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  1. Article: Oxytocin stimulates myometrial guanosine triphosphatase and phospholipase-C activities via coupling to G alpha q/11.

    Ku, C Y / Qian, A / Wen, Y / Anwer, K / Sanborn, B M

    Endocrinology

    1995  Volume 136, Issue 4, Page(s) 1509–1515

    Abstract: ... G alpha q and G alpha 11. Neutralization of the antibody by preincubation with antigenic peptide ... and phospholipase-C activities, and the stimulations were also inhibited by anti-G alpha q/11 IgG ... Immunoreactive GTP-binding proteins, G alpha q and G alpha 11, and phospholipase-C beta 3 isoforms were present ...

    Abstract Oxytocin stimulates phosphoinositide turnover in myometrium. To elucidate whether the coupling mechanism involves the interaction of oxytocin receptor with GTP-binding proteins, we examined oxytocin stimulation of guanosine triphosphatase (GTPase) activity and phospholipase-C activity in rat and human myometrial membranes. Oxytocin consistently stimulated both GTPase and phospholipase-C activities, and both stimulations were attenuated by an antibody directed against the carboxyl-terminals of the GTP-binding proteins, G alpha q and G alpha 11. Neutralization of the antibody by preincubation with antigenic peptide reversed this inhibition. [Thr4,Gly7]oxytocin, a specific oxytocin receptor agonist, stimulated both GTPase and phospholipase-C activities, and the stimulations were also inhibited by anti-G alpha q/11 IgG. Immunoreactive GTP-binding proteins, G alpha q and G alpha 11, and phospholipase-C beta 3 isoforms were present in myometrial membranes. These results indicate that stimulation of phospholipase-C activity by oxytocin in myometrium is mediated via G alpha q, G alpha 11, or a closely related GTP-binding protein, probably coupling to phospholipase-C beta.
    MeSH term(s) Animals ; Antibodies/pharmacology ; Cell Membrane/enzymology ; Female ; GTP Phosphohydrolases/metabolism ; GTP-Binding Proteins/immunology ; GTP-Binding Proteins/physiology ; Humans ; Immunoglobulin G/pharmacology ; Myometrium/enzymology ; Oxytocin/agonists ; Oxytocin/analogs & derivatives ; Oxytocin/pharmacology ; Rats ; Receptors, Oxytocin/physiology ; Type C Phospholipases/metabolism
    Chemical Substances Antibodies ; Immunoglobulin G ; Receptors, Oxytocin ; Oxytocin (50-56-6) ; oxytocin, Thr(4)-Gly(7)- (60786-59-6) ; Type C Phospholipases (EC 3.1.4.-) ; GTP Phosphohydrolases (EC 3.6.1.-) ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 1995-04
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endo.136.4.7895660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.72: Show issues Location:
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  2. Article: Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11).

    Qian, A / Wang, W / Sanborn, B M

    Cellular signalling

    1998  Volume 10, Issue 2, Page(s) 101–105

    Abstract: In order to probe the nature of oxytocin receptor (OTR)/G alpha(q/11) protein coupling, we examined ... in COSM6 cells overexpressing OTR and G alpha(q). Co-expression of G alpha(q) enhanced the oxytocin ... and G alpha(q/11), oxytocin stimulated phosphoinositide turnover with an EC50 of 48 nM. Co ...

    Abstract In order to probe the nature of oxytocin receptor (OTR)/G alpha(q/11) protein coupling, we examined the effect of co-expression of OTR intracellular domains on oxytocin-stimulated phosphoinositide turnover in COSM6 cells overexpressing OTR and G alpha(q). Co-expression of G alpha(q) enhanced the oxytocin response maximally at a pOTR/pG alpha(q) plasmid transfection ratio of 1:0.16. In cells co-expressing OTR and G alpha(q/11), oxytocin stimulated phosphoinositide turnover with an EC50 of 48 nM. Co-transfection with plasmids expressing OTR intracellular domains inhibited oxytocin-stimulated phosphoinositide turnover by 23 +/- 6% (1i), 37 +/- 4% (2i), 55 +/- 6% (3i), and 40 +/- 6% (4i), respectively (P < 0.01). Expression of the 3i loop of the alpha(1B)-adrenergic receptor, which also couples to G alpha(q/11), inhibited phosphoinositide turnover by 35 +/- 2% (P < 0.01), while expression of the 3i loop of the dopamine 1A receptor, which couples to G alpha(s), had no effect. While these data indicate a functional role for the OTR 3i loop, they also suggest that interactions with more than one intracellular domain probably mediate the coupling of OTR to the G alpha(q/11) class of GTP-binding proteins.
    MeSH term(s) Amino Acid Sequence ; Animals ; Binding Sites ; COS Cells ; GTP-Binding Proteins/metabolism ; Humans ; Molecular Sequence Data ; Phosphatidylinositols/metabolism ; Receptors, Oxytocin/metabolism ; Recombinant Proteins/metabolism ; Transfection
    Chemical Substances Phosphatidylinositols ; Receptors, Oxytocin ; Recombinant Proteins ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 1998-02
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1002702-6
    ISSN 0898-6568
    ISSN 0898-6568
    DOI 10.1016/s0898-6568(97)00097-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2579: Show issues Location:
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  3. Article: [Is autoimmune cholangitis-anti-mitochondrial antibody-negative primary biliary cholangitis still an independent disease?]

    Qian, J D / Wang, G Q

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2019  Volume 27, Issue 5, Page(s) 393–396

    Abstract: Autoimmune cholangitis (AIC) was first reported in 1987 as a chronic cholestatic disease that occurs predominantly in middle-aged women and has a common clinical manifestations, biochemical abnormalities and pathological changes with primary biliary ... ...

