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  1. Article ; Online: Prevention and management of paravalvular regurgitation after transcatheter aortic valve implantation.

    Chung, Christine J / Otto, Catherine M

    European heart journal

    2023  Volume 44, Issue 15, Page(s) 1340–1342

    MeSH term(s) Humans ; Transcatheter Aortic Valve Replacement/adverse effects ; Prognosis ; Aortic Valve/surgery ; Aortic Valve Insufficiency/etiology ; Aortic Valve Insufficiency/therapy
    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad151
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 640: Show issues

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  2. Article ; Online: Surgical and transcatheter treatments of mechanical complications of acute myocardial infarction.

    McCabe, James M / Chung, Christine J

    Heart (British Cardiac Society)

    2024  Volume 110, Issue 7, Page(s) 531–539

    MeSH term(s) Humans ; Myocardial Infarction/therapy ; Heart Rupture, Post-Infarction/etiology
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2022-321573
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    Ui IV Zs.40: Show issues Location:
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    Zs.MO 112: Show issues

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  3. Article ; Online: Emerging transcatheter therapies for tricuspid valve disease.

    Chung, Christine J / George, Isaac

    JTCVS open

    2020  Volume 2, Page(s) 14–19

    Language English
    Publishing date 2020-04-13
    Publishing country Netherlands
    Document type Editorial
    ISSN 2666-2736
    ISSN (online) 2666-2736
    DOI 10.1016/j.xjon.2020.04.003
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  4. Article ; Online: Exertional desaturations after COVID-19: A case for PFO closure.

    Yogeswaran, Vidhushei / Chung, Christine J / Kirkpatrick, James N

    Echocardiography (Mount Kisco, N.Y.)

    2022  Volume 39, Issue 12, Page(s) 1635–1638

    Abstract: We present a case of a woman with past medical history notable for mild COVID-19 infection who presented with dyspnea on exertion, then developed progressively worsening exertional desaturations and was found to have a patent foramen ovale (PFO). ... ...

    Abstract We present a case of a woman with past medical history notable for mild COVID-19 infection who presented with dyspnea on exertion, then developed progressively worsening exertional desaturations and was found to have a patent foramen ovale (PFO). Extensive cardiopulmonary testing revealed no clear alternate etiology for her symptoms. After much discussion, she underwent successful closure of the PFO with complete resolution of her symptoms and significantly improved exertional desaturation.
    MeSH term(s) Humans ; COVID-19
    Language English
    Publishing date 2022-11-29
    Publishing country United States
    Document type Case Reports ; Journal Article ; Comment
    ZDB-ID 843645-9
    ISSN 1540-8175 ; 0742-2822
    ISSN (online) 1540-8175
    ISSN 0742-2822
    DOI 10.1111/echo.15500
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    Zs.A 2170: Show issues Location:
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    Zs.MO 359: Show issues

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  5. Article ; Online: First-in-Human Percutaneous Excision of a Failed MitraClip Followed by Transcatheter Mitral Valve Replacement.

    Elison, David / Aldea, Gabriel / Jelacic, Srjdan / Chung, Christine J / Mackensen, G Burkhard / McCabe, James M

    JACC. Cardiovascular interventions

    2024  Volume 17, Issue 4, Page(s) 571–573

    MeSH term(s) Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Treatment Outcome ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/surgery ; Heart Valve Prosthesis Implantation/adverse effects ; Cardiac Catheterization/adverse effects
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2023.11.023
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    Zs.A 6669: Show issues Location:
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  6. Article ; Online: Habitual Physical Activity: Functional Assessment in Patients With Severe Aortic Stenosis Treated With TAVR.

    Chung, Christine J / Kirtane, Ajay J

    JACC. Cardiovascular interventions

    2019  Volume 12, Issue 8, Page(s) 790–792

    MeSH term(s) Aged ; Aortic Valve Stenosis/surgery ; Exercise ; Frailty ; Humans ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
    Language English
    Publishing date 2019-04-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2019.03.010
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    Zs.A 6669: Show issues Location:
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  7. Article ; Online: Identification of a Biomarker Panel from Genome-Wide Methylation to Detect Early HPV-Associated Oropharyngeal Cancer.

    Dickey, Brittney L / Putney, Ryan M / Schell, Michael J / Berglund, Anders E / Amelio, Antonio L / Caudell, Jimmy J / Chung, Christine H / Giuliano, Anna R

    Cancer prevention research (Philadelphia, Pa.)

    2024  Volume 17, Issue 4, Page(s) 169–176

    Abstract: As oropharyngeal cancer (OPC) associated with human papillomavirus (HPV) increases in men, the need for a screening test to diagnose OPC early is crucial. This study agnostically identified differentially methylated CpG sites to identify additional ... ...

