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  1. Article: Biomarkers for colorectal cancer chemotherapy: Recent updates and future perspective.

    Lee, P Y / Md Azhan, F S / Low, T Y

    The Malaysian journal of pathology

    2023  Volume 45, Issue 3, Page(s) 317–331

    Abstract: During the last few decades, the treatment options available for patients with metastatic colorectal cancer (mCRC) have undergone continuous improvements, transitioning from conventional chemotherapy to targeted therapy. These therapeutic innovations ... ...

    Abstract During the last few decades, the treatment options available for patients with metastatic colorectal cancer (mCRC) have undergone continuous improvements, transitioning from conventional chemotherapy to targeted therapy. These therapeutic innovations have led to significant improvements in patient clinical outcomes. However, there remains a need to improve the outcome for many CRC patients. Chemotherapy remains a cornerstone of CRC treatment, but the wide variability in tumour response and adverse reactions to chemotherapy poses a challenge to cancer treatment management. As a result, there is an unmet need to identify predictive biomarkers of chemotherapeutic response to guide treatment decisions. In this review, we summarise the conventional biomarkers used to predict chemotherapy responses in CRC and provide an overview of emerging predictive biomarkers based on the current understanding of the molecular biology of treatment response. Finally, we explore the challenges and future prospects of biomarker discovery to improve the prediction of patient response and ensure optimal treatment management for patients with metastatic CRC.
    MeSH term(s) Humans ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Biomarkers ; Biomarkers, Tumor
    Chemical Substances Biomarkers ; Biomarkers, Tumor
    Language English
    Publishing date 2023-12-29
    Publishing country Malaysia
    Document type Review ; Journal Article
    ZDB-ID 604751-8
    ISSN 0126-8635
    ISSN 0126-8635
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1769: Show issues Location:
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  2. Article: Indolent T Cell Lymphoproliferation of the Gastrointestinal Tract: An Evolving Disease Entity.

    Wang, Luke / Koh, Elaine / Kumar, Beena / Low, Michael S Y

    Hematology reports

    2024  Volume 16, Issue 2, Page(s) 179–184

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2586645-X
    ISSN 2038-8330 ; 2038-8322
    ISSN (online) 2038-8330
    ISSN 2038-8322
    DOI 10.3390/hematolrep16020018
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  3. Article ; Online: Single-surgeon perspective: is there ever a need to open extension-type supracondylar fractures?

    Low, Lyndon Y H / Barry, Marzanne E / Condell, Ross / Clesham, Kevin / Devitt, Aiden T

    Irish journal of medical science

    2023  Volume 192, Issue 6, Page(s) 2845–2849

    Abstract: Background: Supracondylar humerus fractures (SCHFs) represent the most common pediatric elbow fracture, constituting approximately 12-17% of all pediatric fractures. The vast majority of operative supracondylar humerus fractures are treated with closed ... ...

