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  1. Article ; Online: Effect of Awake Prone Positioning in non-Intubated COVID-19 Patients with Acute Hypoxemic Respiratory Failure: A Systematic Review and Meta-Analysis.

    Kang, Hanyujie / Gu, Xueqing / Tong, Zhaohui

    Journal of intensive care medicine

    2022  Volume 37, Issue 11, Page(s) 1493–1503

    Abstract: Background: Awake prone positioning (APP) has been considered as a feasible treatment for patients with acute hypoxemic respiratory failure in non-intubated coronavirus disease 2019 (COVID-19). However, the efficacy and safety of APP remain uncertain. ... ...

    Abstract Background: Awake prone positioning (APP) has been considered as a feasible treatment for patients with acute hypoxemic respiratory failure in non-intubated coronavirus disease 2019 (COVID-19). However, the efficacy and safety of APP remain uncertain. This meta-analysis aims to assess the effect of APP on intubation rate and mortality in COVID-19 patients with acute respiratory failure.
    Methods: Relevant studies published from January 1, 2020, to June 17, 2022, were systematically searched. The primary outcomes were the intubation rate and mortality; the secondary outcome was the incidence of adverse events.
    Results: Of 5746 identified publications, 22 were eligible for inclusion in the meta-analysis (N = 5146 patients). In comparison to the non-APP group, APP could decrease the intubation rates (OR 0.64; 95% CI 0.48-0.83;
    Conclusion: Our results demonstrated that APP could be an effective strategy to avoid intubation without detrimental effects in non-intubated patients with COVID-19, especially for patients requiring HFNC or NIV, and the daily APP duration with the target of minimally eight hours was suggested. In the subgroup of RCTs, the pooled results did not demonstrate any benefit of APP on mortality. Given the limited number of RCTs, further high-quality RCTs are needed to confirm the results.
    Inplasy registration number: INPLASY2021110037.
    MeSH term(s) COVID-19/therapy ; Humans ; Noninvasive Ventilation ; Oxygen Inhalation Therapy ; Prone Position ; Respiratory Insufficiency/therapy ; Wakefulness
    Language English
    Publishing date 2022-08-25
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 632828-3
    ISSN 1525-1489 ; 0885-0666
    ISSN (online) 1525-1489
    ISSN 0885-0666
    DOI 10.1177/08850666221121593
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    Zs.A 2158: Show issues Location:
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  2. Article ; Online: Asymptomatic cases with SARS-CoV-2 infection.

    Wang, Yishan / Kang, Hanyujie / Liu, Xuefeng / Tong, Zhaohui

    Journal of medical virology

    2020  Volume 92, Issue 9, Page(s) 1401–1403

    Abstract: On 31 March 2020, Chinese Health Authorization announced that numbers of asymptomatic cases with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection will be made to the public daily. This was a very important step since different ... ...

    Abstract On 31 March 2020, Chinese Health Authorization announced that numbers of asymptomatic cases with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection will be made to the public daily. This was a very important step since different counties have different capacities for the detection of SARS-CoV-2 infection and control strategy for the Coronavirus Disease 2019 outbreak. We summarized the characteristics of asymptomatic SARS-CoV-2 infections and the transmission potential of asymptomatic cases. Then we provided guidelines for the management of asymptomatic cases through quarantine and nucleic acid/serology tests.
    MeSH term(s) Asymptomatic Infections/epidemiology ; COVID-19/epidemiology ; China ; Humans ; Pandemics
    Keywords covid19
    Language English
    Publishing date 2020-05-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25990
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  3. Article ; Online: Effect of different levels of PEEP on mortality in ICU patients without acute respiratory distress syndrome: systematic review and meta-analysis with trial sequential analysis.

    Shao, Shuai / Kang, Hanyujie / Qian, Zhenbei / Wang, Yingquan / Tong, Zhaohui

    Journal of critical care

    2021  Volume 65, Page(s) 246–258

    Abstract: Objective: To determine whether higher positive end- expiratory pressure (PEEP) could provide a survival advantage for patients without acute respiratory distress syndrome (ARDS) compared with lower PEEP.: Methods: Eligible studies were identified ... ...

