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Article ; Online: From lab to society

Renan Gonçalves Leonel daSilva / Alessandro Blasimme

Bioengineering & Translational Medicine, Vol 9, Iss 1, Pp n/a-n/a (2024)

Fostering clinical translation of molecular systems engineering

2024

Abstract: Abstract Over the last decade, bioengineering has seen a sustained growth in scientific publications, patents, and clinical trials. As the field attempts to bridge the gap between discovery and clinical application, a broader societal dialogue is needed ... ...

Abstract	Abstract Over the last decade, bioengineering has seen a sustained growth in scientific publications, patents, and clinical trials. As the field attempts to bridge the gap between discovery and clinical application, a broader societal dialogue is needed to build public trust and address potential ethical, societal, and regulatory challenges. In this essay, we discuss societal aspects linked to the clinical use of biomedical engineering approaches and technologies, with a specific focus on molecular systems engineering. Drawing on data from interviews with 24 scientists, we identified four key aspects for fostering societal support for translational efforts in this domain: (1) effective science communication and internal awareness; (2) open societal dialogue; (3) fair and equitable access to new technologies; and (4) adequate science and technology policies. We conclude that molecular systems engineering would benefit from anticipating future challenges with the view of building a robust bond of trust with lay publics, regulators, and society at large.
Keywords	biomedical engineering ; engagement ; molecular systems engineering ; science policy ; society ; trust ; Chemical engineering ; TP155-156 ; Biotechnology ; TP248.13-248.65 ; Therapeutics. Pharmacology ; RM1-950
Subject code	170
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Organ chip research in Europe: players, initiatives, and policies.

da Silva, Renan Gonçalves Leonel / Blasimme, Alessandro

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1237561

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-09-04
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1237561
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: From lab to society: Fostering clinical translation of molecular systems engineering.

da Silva, Renan Gonçalves Leonel / Blasimme, Alessandro

Bioengineering & translational medicine

2023 Volume 9, Issue 1, Page(s) e10564

Abstract: Over the last decade, bioengineering has seen a sustained growth in scientific publications, patents, and clinical trials. As the field attempts to bridge the gap between discovery and clinical application, a broader societal dialogue is needed to build ... ...

Abstract	Over the last decade, bioengineering has seen a sustained growth in scientific publications, patents, and clinical trials. As the field attempts to bridge the gap between discovery and clinical application, a broader societal dialogue is needed to build public trust and address potential ethical, societal, and regulatory challenges. In this essay, we discuss societal aspects linked to the clinical use of biomedical engineering approaches and technologies, with a specific focus on molecular systems engineering. Drawing on data from interviews with 24 scientists, we identified four key aspects for fostering societal support for translational efforts in this domain: (1) effective science communication and internal awareness; (2) open societal dialogue; (3) fair and equitable access to new technologies; and (4) adequate science and technology policies. We conclude that molecular systems engineering would benefit from anticipating future challenges with the view of building a robust bond of trust with lay publics, regulators, and society at large.
Language	English
Publishing date	2023-06-22
Publishing country	United States
Document type	Journal Article
ISSN	2380-6761
ISSN	2380-6761
DOI	10.1002/btm2.10564
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Long Covid requires a global response centred on equity and dialogue.

Au, Larry / Capotescu, Cristian / Curi, Amanda / Gonçalves Leonel da Silva, Renan / Eyal, Gil

Global health action

2023 Volume 16, Issue 1, Page(s) 2244757

Abstract: Long Covid, or Post-Covid Conditions, is a global health problem. Yet we know strikingly little about the different experiences of Long Covid patients cross-nationally. To address this shortcoming, we conducted an online survey of Long Covid patients ... ...