    Abstract Background: Supracondylar humerus fractures (SCHFs) represent the most common pediatric elbow fracture, constituting approximately 12-17% of all pediatric fractures. The vast majority of operative supracondylar humerus fractures are treated with closed reduction and percutaneous pinning (CRPP); however, the estimated rate of SCHFs requiring open reduction is approximately 12.7%.
    Aim: This study aims to analyze the likelihood of open reduction in pediatric extension-type SCHFs and to reaffirm the traditional teaching of reduction techniques described by Smith and Rang.
    Methods: A single-surgeon retrospective analysis of 56 operative pediatric SCH cases (51 extension-type, 6 flexion-type) who underwent either CRPP or open reduction over a 16-year period was performed. All cases were performed using the aforementioned reduction technique. The Modified Gartland's classification was utilized in the analysis of extension-type SCHF radiographs.
    Results: Gartland IIA fractures constituted 38% of SCHFs, 9% of Gartland IIB, 43% of Gartland III, and 7% of flexion-type. The rate of open reduction in SCHFs was 1.8% (1 out of 56 cases), performed in a flexion-type injury. All extension-type fractures were successfully managed with either CRPP or manipulation and casting alone. Of the cases requiring CRPP, 45% were divergent lateral wires, and 55% were crossed wires.
    Conclusions: In our series, a 1.8% rate of open reduction was indicated in flexion-type SCH fractures. All 52 cases of extension-type SCHFs were successfully managed with closed reduction with or without percutaneous pinning. Successful closed reduction using the concept of intact periosteal hinge to aid and maintain reduction is crucial.
    MeSH term(s) Child ; Humans ; Retrospective Studies ; Fracture Fixation, Internal/methods ; Treatment Outcome ; Humeral Fractures/surgery ; Surgeons
    Language English
    Publishing date 2023-02-28
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 390895-1
    ISSN 1863-4362 ; 0021-1265
    ISSN (online) 1863-4362
    ISSN 0021-1265
    DOI 10.1007/s11845-023-03294-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 323: Show issues Location:
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  4. Article ; Online: First molecular detection of porcine circovirus type 4 (PCV4) in Malaysia.

    Tan, C Y / Thanawongnuwech, R / Arshad, S S / Hassan, L / Lee, C Y / Low, S E / Fong, W C M / Ooi, P T

    Tropical biomedicine

    2023  Volume 40, Issue 3, Page(s) 301–306

    Abstract: Porcine circovirus type 4 (PCV4) is the newest member in the porcine circovirus family, first reported in 2020. To date, the presence of PCV4 has only been reported in China, South Korea and most recently in Thailand. Detection of PCV4 have been reported ...

    Abstract Porcine circovirus type 4 (PCV4) is the newest member in the porcine circovirus family, first reported in 2020. To date, the presence of PCV4 has only been reported in China, South Korea and most recently in Thailand. Detection of PCV4 have been reported in various production stages of pigs from piglets, finishers to sows; associated with a myriad of clinical manifestations including porcine dermatitis and nephropathy syndrome (PDNS), postweaning multisystemic wasting syndrome (PMWS), respiratory, enteric and neurological diseases. While successful virus isolation and culture has yet to be reported, pathogenicity of PCV4 has been demonstrated through infectious clone studies. The objective of this study is to investigate the presence of PCV4 in Malaysian porcine population to update the epidemiology of porcine circoviruses in Malaysia. A total of 49 samples from commercial intensive pig farms, abattoir and wild boar population were subjected to conventional polymerase chain reaction assay to detect PCV4 capsid (cap) genome. Resulting cap nucleotide sequences were analyzed for maximum likelihood phylogeny relationship. Results revealed that PCV4 is present in Peninsular Malaysia at a molecular prevalence of 4.08% (2 / 49 samples). Both PCV4 positive samples originated from clinically healthy finishers. Malaysian PCV4 strains were classified as genotype PCV4b, and were found to be phylogenetically distinct from the China, South Korea and Thailand strains. With this latest update of the novel PCV4 in Malaysia, it is clear that more attention needs to be given to the investigation of novel porcine circoviruses (PCV) and management of PCV diseases.
    MeSH term(s) Swine ; Animals ; Swine Diseases/epidemiology ; Circovirus/genetics ; Malaysia/epidemiology ; Circoviridae Infections/epidemiology ; Circoviridae Infections/veterinary ; Circoviridae Infections/genetics ; Base Sequence ; Capsid Proteins/genetics ; Phylogeny
    Chemical Substances Capsid Proteins
    Language English
    Publishing date 2023-10-28
    Publishing country Malaysia
    Document type Journal Article
    ZDB-ID 1068371-9
    ISSN 2521-9855 ; 0127-5720
    ISSN (online) 2521-9855
    ISSN 0127-5720
    DOI 10.47665/tb.40.3.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3269: Show issues Location:
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  5. Article: Massive Tibial Bone Regeneration with Autologous Peripheral Blood Stem Cells using Ilizarov Bone Transport: A Case Report.