    Abstract Objective: To determine whether higher positive end- expiratory pressure (PEEP) could provide a survival advantage for patients without acute respiratory distress syndrome (ARDS) compared with lower PEEP.
    Methods: Eligible studies were identified through searches of Embase, Cochrane Library, Web of Science, Medline, and Wanfang database from inception up to 1 June 2021. Trial sequential analysis (TSA) was used in this meta-analysis.
    Data synthesis: Twenty-seven randomized controlled trials (RCTs) were identified for further evaluation. Higher and lower PEEP arms included 1330 patients and 1650 patients, respectively. A mean level of 9.6±3.4 cmH
    Conclusions: Our results suggest that a lower PEEP ventilation strategy was non-inferior to a higher PEEP ventilation strategy in ICU patients without ARDS, with no increased risk of all-cause mortality and 28-day mortality. Further high-quality RCTs should be performed to confirm these findings.
    MeSH term(s) Humans ; Intensive Care Units ; Length of Stay ; Positive-Pressure Respiration ; Respiration, Artificial ; Respiratory Distress Syndrome/therapy
    Language English
    Publishing date 2021-07-03
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2021.06.015
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    Zs.A 2152: Show issues Location:
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  4. Article ; Online: Combination of RT-qPCR testing and clinical features for diagnosis of COVID-19 facilitates management of SARS-CoV-2 outbreak.

    Wang, Yishan / Kang, Hanyujie / Liu, Xuefeng / Tong, Zhaohui

    Journal of medical virology

    2020  Volume 92, Issue 6, Page(s) 538–539

    MeSH term(s) Betacoronavirus/genetics ; Betacoronavirus/pathogenicity ; COVID-19 ; COVID-19 Testing ; China/epidemiology ; Clinical Laboratory Techniques/methods ; Clinical Laboratory Techniques/standards ; Communicable Disease Control/organization & administration ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Cough/diagnosis ; Cough/physiopathology ; Cough/virology ; Disease Management ; Disease Outbreaks ; False Negative Reactions ; Fever/diagnosis ; Fever/physiopathology ; Fever/virology ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; Practice Guidelines as Topic ; Reagent Kits, Diagnostic/standards ; Real-Time Polymerase Chain Reaction/standards ; SARS-CoV-2 ; Tomography, X-Ray Computed
    Chemical Substances Reagent Kits, Diagnostic
    Keywords covid19
    Language English
    Publishing date 2020-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25721
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  5. Article ; Online: Asymptomatic cases with SARS‐CoV‐2 infection

    Wang, Yishan / Kang, Hanyujie / Liu, Xuefeng / Tong, Zhaohui

    Journal of Medical Virology

    2020  Volume 92, Issue 9, Page(s) 1401–1403

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25990
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  6. Article ; Online: Early neuromuscular blocking agents for adults with acute respiratory distress syndrome

    Shuai Shao / Hanyujie Kang / Zhaohui Tong

    BMJ Open, Vol 10, Iss

    a systematic review, meta-analysis and meta-regression

    2020  Volume 11

    Abstract: Objective To determine whether neuromuscular blocking agents (NMBAs) can decrease the mortality of patients with acute respiratory distress syndrome (ARDS) and improve their clinical outcomes.Design Systematic review, meta-analysis and meta-regression ... ...

