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Article ; Online: Advances in axial spondyloarthritis: Learning from the leaders.

Ramiro, Sofia / Haroon, Nigil

Best practice & research. Clinical rheumatology

2023 Volume 37, Issue 3, Page(s) 101877

MeSH term(s)	Humans ; Spondylarthritis/therapy ; Spondylitis, Ankylosing ; Axial Spondyloarthritis
Language	English
Publishing date	2023-11-18
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	2052323-3
ISSN	1532-1770 ; 1521-6942
ISSN (online)	1532-1770
ISSN	1521-6942
DOI	10.1016/j.berh.2023.101877
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Article: Einschränkung der Arbeitsfähigkeit bei Patienten mit einer axialen Spondyloarthritis

Nikiphorou, Elena / Ramiro, Sofia

Morbus-Bechterew-Journal

2022 Volume 43, Issue 170, Page(s) 21

Language	German
Document type	Article
ZDB-ID	2119820-2
ISSN	1861-2105
Database	Current Contents Medicine

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Article ; Online: Translation and cross-cultural adaptation of the modified Short QUestionnaire to Assess Health-enhancing physical activity (mSQUASH) into Turkish.

Ayan, Gizem / Ramiro, Sofia / Santos, Fernando M / Spoorenberg, Anneke / Arends, Suzanne / Kilic, Levent

ARP rheumatology

2024 Volume 2, Issue 4, Page(s) 307–314

Abstract: Aims The aim was to translate and cross-culturally adapt the modified Short Questionnaire to Assess Health-enhancing physical activity (mSQUASH) into Turkish Methods The mSQUASH was translated into Turkish and backward-translation into Dutch was ... ...

Title translation	Translation and cross-cultural adaptation of the modified Short QUestionnaire to Assess Health-enhancing physical activity (mSQUASH) into Turkish.
Abstract	Aims The aim was to translate and cross-culturally adapt the modified Short Questionnaire to Assess Health-enhancing physical activity (mSQUASH) into Turkish Methods The mSQUASH was translated into Turkish and backward-translation into Dutch was performed afterwards using the Beaton method. After the Turkish version was reviewed and revised by an expert committee that included translators, two patients and the research team a pre-final version was produced. The-pre final version then entered a field-test with cognitive debriefing in 10 patients with axSpA. The final result was the Turkish mSQUASH version. Results The translation process went without difficulties. Small discrepancies were either resolved during the synthesis or expert consensus meetings. Mean (SD) time to complete the mSQUASH was 6.1 (2.4) minutes in field-test procedure. The cognitive debriefing showed that the items of the Turkish mSQUASH were clear, relevant, easy to understand and easy to complete. None of the patients reported that an important aspect of physical activity was missing from the questionnaire items. Patients raised the concern that not all sport examples were culturally suitable; tennis was replaced by volleyball and basketball after the cognitive debriefing, to make it more appropriate to the Turkish culture. Conclusion The final Turkish version of the mSQUASH showed acceptable linguistic and field validity for use in both clinical practice and research. However, further assessment of the psychometric properties (validity and reliability) of the Turkish version of the mSQUASH is needed before it can be implemented.
MeSH term(s)	Humans ; Cross-Cultural Comparison ; Reproducibility of Results ; Translations ; Exercise ; Surveys and Questionnaires
Language	English
Publishing date	2024-01-04
Publishing country	Portugal
Document type	Journal Article
ISSN	2795-4552
ISSN (online)	2795-4552
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Article ; Online: Tofacitinib onveiliger dan TNF-α-remmer bij reumatoïde artritis.

Ramiro, Sofia / Landewé, Robert / van der Heijde, Désirée

Nederlands tijdschrift voor geneeskunde

2022 Volume 166

Abstract: Tofacitinib is a relatively new oral drug for the treatment of rheumatoid arthritis. The ORAL surveillance study shows in a direct comparison that more patients with RA develop a 'major adverse cardiovascular event' (MACE) or malignancy during treatment ... ...