Abstract	Long Covid, or Post-Covid Conditions, is a global health problem. Yet we know strikingly little about the different experiences of Long Covid patients cross-nationally. To address this shortcoming, we conducted an online survey of Long Covid patients active on social media in the U.S. (
MeSH term(s)	Humans ; COVID-19/epidemiology ; Post-Acute COVID-19 Syndrome ; Global Health ; Social Media ; Surveys and Questionnaires
Language	English
Publishing date	2023-08-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2540569-X
ISSN	1654-9880 ; 1654-9880
ISSN (online)	1654-9880
ISSN	1654-9880
DOI	10.1080/16549716.2023.2244757
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: How Do Molecular Systems Engineering Scientists Frame the Ethics of Their Research?

da Silva, Renan Gonçalves Leonel / Blasimme, Alessandro / Vayena, Effy / Ormond, Kelly E

AJOB empirical bioethics

2024 , Page(s) 1–10

Abstract: Background: There are intense discussions about the ethical and societal implications of biomedical engineering, but little data to suggest how scientists think about the ethics of their work. The aim of this study is to describe how scientists frame ... ...

Abstract	Background: There are intense discussions about the ethical and societal implications of biomedical engineering, but little data to suggest how scientists think about the ethics of their work. The aim of this study is to describe how scientists frame the ethics of their research, with a focus on the field of molecular systems engineering. Methods: Semi-structured qualitative interviews were conducted during 2021-2022, as part of a larger study. This analysis includes a broad question about how participants view ethics as related to their work, with follow up probes about the topics they consider most important. Interviews were transcribed, inductively coded by two researchers to consensus, and analyzed thematically. Results: Twenty-four scientists participated in the study. Interviewees hold positions as professors, principal investigators, and senior staff researchers in universities or research institutes in the United States and Europe. Among those scientists who reported reflecting on ethical considerations in their work, many equated ethics with research ethics topics (e.g., safety, replicability), or with regulation and guidelines. Participants expressed the view that ethical issues are primarily relevant for clinical trials of bioengineered products, or for those working with animal or human subjects. Scientists described their research as "too early" or "not examining anything living" with regard to ethical reflection. Finally, many felt that ethics is seen as territory for experts and therefore beyond scientists' competencies. Conclusions: Molecular systems engineering scientists currently focus on regulatory aspects as the framework for their ethical analyses. They describe using a framework to define when life arises, as a means to determine when further ethical engagement is warranted. Further research is needed to investigate how scientists relate to the ethics of their scientific work, and build consensus around concepts of life, autonomous behavior, and physiological relevance of bioengineered systems.
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2763190-4
ISSN	2329-4523 ; 2329-4515
ISSN (online)	2329-4523
ISSN	2329-4515
DOI	10.1080/23294515.2024.2302994
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Long Covid requires a global response centred on equity and dialogue

Larry Au / Cristian Capotescu / Amanda Curi / Renan Gonçalves Leonel da Silva / Gil Eyal

Global Health Action, Vol 16, Iss

2023 Volume 1

Abstract	Long Covid, or Post-Covid Conditions, is a global health problem. Yet we know strikingly little about the different experiences of Long Covid patients cross-nationally. To address this shortcoming, we conducted an online survey of Long Covid patients active on social media in the U.S. (n = 334, October to December 2021) and Brazil (n = 144, January to April 2022). Our analysis of short answer responses indicates patient dissatisfaction with medical care provided for Long Covid in both the U.S. and Brazil. For Long Covid patients in Brazil, there were additional concerns raised about the lack of local expertise about their condition. Based on these results, we urge policymakers to expand the education of medical professionals in order to raise awareness of Long Covid. Experts in the Global North should also be encouraged to engage in dialogue with patient groups and experts in the Global South, in order to better understand how local contexts shape the experience of Long Covid.
Keywords	long covid ; chronic illness ; global south ; patient experiences ; health communication ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Como a comunidade internacional da medicina de precisão tem se posicionado diante dos desafios impostos pela pandemia da COVID-19?

