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  1. Article: Rethinking neuromyelitis optica (Devic disease).

    Cross, Shelley Ann

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2007  Volume 27, Issue 1, Page(s) 57–60

    Abstract: Neuromyelitis optica (NMO), or Devic disease, has been distinguished from multiple sclerosis (MS) by the presence of optic neuritis that is usually bilateral, simultaneous, and often severe, myelopathic findings accompanied by longitudinally extensive ... ...

    Abstract Neuromyelitis optica (NMO), or Devic disease, has been distinguished from multiple sclerosis (MS) by the presence of optic neuritis that is usually bilateral, simultaneous, and often severe, myelopathic findings accompanied by longitudinally extensive spinal cord imaging abnormalities, no brain imaging abnormalities typical of MS, and often rapid progression to debility and even death. Researchers at the Mayo Clinic have identified an immunoglobulin marker of NMO (the "NMO antibody") that binds selectively to the aquaphorin-4 water channel and may play a causative role. This marker has been found in Japanese patients with opticospinal MS, prompting the suggestion that NMO and Japanese opticospinal MS are the same disorder. The NMO antibody, which predicts frequent relapse of myelopathy and optic neuritis, is also found in patients with lupus erythematosus and Sjögren syndrome who also have severe optic neuritis and longitudinally extensive myelitis. Because this antibody is also found in patients with optic neuritis and myelitis who have brain signal abnormalities atypical of MS, the diagnosis of NMO has been revised to allow inclusion of these brain imaging abnormalities. Proper distinction of NMO from MS is important because the two disorders may respond differently to immune modulatory therapy.
    MeSH term(s) Antibodies, Anti-Idiotypic/immunology ; Diagnosis, Differential ; Humans ; Immunoglobulin G/immunology ; Magnetic Resonance Imaging ; Neuromyelitis Optica/classification ; Neuromyelitis Optica/diagnosis ; Neuromyelitis Optica/immunology
    Chemical Substances Antibodies, Anti-Idiotypic ; Immunoglobulin G
    Language English
    Publishing date 2007-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0b013e3180334d27
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cells, cells, and more cells.

    Bhatti, M Tariq / Gres, Katherine E / Petitto, Virginia B / Cross, Shelley Ann

    Survey of ophthalmology

    2007  Volume 52, Issue 3, Page(s) 315–324

    Abstract: A 64-year-old woman presented with bilateral optic nerve swelling, vitreous cells, and cerebrospinal fluid monocytic pleocytosis. A chest radiograph and computed tomography demonstrated a lesion in the left lung, which histologically was confirmed to be ... ...

    Abstract A 64-year-old woman presented with bilateral optic nerve swelling, vitreous cells, and cerebrospinal fluid monocytic pleocytosis. A chest radiograph and computed tomography demonstrated a lesion in the left lung, which histologically was confirmed to be a small-cell lung carcinoma. The serum was positive for the anti-CV2 (anti-CRMP-5) antibody. Following treatment with chemoradiation the optic nerve swelling and vitritis resolved. The differential diagnosis of uveal-meningeal diseases is discussed and the pathophysiology and clinical manifestations of paraneoplastic syndromes reviewed.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Small Cell/diagnostic imaging ; Carcinoma, Small Cell/pathology ; Carcinoma, Small Cell/therapy ; Combined Modality Therapy ; Eye Diseases/diagnostic imaging ; Eye Diseases/pathology ; Eye Diseases/therapy ; Female ; Humans ; Lung Neoplasms ; Magnetic Resonance Imaging ; Middle Aged ; Nerve Tissue Proteins/blood ; Papilledema/diagnostic imaging ; Papilledema/pathology ; Papilledema/therapy ; Paraneoplastic Syndromes/diagnostic imaging ; Paraneoplastic Syndromes/pathology ; Paraneoplastic Syndromes/therapy ; Radiography, Thoracic ; Radiotherapy, Conformal ; Tomography, X-Ray Computed ; Vitreous Body/pathology
    Chemical Substances Nerve Tissue Proteins ; DPYSL5 protein, human (EC 3.-)
    Language English
    Publishing date 2007-04-25
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 391346-6
    ISSN 1879-3304 ; 0039-6257
    ISSN (online) 1879-3304
    ISSN 0039-6257
    DOI 10.1016/j.survophthal.2007.02.009
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  3. Article ; Online: Heightened muscle inflammation susceptibility may impair regenerative capacity in aging humans.

    Merritt, Edward K / Stec, Michael J / Thalacker-Mercer, Anna / Windham, Samuel T / Cross, James M / Shelley, David P / Craig Tuggle, S / Kosek, David J / Kim, Jeong-Su / Bamman, Marcas M

    Journal of applied physiology (Bethesda, Md. : 1985)

    2013  Volume 115, Issue 6, Page(s) 937–948

    Abstract: The regenerative response of skeletal muscle to mechanically induced damage is impaired with age. Previous work in our laboratory suggests this may result from higher proinflammatory signaling in aging muscle at rest and/or a greater inflammatory ... ...

    Abstract The regenerative response of skeletal muscle to mechanically induced damage is impaired with age. Previous work in our laboratory suggests this may result from higher proinflammatory signaling in aging muscle at rest and/or a greater inflammatory response to damage. We, therefore, assessed skeletal muscle proinflammatory signaling at rest and 24 h after unaccustomed, loaded knee extension contractions that induced modest muscle damage (72% increase in serum creatine kinase) in a cohort of 87 adults across three age groups (AGE40, AGE61, and AGE76). Vastus lateralis muscle gene expression and protein cell signaling of the IL-6 and TNF-α pathways were determined by quantitative PCR and immunoblot analysis. For in vitro studies, cell signaling and fusion capacities were compared among primary myoblasts from young (AGE28) and old (AGE64) donors treated with TNF-α. Muscle expression was higher (1.5- to 2.1-fold) in AGE76 and AGE61 relative to AGE40 for several genes involved in IL-6, TNF-α, and TNF-like weak inducer of apoptosis signaling. Indexes of activation for the proinflammatory transcription factors signal transducer and activator of transcription-3 and NF-κB were highest in AGE76. Resistance loading reduced gene expression of IL-6 receptor, muscle RING finger 1, and atrogin-1, and increased TNF-like weak inducer of apoptosis receptor expression. Donor myoblasts from AGE64 showed impaired differentiation and fusion in standard media and greater NF-κB activation in response to TNF-α treatment (compared with AGE28). We show for the first time that human aging is associated with muscle inflammation susceptibility (i.e., higher basal state of proinflammatory signaling) that is present in both tissue and isolated myogenic cells and likely contributes to the impaired regenerative capacity of skeletal muscle in the older population.
    MeSH term(s) Adult ; Aged ; Aging/pathology ; Aging/physiology ; Female ; Humans ; Inflammation/pathology ; Inflammation/physiopathology ; Inflammation Mediators/physiology ; Interleukin-6/metabolism ; Male ; Middle Aged ; Muscle, Skeletal/injuries ; Muscle, Skeletal/pathology ; Muscle, Skeletal/physiopathology ; Muscular Atrophy/pathology ; Muscular Atrophy/physiopathology ; Myoblasts, Skeletal/physiology ; Regeneration/physiology ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances IL6 protein, human ; Inflammation Mediators ; Interleukin-6 ; STAT3 Transcription Factor ; STAT3 protein, human ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2013-05-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00019.2013
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  4. Article ; Online: Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.

