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  1. Article ; Online: A retrospective, observational study analysing effectiveness of sotrovimab in preventing hospitalisation and deaths from COVID-19 and which subgroup of high-risk patients are more likely to benefit due to the absence of COVID-19 spike antibody post vaccination.

    Bello, Zainab / Jayakrishnan, Nirmal / Watson, Joanne

    Clinical medicine (London, England)

    2024  Volume 23, Issue Suppl 6, Page(s) 65

    MeSH term(s) Humans ; Retrospective Studies ; COVID-19 ; Antibodies, Monoclonal, Humanized/therapeutic use
    Chemical Substances sotrovimab (1MTK0BPN8V) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.23-6-s65
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5439: Show issues Location:
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  2. Article ; Online: Adherence to recommended hospital waste management practices by healthcare workers at Murtala Muhammad Specialist Hospital Kano, Nigeria.

    Yakubu, Zainab Muhammad / Bello, Isah Mohammed / Tsiga-Ahmed, Fatimah

    The Pan African medical journal

    2023  Volume 44, Page(s) 124

    Abstract: Introduction: the aim of this study was to determine what proportion of patients with confirmed esophageal cancer at the largest hospital in the country were recorded in the Zambia National Cancer Registry (ZNCR).: Methods: we reviewed esophageal ... ...

    Abstract Introduction: the aim of this study was to determine what proportion of patients with confirmed esophageal cancer at the largest hospital in the country were recorded in the Zambia National Cancer Registry (ZNCR).
    Methods: we reviewed esophageal cancer records at the University Teaching Hospital (UTH) and ZNCR, between 2015 and 2017. Using Stata version 15, data were summarised and the Kruskal-Wallis was used to compute comparisons, Kaplan-Meier curves for survival estimates and Cox regression for associated factors.
    Results: included in the final analysis were records for 222 patients with confirmed esophageal cancer and of these 51/222 (41%) were appearing in the ZNCR. The mean age of the patients was 56.2 years (SD, 13.0) and only 2/222 (1%) were confirmed alive at the time of data analysis. The median time from endoscopic diagnosis to histological confirmation was 12.5 days (IQR 7.5 - 21.5) and arrival at the Cancer Diseases Hospital (CDH) for treatment was 20 days (IQR 10 - 34). The overall median survival time in the study was 259 days (CI 95%; 151 - 501). Age, sex, time to diagnosis, histological classification and grade of tumour did not show any evidence of predicting survival in both the univariate and multivariable cox regression model (p>0.05).
    Conclusion: a significant proportion of esophageal cancer cases seen at UTH were not included in the national registry suggesting that official figures for the prevalence of esophageal cancer in Zambia are underestimated. There is an urgent need to improve the collection of data on esophageal cancer in Zambia.
    MeSH term(s) Humans ; Middle Aged ; Nigeria/epidemiology ; Hospitals, Teaching ; Waste Management ; Health Personnel ; Esophageal Neoplasms/epidemiology
    Language English
    Publishing date 2023-03-14
    Publishing country Uganda
    Document type Review ; Journal Article
    ZDB-ID 2514347-5
    ISSN 1937-8688 ; 1937-8688
    ISSN (online) 1937-8688
    ISSN 1937-8688
    DOI 10.11604/pamj.2023.44.124.34618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Computer-aided drug discovery of c-Abl kinase inhibitors from plant compounds against chronic myeloid leukemia.

    Alshehri, Mohammed M / Kumar, Neeraj / Kuthi, Najwa Ahmad / Olaide, Zainab / Alshammari, Mohammed Kanan / Bello, Ridwan Opeyemi / Alghazwni, Mohammed Khalid / Alshehri, Ahmed Mughram / Alshlali, Omaymah Mohammed / Ashimiyu-Abdusalam, Zainab / Umar, Haruna Isiyaku

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–21

    Abstract: Chronic myeloid leukemia (CML) is a hematological malignancy characterized by the neoplastic transformation of hematopoietic stem cells, driven by the Philadelphia (Ph) chromosome resulting from a translocation between chromosomes 9 and 22. This Ph ... ...

    Abstract Chronic myeloid leukemia (CML) is a hematological malignancy characterized by the neoplastic transformation of hematopoietic stem cells, driven by the Philadelphia (Ph) chromosome resulting from a translocation between chromosomes 9 and 22. This Ph chromosome harbors the breakpoint cluster region (BCR) and the Abelson (ABL) oncogene (BCR-ABL1) which have a constitutive tyrosine kinase activity. However, the tyrosine kinase activity of BCR-ABL1 have been identified as a key player in CML initiation and maintenance through c-Abl kinase. Despite advancements in tyrosine kinase inhibitors, challenges such as efficacy, safety concerns, and recurring drug resistance persist. This study aims to discover potential c-Abl kinase inhibitors from plant compounds with anti-leukemic properties, employing drug-likeness assessment, molecular docking, in silico pharmacokinetics (ADMET) screening, density function theory (DFT), and molecular dynamics simulations (MDS). Out of 58 screened compounds for drug-likeness, 44 were docked against c-Abl kinase. The top hit compound (isovitexin) and nilotinib (control drug) were subjected to rigorous analyses, including ADMET profiling, DFT evaluation, and MDS for 100 ns. Isovitexin demonstrated a notable binding affinity (-15.492 kcal/mol), closely comparable to nilotinib (-16.826 kcal/mol), showcasing a similar binding pose and superior structural stability and reactivity. While these findings suggest isovitexin as a potential c-Abl kinase inhibitor, further validation through urgent
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2329297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Retcam shuttle images of developing retinopathy of prematurity.

