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  1. Article ; Online: It's a marathon not a sprint: the need for long-term monitoring of myocardial dysfunction in COVID-19.

    Truong, Vien T / Palmer, Cassady / Chung, Eugene S / Mazur, Wojciech

    The international journal of cardiovascular imaging

    2022  

    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Editorial
    ZDB-ID 2055311-0
    ISSN 1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
    ISSN (online) 1875-8312 ; 1573-0743
    ISSN 1569-5794 ; 0167-9899
    DOI 10.1007/s10554-022-02527-w
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    Zs.A 2104: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Sports Cardiology: The Transition of Fellow-in-Training to Early Career Physician.

    Husaini, Mustafa / Kline, Kristopher P / Chukumerije, Merije / Emery, Michael S / Martinez, Matthew W / Chung, Eugene H

    JACC. Case reports

    2022  Volume 4, Issue 17, Page(s) 1143–1146

    Language English
    Publishing date 2022-09-07
    Publishing country Netherlands
    Document type Editorial
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2022.04.011
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  3. Article: Hybridizing mechanistic mathematical modeling with deep learning methods to predict individual cancer patient survival after immune checkpoint inhibitor therapy.

    Butner, Joseph D / Dogra, Prashant / Chung, Caroline / Koay, Eugene J / Welsh, James W / Hong, David S / Cristini, Vittorio / Wang, Zhihui

    Research square

    2024  

    Abstract: We present a study where predictive mechanistic modeling is used in combination with deep learning methods to predict individual patient survival probabilities under immune checkpoint inhibitor (ICI) therapy. This hybrid approach enables prediction based ...

    Abstract We present a study where predictive mechanistic modeling is used in combination with deep learning methods to predict individual patient survival probabilities under immune checkpoint inhibitor (ICI) therapy. This hybrid approach enables prediction based on both measures that are calculable from mechanistic models (but may not be directly measurable in the clinic) and easily measurable quantities or characteristics (that are not always readily incorporated into predictive mechanistic models). The mechanistic model we have applied here can predict tumor response from CT or MRI imaging based on key mechanisms underlying checkpoint inhibitor therapy, and in the present work, its parameters were combined with readily-available clinical measures from 93 patients into a hybrid training set for a deep learning time-to-event predictive model. Analysis revealed that training an artificial neural network with both mechanistic modeling-derived and clinical measures achieved higher per-patient predictive accuracy based on event-time concordance, Brier score, and negative binomial log-likelihood-based criteria than when only mechanistic model-derived values or only clinical data were used. Feature importance analysis revealed that both clinical and model-derived parameters play prominent roles in neural network decision making, and in increasing prediction accuracy, further supporting the advantage of our hybrid approach. We anticipate that many existing mechanistic models may be hybridized with deep learning methods in a similar manner to improve predictive accuracy through addition of additional data that may not be readily implemented in mechanistic descriptions.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-4151883/v1
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  4. Article: A Review of Heart Failure in Patients with COVID-19.

    Bashir, Hanad / Yildiz, Mehmet / Cafardi, John / Bhatia, Ankit / Garcia, Santiago / Henry, Timothy D / Chung, Eugene S

    Heart failure clinics

    2023  Volume 19, Issue 2S, Page(s) e1–e8

    Abstract: The interplay of COVID-19 and heart failure is complex and involves direct and indirect effects. Patients with existing heart failure develop more severe COVID-19 symptoms and have worse clinical outcomes. Pandemic-related policies and protocols have ... ...

    Abstract The interplay of COVID-19 and heart failure is complex and involves direct and indirect effects. Patients with existing heart failure develop more severe COVID-19 symptoms and have worse clinical outcomes. Pandemic-related policies and protocols have negatively affected care for cardiovascular conditions and established hospital protocols, which is particularly important for patients with heart failure.
    MeSH term(s) Humans ; COVID-19/complications ; COVID-19/epidemiology ; SARS-CoV-2 ; Heart Failure/epidemiology ; Heart Failure/therapy ; Cardiovascular Diseases
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2212019-1
    ISSN 1551-7136
    ISSN 1551-7136
    DOI 10.1016/j.hfc.2023.03.002
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    Zs.A 6554: Show issues Location:
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  5. Article ; Online: Targeting the Worst Symptom in Acute Heart Failure: A Tailored Approach.

    Chung, Eugene S / Egnaczyk, Gregory F

    Journal of cardiac failure

    2016  Volume 22, Issue 11, Page(s) 859–860

    Language English
    Publishing date 2016
    Publishing country United States
    Document type Editorial
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2016.09.002
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    Zs.A 4340: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Systolic Heart Failure is Associated with Higher Mortality Among Patients Undergoing Transcatheter Aortic Valve Replacement: A Nationwide Analysis.