    Potter, Paul K / Bowl, Michael R / Jeyarajan, Prashanthini / Wisby, Laura / Blease, Andrew / Goldsworthy, Michelle E / Simon, Michelle M / Greenaway, Simon / Michel, Vincent / Barnard, Alun / Aguilar, Carlos / Agnew, Thomas / Banks, Gareth / Blake, Andrew / Chessum, Lauren / Dorning, Joanne / Falcone, Sara / Goosey, Laurence / Harris, Shelley /
    Haynes, Andy / Heise, Ines / Hillier, Rosie / Hough, Tertius / Hoslin, Angela / Hutchison, Marie / King, Ruairidh / Kumar, Saumya / Lad, Heena V / Law, Gemma / MacLaren, Robert E / Morse, Susan / Nicol, Thomas / Parker, Andrew / Pickford, Karen / Sethi, Siddharth / Starbuck, Becky / Stelma, Femke / Cheeseman, Michael / Cross, Sally H / Foster, Russell G / Jackson, Ian J / Peirson, Stuart N / Thakker, Rajesh V / Vincent, Tonia / Scudamore, Cheryl / Wells, Sara / El-Amraoui, Aziz / Petit, Christine / Acevedo-Arozena, Abraham / Nolan, Patrick M / Cox, Roger / Mallon, Anne-Marie / Brown, Steve D M

    Nature communications

    2016  Volume 7, Page(s) 12444

    Abstract: Determining the genetic bases of age-related disease remains a major challenge requiring a spectrum of approaches from human and clinical genetics to the utilization of model organism studies. Here we report a large-scale genetic screen in mice employing ...

    Abstract Determining the genetic bases of age-related disease remains a major challenge requiring a spectrum of approaches from human and clinical genetics to the utilization of model organism studies. Here we report a large-scale genetic screen in mice employing a phenotype-driven discovery platform to identify mutations resulting in age-related disease, both late-onset and progressive. We have utilized N-ethyl-N-nitrosourea mutagenesis to generate pedigrees of mutagenized mice that were subject to recurrent screens for mutant phenotypes as the mice aged. In total, we identify 105 distinct mutant lines from 157 pedigrees analysed, out of which 27 are late-onset phenotypes across a range of physiological systems. Using whole-genome sequencing we uncover the underlying genes for 44 of these mutant phenotypes, including 12 late-onset phenotypes. These genes reveal a number of novel pathways involved with age-related disease. We illustrate our findings by the recovery and characterization of a novel mouse model of age-related hearing loss.
    MeSH term(s) Aging/genetics ; Animals ; Cochlea/metabolism ; Disease Models, Animal ; Epithelium/ultrastructure ; Evoked Potentials, Auditory, Brain Stem/physiology ; Female ; Genetic Testing ; Hearing/genetics ; Male ; Mice, Inbred C57BL ; Mutagenesis/genetics ; Mutation/genetics ; Pedigree ; Phenotype
    Language English
    Publishing date 2016-08-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/ncomms12444
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  5. Article ; Online: Consumption of Meat, Fish, Dairy Products, and Eggs and Risk of Ischemic Heart Disease.

    Key, Timothy J / Appleby, Paul N / Bradbury, Kathryn E / Sweeting, Michael / Wood, Angela / Johansson, Ingegerd / Kühn, Tilman / Steur, Marinka / Weiderpass, Elisabete / Wennberg, Maria / Lund Würtz, Anne Mette / Agudo, Antonio / Andersson, Jonas / Arriola, Larraitz / Boeing, Heiner / Boer, Jolanda M A / Bonnet, Fabrice / Boutron-Ruault, Marie-Christine / Cross, Amanda J /
    Ericson, Ulrika / Fagherazzi, Guy / Ferrari, Pietro / Gunter, Marc / Huerta, José María / Katzke, Verena / Khaw, Kay-Tee / Krogh, Vittorio / La Vecchia, Carlo / Matullo, Giuseppe / Moreno-Iribas, Conchi / Naska, Androniki / Nilsson, Lena Maria / Olsen, Anja / Overvad, Kim / Palli, Domenico / Panico, Salvatore / Molina-Portillo, Elena / Quirós, J Ramón / Skeie, Guri / Sluijs, Ivonne / Sonestedt, Emily / Stepien, Magdalena / Tjønneland, Anne / Trichopoulou, Antonia / Tumino, Rosario / Tzoulaki, Ioanna / van der Schouw, Yvonne T / Verschuren, W M Monique / di Angelantonio, Emanuele / Langenberg, Claudia / Forouhi, Nita / Wareham, Nick / Butterworth, Adam / Riboli, Elio / Danesh, John

    Circulation

    2019  Volume 139, Issue 25, Page(s) 2835–2845

    Abstract: Background: There is uncertainty about the relevance of animal foods to the pathogenesis of ischemic heart disease (IHD). We examined meat, fish, dairy products, and eggs and risk for IHD in the pan-European EPIC cohort (European Prospective ... ...

    Abstract Background: There is uncertainty about the relevance of animal foods to the pathogenesis of ischemic heart disease (IHD). We examined meat, fish, dairy products, and eggs and risk for IHD in the pan-European EPIC cohort (European Prospective Investigation Into Cancer and Nutrition).
    Methods: In this prospective study of 409 885 men and women in 9 European countries, diet was assessed with validated questionnaires and calibrated with 24-hour recalls. Lipids and blood pressure were measured in a subsample. During a mean of 12.6 years of follow-up, 7198 participants had a myocardial infarction or died of IHD. The relationships of animal foods with risk were examined with Cox regression with adjustment for other animal foods and relevant covariates.
    Results: The hazard ratio (HR) for IHD was 1.19 (95% CI, 1.06-1.33) for a 100-g/d increment in intake of red and processed meat, and this remained significant after exclusion of the first 4 years of follow-up (HR, 1.25 [95% CI, 1.09-1.42]). Risk was inversely associated with intakes of yogurt (HR, 0.93 [95% CI, 0.89-0.98] per 100-g/d increment), cheese (HR, 0.92 [95% CI, 0.86-0.98] per 30-g/d increment), and eggs (HR, 0.93 [95% CI, 0.88-0.99] per 20-g/d increment); the associations with yogurt and eggs were attenuated and nonsignificant after exclusion of the first 4 years of follow-up. Risk was not significantly associated with intakes of poultry, fish, or milk. In analyses modeling dietary substitutions, replacement of 100 kcal/d from red and processed meat with 100 kcal/d from fatty fish, yogurt, cheese, or eggs was associated with ≈20% lower risk of IHD. Consumption of red and processed meat was positively associated with serum non-high-density lipoprotein cholesterol concentration and systolic blood pressure, and consumption of cheese was inversely associated with serum non-high-density lipoprotein cholesterol.
    Conclusions: Risk for IHD was positively associated with consumption of red and processed meat and inversely associated with consumption of yogurt, cheese, and eggs, although the associations with yogurt and eggs may be influenced by reverse causation bias. It is not clear whether the associations with red and processed meat and cheese reflect causality, but they were consistent with the associations of these foods with plasma non-high-density lipoprotein cholesterol and for red and processed meat with systolic blood pressure, which could mediate such effects.
    MeSH term(s) Adult ; Aged ; Biomarkers/blood ; Blood Pressure ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; Dairy Products/adverse effects ; Diet Surveys ; Diet, Healthy ; Eggs/adverse effects ; Europe/epidemiology ; Female ; Humans ; Male ; Meat/adverse effects ; Middle Aged ; Myocardial Ischemia/blood ; Myocardial Ischemia/epidemiology ; Myocardial Ischemia/physiopathology ; Myocardial Ischemia/prevention & control ; Nutritive Value ; Prospective Studies ; Protective Factors ; Recommended Dietary Allowances ; Risk Assessment ; Risk Factors ; Risk Reduction Behavior ; Seafood/adverse effects ; Time Factors
    Chemical Substances Biomarkers ; Cholesterol, HDL
    Language English
    Publishing date 2019-04-22
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.118.038813
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  6. Article ; Online: 2023 Canadian Surgery Forum: Sept. 20-23, 2023.