    Saw, K Y / Gill, R / Low, T C

    Malaysian orthopaedic journal

    2020  Volume 14, Issue 3, Page(s) 166–169

    Abstract: This is a case report of a Gustilo-Anderson Type IIIB comminuted open right tibial fracture with massive bone loss, complicated by methicillin-resistant Staphylococus aureus (MRSA) infection. Non-viable and contaminated bony fragments were removed and ... ...

    Abstract This is a case report of a Gustilo-Anderson Type IIIB comminuted open right tibial fracture with massive bone loss, complicated by methicillin-resistant Staphylococus aureus (MRSA) infection. Non-viable and contaminated bony fragments were removed and infected bone resected. Soft tissue coverage and antibiotics were effective against the MRSA infection. A unifocal bone transport with the Ilizarov method regenerated 13cm of the missing tibia. Autologous peripheral blood stem cells (PBSC) injections into the osteogenesis site boosted bone regeneration and consolidation with a shortened Bone Healing index (BHI) of 23 days/cm.
    Language English
    Publishing date 2020-12-10
    Publishing country Malaysia
    Document type Case Reports
    ZDB-ID 2621480-5
    ISSN 1985-2533
    ISSN 1985-2533
    DOI 10.5704/MOJ.2011.026
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  6. Article ; Online: Transport Study of Charge-Carrier Scattering in Monolayer WSe_{2}.

    Joe, Andrew Y / Pistunova, Kateryna / Kaasbjerg, Kristen / Wang, Ke / Kim, Bumho / Rhodes, Daniel A / Taniguchi, Takashi / Watanabe, Kenji / Hone, James / Low, Tony / Jauregui, Luis A / Kim, Philip

    Physical review letters

    2024  Volume 132, Issue 5, Page(s) 56303

    Abstract: ... dependent scattering amplitude of strong defects calculated using the T-matrix approximation. Utilizing long ...

    Abstract Employing flux-grown single crystal WSe_{2}, we report charge-carrier scattering behaviors measured in h-BN encapsulated monolayer field effect transistors. We observe a nonmonotonic change of transport mobility as a function of hole density in the degenerately doped sample, which can be explained by energy dependent scattering amplitude of strong defects calculated using the T-matrix approximation. Utilizing long mean-free path (>500  nm), we also demonstrate the high quality of our electronic devices by showing quantized conductance steps from an electrostatically defined quantum point contact, showing the potential for creating ultrahigh quality quantum optoelectronic devices based on atomically thin semiconductors.
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.132.056303
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  7. Article ; Online: Restructuring the surgical service during the COVID-19 pandemic: experience from a tertiary institution in Singapore.

    Low, T Y / So, J B Y / Madhavan, K K / Hartman, M

    The British journal of surgery

    2020  Volume 107, Issue 8, Page(s) e252

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Disease Transmission, Infectious/prevention & control ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Quality Assurance, Health Care/methods ; Risk Factors ; SARS-CoV-2 ; Singapore ; Surgical Procedures, Operative/standards
    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country England
    Document type Letter
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.11701
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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.66: Show issues Location:
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  8. Article ; Online: Wellbeing of Surgical Staff since the COVID-19 Pandemic.

    Low, T Y / So, J B Y / Madhavan, K K / Hartman, M

    The British journal of surgery

    2020  Volume 107, Issue 11, Page(s) e478

    MeSH term(s) Administrative Personnel/psychology ; Burnout, Professional/epidemiology ; COVID-19/epidemiology ; Compassion Fatigue/epidemiology ; General Surgery ; Humans ; Medical Staff, Hospital/psychology ; Nursing Staff, Hospital/psychology ; Occupational Stress/epidemiology ; Pandemics ; Surveys and Questionnaires
    Keywords covid19
    Language English
    Publishing date 2020-08-21
    Publishing country England
    Document type Letter
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.11937
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  9. Article ; Online: Anti-inflammatory effects of hunger are transmitted to the periphery via projection-specific AgRP circuits.