    Abstract As oropharyngeal cancer (OPC) associated with human papillomavirus (HPV) increases in men, the need for a screening test to diagnose OPC early is crucial. This study agnostically identified differentially methylated CpG sites to identify additional biomarkers to improve screening for early OPC.DNA was extracted from oral gargles of 89 early cases and 108 frequency matched healthy controls, and processed for genome-wide methylation using the Illumina Infinium MethylationEPIC BeadChip. Selected sites were combined with our prior methylation data in the EPB41L3 gene (CpG sites 438, 427, and 425) and oral HPV16 and HPV18 status were considered as binary variables (positive/negative). Lasso regression identified CpG sites strongly associated with early OPC. ROC curves with AUC were generated. The panel was validated utilizing bootstrap resampling.Machine learning analyses identified 14 markers that are significantly associated with early OPC, including one EPB41L3 CpG site (438) and oral HPV16 status. A final model was trained on all available samples using the discovered panel and was able to predict early OPC compared with controls with an AUC of 0.970 on the training set. In the bootstrap validation sets, the average AUC was 0.935, indicating adequate internal validity.Our data suggest that this panel can detect OPC early, however external validation of this panel is needed. Further refinement of a panel of biomarkers to diagnose OPC earlier is urgently needed to prevent complex treatment of OPC and associated comorbidities, while reducing risk of recurrence.
    Prevention relevance: This study identified biomarkers using genome-wide methylation to create a panel capable of discerning early oropharyngeal cancer (OPC) from those without OPC. Such a biomarker panel would be an effective tool to detect OPC early and prevent complications of treatment associated with later diagnosis.
    MeSH term(s) Male ; Humans ; Human Papillomavirus Viruses ; Papillomavirus Infections/complications ; Papillomavirus Infections/diagnosis ; Oropharyngeal Neoplasms/diagnosis ; Oropharyngeal Neoplasms/genetics ; Biomarkers, Tumor/genetics ; Human papillomavirus 16/genetics ; Methylation ; Microfilament Proteins
    Chemical Substances Biomarkers, Tumor ; EPB41L3 protein, human ; Microfilament Proteins
    Language English
    Publishing date 2024-01-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2434717-6
    ISSN 1940-6215 ; 1940-6207
    ISSN (online) 1940-6215
    ISSN 1940-6207
    DOI 10.1158/1940-6207.CAPR-23-0317
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    Zs.A 6766: Show issues Location:
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  8. Article ; Online: Geographic pair matching in large-scale cluster randomized trials.

    Arnold, Benjamin F / Rerolle, Francois / Tedijanto, Christine / Njenga, Sammy M / Rahman, Mahbubur / Ercumen, Ayse / Mertens, Andrew / Pickering, Amy J / Lin, Audrie / Arnold, Charles D / Das, Kishor / Stewart, Christine P / Null, Clair / Luby, Stephen P / Colford, John M / Hubbard, Alan E / Benjamin-Chung, Jade

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1069

    Abstract: Cluster randomized trials are often used to study large-scale public health interventions. In large trials, even small improvements in statistical efficiency can have profound impacts on the required sample size and cost. Location integrates many socio- ... ...

    Abstract Cluster randomized trials are often used to study large-scale public health interventions. In large trials, even small improvements in statistical efficiency can have profound impacts on the required sample size and cost. Location integrates many socio-demographic and environmental characteristics into a single, readily available feature. Here we show that pair matching by geographic location leads to substantial gains in statistical efficiency for 14 child health outcomes that span growth, development, and infectious disease through a re-analysis of two large-scale trials of nutritional and environmental interventions in Bangladesh and Kenya. Relative efficiencies from pair matching are ≥1.1 for all outcomes and regularly exceed 2.0, meaning an unmatched trial would need to enroll at least twice as many clusters to achieve the same level of precision as the geographically pair matched design. We also show that geographically pair matched designs enable estimation of fine-scale, spatially varying effect heterogeneity under minimal assumptions. Our results demonstrate broad, substantial benefits of geographic pair matching in large-scale, cluster randomized trials.
    MeSH term(s) Child ; Humans ; Randomized Controlled Trials as Topic ; Sample Size ; Public Health ; Kenya ; Bangladesh ; Cluster Analysis ; Research Design
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45152-y
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  9. Article ; Online: Complexes of tubulin oligomers and tau form a viscoelastic intervening network cross-bridging microtubules into bundles.

    Kohl, Phillip A / Song, Chaeyeon / Fletcher, Bretton J / Best, Rebecca L / Tchounwou, Christine / Garcia Arceo, Ximena / Chung, Peter J / Miller, Herbert P / Wilson, Leslie / Choi, Myung Chul / Li, Youli / Feinstein, Stuart C / Safinya, Cyrus R

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2362

    Abstract: The axon-initial-segment (AIS) of mature neurons contains microtubule (MT) fascicles (linear bundles) implicated as retrograde diffusion barriers in the retention of MT-associated protein (MAP) tau inside axons. Tau dysfunction and leakage outside of the ...

    Abstract The axon-initial-segment (AIS) of mature neurons contains microtubule (MT) fascicles (linear bundles) implicated as retrograde diffusion barriers in the retention of MT-associated protein (MAP) tau inside axons. Tau dysfunction and leakage outside of the axon is associated with neurodegeneration. We report on the structure of steady-state MT bundles in varying concentrations of Mg
    MeSH term(s) Microtubules/metabolism ; Scattering, Small Angle ; tau Proteins/metabolism ; Tubulin/metabolism ; X-Ray Diffraction ; Humans
    Chemical Substances tau Proteins ; Tubulin ; MAPT protein, human
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46438-x
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  10. Article ; Online: Leader identity: Resisting conformity and reconstructing how we define "Leader".

    Chung, Jessica / Navarro, Christine D

    New directions for student leadership

    2022  Volume 2021, Issue 172, Page(s) 35–43

    Abstract: Leadership educators often acknowledge the need to embrace and honor diverse lived experiences and different ways we acquire knowledge and demonstrate leadership. However, do our practices and expectations really reflect this? How do we ensure we are not ...

    Abstract Leadership educators often acknowledge the need to embrace and honor diverse lived experiences and different ways we acquire knowledge and demonstrate leadership. However, do our practices and expectations really reflect this? How do we ensure we are not perpetuating expectations and structures rooted in White supremacist culture?
    MeSH term(s) Humans ; Leadership ; Social Behavior
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2823407-8
    ISSN 2373-3357 ; 2373-3349
    ISSN (online) 2373-3357
    ISSN 2373-3349
    DOI 10.1002/yd.20467
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    Einzelsignatur: Show issues

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