Title translation	What do the results of the ORAL surveillance study mean for the treatment of rheumatoid arthritis with tofacitinib?
Abstract	Tofacitinib is a relatively new oral drug for the treatment of rheumatoid arthritis. The ORAL surveillance study shows in a direct comparison that more patients with RA develop a 'major adverse cardiovascular event' (MACE) or malignancy during treatment with tofacitinib than during treatment with a tumor necrosis factor (TNF) inhibitor. The reliability of the study, the generalisability and interpretation of the results, as well as their implication for daily practice are discussed here.
MeSH term(s)	Antirheumatic Agents/adverse effects ; Arthritis, Rheumatoid/drug therapy ; Humans ; Piperidines ; Protein Kinase Inhibitors/adverse effects ; Pyrimidines ; Pyrroles/adverse effects ; Reproducibility of Results ; Treatment Outcome
Chemical Substances	Antirheumatic Agents ; Piperidines ; Protein Kinase Inhibitors ; Pyrimidines ; Pyrroles ; tofacitinib (87LA6FU830)
Language	Dutch
Publishing date	2022-06-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Article ; Online: Looking through the window of opportunity in axial spondyloarthritis?

Benavent, Diego / Capelusnik, Dafne / Ramiro, Sofia / Navarro-Compán, Victoria

Joint bone spine

2023 Volume 90, Issue 6, Page(s) 105603

Abstract: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that affects the spine and sacroiliac joints, that can lead to irreversible structural damage. Early detection and timely intervention are crucial for preventing long-term structural ... ...

Abstract	Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that affects the spine and sacroiliac joints, that can lead to irreversible structural damage. Early detection and timely intervention are crucial for preventing long-term structural damage, improving quality of life, and reducing the burden of the disease. The concept of a window of opportunity suggests that an early intervention in the reversible stage of the disease can lead to improved long-term outcomes. However, it is unclear whether this concept applies in axSpA. Recent advances in axSpA management, including the use of diagnostic techniques such as magnetic resonance imaging as well as the use of advanced therapies, have shown promise in improving outcomes. However, studies investigating the potential window of opportunity in axSpA by assessing the impact of an early treatment on clinical outcomes have yielded inconclusive results. One of the reasons behind this is the lack of a standardized definition of early axSpA. The Assessment of Spondyloarthritis International Society (ASAS)-SPEAR (SPondyloarthritis EARly) project has set the ground for it by working on a consensus definition of early axSpA. Randomized controlled trials specifically focused on the comparison between treating axSpA in the early and late stages of the disease and using the standardised definition of early axSpA are essential to understand better the potential benefits of an early treatment on clinical outcomes. Additionally, it would be relevant to assess the long-term outcomes of early axSpA treatment, especially regarding structural damage, to better grasp the concept of the window of opportunity in axSpA.
MeSH term(s)	Humans ; Quality of Life ; Spondylarthritis/diagnostic imaging ; Spondylarthritis/therapy ; Sacroiliac Joint/diagnostic imaging ; Sacroiliac Joint/pathology ; Spine ; Magnetic Resonance Imaging ; Axial Spondyloarthritis ; Spondylitis, Ankylosing/pathology
Language	English
Publishing date	2023-06-22
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020487-5
ISSN	1778-7254 ; 1297-319X
ISSN (online)	1778-7254
ISSN	1297-319X
DOI	10.1016/j.jbspin.2023.105603
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Article ; Online: Biological DMARDs and disease modification in axial spondyloarthritis

Sofia Ramiro / Alexandre Sepriano

RMD Open, Vol 7, Iss

a review through the lens of causal inference

2021 Volume 2

Abstract: Axial spondyloarthritis (axSpA) is a chronic rheumatic disease characterised by inflammation predominantly involving the spine and the sacroiliac joints. In some patients, axial inflammation leads to irreversible structural damage that in the spine is ... ...