    Brière, Raphaëlle / Émond, Marce / Benhamed, Axel / Blanchard, Pierre-Gilles / Drolet, Sébastien / Habashi, Rogeh / Golbon, Bahar / Shellenberger, Jonas / Pasternak, Jesse / Merchant, Shaila / La, Julie / Sawhney, Monakshi / Brogly, Susan / Cadili, Lina / Horkoff, Michael / Ainslie, Scott / Demetrick, Jeffrey / Chai, Brian / Wiseman, Kevin /
    Hwang, Hamish / Alhumoud, Zainab / Salem, Amro / Lau, Rebecca / Aw, Katherine / Nessim, Carolyn / Gawad, Nada / Alibhai, Kameela / Towaij, Chelsea / Doan, Danielle / Raîche, Isabelle / Valji, Rahim / Turner, Simon / Balmes, Patricia Nicole / Hameed, S Morad / Tan, Jun Guang Kendric / Wijesuriya, Ruwan / Hew, Nicole Lee Chui / Lund, Matthew / Hawel, Jeffrey / Gregor, Jamie / Leslie, Ken / Lenet, Tori / McIsaac, Daniel / Hallet, Julie / Jerath, Angela / Lalu, Manoj / Nicholls, Stuart / Presseau, Justin / Tinmouth, Alan / Verret, Michael / Wherrett, Christopher / Fergusson, Dean / Martel, Guillaume / Sharma, Sahil / McKechnie, Tyler / Talwar, Gaurav / Patel, Janhavi / Heimann, Luke / Doumouras, Aristithes / Hong, Dennis / Eskicioglu, Cagla / Wang, Christine / Guo, Michael / Huang, Longlong / Sun, Shaun / Davis, Noelle / Wang, Julian / Skulsky, Samuel / Sikora, Lindsey / Son, Hyo Jin / Gee, Denise / Gomez, David / Jung, James / Selvam, Rajajee / Seguin, Nieve / Zhang, Lisa / Lacaille-Ranger, Ariane / Moloo, Husein / Follett, Alicia / Holly / Organ, Michael / Pace, David / Balvardi, Saba / Kaneva, Pepa / Semsar-Kazerooni, Koorosh / Mueller, Carmen / Vassiliou, Melina / Al Mahroos, Mohammed / Fiore, Julio F / Schwartzman, Kevin / Feldman, Liane / Karimuddin, Ahmer / Liu, Gui Ping / Crump, Trafford / Sutherland, Jason / Hickey, Kala / Bonisteel, Erin M / Umali, Jurgienne / Dogar, Ibrahim / Warden, Geoffrey / Boone, Darrell / Mathieson, Alexander / Hogan, Michael / Li, Yiran / Best, Gordon / Leong, Rachel / Wiseman, Sam / Alaoui, Ahmed Amine / Hajjar, Roy / Wassef, Evelyne / Metellus, Danny Sebastien / Dagbert, François / Loungnarath, Rasmy / Ratelle, Richard / Schwenter, Frank / Debroux, Éric / Wassef, Ramses / Gagnon-Konamna, Marianne / Pomp, Alfons / Richard, Carole S / Sebajang, Herawaty / Santos, Manuela M / Shi, Ge / Leung, Regina / Lim, Christina / Knowles, Sarah / Parmar, Simran / Debru, Estifanos / Mohamed, Fardowsa / Anakin, Megan / Lee, Yung / Samarasinghe, Yasith / Khamar, Jigish / Petrisor, Bradley / Yang, Ilun / Mughal, Hanaa N / Bhugio, Mumtaz / Gok, Muhammed A / Khan, Usman A / Fernandes, Alisha R / Spence, Richard / Porter, Geoffrey / Hoogerboord, C Marius / Neumann, Katerina / Pillar, Michal / Manhas, Neraj / Melck, Adrienne / Kazi, Tania / Jessani, Ghazal / Tessier, Léa / Archer, Vicki / Park, Lily / Cohen, Dan / Parpia, Sameer / Bhandari, Mohit / Dionne, Joanna / Bolin, Sara / Afford, Rebecca / Armstrong, Madeleine / Grant, Aaron / Van Koughnett, Julie Ann / Clement, Elizabeth / Lange, Claire / Roshan, Aishwi / Scott, Tracy / Nadeau, Kara / Macmillan, Jennifer / Wilson, Jaime / Deschenes, Madeleine / Nurullah, Aruba / Cahill, Caitlin / Chen, Victoria H / Patterson, Keiko M / Wiseman, Sam M / Wen, Betty / Bhudial, Joshua / Barton, Anise / Lie, Jessica / Park, Chan Mi / Yang, Laiji / Gouskova, Natalia / Kim, Dae Hyun / Morris-Janzen, Dunavan / McLellan, Alastair / Archer, Victoria / Cloutier, Zacharie / Berg, Annie / Wiercioch, Wojtek / Labonté, Joëlle / Bisson, Pascale / Bégin, André / Cheng-Oviedo, Sonia Gabriela / Collin, Yves / Hossain, Intekhab / Ellsmere, James / El-Kefraoui, Charbel / Do, Uyen / Miller, Andrew / Kouyoumdjian, Araz / Cui, David / Khorasani, Elahe / Landry, Tara / Amar-Zifkin, Alexandre / Lee, Lawrence / Fiore, Julio / Au, Tran Michelle / Oppenheimer, Mark / Logsetty, Sarvesh / AlShammari, Raghad / AlAbri, Mohammad / Brown, Carl / Raval, Manoj J / Phang, Paul Terry / Bird, Samantha / Baig, Zarrukh / Abu-Omar, Nawaf / Gill, Dilip / Suresh, Soumiya / Ginther, Nathan / Karpinski, Marta / Ghuman, Amandeep / Malik, Peter R A / Zabolotniuk, Taryn / Mashal, Sarah / Boulanger, Nathalie / Watt, Larry / Razek, Tarek / Fata, Paola / Grushka, Jeremy / Wong, Evan G / Landry, Maxim / Mackey, Sarah / Fairbridge, Nicholas / Greene, Alison / Borgoankar, Mark / Kim, Cullen / DeCarvalho, Diana / Wigen, Robin / Walser, Emily / Davidson, Jacob / Dorward, Michael / Muszynski, Leanne / Dann, Celia / Seemann, Natashia / Lam, Jennifer / Harding, Kaitlyn / Lowik, A J / Guinard, Caroline / Ma, Odelle / Mocanu, Valentin / Lin, Andrea / Karmali, Shahzeer / Bigam, David / Greaves, Grant / Parker, Brent / Nguyen, Vu / Ahmed, Azim / Yee, Belinda / Perren, Joël / Norman, Mathew / Grey, Morgan / Perini, Rafael / Jowhari, Fahd / Bak, Adrian / Drung, Jeremy / Allen, Laura / Wiseman, Daniele / Moffat, Bradley / Lee, Jeremy K H / McGuire, Catherine / Tudorache, Mihaela / Park, Lily J / Borges, Flavia K / Nenshi, Rahima / Jacka, Michael / Heels-Ansdell, Diane / Simunovic, Marko / Bogach, Jessica / Serrano, Pablo E / Thabane, Lehana / Devereaux, P J / Farooq, Sauleha / Lester, Erica / Kung, Janice / Bradley, Nori / Ahn, San / Prince, Nicole / Cheng-Boivin, Olivia / Wang, Harry / Quartermain, Liam / Tan, Sherry / Shamess, Jennifer / Simard, Mathilde / Vigil, Humberto / Hanna, Mary / Azam, Riordan / Ko, Gary / Zhu, Mayanne / Raveendran, Yanuga / Lam, Christine / Tang, Janet / Bajwa, Amrit / Englesakis, Marina / Reel, Emma / Cleland, Jordan / Snell, Laura / Lorello, Gianni / Cil, Tulin / Ahn, Hilalion San / Dube, Catherine / Smith, David / Leclerc, Alexie / Rostom, Alaa / Calo, Natalia / Thavorn, Kednapa / Laplante, Simon / Liu, Louis / Khan, Nadia / Okrainec, Allan / Bruyninx, Gladys / Georgescu, Ilinca / Khokhotva, Vladislav / Yang, Shuling / Spoyalo, Karina / Rebello, Thais Ayres / Chhipi-Shrestha, Gyan / Mayson, Kelly / Sadiq, Rehan / Hewage, Kasun / MacNeill, Andrea / Muncner, Susan / Li, Mo Yu / Mihajlovic, Igor / Dykstra, Mark / Snelgrove, Ryan / Wang, Haili / Schweitzer, Christina / Garcha, Ivneet / Jogiat, Uzair / Baracos, Vickie / Turner, Simon R / Eurich, Dean / Filafilo, Heather / Rouhi, Armin / Bédard, Alexandre / Bédard, Eric L R / Patel, Yogita S / Alaichi, Jacob A / Agzarian, John / Hanna, Wael C / Provost, Esther / Shayegan, Bobby / Adili, Anthony / Mistry, Nikkita / Gatti, Anthony A / Farrokhyar, Forough / Xie, Feng / Sullivan, Kerrie A / Liberman, Moishe / Gonzalez, Anne V / Nayak, Rahul / Yasufuku, Kazuhiro / Cross, Sam / Haché, Pier-Luc / Galvaing, Geraud / Simard, Serge / Grégoire, Jocelyn / Bussières, Jean / Lacasse, Yves / Sassi, Sami / Champagne, Catherine / Laliberté, Anne-Sophie / Jeong, Jin Yong / Wilson, Hillary / Blakely, Pam / Dang, Jerry / Sun, Warren / Wong, Clarence / Hakim, Suhail Yaqoob / Azizi, Samim / El-Menyar, Ayman / Rizoli, Sandro / Al-Thani, Hassan / French, Daniel / Li, Chao / Gossen, Shiloh / Bailey, Jon / Tibbo, Phil / Crocker, Candice / Bondzi-Simpson, Adom / Ribeiro, Tiago / Kidane, Biniam / Ko, Michael / Coburn, Natalie / Kulkarni, Girish / Ramzee, Ahmed Faidh / Afifi, Ibrahim / Alani, Mushrek / Chughtai, Talat / Huo, Bright / Manos, Daria / Xu, Zhaolin / Kontouli, Katerina-Maria / Chun, Samuel / Fris, John / Wallace, Allison M R / French, Daniel G / Giffin, Catherine / Dayan, Gabriel / Farivar, Alexander / Weessies, Cara / Robinson, Madeline / Bednarek, Leeann / Buduhan, Gordon / Liu, Richard / Tan, Lawrence / Srinathan, Sadeesh K / Nasralla, Awrad / Safieddine, Najib / Gazala, Sayf / Simone, Carmine / Ahmadi, Negar / Hilzenrat, Roy / Blitz, Maurice / Deen, Shaun / Humer, Michael / Jugnauth, Anand / Kerr, Laura / Sun, Simon / Browne, Ikennah / Patel, Yogita / Hanna, Wael / Loshusan, Brandon / Shamsil, Arefin / Naish, Michael D / Qiabi, Mehdi / Patel, Rajni / Malthaner, Richard / Pooja, Patel / Roberto, Ribeiro / Greg, Hirsch / Daniel, French / Huynh, Caroline / Sharma, Sohat / Vieira, Arthur / Jain, Fagun / Lee, Yejun / Mousa-Doust, Dorsa / Costa, Jonice / Mezei, Michelle / Chapman, Kristine / Briemberg, Hannah / Jack, Kristin / Grant, Kyle / Choi, James / Yee, John / McGuire, Anna L / Abdul, Sami Aftab / Khazoom, Francois / Gilbert, Sebastien / Sundaresan, Sudhir / Jones, Daniel / Seely, Andrew J E / Villeneuve, Patrick J / Maziak, Donna E / Pigeon, Claudie-Anne / Frigault, Jonathan / Roy, Ève-Marie / Bujold-Pitre, Kristopher / Courval, Valérie / Tessier, Lea / Gangam, Nirupa / Lee, Jay / Patel, Ashaka / Ichhpuniani, Simarpreet / Elder, Geoffrey / Chen, Andrew / Logie, Kathleen / Benko, Randy / Castelo, Matthew / Paszat, Lawrence / Hansen, Bettina / Scheer, Adena / Faught, Neil / Nguyen, Lena / Baxter, Nancy / Wu, Kathy / Passos, Edward / Sachdeva, Anjali / Fei, Linda Y N / Caycedo, Antonio / Patel, Sunil / Popa, Teodora / Boudreau, Lee / Grin, Andrea / Wang, Tao / Phang, Terry / Raval, Manoj / Candy, Sydney / Nanda, Kareena / Li, Christine / Kroeker, Karen / Roy, Haven / Helewa, Ramzi M / Johnson, Garrett / Singh, Harminder / Hyun, Eric / Moffatt, Dana / Vergis, Ashley / Balmes, Patricia / Liu, Jerry / Webber, Sandra / Shariff, Farhana / Hochman, Dave / Park, Jason / Robitaille, Stephan / Wang, Anna / Maalouf, Michael / Alali, Naser / Elhaj, Hiba / Liberman, Sender / Charlebois, Patrick / Stein, Barry / Hu, Richard / Williams, Lara / Musselman, Reilly / Lemke, Maddy / Samarasinghe, Nadeesha / Vogt, Kelly / Brackstone, Muriel / Zwiep, Terry / Alam, Armaghan / Ghuman, Anu / James, Nicholas / Van Koughnett, Julie Ann / Laczko, Dora / Lee, Stephanie / Sritharan, Praveen / Hershorn, Olivia / Phang, P Terry / Chen, Alex / Boutros, Marylise / Caminsky, Natasha / Dumitra, Teodora / Faris-Sabboobeh, Sarah / Demian, Marie / Rigas, Georgia / Monton, Olivia / Smith, Allister / Moon, Jeongyoon / Garfinkle, Richard / Vasilevsky, Carol-Ann / Rajabiyazdi, Fateme / Courage, Emily / LeBlanc, Danielle / Benesch, Matthew / Hartwig, Katia / Armstrong, Casey / Engelbrecht, Reniel / Fagan, Mitchell / Borgaonkar, Mark / Shanahan, Jessica / Salama, Ebram / Arsenault, Mylène / Leon, Nathalie / Loiselle, Carmen / Rajabiyazdi, Fatemeh / Brennan, Kelly / Rai, Mandip / Farooq, Ameer / McClintock, Chad / Kong, Weidong / Boukhili, Neyla / Paradis, Tiffany / Liberman, A Sender / Feldman, Liane S / Abner, Deborah / Alam, Tarik / Beyer, Elaine / Evans, Michele / Hill, Mary / Johnston, Debra / Lohnes, Karla / Menard, Svea / Pitcher, Nicole / Sair, Kelly / Smith, Bev / Yarjau, Bonita / LeBlanc, Kimberly / Karimuddin, Ahmer A / Brown, Carl J / MacDonell, Karen / Harvey, Alexandra / Mckechnie, Tyler / Matta, Mirna / Baker, Laura / Hopkins, Jessica / Rochon, Ryan / Buie, Donald / MacLean, Anthony / Macdonald, Hugh / Wiseman, Vanessa / Booth, Chris / Hann, Tim / Ricci, Alessandro / Kakkar, Rohan / Gonzalez, Emmanuel / Fragoso, Gabriela / Oliero, Manon / Rendos, Hervé Vennin / Djediai, Souad / Cuisiniere, Thibault / Laplante, Patrick / Gerkins, Claire / Ajayi, Ayodeji Samuel / Diop, Khoudia / Taleb, Nassima / Thérien, Sophie / Schampaert, Frédéricke / Alratrout, Hefzi / Cailhier, Jean-François / Routy, Bertrand / Annabi, Borhane / Brereton, Nicholas J B / Richard, Carole / Gimon, Tamara / MacRae, Helen / de Buck van Overstraeten, Anthony / Brar, Mantaj / Chadi, Sami / Kennedy, Erin / Rashanov, Pavel / Alsayari, Rehab / Calvé, Annie / Cuisinière, Thibault / Debroux, Eric / Schmocker, Selina / Stotland, Peter / Jhaveri, Kartik / Kirsch, Richard / Alnajem, Hafssah / Alibrahim, Huseen / Giundi, Christian / Munir, Haroon / Safar, Ali / Sabboobeh, Sarah / Holland, Jessica / Abtahi, Sean / Chhor, Allison / Caminsky, Natasha Grace / Moon, Jenny Jeongyoon / Marinescu, Daniel / Pang, Allison / Al-Abri, Mohammed / Gee, Elliott / Morena, Nina / Ben-Zvi, Libby / Hayman, Victoria / Hou, Mary / Nguyen, Diana / Rentschler, Carrie A / Meguerditchian, Ari N / Mir, Zuhaib / Fei, Linda / McKeown, Sandra / Dinchong, Rachelle / Cofie, Nicholas / Dalgarno, Nancy / Cheifetz, Rona / Jaffer, Alisha / Cullinane, Carolyn / Feeney, Gerard / Jalali, Amirhossein / Merrigan, Anne / Baban, Chwanrow / Buckley, Juliette / Tormey, Shona / Wu, Rongrong / Takabe, Kazuaki / O'Brien, Shalana / Kazazian, Karineh / Abdalaty, Ali Hosni / Brezden, Christine / Burkes, Ron / Chen, Eric / Govindarajan, Anand / Jang, Raymond / Lukovic, Jelena / Mesci, Aruz / Quereshy, Fayez / Swallow, Carol / Marini, Wanda / Zheng, Weiyue / Murakami, Kiichi / Ohashi, Pamela / Reedijk, Michael / Ivankovic, Victoria / Han, Lewis / Gresham, Louise / Mallick, Ranjeeta / Auer, Rebecca / Fontebasso, Adam / Lee, Alex / Bernard-Bedard, Ericka / Wong, Boaz / Li, Heidi / Grose, Elysia / Brandts-Longtin, Olivier / Aw, Katie / Abed, Ahmad / Stevenson, James / Sheikh, Rahat / Chen, Richard / Johnson-Obaseki, Stephanie / Hennessey, Rachel Liu / Meneghetti, Adam T / Bildersheim, Michael / Bouchard-Fortier, Antoine / Nelson, Gregg / Mack, Lloyd / Ghasemi, Farhad / Naeini, Mahtab Malekian / Parsyan, Armen / Kaur, Yuvreet / Covelli, Andrea / Elimova, Elena / Panov, Elan / Brierley, James / Burnett, Bev / Eom, Ashley / Kirkwood, David / Hodgson, Nicole / Whelan, Timothy / Levine, Mark / Parvez, Elena / Ng, Deanna / Lee, Kiera / Lu, Yi Qing / Kim, Dae Kyum / Magalhaes, Marco / Grigor, Emma / Arnaout, Angel / Zhang, Jing / Yee, Elliott K / Look Hong, Nicole J / Wright, Frances C / Gandhi, Sonal / Jerzak, Katarzyna J / Eisen, Andrea / Roberts, Amanda / Ben Lustig, Daniel / Quan, May Lynn / Phan, Tien / Cao, Jeff / Bayley, Conrad / Watanabe, Akie / Yao, Susan / Prisman, Eitan / Groot, Gary / Mitmaker, Elliot / Walker, Ross / Wu, Jonn / Lai, Chi Kien / Eskander, Antoine / Wasserman, Jonathan / Mercier, Frederic / Roth, Kathryn / Gill, Sabrina / Villamil, Carlos / Goldstein, David / Munro, Vicki / Pathak, Alok / Lee, Debon / Nguyen, Anne / Rajendran, Luckshi / Claasen, Marco / Ivanics, Tommy / Selzner, Nazia / McGilvray, Ian / Cattral, Mark / Ghanekar, Anand / Moulton, Carol-Anne / Reichman, Trevor / Shwaartz, Chaya / Metser, Ur / Winter, Erin / Gallinger, Steven / Sapisochin, Gonzalo / Glinka, Juan / Waugh, Evelyn / Skaro, Anton / Tang, Epharaim / Charbonneau, Janyssa / Brind'Amour, Alexandre / Turgeon, Alexis F / O'Connor, Sarah / Couture, Thomas / Wang, Yifan / Yoshino, Osamu / Driedger, Michael / Beckman, Michael / Vrochides, Dionisios / Martinie, John / Alabduljabbar, Abdulrahman / Aali, Maral / Lightfoot, Christopher / Gala-Lopez, Boris / Labelle, Maud / D'Aragon, Frédérick / Hirpara, Dhruvin / Irish, Jonathan / Rashid, Mohammed / Martin, Tharsiya / Zhu, Alice / McKnight, Leah / Hunter, Amber / Jayaraman, Shiva / Wei, Alice / Wright, Frances / Mallette, Katlin / Elnahas, Ahmad / Alkhamesi, Nawar / Schlachta, Christopher / Tang, Ephraim / Punnen, Subin / Zhong, Jade / Yang, Yuwei / Streith, Lucas / Yu, Jordan / Chung, Stephen / Kim, Peter / Chartier-Plante, Stephanie / Segedi, Maja / Bleszynski, Michael / White, Molly / Tsang, Melanie E / Lam-Tin-Cheung, Kimberley / Tsang, Melanie / Greene, Brittany / Pouramin, Panthea / Allen, Susan / Evan Nelson, David / Walsh, Mark / Côté, Julien / Rebolledo, Rolando / Borie, Mélanie / Menaouar, Ahmed / Landry, Carolyne / Plasse, Marylène / Létourneau, Richard / Dagenais, Michel / Rong, Zhixia / Roy, André / Beaudry-Simoneau, Eve / Vandenbroucke-Menu, Franck / Lapointe, Réal / Ferraro, Pasquale / Sarkissian, Shant Der / Noiseux, Nicolas / Turcotte, Simon / Haddad, Yara / Bernard, Antoine / Lafortune, Clara / Brassard, Nathalie / Roy, Annie / Perreault, Claude / Mayer, Gaétan / Marcinkiewicz, Mieczyslaw / Mbikay, Majambu / Chrétien, Michel / Sinclair, Lynne / Shin, Elizabeth / Engelage, Crystal / Muaddi, Hala / Flemming, Jennifer / Dawson, Laura / O'Kane, Grainne / Feld, Jordan / Cleary, Sean / Hamel, Anthonie / Marcoux, Camille / Ngo, Thanh-Quan Philips / Deshaies, Isabelle / Mansouri, Sarah / Amhis, Nawal / Léveillé, Maxime / Lawson, Christine / Achard, Carol / Ilkow, Carolina / Tai, Lee-Hwa / Griffiths, Christopher / D'Souza, Daniel / Rodriguez, Felipe / Panton, O Neely M / Chiu, Chieh Jack / Henao, Oscar / Netto, Fernando Spencer / Mainprize, Marguerite / Jatana, Sukhdeep / Verhoeff, Kevin / Birch, Daniel / Switzer, Noah / Hetherington, Alexandra / Al-Ghaithi, Najla / Vourtzoumis, Phil / Demyttenaere, Sebastian / Court, Olivier / Andalib, Amin / Madsen, Karen / Wu, Ted / He, Wenjing / Hardy, Krista / Zmudzinski, Marta / Daenick, Felica / Linton, Janice / Fowler-Woods, Melinda / Fowler-Woods, Amanda / Shingoose, Geraldine / Molnar, Amber / Nguyen, Francis / Schneider, Romano / Fecso, Andras B / Sharma, Priya / Maeda, Azusa / Jackson, Timothy / McLean, Cheynne / MacVicar, Sarah / McLennan, Steffane / Purich, Kieran / Birch, Daniel W / Switzer, Noah J / Jeffery, Lisa / Ryley, Alexis / Schellenberg, Morgan / Owattanapanich, Natthida / Emigh, Brent / Nichols, Chance / Dilday, Joshua / Ugarte, Chaiss / Onogawa, Atsushi / Matsushima, Kazuhide / Martin, Matthew J / Inaba, Kenji / Shapiro, Doug / Im, Daniel / Lam, Lydia / Rezende-Neto, Joao / Lemke, Madeline / Leeper, William / Walser, Eric / Bateni, Sarah / Barabash, Victoria / Barr, Austin / Chan, Wing / Warraich, Ahmed / Gillman, Lawrence / Ziesmann, Markus / Momic, Jovana / Yassin, Nouf / Kim, Mella / Makish, Amy / Smith, Shane / Ball, Ian / Moffat, Brad / Parry, Neil / Kroeker, Jenna / Evans, David / Fansia, Nahal / Notik, Chana / Coyle, Guire / Seben, David / Smith, Jaiden / Tanenbaum, Brandy / Freedman, Corey / Nathens, Avery / Fowler, Robert / Patel, Prachikumari / Elrick, Tim / Ewing, Meghan / Di Marco, Steven / Engels, Paul / Di Sante, Emily / Vincent, Jessica / Tsiplova, Kate / El-Sayes, Abdullah / Connell, Matthew / Klooster, Amanda / Beck, Jenna / Strickland, Matt / Anantha, Ram / Groszman, Lilly / Caminsky, Natasha G / Livergant, Rachel / McDonald, Brooke / Binda, Catherine / Luthra, Shreya / Ebert, Nicole / Falk, Ryan / Joos, Emilie