    Bello, Zainab

    BMJ case reports

    2014  Volume 2014

    MeSH term(s) Female ; Humans ; Infant, Newborn ; Infant, Premature ; Mass Screening ; Retinal Diseases/diagnosis ; Retinopathy of Prematurity/diagnosis
    Language English
    Publishing date 2014-09-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2014-206826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Evaluation of traditional and machine learning approaches for modeling volatile fatty acid concentrations in anaerobic digestion of sludge: potential and challenges.

    Abubakar, Umar Alfa / Lemar, Gul Sanga / Bello, Al-Amin Danladi / Ishaq, Aliyu / Dandajeh, Aliyu Adamu / Jagun, Zainab Toyin / Houmsi, Mohamad Rajab

    Environmental science and pollution research international

    2024  

    Abstract: This study evaluates models for predicting volatile fatty acid (VFA) concentrations in sludge processing, ranging from classical statistical methods (Gaussian and Surge) to diverse machine learning algorithms (MLAs) such as Decision Tree, XGBoost, ... ...

    Abstract This study evaluates models for predicting volatile fatty acid (VFA) concentrations in sludge processing, ranging from classical statistical methods (Gaussian and Surge) to diverse machine learning algorithms (MLAs) such as Decision Tree, XGBoost, CatBoost, LightGBM, Multiple linear regression (MLR), Support vector regression (SVR), AdaBoost, and GradientBoosting. Anaerobic bio-methane potential tests were carried out using domestic wastewater treatment primary and secondary sludge. The tests were monitored over 40 days for variations in pH and VFA concentrations under different experimental conditions. The data observed was compared to predictions from the Gaussian and Surge models, and the MLAs. Based on correlation analysis using basic statistics and regression, the Gaussian model appears to be a consistent performer, with high R
    Language English
    Publishing date 2024-04-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-33281-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The influence of various chemical oxygen demands on microbial fuel cells performance using leachate as a substrate.

    Ishaq, Aliyu / Said, Mohd Ismid Mohd / Azman, Shamila Binti / Houmsi, Mohammed Rajab / Isah, Abubakar Sadiq / Jagun, Zainab Toyin / Mohammad, Shamsuddeen Jumande / Bello, Al Amin Danladi / Abubakar, Umar Alfa

    Environmental science and pollution research international

    2024  

    Abstract: Microbial fuel cells (MFCs), hailed as a promising technology, hold the potential to combat various wastewater pollutants while simultaneously converting their chemical energy into electricity through biocatalysts. This study explores the applicability ... ...

    Abstract Microbial fuel cells (MFCs), hailed as a promising technology, hold the potential to combat various wastewater pollutants while simultaneously converting their chemical energy into electricity through biocatalysts. This study explores the applicability of a dual compartment MFC (DC-MFC) under varying conditions, targeting the removal of chemical oxygen demand (COD) from landfill leachate and electricity generation. In this setup, anaerobic sludge from a wastewater treatment plant serves as the inoculum in the anode compartment of the MFC, with a Nafion117 membrane acting as the separator between MFC units. The cathode compartments are filled with distilled water and continually aerated for 24 h to enhance air supply. The study assesses the MFC's performance across different COD concentrations, focusing on COD removal, power generation, and Coulombic efficiency. The findings reveal that COD removal efficiency is notably enhanced at higher concentrations of organic matter. Specifically, at a COD concentration of 3325.0 mg L
    Language English
    Publishing date 2024-01-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-32090-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: An integrative computational approach for the identification of dual inhibitors of isocitrate dehydrogenase 1 and 2 from phytocompounds of

    Bello, Ridwan Opeyemi / Okunlola, Salihaat Toyin / Kumar, Neeraj / Victor, Omoboyede / Jimoh, Tajudeen O / Abdulsalam, Zainab Naeem / Kehinde, Idayat Oyinkansola / Umar, Haruna Isiyaku

    Journal of biomolecular structure & dynamics

    2023  , Page(s) 1–17

    Abstract: Genetic alterations of the genes encoding the isocitrate dehydrogenase (IDH) enzymes have been identified in about 20% of acute myeloid leukemia (AML) cases as well as many other forms of cancers. Notable among these alterations are the neomorphic ... ...

