

    2022  Volume 5, Issue 11, Page(s) e2242295

    MeSH term(s) Child ; Humans ; Child, Hospitalized ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; SARS-CoV-2 ; Vaccination ; Parents
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-11-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.42295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Antibiotic Resistance of

    Assad, Zein / Cohen, Robert / Varon, Emmanuelle / Levy, Corinne / Bechet, Stéphane / Corrard, François / Werner, Andreas / Ouldali, Naïm / Bonacorsi, Stéphane / Rybak, Alexis

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 11

    Abstract: Haemophilus ... ...

    Abstract Haemophilus influenzae
    Language English
    Publishing date 2023-11-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12111605
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