Renan Gonçalves Leonel da Silva / Jorge Alberto Bernstein Iriart

Cadernos de Saúde Pública, Vol 37, Iss

2021 Volume 4

Abstract: Medicina de precisão pode ser definida como um movimento de transformação da biomedicina contemporânea que orienta a atividade de pesquisa acadêmica, modelos de negócios e o desenvolvimento de produtos e serviços de saúde desenhados individualmente para ... ...

Abstract	Medicina de precisão pode ser definida como um movimento de transformação da biomedicina contemporânea que orienta a atividade de pesquisa acadêmica, modelos de negócios e o desenvolvimento de produtos e serviços de saúde desenhados individualmente para o usuário, baseado em informações genéticas e outros marcadores biomédicos dos pacientes. Ao longo dos últimos anos, essa comunidade tem sido bastante atuante no cenário científico internacional. No entanto, durante a pandemia da COVID-19 ainda não ficou claro quais posicionamentos ou estratégias têm sido adotadas por esses grupos para o enfrentamento da crise sanitária. O objetivo deste artigo é compreender como a comunidade internacional da medicina de precisão está reagindo à pandemia da COVID-19, e em que estão baseadas as suas abordagens e potenciais soluções sugeridas para a mitigação dos efeitos negativos causados pelo aumento das infecções pelo novo coronavírus. Para tanto, foi feita pesquisa documental em 28 documentos provenientes de 18 fontes selecionadas, em que analisou-se as narrativas difundidas pelos profissionais da medicina de precisão em artigos científicos, editoriais, comentários, perspectivas, notícias de jornais e boletins e conferência virtual da Coalizão de Medicina Personalizada (PMC, em inglês). Com isso, buscou-se compreender como esses grupos imaginam uma nova configuração sociotécnica para o enfrentamento da pandemia e de seus efeitos.
Keywords	Medicina de Precisão ; Ciência ; Tecnologia e Sociedade ; Agenda de Pesquisa em Saúde ; COVID-19 ; Medicine ; R ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rethinking approaches of science, technology, and innovation in healthcare during the COVID-19 pandemic: the challenge of translating knowledge infrastructures to public needs.

da Silva, Renan Gonçalves Leonel / Chammas, Roger / Novaes, Hillegonda Maria Dutilh

Health research policy and systems

2021 Volume 19, Issue 1, Page(s) 104

Abstract: The coronavirus disease 2019 (COVID-19) outbreak made it clear that despite the potential of science, technology, and innovation (ST&I) to positively impact healthcare systems worldwide, as shown by the rapid development of SARS-CoV-2 test diagnostics ... ...

Abstract	The coronavirus disease 2019 (COVID-19) outbreak made it clear that despite the potential of science, technology, and innovation (ST&I) to positively impact healthcare systems worldwide, as shown by the rapid development of SARS-CoV-2 test diagnostics and new mRNA vaccines, healthcare stakeholders have faced significant challenges in responding to the crisis through well-integrated ST&I-oriented health initiatives and policies. Therefore, the pandemic has mobilized experts, industry, and governments to evaluate alternative trajectories to promote a more efficient dialogue between ST&I and public health. This article presents a critical thinking about the contemporary asymmetries in the technical and political infrastructures available for particular approaches in ST&I in health, such as precision medicine, and for public health systems worldwide, uncovering a persistent gap in the translation of knowledge and technologies to adequately coordinated responses to the pandemic. We stimulate the understanding of this process as a matter of translation between platforms of knowledge and policy rationales shaped by different institutionalized frames of organizational practices and agendas. We draw attention to the need to strengthen governance tools for the promotion of ST&I as a strategic component of the post-pandemic agenda in public health, to prepare societies to respond efficiently to future emergencies.
MeSH term(s)	COVID-19 ; Delivery of Health Care ; Humans ; Pandemics/prevention & control ; Public Health ; SARS-CoV-2 ; Technology
Language	English
Publishing date	2021-07-21
Publishing country	England
Document type	Letter
ZDB-ID	2101196-5
ISSN	1478-4505 ; 1478-4505
ISSN (online)	1478-4505
ISSN	1478-4505
DOI	10.1186/s12961-021-00760-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Rethinking approaches of science, technology, and innovation in healthcare during the COVID-19 pandemic