    Abstract Genetic alterations of the genes encoding the isocitrate dehydrogenase (IDH) enzymes have been identified in about 20% of acute myeloid leukemia (AML) cases as well as many other forms of cancers. Notable among these alterations are the neomorphic IDH1_R132H and IDH2_R140Q mutations which lead to the production of an oncometabolite. Hence, their inhibition is widely considered a therapeutic strategy in the treatment of many cancers. While many inhibitors of the mutant enzymes have been developed, an inhibitor that is capable of co-inhibiting both enzymes are currently lacking while drug resistance has also limited the clinical usage of previously identified mono inhibitors. Consequently, this study employed molecular modeling approaches, such as molecular docking, molecular mechanics generalized Born Surface area (MM/GBSA), molecular dynamics (MD) simulation, and density functional theory (DFT) analysis to identify potential dual inhibitors of the previously mentioned mutant IDH1/2 from the phytocompounds of
    Language English
    Publishing date 2023-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2245494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Article: Antiprotozoal Effect of Snake Venoms and Their Fractions: A Systematic Review.

    Abdullahi, Zainab U / Musa, Salihu S / He, Daihai / Bello, Umar M

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 12

    Abstract: Background: Protozoal infection is a lingering public health issue of great concern, despite efforts to produce drugs and vaccines against it. Recent breakthrough research has discovered alternative antiprotozoal agents encompassing the use of snake ... ...

    Abstract Background: Protozoal infection is a lingering public health issue of great concern, despite efforts to produce drugs and vaccines against it. Recent breakthrough research has discovered alternative antiprotozoal agents encompassing the use of snake venoms and their components to cure these infections. This study collated the existing literature to examine the antiprotozoal effect of snake venoms and their fractions.
    Methods: We conducted a systematic review following the PRISMA guidelines. The PubMed and Embase databases were searched from their inception until 13 October 2021. Articles were screened at the title, abstract and full-text phases. Some additional studies were obtained through the manual search process.
    Results: We identified 331 studies via the electronic database and manual searches, of which 55 reporting the antiprotozoal effect of snake venoms and their components were included in the review. Around 38% of studies examined the effect of whole crude venoms, and a similar percentage evaluated the effect of a proportion of enzymatic phospholipase A2 (PLA2). In particular, this review reports around 36 PLA2 activities and 29 snake crude venom activities. We also report the notable phenomenon of synergism with PLA2 isoforms of
    Conclusion: This study highlights the impact of snake venoms and their fractions on controlling protozoal infections and suggests the need to examine further the effectiveness of other venom components, such as metalloproteinase, serine protease and three-finger toxins. Future research questions in this field must be redirected toward synergism in snake venom components, based on pharmacological usage and in the context of toxicology. Ascertaining the effects of snake venoms and their components on other protozoal species that have not yet been studied is imperative.
    Language English
    Publishing date 2021-12-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10121632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Smart waste bin monitoring using IoT for sustainable biomedical waste management.

    Ishaq, Aliyu / Mohammad, Shamsuddeen Jumande / Bello, Al-Amin Danladi / Wada, Surajo Abubakar / Adebayo, Adejimi / Jagun, Zainab Toyin

    Environmental science and pollution research international

    2023  

    Abstract: Suboptimal management of healthcare waste poses a significant concern that can be effectively tackled by implementing Internet of Things (IoT) solutions to enhance trash monitoring and disposal processes. The potential utilisation of the Internet of ... ...

    Abstract Suboptimal management of healthcare waste poses a significant concern that can be effectively tackled by implementing Internet of Things (IoT) solutions to enhance trash monitoring and disposal processes. The potential utilisation of the Internet of Things (IoT) in addressing the requirements associated with biomedical waste management within the Kaduna area was examined. The study included a selection of ten hospitals, chosen based on the criterion of having access to wireless Internet connectivity. The issue of biomedical waste is significant within the healthcare sector since it accounts for a considerable amount of overall waste generation, with estimates ranging from 43.62 to 52.47% across various facilities. Utilisation of (IoT) sensors resulted in the activation of alarms and messages to facilitate the prompt collection of waste. Data collected from these sensors was subjected to analysis to discover patterns and enhance the overall efficiency of waste management practices. The study revealed a positive correlation between the quantity of hospital beds and the daily garbage generated. Notably, hospitals with a higher number of beds were observed to generate a much greater amount of waste per bed. Hazardous waste generated varies by hospital, with one hospital leading in sharps waste (10.98 kgd
    Language English
    Publishing date 2023-10-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-30240-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: An examination of the factors affecting the adoption of E-training in the Nigerian civil service sector

    Zainab, Bello / Faizuniah Pangil / Bhatti, Muhammad Awais

    Global business and organizational excellence : a review of research & best practices Vol. 36, No. 4 , p. 33-42

    2017  Volume 36, Issue 4, Page(s) 33–42

    Author's details Bello Zainab, Muhammad Awais Bhatti, Faizuniah Pangil
    Keywords Öffentlicher Dienst ; Betriebliches Bildungsmanagement ; Nigeria
    Language English
    Publisher Wiley
    Publishing place Hoboken, NJ
    Document type Article
    ZDB-ID 2272974-4 ; 2322782-5
    ISSN 1932-2062 ; 1932-2054
    ISSN (online) 1932-2062
    ISSN 1932-2054
    Database ECONomics Information System

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