Abstract	Axial spondyloarthritis (axSpA) is a chronic rheumatic disease characterised by inflammation predominantly involving the spine and the sacroiliac joints. In some patients, axial inflammation leads to irreversible structural damage that in the spine is usually quantified by the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS). Available therapeutic options include biological disease-modifying antirheumatic drugs (bDMARDs), which have been proven effective in suppressing inflammation in several randomised controlled trials (RCT), the gold standard for evaluating causal treatment effects. RCTs are, however, unfeasible for testing structural effects in axSpA mainly due to the low sensitivity to change of the mSASSS. The available literature therefore mainly includes observational research, which poses serious challenges to the determination of causality. Here, we review the studies testing the effect of bDMARDs on spinal radiographic progression, making use of the principles of causal inference. By exploring the assumptions of causality under counterfactual reasoning (exchangeability, positivity and consistency), we distinguish between studies that likely have reported confounded treatment effects and studies that, on the basis of their design, have more likely reported causal treatment effects. We conclude that bDMARDs might, indirectly, interfere with spinal radiographic progression in axSpA by their effect on inflammation. Innovations in imaging are expected, so that placebo-controlled trials can in the future become a reality. In the meantime, causal inference analysis using observational data may contribute to a better understanding of whether disease modification is possible in axSpA.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Translation and cross-cultural adaptation of coping with rheumatic stressors instrument into Turkish language.

Ayan, Gizem / Ramiro, Sofia / Pimentel-Santos, Fernando M / van Lankveld, Wim / Kilic, Levent

International journal of rheumatic diseases

2023 Volume 26, Issue 6, Page(s) 1183–1186

MeSH term(s)	Humans ; Cross-Cultural Comparison ; Language ; Translations ; Adaptation, Psychological ; Surveys and Questionnaires ; Reproducibility of Results ; Psychometrics
Language	English
Publishing date	2023-01-25
Publishing country	England
Document type	Letter
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.14577
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Article ; Online: Tapering or discontinuation of biological disease-modifying antirheumatic drugs in axial spondyloarthritis: A review of the literature and discussion on current practice.

Webers, Casper / Nikiphorou, Elena / Boonen, Annelies / Ramiro, Sofia

Joint bone spine

2022 Volume 90, Issue 1, Page(s) 105482

Abstract: Biological disease-modifying antirheumatic drugs (bDMARDs) have taken up an important role in the management of axial spondyloarthritis. Once stable remission or low disease activity has been achieved with bDMARDs, it may be possible to maintain this ... ...

Abstract	Biological disease-modifying antirheumatic drugs (bDMARDs) have taken up an important role in the management of axial spondyloarthritis. Once stable remission or low disease activity has been achieved with bDMARDs, it may be possible to maintain this state with lower levels of these drugs. Studies consistently demonstrate that tapering of tumor necrosis factor alpha inhibitors (TNFi) is not inferior to full-dose continuation in terms of maintaining treatment response, while data for tapering of interleukin-17 inhibitors (IL-17i) is lacking. Complete discontinuation of TNFi and IL-17i, however, often results in relapse and should not be recommended at this moment. Clear safety benefits of tapering or discontinuation have not been shown, although studies were typically not designed to address this. Current evidence does not support specific tapering or discontinuation strategies, although stepwise disease activity-guided regimens do allow for a more personalized approach and might be preferred. The definition of what constitutes an appropriate disease state to initiate tapering or discontinuation is unclear, and requires further study. Also, reliable predictors of successful tapering and discontinuation have not yet been identified. Fortunately, if tapering or discontinuation fails, most patients are able to regain disease control when reverted to the original bDMARD regimen. Finally, most patients indicate that, when asked, they would be willing to try tapering if the rationale is clear and if it is in their best interests. The decision to taper or discontinue should be made through shared decision-making, as this could improve the likelihood of success.
MeSH term(s)	Humans ; Antirheumatic Agents/therapeutic use ; Tumor Necrosis Factor-alpha ; Axial Spondyloarthritis ; Remission Induction
Chemical Substances	Antirheumatic Agents ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2022-11-04
Publishing country	France
Document type	Review ; Journal Article
ZDB-ID	2020487-5
ISSN	1778-7254 ; 1297-319X
ISSN (online)	1778-7254
ISSN	1297-319X
DOI	10.1016/j.jbspin.2022.105482
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Article ; Online: Work Disability in Axial Spondyloarthritis.

Nikiphorou, Elena / Ramiro, Sofia

Current rheumatology reports

2020 Volume 22, Issue 9, Page(s) 55

Abstract: Purpose of review: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that typically affects people of working age. Work-related outcomes are therefore important to study, both from an individual but also a societal perspective. Through ... ...