    Canadian journal of surgery. Journal canadien de chirurgie

    2023  Volume 66, Issue 6 Suppl 1, Page(s) S54–S136

    Language English
    Publishing date 2023-12-13
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 410651-9
    ISSN 1488-2310 ; 0008-428X
    ISSN (online) 1488-2310
    ISSN 0008-428X
    DOI 10.1503/cjs.014223
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  7. Article: Treatment of patients with substance use disorders, second edition. American Psychiatic Association.

    Kleber, Herbert D / Weiss, Roger D / Anton, Raymond F / Rounsaville, Bruce J / George, Tony P / Strain, Eric C / Greenfield, Shelly F / Ziedonis, Douglas M / Kosten, Thomas R / Hennessy, Grace / O'Brien, Charles P / Connery, Hilary Smith / McIntyre, John S / Charles, Sara C / Anzia, Daniel J / Nininger, James E / Cook, Ian A / Summergrad, Paul / Finnerty, Molly T /
    Woods, Sherwyn M / Johnson, Bradley R / Yager, Joel / Pyles, Robert / Lurie, Lawrence / Cross, C Deborah / Walker, R Dale / Peele, Roger / Barnovitz, Mary Ann / Gray, Sheila Hafter / Shemo, John P D / Saxena, Sunil / Tonnu, Tina / Kunkle, Robert / Albert, Amy B / Fochtmann, Laura J / Hart, Claudia / Regier, Darrel

    The American journal of psychiatry

    2006  Volume 163, Issue 8 Suppl, Page(s) 5–82

    MeSH term(s) Goals ; Humans ; Patient Care Planning ; Psychotherapy/methods ; Psychotropic Drugs/therapeutic use ; Substance-Related Disorders/drug therapy ; Substance-Related Disorders/psychology ; Substance-Related Disorders/therapy
    Chemical Substances Psychotropic Drugs
    Language English
    Publishing date 2006-08
    Publishing country United States
    Document type Guideline ; Journal Article ; Practice Guideline
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
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  8. Article: Treatment of patients with substance use disorders, second edition. American Psychiatric Association.

    Kleber, Herbert D / Weiss, Roger D / Anton, Raymond F / George, Tony P / Greenfield, Shelly F / Kosten, Thomas R / O'Brien, Charles P / Rounsaville, Bruce J / Strain, Eric C / Ziedonis, Douglas M / Hennessy, Grace / Connery, Hilary Smith / McIntyre, John S / Charles, Sara C / Anzia, Daniel J / Cook, Ian A / Finnerty, Molly T / Johnson, Bradley R / Nininger, James E /
    Summergrad, Paul / Woods, Sherwyn M / Yager, Joel / Pyles, Robert / Cross, C Deborah / Peele, Roger / Shemo, John P D / Lurie, Lawrence / Walker, R Dale / Barnovitz, Mary Ann / Gray, Sheila Hafter / Saxena, Sunil / Tonnu, Tina / Kunkle, Robert / Albert, Amy B / Fochtmann, Laura J / Hart, Claudia / Regier, Darrel

    The American journal of psychiatry

    2007  Volume 164, Issue 4 Suppl, Page(s) 5–123

    MeSH term(s) Alcohol-Related Disorders/drug therapy ; Alcohol-Related Disorders/psychology ; Alcohol-Related Disorders/therapy ; Behavior Therapy ; Cocaine-Related Disorders/drug therapy ; Cocaine-Related Disorders/psychology ; Cocaine-Related Disorders/therapy ; Combined Modality Therapy ; Female ; Humans ; Marijuana Abuse/drug therapy ; Marijuana Abuse/psychology ; Marijuana Abuse/therapy ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/psychology ; Opioid-Related Disorders/therapy ; Pregnancy ; Pregnancy Complications/drug therapy ; Pregnancy Complications/psychology ; Pregnancy Complications/therapy ; Psychotherapy/methods ; Psychotropic Drugs/therapeutic use ; Substance-Related Disorders/drug therapy ; Substance-Related Disorders/psychology ; Substance-Related Disorders/therapy ; Tobacco Use Disorder/drug therapy ; Tobacco Use Disorder/psychology ; Tobacco Use Disorder/therapy ; Treatment Outcome
    Chemical Substances Psychotropic Drugs
    Language English
    Publishing date 2007-04
    Publishing country United States
    Document type Journal Article ; Practice Guideline ; Review
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.