    Abstract Autoimmune cholangitis (AIC) was first reported in 1987 as a chronic cholestatic disease that occurs predominantly in middle-aged women and has a common clinical manifestations, biochemical abnormalities and pathological changes with primary biliary cholangitis (PBC). However, serum anti-mitochondrial antibodies (AMA) are negative, and ANA and/or smooth muscle antibody positive rates are higher. The treatment response and prognosis with ursodeoxycholic acid and steroids is poor, thus it needs to be treated with immunosuppressive agents. Presently, the exact pathological mechanism of AIC is still unclear, and there is no unified assertion that classifies it as a new autoimmune liver disease or AMA-negative PBC. This article reviews the worldwide published work on AIC and compares them with PBC.
    MeSH term(s) Antibodies, Antinuclear/immunology ; Autoantibodies/immunology ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Cholangitis/immunology ; Cholangitis/pathology ; Female ; Humans ; Liver Cirrhosis, Biliary/immunology ; Middle Aged
    Chemical Substances Antibodies, Antinuclear ; Autoantibodies
    Language Chinese
    Publishing date 2019-06-04
    Publishing country China
    Document type Journal Article ; Review
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.issn.1007-3418.2019.05.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Response to: Eosinophil count in severe coronavirus disease 2019.

    Qian, G-Q / Zhang, X / Ma, A H Y / Yang, N-B

    QJM : monthly journal of the Association of Physicians

    2020  Volume 113, Issue 7, Page(s) 513–514

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Eosinophils ; Humans ; Leukocyte Count ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-21
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcaa138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Missense mutation of SPRY4 gene in Kallmann syndrome: a case report].

    Hui, Q / Zhang, Q / Qian, G F

    Zhonghua nei ke za zhi

    2023  Volume 62, Issue 7, Page(s) 860–863

    MeSH term(s) Humans ; Kallmann Syndrome/genetics ; Mutation, Missense ; Mutation
    Language Chinese
    Publishing date 2023-07-02
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 754223-9
    ISSN 0578-1426
    ISSN 0578-1426
    DOI 10.3760/cma.j.cn112138-20221009-00744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1620: Show issues Location:
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  6. Article: [Management strategies for chronic liver disease-related thrombocytopenia].

    Qian, J D / Yao, T T / Wang, Y / Wang, G Q

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2021  Volume 29, Issue 9, Page(s) 896–899

    Abstract: Chronic liver disease causes bleeding and coagulation system abnormalities through a variety of mechanisms. Thrombocytopenia is a common complication of chronic liver disease. Patients with chronic liver disease, especially liver cirrhosis, often face ... ...

    Abstract Chronic liver disease causes bleeding and coagulation system abnormalities through a variety of mechanisms. Thrombocytopenia is a common complication of chronic liver disease. Patients with chronic liver disease, especially liver cirrhosis, often face more invasive examinations or surgeries, which brings great challenges to clinical diagnosis and treatment. Traditional platelet transfusion is the main clinical intervention. With the approval of thrombopoietin receptor agonists, the current management standards for chronic liver disease-related thrombocytopenia may face changes. This article reviews the current main non-pharmacological and pharmacological interventions for chronic liver disease-related thrombocytopenia, and put forwards the corresponding clinical management improvement strategies based on the efficacy and limitations of these interventions.
    MeSH term(s) Hemorrhage ; Humans ; Liver Cirrhosis ; Liver Diseases/complications ; Liver Diseases/therapy ; Thrombocytopenia/etiology ; Thrombocytopenia/therapy
    Language Chinese
    Publishing date 2021-10-12
    Publishing country China
    Document type Journal Article ; Review
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20200609-00304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Response to: COIVD-19 disease: tackling a pandemic in 21st century.

    Qian, G-Q / Ma, A H Y / Yang, N-B / Ruan, L-M

    QJM : monthly journal of the Association of Physicians

    2020  Volume 113, Issue 7, Page(s) 521–522

    MeSH term(s) COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcaa118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Lipoleiomyosarcoma of the posterior mediastinum.

    Tong, J-J / Li, X-J / Li, G-X / Qian, G-Q

    QJM : monthly journal of the Association of Physicians

    2018  Volume 111, Issue 3, Page(s) 191–192

    MeSH term(s) Adult ; Humans ; Leiomyosarcoma/diagnostic imaging ; Leiomyosarcoma/surgery ; Liposarcoma/diagnostic imaging ; Liposarcoma/surgery ; Male ; Mediastinal Neoplasms/diagnostic imaging ; Mediastinal Neoplasms/surgery ; Mixed Tumor, Malignant/diagnostic imaging ; Mixed Tumor, Malignant/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2018-01-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcx256
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  10. Article ; Online: Synthesis of the ABCD Ring System of Azaspiracid We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, a predoctoral fellowship from Bristol-Myers Squibb (to F.B.), postdoctoral fellowships from The Skaggs Institute for Research (to W.Q.), the Academy of Finland, the Ella and Georg Ehrnrooth Foundation and the Tauno Tönning Foundation (all to P.M.P.), and Bayer AG (to J.H.), as well as grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.

    Nicolaou, K. C. / Qian, Wenyuan / Bernal, Federico / Uesaka, Noriaki / Pihko, Petri M. / Hinrichs, Jürgen

    Angewandte Chemie (International ed. in English)

    2001  Volume 40, Issue 21, Page(s) 4068–4071

    Language English
    Publishing date 2001-11-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
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