    Klima, Michelle L / Kruger, Kayla A / Goldstein, Nitsan / Pulido, Santiago / Low, Aloysius Y T / Assenmacher, Charles-Antoine / Alhadeff, Amber L / Betley, J Nicholas

    Cell reports

    2023  Volume 42, Issue 11, Page(s) 113338

    Abstract: Caloric restriction has anti-inflammatory effects. However, the coordinated physiological actions that lead to reduced inflammation in a state of caloric deficit (hunger) are largely unknown. Using a mouse model of injury-induced peripheral inflammation, ...

    Abstract Caloric restriction has anti-inflammatory effects. However, the coordinated physiological actions that lead to reduced inflammation in a state of caloric deficit (hunger) are largely unknown. Using a mouse model of injury-induced peripheral inflammation, we find that food deprivation reduces edema, temperature, and cytokine responses that occur after injury. The magnitude of the anti-inflammatory effect that occurs during hunger is more robust than that of non-steroidal anti-inflammatory drugs. The effects of hunger are recapitulated centrally by activity in nutrient-sensing hypothalamic agouti-related protein (AgRP)-expressing neurons. We find that AgRP neurons projecting to the paraventricular nucleus of the hypothalamus rapidly and robustly reduce inflammation and mediate the majority of hunger's anti-inflammatory effects. Intact vagal efferent signaling is required for the anti-inflammatory action of hunger, revealing a brain-to-periphery pathway for this reduction in inflammation. Taken together, these data begin to unravel a potent anti-inflammatory pathway engaged by hypothalamic AgRP neurons to reduce inflammation.
    MeSH term(s) Humans ; Hunger/physiology ; Agouti-Related Protein/metabolism ; Hypothalamus/metabolism ; Neurons/metabolism ; Inflammation/metabolism
    Chemical Substances Agouti-Related Protein
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.113338
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  10. Article ; Online: Sporadic Meningioangiomatosis Presenting as a Middle Cranial Fossa Arachnoid Cyst.

    Chan, Brian Y L / Merchant, Khurshid Z / Teo, Jennifer G C / Chang, Kenneth T E / Low, David C Y / Low, Sharon Y Y

    World neurosurgery

    2020  Volume 137, Page(s) 247–251

    Abstract: Background: Meningioangiomatosis is an extremely rare meningovascular disease of the central nervous system that is characterized by the proliferation of leptomeninges, cortical vessels, and perivascular spindled cells. Although it is a benign, ... ...

    Abstract Background: Meningioangiomatosis is an extremely rare meningovascular disease of the central nervous system that is characterized by the proliferation of leptomeninges, cortical vessels, and perivascular spindled cells. Although it is a benign, neoplastic disorder that carries a good prognosis after surgical excision, initial diagnosis may be challenging as radiologic findings are often variable and nonspecific.
    Case description: In this report, we describe an unusual presentation of meningioangiomatosis presenting as a symptomatic middle cranial fossa arachnoid cyst.
    Conclusions: In view of the unexpected diagnosis and infrequency of this condition, the case is discussed in collaboration with current literature and management strategies.
    MeSH term(s) Angiomatosis/diagnosis ; Angiomatosis/diagnostic imaging ; Angiomatosis/surgery ; Arachnoid Cysts/diagnosis ; Arachnoid Cysts/diagnostic imaging ; Cerebrovascular Disorders/diagnosis ; Cerebrovascular Disorders/pathology ; Cranial Fossa, Middle/diagnostic imaging ; Craniotomy ; Diagnosis, Differential ; Eye Diseases/etiology ; Humans ; Infant ; Magnetic Resonance Imaging ; Male ; Meninges/pathology ; Neurosurgical Procedures/methods ; Treatment Outcome
    Language English
    Publishing date 2020-02-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.02.043
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1159: Show issues Location:
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