    Lawrenson, Kate / Kar, Siddhartha / McCue, Karen / Kuchenbaeker, Karoline / Michailidou, Kyriaki / Tyrer, Jonathan / Beesley, Jonathan / Ramus, Susan J / Li, Qiyuan / Delgado, Melissa K / Lee, Janet M / Aittomäki, Kristiina / Andrulis, Irene L / Anton-Culver, Hoda / Arndt, Volker / Arun, Banu K / Arver, Brita / Bandera, Elisa V / Barile, Monica /
    Barkardottir, Rosa B / Barrowdale, Daniel / Beckmann, Matthias W / Benitez, Javier / Berchuck, Andrew / Bisogna, Maria / Bjorge, Line / Blomqvist, Carl / Blot, William / Bogdanova, Natalia / Bojesen, Anders / Bojesen, Stig E / Bolla, Manjeet K / Bonanni, Bernardo / Børresen-Dale, Anne-Lise / Brauch, Hiltrud / Brennan, Paul / Brenner, Hermann / Bruinsma, Fiona / Brunet, Joan / Buhari, Shaik Ahmad / Burwinkel, Barbara / Butzow, Ralf / Buys, Saundra S / Cai, Qiuyin / Caldes, Trinidad / Campbell, Ian / Canniotto, Rikki / Chang-Claude, Jenny / Chiquette, Jocelyne / Choi, Ji-Yeob / Claes, Kathleen B M / Cook, Linda S / Cox, Angela / Cramer, Daniel W / Cross, Simon S / Cybulski, Cezary / Czene, Kamila / Daly, Mary B / Damiola, Francesca / Dansonka-Mieszkowska, Agnieszka / Darabi, Hatef / Dennis, Joe / Devilee, Peter / Diez, Orland / Doherty, Jennifer A / Domchek, Susan M / Dorfling, Cecilia M / Dörk, Thilo / Dumont, Martine / Ehrencrona, Hans / Ejlertsen, Bent / Ellis, Steve / Engel, Christoph / Lee, Eunjung / Evans, D Gareth / Fasching, Peter A / Feliubadalo, Lidia / Figueroa, Jonine / Flesch-Janys, Dieter / Fletcher, Olivia / Flyger, Henrik / Foretova, Lenka / Fostira, Florentia / Foulkes, William D / Fridley, Brooke L / Friedman, Eitan / Frost, Debra / Gambino, Gaetana / Ganz, Patricia A / Garber, Judy / García-Closas, Montserrat / Gentry-Maharaj, Aleksandra / Ghoussaini, Maya / Giles, Graham G / Glasspool, Rosalind / Godwin, Andrew K / Goldberg, Mark S / Goldgar, David E / González-Neira, Anna / Goode, Ellen L / Goodman, Marc T / Greene, Mark H / Gronwald, Jacek / Guénel, Pascal / Haiman, Christopher A / Hall, Per / Hallberg, Emily / Hamann, Ute / Hansen, Thomas V O / Harrington, Patricia A / Hartman, Mikael / Hassan, Norhashimah / Healey, Sue / Heitz, Florian / Herzog, Josef / Høgdall, Estrid / Høgdall, Claus K / Hogervorst, Frans B L / Hollestelle, Antoinette / Hopper, John L / Hulick, Peter J / Huzarski, Tomasz / Imyanitov, Evgeny N / Isaacs, Claudine / Ito, Hidemi / Jakubowska, Anna / Janavicius, Ramunas / Jensen, Allan / John, Esther M / Johnson, Nichola / Kabisch, Maria / Kang, Daehee / Kapuscinski, Miroslav / Karlan, Beth Y / Khan, Sofia / Kiemeney, Lambertus A / Kjaer, Susanne Kruger / Knight, Julia A / Konstantopoulou, Irene / Kosma, Veli-Matti / Kristensen, Vessela / Kupryjanczyk, Jolanta / Kwong, Ava / de la Hoya, Miguel / Laitman, Yael / Lambrechts, Diether / Le, Nhu / De Leeneer, Kim / Lester, Jenny / Levine, Douglas A / Li, Jingmei / Lindblom, Annika / Long, Jirong / Lophatananon, Artitaya / Loud, Jennifer T / Lu, Karen / Lubinski, Jan / Mannermaa, Arto / Manoukian, Siranoush / Le Marchand, Loic / Margolin, Sara / Marme, Frederik / Massuger, Leon F A G / Matsuo, Keitaro / Mazoyer, Sylvie / McGuffog, Lesley / McLean, Catriona / McNeish, Iain / Meindl, Alfons / Menon, Usha / Mensenkamp, Arjen R / Milne, Roger L / Montagna, Marco / Moysich, Kirsten B / Muir, Kenneth / Mulligan, Anna Marie / Nathanson, Katherine L / Ness, Roberta B / Neuhausen, Susan L / Nevanlinna, Heli / Nord, Silje / Nussbaum, Robert L / Odunsi, Kunle / Offit, Kenneth / Olah, Edith / Olopade, Olufunmilayo I / Olson, Janet E / Olswold, Curtis / O'Malley, David / Orlow, Irene / Orr, Nick / Osorio, Ana / Park, Sue Kyung / Pearce, Celeste L / Pejovic, Tanja / Peterlongo, Paolo / Pfeiler, Georg / Phelan, Catherine M / Poole, Elizabeth M / Pylkäs, Katri / Radice, Paolo / Rantala, Johanna / Rashid, Muhammad Usman / Rennert, Gad / Rhenius, Valerie / Rhiem, Kerstin / Risch, Harvey A / Rodriguez, Gus / Rossing, Mary Anne / Rudolph, Anja / Salvesen, Helga B / Sangrajrang, Suleeporn / Sawyer, Elinor J / Schildkraut, Joellen M / Schmidt, Marjanka K / Schmutzler, Rita K / Sellers, Thomas A / Seynaeve, Caroline / Shah, Mitul / Shen, Chen-Yang / Shu, Xiao-Ou / Sieh, Weiva / Singer, Christian F / Sinilnikova, Olga M / Slager, Susan / Song, Honglin / Soucy, Penny / Southey, Melissa C / Stenmark-Askmalm, Marie / Stoppa-Lyonnet, Dominique / Sutter, Christian / Swerdlow, Anthony / Tchatchou, Sandrine / Teixeira, Manuel R / Teo, Soo H / Terry, Kathryn L / Terry, Mary Beth / Thomassen, Mads / Tibiletti, Maria Grazia / Tihomirova, Laima / Tognazzo, Silvia / Toland, Amanda Ewart / Tomlinson, Ian / Torres, Diana / Truong, Thérèse / Tseng, Chiu-Chen / Tung, Nadine / Tworoger, Shelley S / Vachon, Celine / van den Ouweland, Ans M W / van Doorn, Helena C / van Rensburg, Elizabeth J / Van't Veer, Laura J / Vanderstichele, Adriaan / Vergote, Ignace / Vijai, Joseph / Wang, Qin / Wang-Gohrke, Shan / Weitzel, Jeffrey N / Wentzensen, Nicolas / Whittemore, Alice S / Wildiers, Hans / Winqvist, Robert / Wu, Anna H / Yannoukakos, Drakoulis / Yoon, Sook-Yee / Yu, Jyh-Cherng / Zheng, Wei / Zheng, Ying / Khanna, Kum Kum / Simard, Jacques / Monteiro, Alvaro N / French, Juliet D / Couch, Fergus J / Freedman, Matthew L / Easton, Douglas F / Dunning, Alison M / Pharoah, Paul D / Edwards, Stacey L / Chenevix-Trench, Georgia / Antoniou, Antonis C / Gayther, Simon A

    Nature communications

    2016  Volume 7, Page(s) 12675

    Abstract: A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs ... ...

    Abstract A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10(-20)), ER-negative BC (P=1.1 × 10(-13)), BRCA1-associated BC (P=7.7 × 10(-16)) and triple negative BC (P-diff=2 × 10(-5)). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10(-3)) and ABHD8 (P<2 × 10(-3)). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3'-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk.
    MeSH term(s) Alleles ; Asian People/genetics ; Black People/genetics ; Breast Neoplasms/genetics ; Chromosomes, Human, Pair 19/genetics ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotype ; Humans ; Ovarian Neoplasms/genetics ; Polymorphism, Single Nucleotide ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2016-09-07
    Publishing country England
    Document type Adaptive Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/ncomms12675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers.