    Abstract Objective To determine whether neuromuscular blocking agents (NMBAs) can decrease the mortality of patients with acute respiratory distress syndrome (ARDS) and improve their clinical outcomes.Design Systematic review, meta-analysis and meta-regression.Data sources PubMed, Embase, Cochrane Library, Web of Science and ClinicalTrials.gov.Methods Randomised controlled trials (RCTs) comparing the treatment effect of NMBAs with that of placebo (or traditional treatment) in patients with ARDS were carefully selected. The primary outcome was 90-day mortality. The secondary outcomes were 21–28 days mortality, NMBA-related complications (barotrauma, pneumothorax and intensive care unit (ICU)-acquired muscle weakness), days free of ventilation and days not in the ICU by day 28, Medical Research Council score, Acute Physiology and Chronic Health Evaluation II score and arterial oxygen tension (PaO2)/fractional inspired oxygen (FiO2) (at 48 hours and 72 hours). Random-effects meta-regression was used to explore models involving potential moderators. Trial sequential analysis was performed to estimate the cumulative effect on mortality across RCTs.Results NMBAs were not associated with reduced 90-day mortality (risk ratio (RR) 0.85; 95% CI 0.66 to 1.09; p=0.20). However, they decreased the 21–28 days mortality (RR 0.71; 95% CI 0.53 to 0.96; p=0.02) and the rates of pneumothorax (RR 0.46; 95% CI 0.28 to 0.77; p=0.003) and barotrauma (RR 0.56; 95% CI 0.37 to 0.86; p=0.008). In addition, NMBAs increased PaO2/FiO2 at 48 hours (mean difference (MD) 18.91; 95% CI 4.29 to 33.53; p=0.01) and 72 hours (MD 12.27; 95% CI 4.65 to 19.89; p=0.002). Meta-regression revealed an association between sample size (p=0.042) and short-term mortality. Publication year (p=0.050), sedation strategy (p=0.047) and sample size (p=0.046) were independently associated with PaO2/FiO2 at 48 hours.Conclusions In summary, the results suggested that use of NMBAs might reduce 21–28 days mortality, NMBA-related complications and oxygenation. However, NMBAs did ...
    Keywords Medicine ; R
    Subject code 310
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Effect of convalescent blood products for patients with severe acute respiratory infections of viral etiology: A systematic review and meta-analysis.

    Shao, Shuai / Wang, Yishan / Kang, Hanyujie / Tong, Zhaohui

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Volume 102, Page(s) 397–411

    Abstract: Objectives: The aim of this study was to determine whether convalescent blood products (CBPs) offer a survival advantage for patients with severe acute respiratory infections of viral etiology.: Methods: Up-to-date trials were identified by the ... ...

    Abstract Objectives: The aim of this study was to determine whether convalescent blood products (CBPs) offer a survival advantage for patients with severe acute respiratory infections of viral etiology.
    Methods: Up-to-date trials were identified by the authors through searches of the MEDLINE, Embase, Cochrane Library, Web of Science, ClinicalTrials.gov, and medRxiv databases from inception up to September 14, 2020. Meta-analyses were performed using a random-effects model.
    Results: According to the observational studies, patients who received CBPs showed a decline in all-cause mortality compared with patients who did not receive CBPs (odds ratio (OR) 0.36, 95% confidence interval (CI) 0.23-0.56; p < 0.00001). However, the randomized controlled trials (RCTs) showed no difference between the intervention group and the control group regarding all-cause mortality (OR 0.82, 95% CI 0.57-1.19; p = 0.30). The use of CBPs did not increase the risk of adverse events (OR 0.88, 95% CI 0.60-1.29; p = 0.51). Using CBPs earlier compared with using CBPs later was associated with a significant reduction in all-cause mortality (OR 0.18, 95% CI 0.08-0.40; p < 0.0001).
    Conclusions: Based on the outcomes of RCTs, CBPs may not decrease all-cause mortality. Furthermore, compared with later initiation of CBP therapy, earlier initiation of this therapy may decrease the rate of mortality.
    MeSH term(s) Adult ; Aged ; COVID-19/mortality ; COVID-19/therapy ; Cause of Death ; Female ; Humans ; Immunization, Passive ; Male ; Middle Aged ; Randomized Controlled Trials as Topic ; SARS-CoV-2 ; COVID-19 Serotherapy
    Keywords covid19
    Language English
    Publishing date 2020-09-28
    Publishing country Canada
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.09.1443
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    Zs.A 4516: Show issues Location:
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  8. Article ; Online: Retest positive for SARS-CoV-2 RNA of "recovered" patients with COVID-19: Persistence, sampling issues, or re-infection?

    Kang, Hanyujie / Wang, Yishan / Tong, Zhaohui / Liu, Xuefeng

    Journal of medical virology

    2020  Volume 92, Issue 11, Page(s) 2263–2265

    Abstract: Retest Positive" for severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) from "recovered" coronavirus disease-19 (COVID-19) has been reported and raised several important questions for this novel coronavirus and COVID-19 disease. In ... ...