Abstract	Purpose of review: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that typically affects people of working age. Work-related outcomes are therefore important to study, both from an individual but also a societal perspective. Through this review of the literature, we explore the impact of axSpA on key work outcomes including work and productivity loss and predictors for these. Recent findings: Recent evidence confirms that axSpA is associated with substantial consequences on the ability to work. Reassuringly, early treatment and use of biologics have been associated with improved wok outcomes highlighting the importance of prompt diagnosis and management. High disease activity, labour-intensive jobs, poor physical function and impaired spinal mobility are among identified predictors of adverse work outcomes in axSpA. The impact of axSpA on work outcomes is considerable and necessitates optimal intervention, including suppression of disease activity, to enhance people's chances of remaining in work.
MeSH term(s)	Absenteeism ; Biological Products/therapeutic use ; Disability Evaluation ; Efficiency ; Humans ; Spondylarthritis/diagnosis
Chemical Substances	Biological Products
Language	English
Publishing date	2020-07-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057357-1
ISSN	1534-6307 ; 1523-3774
ISSN (online)	1534-6307
ISSN	1523-3774
DOI	10.1007/s11926-020-00932-5
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Article ; Online: Concentración de cortisol sanguíneo como respuesta a la manipulación recurrente en donadoras de embriones Holstein mestizas

Gabriela Sofía Garay–Peña / Andrés Santiago Jácome–Aucay / Jorge Bolívar Dután–Sanango / Ermes Ramiro Rodas–Carpio / Luis Eduardo Ayala–Guanga

Revista Científica, Vol 34, Iss

2024 Volume 1

Abstract: Se determinó la respuesta neuro–endócrina de la donadora al reducir el número de aplicaciones de hormona folículo–estimulante (FSH) como factor de superovulación. Ocho vacas Holstein mestizas fueron distribuidas aleatoriamente en dos tratamientos (T): T1 ...

Abstract	Se determinó la respuesta neuro–endócrina de la donadora al reducir el número de aplicaciones de hormona folículo–estimulante (FSH) como factor de superovulación. Ocho vacas Holstein mestizas fueron distribuidas aleatoriamente en dos tratamientos (T): T1 (n=4) recibieron una dosis de 200 mg de FSH vía epidural (EP) en el día 4 del protocolo de superovulación (SOV), en T2 se administró 300 mg de FSH repartidas en 8 dosis decrecientes vía intramuscular (IM), los días 4; 5; 6 y 7 del protocolo en la mañana y tarde. La concentración de cortisol se determinó a las 0; 2; 4; 6 ,24; 26; 28; 30; 48; 50; 52; 64; 72; 74; 76 y 78 horas (h) del día 4. La frecuencia cardiaca (FC), respiratoria (FR) y los niveles de glucosa fueron evaluados el día 4 a las 05h45; 06h05; 08h00; 10h00; 12h00; 17h45 y 18h05. El cortisol a las 0h fue similar en los dos T: T1 (10,9 ± 0,24 µg·dL-1) y T2 (10,8 ± 0,33 µg·dL-1) y alcanzó su mayor nivel a las 4h en T1 (15,8 ± 1,39 µg·dL-1) y en T2 (16,4 ± 0,28 µg·dL-1) sin diferencia entre T (P>0,05). En las siguientes valoraciones, el cortisol disminuyó a niveles basales en los dos T. La FC a las 05h45, mostró valores similares en T1 (65,3 ± 1,65 pul·min-1) y en T2 (66,3 ± 1,43 pul·min-1); sin embargo, a las 06h05 FC se incrementó en T1 (74,3 ± 1,54 pul·min-1) y en T2 (84,2 ± 1,73 pul·min-1) y disminuyó a partir de las 08h00. Igual comportamiento fue observado con la FR y la glucosa. Se concluye que llevar a la donadora a la manga de sujeción para administrar FSH, constituye un factor estresante que incrementa la FC, FR, cortisol y glucosa, factores que influyen sobre el porcentaje de ovulaciones en los dos T.
Keywords	Cortisol ; epidural ; donadoras ; Holstein ; superovulación ; Cattle ; SF191-275 ; Veterinary medicine ; SF600-1100
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Universidad del Zulia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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