    Fatuyi, Michael / Akinti, Segun / Rukayat, Otulana / Md, Najamul Ansari / Ansari, Asimul / Al-Amoodi, Mohammed / Chung, Eugene S / Shemisa, Kamal

    Current problems in cardiology

    2023  Volume 48, Issue 12, Page(s) 101936

    Abstract: Heart failure (HF) is prevalent among patients with aortic stenosis and presents a poor prognosis. In order to better portray outcomes for HF patients undergoing transcatheter aortic valve replacement (TAVR), we evaluated clinical outcomes in patients ... ...

    Abstract Heart failure (HF) is prevalent among patients with aortic stenosis and presents a poor prognosis. In order to better portray outcomes for HF patients undergoing transcatheter aortic valve replacement (TAVR), we evaluated clinical outcomes in patients with systolic vs diastolic heart failure who underwent TAVR in a large nationwide database. We searched the National Inpatient Sample (NIS) for hospitalized adult patients who underwent TAVR with coexisting history of systolic (SHF) or diastolic heart failure (DHF) as a secondary diagnosis using the ICD-10 codes. The primary outcome was in-hospital mortality, with secondary outcomes of cardiac arrest (CA), cardiogenic shock (CS), respiratory failure (RF), Non-ST elevation myocardial infarction (NSTEMI), acute kidney injury (AKI), use of cardiac and respiratory assist device, and health care utilization defined as length of stay, average hospital cost (AHC) and patient charge (APC). Both univariate and multivariate logistic, generalized linear, and Poisson regression analyses were used to evaluate and test the outcomes. A P-value of <0.05 was significant. A total of 106,815 patients were admitted to acute care hospitals for TAVR, and 73% had a secondary diagnosis of heart failure (41% had SHF and 59% DHF). SHF group were older (mean age of 78.9 years [SD ± 8.9] vs 79.9 years [SD ± 8.3]) with more males (61.8% vs 48.2%) and white predominant (whites [85.9% vs 87.9%]). Compared to DHF, SHF had higher inpatient mortality (1.75% vs 1.14%, P = 0.003), CA (1.31% vs 0.81%, P = 0.01), NSTEMI (2.52% vs 1.0%, P = 0.001), RF (10.87% vs 8.01%, P = 0.001), and CS (3.94% vs 1.14%, P = 0.001). In addition, SHF had greater LOS (5.1 days vs. .3.9, P = 0.0001) & AHC ($52,901 vs $48,070, P = 0.0001). HF is common among patients admitted for TAVR. SHF had worse CV outcomes, greater use of hospital resources, and higher acute care hospital mortality compared to those with DHF.
    MeSH term(s) Male ; Adult ; Humans ; Aged ; Transcatheter Aortic Valve Replacement/adverse effects ; Aortic Valve/surgery ; Heart Valve Prosthesis Implantation/adverse effects ; Heart Failure, Systolic/etiology ; Heart Failure, Systolic/surgery ; Non-ST Elevated Myocardial Infarction ; Heart Failure, Diastolic/etiology ; Heart Failure, Diastolic/surgery ; Risk Factors ; Treatment Outcome ; Aortic Valve Stenosis/surgery
    Language English
    Publishing date 2023-07-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 441230-8
    ISSN 1535-6280 ; 0146-2806
    ISSN (online) 1535-6280
    ISSN 0146-2806
    DOI 10.1016/j.cpcardiol.2023.101936
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    Se 505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: First responder cardiac health amid the COVID-19 pandemic.

    Rao, Prashant / Friedman, Eli / Chung, Eugene H / Levine, Benjamin D / Isaacs, S Marshal

    Resuscitation

    2020  Volume 156, Page(s) 120–122

    MeSH term(s) Betacoronavirus ; COVID-19 ; Cause of Death/trends ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Emergency Responders/statistics & numerical data ; Female ; Global Health ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Survival Rate/trends
    Keywords covid19
    Language English
    Publishing date 2020-09-19
    Publishing country Ireland
    Document type Letter
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2020.09.023
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    Zs.A 1048: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Cardiorenal syndrome: misgivings about treatment options, clarity on prognosis.