    Abstract "Retest Positive" for severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) from "recovered" coronavirus disease-19 (COVID-19) has been reported and raised several important questions for this novel coronavirus and COVID-19 disease. In this commentary, we discussed several questions: (a) Can SARS-CoV-2 re-infect the individuals who recovered from COVID-19? This question is also associated with other questions: whether or not SARS-CoV-2 infection induces protective reaction or neutralized antibody? Will SARS-CoV-2 vaccines work? (b) Why could some recovered patients with COVID-19 be re-tested positive for SARS-CoV-2 RNA? (c) Are some recovered pwith atients COVID-19 with re-testing positive for SARS-CoV-2 RNA infectious? and (d) How should the COVID-19 patients with retest positive for SARS-CoV-2 be managed?
    MeSH term(s) Antibodies, Viral/blood ; COVID-19/diagnosis ; COVID-19 Nucleic Acid Testing ; Humans ; Immunoglobulin G/blood ; RNA, Viral/isolation & purification ; Reinfection/diagnosis ; SARS-CoV-2 ; Selection Bias
    Chemical Substances Antibodies, Viral ; Immunoglobulin G ; RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-06-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26114
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  9. Article ; Online: Early neuromuscular blocking agents for adults with acute respiratory distress syndrome: a systematic review, meta-analysis and meta-regression.

    Shao, Shuai / Kang, Hanyujie / Tong, Zhaohui

    BMJ open

    2020  Volume 10, Issue 11, Page(s) e037737

    Abstract: Objective: To determine whether neuromuscular blocking agents (NMBAs) can decrease the mortality of patients with acute respiratory distress syndrome (ARDS) and improve their clinical outcomes.: Design: Systematic review, meta-analysis and meta- ... ...

    Abstract Objective: To determine whether neuromuscular blocking agents (NMBAs) can decrease the mortality of patients with acute respiratory distress syndrome (ARDS) and improve their clinical outcomes.
    Design: Systematic review, meta-analysis and meta-regression.
    Data sources: PubMed, Embase, Cochrane Library, Web of Science and ClinicalTrials.gov.
    Methods: Randomised controlled trials (RCTs) comparing the treatment effect of NMBAs with that of placebo (or traditional treatment) in patients with ARDS were carefully selected. The primary outcome was 90-day mortality. The secondary outcomes were 21-28 days mortality, NMBA-related complications (barotrauma, pneumothorax and intensive care unit (ICU)-acquired muscle weakness), days free of ventilation and days not in the ICU by day 28, Medical Research Council score, Acute Physiology and Chronic Health Evaluation II score and arterial oxygen tension (PaO
    Results: NMBAs were not associated with reduced 90-day mortality (risk ratio (RR) 0.85; 95% CI 0.66 to 1.09; p=0.20). However, they decreased the 21-28 days mortality (RR 0.71; 95% CI 0.53 to 0.96; p=0.02) and the rates of pneumothorax (RR 0.46; 95% CI 0.28 to 0.77; p=0.003) and barotrauma (RR 0.56; 95% CI 0.37 to 0.86; p=0.008). In addition, NMBAs increased PaO
    Conclusions: In summary, the results suggested that use of NMBAs might reduce 21-28 days mortality, NMBA-related complications and oxygenation. However, NMBAs did not reduce the 90-day mortality of patients with ARDS, which contradicts a previous meta-analysis.
    Prospero registration number: CRD42019139440.
    MeSH term(s) Adult ; Humans ; Intensive Care Units ; Lung ; Neuromuscular Blocking Agents/therapeutic use ; Prospective Studies ; Respiratory Distress Syndrome/drug therapy
    Chemical Substances Neuromuscular Blocking Agents
    Language English
    Publishing date 2020-11-19
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2020-037737
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  10. Article: Combination of RT-qPCR testing and clinical features for diagnosis of COVID-19 facilitates management of SARS-CoV-2 outbreak

    Wang, Yishan / Kang, Hanyujie / Liu, Xuefeng / Tong, Zhaohui

    J Med Virol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32096564
    Database COVID19

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