    Meeks, Huong D / Song, Honglin / Michailidou, Kyriaki / Bolla, Manjeet K / Dennis, Joe / Wang, Qin / Barrowdale, Daniel / Frost, Debra / McGuffog, Lesley / Ellis, Steve / Feng, Bingjian / Buys, Saundra S / Hopper, John L / Southey, Melissa C / Tesoriero, Andrea / James, Paul A / Bruinsma, Fiona / Campbell, Ian G / Broeks, Annegien /
    Schmidt, Marjanka K / Hogervorst, Frans B L / Beckman, Matthias W / Fasching, Peter A / Fletcher, Olivia / Johnson, Nichola / Sawyer, Elinor J / Riboli, Elio / Banerjee, Susana / Menon, Usha / Tomlinson, Ian / Burwinkel, Barbara / Hamann, Ute / Marme, Frederik / Rudolph, Anja / Janavicius, Ramunas / Tihomirova, Laima / Tung, Nadine / Garber, Judy / Cramer, Daniel / Terry, Kathryn L / Poole, Elizabeth M / Tworoger, Shelley S / Dorfling, Cecilia M / van Rensburg, Elizabeth J / Godwin, Andrew K / Guénel, Pascal / Truong, Thérèse / Stoppa-Lyonnet, Dominique / Damiola, Francesca / Mazoyer, Sylvie / Sinilnikova, Olga M / Isaacs, Claudine / Maugard, Christine / Bojesen, Stig E / Flyger, Henrik / Gerdes, Anne-Marie / Hansen, Thomas V O / Jensen, Allen / Kjaer, Susanne K / Hogdall, Claus / Hogdall, Estrid / Pedersen, Inge Sokilde / Thomassen, Mads / Benitez, Javier / González-Neira, Anna / Osorio, Ana / Hoya, Miguel de la / Segura, Pedro Perez / Diez, Orland / Lazaro, Conxi / Brunet, Joan / Anton-Culver, Hoda / Eunjung, Lee / John, Esther M / Neuhausen, Susan L / Ding, Yuan Chun / Castillo, Danielle / Weitzel, Jeffrey N / Ganz, Patricia A / Nussbaum, Robert L / Chan, Salina B / Karlan, Beth Y / Lester, Jenny / Wu, Anna / Gayther, Simon / Ramus, Susan J / Sieh, Weiva / Whittermore, Alice S / Monteiro, Alvaro N A / Phelan, Catherine M / Terry, Mary Beth / Piedmonte, Marion / Offit, Kenneth / Robson, Mark / Levine, Douglas / Moysich, Kirsten B / Cannioto, Rikki / Olson, Sara H / Daly, Mary B / Nathanson, Katherine L / Domchek, Susan M / Lu, Karen H / Liang, Dong / Hildebrant, Michelle A T / Ness, Roberta / Modugno, Francesmary / Pearce, Leigh / Goodman, Marc T / Thompson, Pamela J / Brenner, Hermann / Butterbach, Katja / Meindl, Alfons / Hahnen, Eric / Wappenschmidt, Barbara / Brauch, Hiltrud / Brüning, Thomas / Blomqvist, Carl / Khan, Sofia / Nevanlinna, Heli / Pelttari, Liisa M / Aittomäki, Kristiina / Butzow, Ralf / Bogdanova, Natalia V / Dörk, Thilo / Lindblom, Annika / Margolin, Sara / Rantala, Johanna / Kosma, Veli-Matti / Mannermaa, Arto / Lambrechts, Diether / Neven, Patrick / Claes, Kathleen B M / Maerken, Tom Van / Chang-Claude, Jenny / Flesch-Janys, Dieter / Heitz, Florian / Varon-Mateeva, Raymonda / Peterlongo, Paolo / Radice, Paolo / Viel, Alessandra / Barile, Monica / Peissel, Bernard / Manoukian, Siranoush / Montagna, Marco / Oliani, Cristina / Peixoto, Ana / Teixeira, Manuel R / Collavoli, Anita / Hallberg, Emily / Olson, Janet E / Goode, Ellen L / Hart, Steven N / Shimelis, Hermela / Cunningham, Julie M / Giles, Graham G / Milne, Roger L / Healey, Sue / Tucker, Kathy / Haiman, Christopher A / Henderson, Brian E / Goldberg, Mark S / Tischkowitz, Marc / Simard, Jacques / Soucy, Penny / Eccles, Diana M / Le, Nhu / Borresen-Dale, Anne-Lise / Kristensen, Vessela / Salvesen, Helga B / Bjorge, Line / Bandera, Elisa V / Risch, Harvey / Zheng, Wei / Beeghly-Fadiel, Alicia / Cai, Hui / Pylkäs, Katri / Tollenaar, Robert A E M / Ouweland, Ans M W van der / Andrulis, Irene L / Knight, Julia A / Narod, Steven / Devilee, Peter / Winqvist, Robert / Figueroa, Jonine / Greene, Mark H / Mai, Phuong L / Loud, Jennifer T / García-Closas, Montserrat / Schoemaker, Minouk J / Czene, Kamila / Darabi, Hatef / McNeish, Iain / Siddiquil, Nadeem / Glasspool, Rosalind / Kwong, Ava / Park, Sue K / Teo, Soo Hwang / Yoon, Sook-Yee / Matsuo, Keitaro / Hosono, Satoyo / Woo, Yin Ling / Gao, Yu-Tang / Foretova, Lenka / Singer, Christian F / Rappaport-Feurhauser, Christine / Friedman, Eitan / Laitman, Yael / Rennert, Gad / Imyanitov, Evgeny N / Hulick, Peter J / Olopade, Olufunmilayo I / Senter, Leigha / Olah, Edith / Doherty, Jennifer A / Schildkraut, Joellen / Koppert, Linetta B / Kiemeney, Lambertus A / Massuger, Leon F A G / Cook, Linda S / Pejovic, Tanja / Li, Jingmei / Borg, Ake / Öfverholm, Anna / Rossing, Mary Anne / Wentzensen, Nicolas / Henriksson, Karin / Cox, Angela / Cross, Simon S / Pasini, Barbara J / Shah, Mitul / Kabisch, Maria / Torres, Diana / Jakubowska, Anna / Lubinski, Jan / Gronwald, Jacek / Agnarsson, Bjarni A / Kupryjanczyk, Jolanta / Moes-Sosnowska, Joanna / Fostira, Florentia / Konstantopoulou, Irene / Slager, Susan / Jones, Michael / Antoniou, Antonis C / Berchuck, Andrew / Swerdlow, Anthony / Chenevix-Trench, Georgia / Dunning, Alison M / Pharoah, Paul D P / Hall, Per / Easton, Douglas F / Couch, Fergus J / Spurdle, Amanda B / Goldgar, David E

    Journal of the National Cancer Institute

    2015  Volume 108, Issue 2

    Abstract: Background: The K3326X variant in BRCA2 (BRCA2*c.9976A>T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations ...

    Abstract Background: The K3326X variant in BRCA2 (BRCA2*c.9976A>T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations might account for this association. There is scant information about the effect of K3326X in other hormone-related cancers.
    Methods: Using weighted logistic regression, we analyzed data from the large iCOGS study including 76 637 cancer case patients and 83 796 control patients to estimate odds ratios (ORw) and 95% confidence intervals (CIs) for K3326X variant carriers in relation to breast, ovarian, and prostate cancer risks, with weights defined as probability of not having a pathogenic BRCA2 variant. Using Cox proportional hazards modeling, we also examined the associations of K3326X with breast and ovarian cancer risks among 7183 BRCA1 variant carriers. All statistical tests were two-sided.
    Results: The K3326X variant was associated with breast (ORw = 1.28, 95% CI = 1.17 to 1.40, P = 5.9x10(-) (6)) and invasive ovarian cancer (ORw = 1.26, 95% CI = 1.10 to 1.43, P = 3.8x10(-3)). These associations were stronger for serous ovarian cancer and for estrogen receptor-negative breast cancer (ORw = 1.46, 95% CI = 1.2 to 1.70, P = 3.4x10(-5) and ORw = 1.50, 95% CI = 1.28 to 1.76, P = 4.1x10(-5), respectively). For BRCA1 mutation carriers, there was a statistically significant inverse association of the K3326X variant with risk of ovarian cancer (HR = 0.43, 95% CI = 0.22 to 0.84, P = .013) but no association with breast cancer. No association with prostate cancer was observed.
    Conclusions: Our study provides evidence that the K3326X variant is associated with risk of developing breast and ovarian cancers independent of other pathogenic variants in BRCA2. Further studies are needed to determine the biological mechanism of action responsible for these associations.
    MeSH term(s) Adult ; Aged ; BRCA2 Protein/genetics ; Breast Neoplasms/genetics ; Codon, Terminator ; Female ; Genetic Predisposition to Disease ; Heterozygote ; Humans ; Logistic Models ; Lysine/genetics ; Male ; Middle Aged ; Neoplasm Invasiveness ; Odds Ratio ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Polymorphism, Single Nucleotide ; Prostatic Neoplasms/genetics ; Risk Assessment ; Risk Factors
    Chemical Substances BRCA2 Protein ; BRCA2 protein, human ; Codon, Terminator ; Lysine (K3Z4F929H6)
    Language English
    Publishing date 2015-11-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djv315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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