Renan Gonçalves Leonel da Silva / Roger Chammas / Hillegonda Maria Dutilh Novaes

Health Research Policy and Systems, Vol 19, Iss 1, Pp 1-

the challenge of translating knowledge infrastructures to public needs

2021 Volume 9

Abstract: Abstract The coronavirus disease 2019 (COVID-19) outbreak made it clear that despite the potential of science, technology, and innovation (ST&I) to positively impact healthcare systems worldwide, as shown by the rapid development of SARS-CoV-2 test ... ...

Abstract	Abstract The coronavirus disease 2019 (COVID-19) outbreak made it clear that despite the potential of science, technology, and innovation (ST&I) to positively impact healthcare systems worldwide, as shown by the rapid development of SARS-CoV-2 test diagnostics and new mRNA vaccines, healthcare stakeholders have faced significant challenges in responding to the crisis through well-integrated ST&I-oriented health initiatives and policies. Therefore, the pandemic has mobilized experts, industry, and governments to evaluate alternative trajectories to promote a more efficient dialogue between ST&I and public health. This article presents a critical thinking about the contemporary asymmetries in the technical and political infrastructures available for particular approaches in ST&I in health, such as precision medicine, and for public health systems worldwide, uncovering a persistent gap in the translation of knowledge and technologies to adequately coordinated responses to the pandemic. We stimulate the understanding of this process as a matter of translation between platforms of knowledge and policy rationales shaped by different institutionalized frames of organizational practices and agendas. We draw attention to the need to strengthen governance tools for the promotion of ST&I as a strategic component of the post-pandemic agenda in public health, to prepare societies to respond efficiently to future emergencies.
Keywords	Science ; Technology ; Innovation ; Public health ; Health research ; Health policy ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Institutional Building of Science and Innovation Diplomacy in Latin America: Toward a Comprehensive Analytical Typology.

da Silva, Renan Gonçalves Leonel / Ferreira, Gabriela Gomes Coelho / Onuki, Janina / de Oliveira, Amâncio Jorge Nunes

Frontiers in research metrics and analytics

2021 Volume 6, Page(s) 654358

Abstract: Science and Innovation Diplomacy (S&ID) has emerged in recent years as a relevant scholarly movement and interdisciplinary research agenda internationally. This field is promoting a significant impact on the understanding of the cultural and political ... ...

Abstract	Science and Innovation Diplomacy (S&ID) has emerged in recent years as a relevant scholarly movement and interdisciplinary research agenda internationally. This field is promoting a significant impact on the understanding of the cultural and political dynamics of Science, Technology and Innovation (ST&I), implementing initiatives from local to global level. Notwithstanding, S&ID is growing asymmetrically around the world, setting up over a particular configuration in the so-called Global South (GS) societies. In Latin America (LA), although S&ID is a recent, unequal and intra-nationally fragmented process, there are important achievements that have been able to create a favorable mix of approaches, agendas, and practices in this field. Addressing the scope of the special issue "Science Diplomacy and Sustainable Development: Perspectives from Latin America," this article aims to present a comprehensive analytical typology to the study of the emerging experiences of S&ID in LA, catching the diversity of this research agenda. This is a qualitative merged method-based study, sustained by a literature review, documentary research, online data analysis, and typology building. We understand S&ID in LA as a tentative re-organization of different states and subnational actors around the study and institutionalization of the governance of contemporary transformations on the systems of ST&I.
Language	English
Publishing date	2021-04-27
Publishing country	Switzerland
Document type	Journal Article
ISSN	2504-0537
ISSN (online)	2504-0537
DOI	10.3389/frma.2021.654358
Database	MEDical Literature Analysis and Retrieval System OnLINE

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