    Chung, Eugene S / Meyer, Theo E

    Journal of cardiac failure

    2015  Volume 21, Issue 2, Page(s) 116–118

    MeSH term(s) Blood Pressure ; Female ; Heart Failure/mortality ; Hemofiltration/mortality ; Humans ; Male ; Renal Dialysis/mortality ; Renal Insufficiency/mortality
    Language English
    Publishing date 2015-02
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2014.11.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4340: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: A Pooled Electronic Consultation Program to Improve Access to Genetics Specialists.

    Folkerts, Emma K / Pelletier, Renée C / Chung, Daniel C / Goldstein, Susan A / Micalizzi, Douglas S / Shannon, Kristen M / Sweetser, David A / Wong, Eugene K / Rehm, Heidi L / Hull, Leland E

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Innovative service delivery models are needed to increase access to genetics specialists. Electronic consultation (e-Consult) programs can connect clinicians with specialists. At Massachusetts General Hospital, an e-Consult service was created to address ...

    Abstract Innovative service delivery models are needed to increase access to genetics specialists. Electronic consultation (e-Consult) programs can connect clinicians with specialists. At Massachusetts General Hospital, an e-Consult service was created to address genomics-related questions. In its first year, the e-Consult service triaged 153 requests and completed 122 in an average of 3.2 days. Of the 95 e-Consults with actionable recommendations, there was documentation that most ordering clinicians followed through (82%). A variety of providers used the service, although the majority (77%) were generalists. E-Consult models should be considered as one way to increase access to genetics care.
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.08.23284667
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  10. Article ; Online: Management strategies and prognosis of patients ineligible for transcatheter mitral valve replacement.

    Hasan, Syeda A / Morsi, Moustafa / Frakes, Belinda S / Bryson, Marien E / Schmidt, Christian W / Seshiah, Puvi / Choo, Joseph / Smith, J Michael / Answini, Geoffrey A / Stewart-Dehner, Terri L / Yasar, Senan J / Jollis, James G / Berlacher, Mark D / Ratajczak, Teresa M / Chung, Eugene S / Kereiakes, Dean J / Garcia, Santiago

    Cardiovascular revascularization medicine : including molecular interventions

    2024  

    Abstract: Background: Transcatheter mitral valve replacement (TMVR) faces anatomical challenges, currently limiting widespread adoption.: Objectives: To describe the natural history and prognosis of patients ineligible for various TMVR devices.: Methods: ... ...

    Abstract Background: Transcatheter mitral valve replacement (TMVR) faces anatomical challenges, currently limiting widespread adoption.
    Objectives: To describe the natural history and prognosis of patients ineligible for various TMVR devices.
    Methods: During a 4-year period (2019-2023) 3 TMVR devices (SAPIEN M3, Intrepid and Alta Valve) became available at a single institution (The Christ Hospital, Cincinnati, OH) in the setting of pivotal clinical trials or early feasibility study. Consenting patients who were deemed ineligible ≥1 of these trials were prospectively studied to capture anatomical reasons for ineligibility, cross-over to alternative mitral valve therapies (surgery or high-risk mitral transcatheter edge to edge repair [M-TEER]), and clinical events.
    Results: A total of 61 patients (out of 71 consenting patients or 85.9 %) were deemed ineligible for TMVR during the study period. The mean age was 79.2 ± 8.8 years, 65.6 % were female, with elevated surgical risk (median STS 4.3, IQR: 2.7-7.3). The 2 most common anatomical reasons for ineligibility were increased risk of left ventricular outflow tract obstruction (LVOTO) (n = 24, 39.3 %) and annular size (n = 29, 47.5 %). During follow-up (median 277 [162-555] days) there were 7 deaths (11.5 %) and 12 (19.7 %) hospitalizations for heart failure. Management strategies included high-risk M-TEER in 11 patients (1 death [9.0 %], 0 HF hospitalizations [0 %]), surgery in 9 patients (0 deaths, 1 HF hospitalizations [11.1 %]), and medical management in 41 patients (6 deaths [14.6 %], 11 HF hospitalizations [26.8 %]) (p = 0.715 for mortality and p = 0.093 for HF hospitalizations). Residual MR ≥ moderate was 0 %, 50 %, and 100 % for surgery, M-TEER and medical treatment, respectively (p < 0.001).
    Conclusions: One third of patients deemed ineligible for TMVR are candidates for high-risk M-TEER or surgery with acceptable morbidity and mortality. Our results have practical implications for patient management.
    Language English
    Publishing date 2024-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212113-4
    ISSN 1878-0938 ; 1553-8389
    ISSN (online) 1878-0938
    ISSN 1553-8389
    DOI 10.1016/j.carrev.2024.02.002
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    Zs.A 5562: Show issues Location:
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